Abstract Public research institutes (PRIs) are pivotal in national and sectoral innovation systems and the transition to a knowledge-based economy. So, the current study has reassessed these institutes’ functions and suggested policy recommendations to augment their influence in moving toward a knowledge-based economy. The findings of this research reveal that functions such as innovation hub and specialized accelerator; strategic and problem-oriented research management platform; standard and regulatory reference; specialized technical service center; center for cooperation, transfer, and dissemination of technology; and the hub of technology and policy intelligence in a specific industrial sector are crucial functions of PRIs in transitioning to a knowledge-based economy. Additionally, to foster a conducive environment for the influence of PRIs in actualizing a knowledge-based economy, policies related to governance and division of responsibilities, stimulation of both supply and demand sides, strengthening the linkage between the supply and demand sides, and provisioning supportive environment and infrastructure are recommended.
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