Assessing fault activity in regions lacking Quaternary sedimentary constraints remains a global challenge. In this study, we used channel slope distribution to examine variations in rock uplift along faults. By comparing channel steepness with published low-temperature thermochronology and paleo-seismic data, we identified deformation changes both perpendicular to and along the Longmen Shan at various time scales. Our data revealed distinct fault segments displaying distinct thrust activities along the Longmen Shan’s strike. In the southern segment, the Dachuan fault exhibited the highest activity, and its movement had persisted for millions of years. In the central segment, the Wenchuan fault was active during theearly Quaternary but has become dormant since the late Pleistocene. Within the past millions of years, the Yingxiu and Pengguan faults displayed significant vertical displacement. Fault activity in the northern Longmen Shan was relatively weak, with the Qingchuan fault transitioning from thrust movement during the Neogene to pure strike-slip activity since the Pleistocene. Overall, the Dachuan and Huya faults exhibited deformation patterns similar to the Yingxiu fault during the Quaternary. Similar to the Yingxiu fault, which triggered the Wenchuan earthquake, the Dachuan and Huya faults possess the capacity to produce significant earthquakes in the future. The variations in deformation perpendicular to and along the Longmen Shan fault system underscore the importance of upper crustal shortening in shaping the rock uplift patterns and topography of the eastern Tibetan Plateau margin.