Secukinumab For Treatment Of Psoriasis Research Articles

Societal economic impact of use secukinumab for treatment of psoriasis in Germany "potentially significant"

Societal economic impact of use secukinumab for treatment of psoriasis in Germany "potentially significant"

18540 Real-world evidence of secukinumab in psoriasis treatment: A meta-analysis of 43 studies

Introduction: Meta-analyses of real-world evidence (RWE) studies provide valuable insights from unselected patient populations in routine clinical practice. Secukinumab, the first fully human monoclonal antibody that selectively neutralizes IL-17A, has shown long lasting effectiveness and safety in moderate to severe plaque psoriasis (PsO). Since its license approval in 2015, many RWE studies have been published. Here, we reviewed all available literature on RWE studies involving secukinumab in patients with moderate to severe PsO to evaluate its effectiveness, drug survival and safety.

A review of secukinumab in psoriasis treatment.

Psoriasis is a systemic immunologic disorder associated with decreased quality of life and numerous co-morbidities, including psoriatic arthritis and cardiovascular disease. Secukinumab, a fully human IgG1 monoclonal antibody, selectively binds IL-17A and is approved by the US FDA and European Medicines Agency for moderate-to-severe plaque psoriasis and psoriatic arthritis. This review examines the efficacy and safety of secukinumab for the treatment of psoriasis using the literature retrieved from the PubMed database. In clinical trials, treatment with secukinumab led to rapid and sustained improvement in Psoriasis Area and Severity Index (PASI) scores, with PASI 90 response rates up to 68.5% at 5 years. Long-term clinical trial and real-world data have established secukinumab as a safe and effective treatment for psoriasis.

Real-world evidence of secukinumab in psoriasis treatment - a meta-analysis of 43 studies.

Real-world evidence (RWE) meta-analyses provide valuable insights from patients in routine clinical practice. Secukinumab, the first fully human monoclonal antibody that neutralizes IL-17A, has shown long-lasting effectiveness and safety in plaque psoriasis (PsO). Since its licence approval in 2015, many RWE studies have been published. The objective of this study was to review all available literature on RWE studies with secukinumab and the secukinumab arm of comparator studies in patients with moderate-to-severe PsO to evaluate its effectiveness, drug survival and safety. https://www.embase.com and https://clinicaltrials.gov databases were searched using prespecified inclusion criteria between 1 January 2015 and 31 May 2019. Using a meta-package and R statistical software to analyse data, key outcomes were measured at 3, 6 and 12months. PASI and DLQI score data were recorded for patients who remained on secukinumab treatment. Overall, 43 studies were included. Drug survival was 90% at 3 and 6months, and 80% at 12months. At 12months, 8% of patients had discontinued treatment due to lack of effectiveness. At 3, 6 and 12months, Psoriasis Area and Severity Index (PASI) 90 scores were as follows: 50%, 53% and 60%, and PASI 100 scores were 36%, 46% and 51%, respectively. At 3, 6 and 12months, 57%, 55% and 65% of patients achieved a Dermatology Life Quality Index (DLQI) score of 0 or 1, respectively. Adverse events were consistent with rates observed in clinical trials with no new safety signals. This meta-analysis strengthens existing evidence on the clinical effectiveness of secukinumab in patients with moderate-to-severe PsO, demonstrating high drug survival rates, high levels of patient-reported outcomes, and good tolerance.

Secukinumab for psoriasis in a patient with hepatitis B

The case reported describes a 48-year-old man with congenital hepatitis B receiving secukinumab for treatment of psoriasis. Some biologic therapies have been associated with an increased risk of reactivation of hepatitis B. In the case of this patient, secukinumab has successfully managed his psoriasis without evidence of hepatitis B virus reactivation.