Secure Message Transmission (SMT) is a two-party cryptographic protocol by which the sender can securely and reliably transmit messages to the receiver using multiple channels. An adversary can corrupt a subset of the channels and commit eavesdropping and tampering attacks over the channels. In this work, we introduce a game-theoretic security model for SMT in which adversaries have some preferences for protocol execution. We define rational “timid” adversaries who prefer to violate security requirements but do not prefer the tampering to be detected. First, we consider the basic setting where a single adversary attacks the protocol. We construct perfect SMT protocols against any rational adversary corrupting all but one of the channels. Since minority corruption is required in the traditional setting, our results demonstrate a way of circumventing the cryptographic impossibility results by a game-theoretic approach. Next, we study the setting in which all the channels can be corrupted by multiple adversaries who do not cooperate. Since we cannot hope for any security if a single adversary corrupts all the channels or multiple adversaries cooperate maliciously, the scenario can arise from a game-theoretic model. We also study the scenario in which both malicious and rational adversaries exist.