ABSTRACT Transgender and gender non-conforming (TGNC) individuals experience greater social adversity and negative social determinants of health compared to cisgender people. This study explored housing security and service use within a probability-based, nationally representative sample. Respondents were adults (264 TGNC; 23,096 cisgender) from the U.S. Federal Reserve Survey of Household Economics and Decision-making. Chi-square and multiple logistic regression analyses compared differences between TGNC and cisgender respondents for housing security indicators and government housing support use. Multivariable analyses were weighted for complex sampling design. Despite a large proportion of TGNC respondents reporting inability to pay their bills (27.9%) and not being homeowners (62.0%), utilization rates for government housing assistance were low (10.4%). Adjusting for covariates, TGNC respondents had significantly greater odds of reporting governmental housing assistance (aOR = 2.64, 95%CI = 1.52–4.60) than cisgender respondents. There was no difference in ability to pay bills or homeownership. Findings indicate that government housing services are reaching TGNC adults relative to cisgender results, but utilization rates remain low despite indicators of high need. Factors influencing utilization and efficacy of services should be assessed in future research to support policy implementation.