Digitization, digitalization, and digital transformation are the levels and stages of digital technology application development. Digital transformation involves using digital data and technology to fundamentally and comprehensively change all aspects of socio-economic life, reshaping the way work is done and relationships are formed in society. Digital transformation in Vietnam is taking place in many fields such as commerce, tourism, business, finance, and education. Vietnam's Ministry of Education and Training has policies, regulations, and programs to promote digital transformation in the industry, from nurse-school education, primary education, secondary education, high school education, vocational education, and higher education. This paper employs quantitative research methods to construct a model investigating the factors influencing digital transformation in the education sector in Vietnam through surveys of educational managers, lecturers, and learners. From data collected with 193 valid responses, using SPSS.22 to process data analyze data, and formulate regression equations the study identified five factors influencing digital transformation in the higher education sector in Vietnam, including Infrastructure resources, Information technology, and the Internet, Government policies, Human Resources, and Readiness for Digital Transformation. The study proposes a few recommendations to relevant parties such as the government, universities, and learners in building and operating digital transformation in teaching and learning at universities.