Secretarial Help Research Articles

Foreword: Critical Alternatives

<div class="page" title="Page 1"><div class="layoutArea"><div class="column"><p><span>1975-1985-1995-2005 — the decennial Aarhus conferences have traditionally been instrumental for setting new agendas for critically engaged thinking about information technology. The conference series is fundamentally interdisciplinary and emphasizes thinking that is firmly anchored in action, intervention, and schol- arly critical practice. With the title Critical Computing – between sense and sen- sibility, the 2005 edition of the conference marked that computing was rapidly seeping into everyday life. </span></p><p><span>In 2015, we see critical alternatives in alignment with utopian principles—that is, the aspiration that life might not only be different but also radically better. At the same time, radically better alternatives do not emerge out of nowhere: they emerged from contested analyses of the mundane present and demand both commitment and labor to work towards them. Critical alternatives matter and make people reflect. </span></p><p><span>The fifth decennial Aarhus conference, Critical Alternatives, in 2015 aims to set new agendas for theory and practice in computing for quality of human life. While the early Aarhus conferences, from 1975 and onwards, focused on computing in working life, computing today is influencing most parts of human life (civic life, the welfare state, health, learning, leisure, culture, intimacy, ...), thereby calling for critical alternatives from a general quality of life perspective. </span></p><p><span>The papers selected for the conference have undergone a meticulous reviewing process looking at methodical soundness as well as potentials for the creating alternatives and provoking debate. Among 71 full and short paper submissions 21 were accepted. The accepted papers span a broad range of positions and concerns ranging from play to politics. </span></p><p><span>We would like to express great thanks for help and support to the numerous peo- ple who have contributed to making the conference possible. In particular we want to thank Marianne Dammand and Ann Mølhave for secretarial help, including reg- istration and hotel arrangements. We want to thank the center for Participatory IT (PIT) and the Department of Computer Science, University of Aarhus for providing resources for the planning and operation of the conference. </span></p><p><span>We hope that the conference will inspire critical and alternative thinking and action for the next decennium. </span></p></div></div></div>

Announcement

Book Reviews Editor or Editors The Editorial Board of Sociology of Health and Illness, on behalf of the Foundation for the Sociology of Health and Illness, are seeking to appoint a Book Reviews Editor or Editors to take up a three-year term of office from 1st October 2014. An honorarium (agreed by the Foundation for the Sociology of Health and Illness) is payable for the above duties. This is currently £1,000 per annum. Book review copy is required seven times per year. Copy usually needs to be supplied in a form that is acceptable to the copy editor (i.e. double spaced). The copy editor serves as an intermediary between the Book Reviews Editor and the publisher, and close co-operation between all these parties is necessary. Completing these tasks takes about one half day per week. Good reliable secretarial help is essential, and reasonable office costs are reimbursed up to £500 per annum. This could include contracted secretarial help. Applicants should be aware that writing book reviews is rarely regarded as an academic priority, and identifying and chasing up reviewers can be time consuming. Candidates for the post should have a track record of writing book reviews themselves, some previous editorial experience, involvement with the BSA medical sociology community and ideally also experience of working with academic journals and an international network of academic and health related contacts. The post can be jointly held, in which case the honorarium and duties are shared as agreed by the post holders, and the appointment is made to both named Book Reviews Editors. The team strongly encourage a joint post of two editors, given the time required to fulfil the role. At the end of one three-year term of office, the Editorial Board can invite the Editor or Editors to continue for one further three-year term of office, should the Editor (or both Editors, in the case of a joint appointment) wish to continue. In the case of joint appointments, if one Editor leaves or resigns, the Board can in exceptional cases co-opt a joint Book Reviews Editor for the remainder of the remaining Editor's term. However, at the end of that term the Editorial Board will open up the post to other applicants as well.

Announcement

Book Reviews Editor or Editors The Editorial Board of Sociology of Health and Illness, on behalf of the Foundation for the Sociology of Health and Illness, are seeking to appoint a Book Reviews Editor or Editors to take up a three-year term of office from 1st October 2014. An honorarium (agreed by the Foundation for the Sociology of Health and Illness) is payable for the above duties. This is currently £1,000 per annum. Book review copy is required seven times per year. Copy usually needs to be supplied in a form that is acceptable to the copy editor (i.e. double spaced). The copy editor serves as an intermediary between the Book Reviews Editor and the publisher, and close co-operation between all these parties is necessary. Completing these tasks takes about one half day per week. Good reliable secretarial help is essential, and reasonable office costs are reimbursed up to £500 per annum. This could include contracted secretarial help. Applicants should be aware that writing book reviews is rarely regarded as an academic priority, and identifying and chasing up reviewers can be time consuming. Candidates for the post should have a track record of writing book reviews themselves, some previous editorial experience, involvement with the BSA medical sociology community and ideally also experience of working with academic journals and an international network of academic and health related contacts. The post can be jointly held, in which case the honorarium and duties are shared as agreed by the post holders, and the appointment is made to both named Book Reviews Editors. The team strongly encourage a joint post of two editors, given the time required to fulfil the role. At the end of one three-year term of office, the Editorial Board can invite the Editor or Editors to continue for one further three-year term of office, should the Editor (or both Editors, in the case of a joint appointment) wish to continue. In the case of joint appointments, if one Editor leaves or resigns, the Board can in exceptional cases co-opt a joint Book Reviews Editor for the remainder of the remaining Editor's term. However, at the end of that term the Editorial Board will open up the post to other applicants as well.

Early repolarization in arrhythmogenic left ventricular cardiomyopathy: insights from cardiac magnetic resonance imaging

Poitiers, Poitiers, France) for secretarial help, Elodie Rogeon (Inserm CIC0802, Poitiers, France) for organizational help and S. Brishoual and G. Mauco (Inserm1082 andBiochemistryDepartment, Poitiers, France) for biological determinations. Adjudication committee members are thanked for their excellent work: type 2 diabetes classification (SH, PJS, Xavier Piguel and Florence Torremocha, Endocrinology department — Poitiers, France), and cardiovascular disease classification (AM, SH, PS). We are grateful to Kurt Liittschwager— Alex Edelman and Associates (Malakoff, France) for editing the English of the manuscript.

Whose letter is it anyway?: an assessment of secretarial involvement in Lady Elizabeth Hatton’s correspondence

Having secretarial help with correspondence was prevalent amongst both the illiterate and the aristocratic, and this practice has been discussed by researchers such as James Daybell. The letters of Lady Elizabeth Hatton are unusual because her secretary is identified as Sir John Holles, which enables the impact of his involvement to be analysed rather than just theorised. The first section of the article uses comparative texts by Holles to try and verify whether or not he was involved in writing those of Hatton’s letters for which he is not explicitly acknowledged. The second section attempts to quantify that involvement by determining whether Hatton would have garnered any benefit from Holles’ handwriting, knowledge of conventions, lexicon, or spelling. The final section traces the changing nature of their relationship to investigate what extra-textual benefits employing Holles may have provided for Hatton and, conversely, the effect of Holles’ own agenda on Hatton’s texts. Holles had earlier been prosecuted by Hatton’s husband, Sir Edward Coke, and openly expressed his hate for the man, both to Hatton and to others. Although it is not possible to retrospectively reconstruct the relative proportions of intellectual input of the two parties into any given text, this article takes a multi-faceted approach to try and unpick the complex issues around authorship and textual ownership.

PROFESSOR MICHAEL WILLIAMS 1935–2009

PROFESSOR MICHAEL WILLIAMS 1935–2009

On the expanding, then contracting scope of scientific publications

My great-grandfather was a professor of theology at the University of Bern and a prolific author of scientific papers and books in the late 19th and early 20th century. For his documentation, he used paper slips of 7 × 15.5 cm, which were specially manufactured according to his specifications. These papers might seem rather tiny, but they were large enough for his hand-written records of theological and historical documents. Obviously, the papers gave him enough space for capturing important biblical messages and divine inspiration. I did not know my great-grandfather personally as he died several years before I was born. But I inherited a large box of his paper slips and, although I have used lots of them over the past 50 years, plenty remain. I find them useful not for archiving purposes, but for momentarily jotting down facts, thoughts and ideas before I forget them. Scientific documentation was an arduous task until the 1960s. It meant going to a library, finding journals and books, extracting the relevant information from these documents and writing it down on paper – be it on paper slips (like my great-grandfather did), on file cards or in notebooks. Photographic reproduction of documents was expensive and restricted to exceptional cases. Few scholars had direct access to good libraries and even fewer could count on secretarial help with copying and archiving information. As many scientific papers were published in …

Letter from the Board of Directors of Astronomy & Astrophysics

1. New A&A memberships and scientific editorial structure for the Letters section At its meeting in Tartu, Estonia on 8 May 2004, the A&A Board of Directors decided to grant observer status on the Board to Brazil, Chile, and Portugal (Sandqvist 2004, A&A, 426, E15). Then on 6–7 May 2005, at its meeting in La Laguna, Spain, the Board of Directors admitted these three countries to full membership in A&A, starting 1 January 2006. The Letters Editor, Dr. P. Schneider, will complete his terms of service on 31 January 2006. A&A is indebted to him for his thoughtful and competent editing over the past several years. As a consequence of his departure, the Board has decided to restructure the manner in which the Letters will be handled as of 1 January 2006. The Associate Editor-in-Chief, Dr. M. Walmsley, will also become Editor-in-Chief for the Letters, and he will forward the Letters to the appropriate topical Associate Editor to organize the reviewing process. Likewise, the Editor-in-Chief, Dr. C. Bertout, will become the Associate Letters-Editor-in-Chief. This change will permit a more specialized treatment of Letters in the future and also allow Letters to benefit from language editing. Hence, after 1 January 2006, manuscripts for Letters should be submitted via the A&A Manuscript Management System (MMS) that is already in place for Main Journal submissions. Letters submitted before that will be handled by the current Letters Editor even after 1 January 2006. 2. New Associate Editor positions Considering both the increased workload on the Associate Editors due to the above change and the continuing specialization of sub-fields in astronomy, the Board decided to open two new positions for Associate Editors, one specialized in Cosmology with a particular interest in theoretical aspects and the other in Observational Stellar Physics . Applications are invited for these two new positions. The Associate Editors are expected to have a broad knowledge of astronomy and astrophysics and to have expertise in one of these two sub-fields. Candidates should have a strong record of published research in astronomy and astrophysics, should have experience as a referee and/or journal editor, and be prepared to commit the time needed to oversee the peer review of up to three hundred papers per year. Limited support for office equipment and secretarial help, as well as an annual indemnity, will be provided to the Associate Editors, and the initial term of appointment is three years. Applicants should submit a curriculum vitae, a list of publications, and a concise covering letter that summarizes the candidate's qualifications and the reasons for seeking an Associate Editor position. The likelihood of support from the home institute for the task should also be discussed in the application. Applications should preferably be e-mailed or sent/faxed to the Chairman of the Board of Directors: Dr. Georges Meynet, Geneva Observatory, 1290 Sauverny, Switzerland, email georges.meynet@obs.unige.ch, Fax:+41 22 37 92205. Applications received by 1 October 2005 will receive full consideration, while informal inquiries about the positions may be directed by e-mail to Georges Meynet. On behalf of the Board of Directors Georges Meynet

Ambulatory Blood Pressure for Cardiovascular Risk Stratification

Ambulatory blood pressure (ABP) monitoring is increasingly recognized as a valuable tool to refine prediction of cardiovascular risk related to blood pressure (BP).1 After the first landmark study published by Perloff and colleagues 24 years ago,2 several longitudinal event-based studies provided unequivocal evidence of an independent association between ABP and risk of cardiovascular disease. Although experimental procedures and statistical analyses varied from study to study, ABP generally improved cardiovascular risk stratification over and beyond traditional risk factors, including clinic BP.3 The Table, obtained through an electronic search of literature using the terms “ambulatory blood pressure” and “prognosis,” shows a list of longitudinal event-based studies performed by independent groups. It is worth noting that the list of available studies is longer because each group generally published other analyses of their database. Only the first-appearing or main contribution from each group has been included in the Table. View this table: Longitudinal Event-Based Studies From Independent Groups That Addressed the Prognostic Value of ABP Article p 2145 Three aspects of available investigations deserve special mention. First, the prognostic value of ABP has been examined not only in subjects with clinical diagnosis of hypertension but also in the general population and in a variety of settings, including diabetes mellitus, renal failure, and cerebrovascular disease. Second, subjects could be untreated or treated at the time of ABP monitoring. This point may raise concerns, because drug treatment could exert unpredictable effects on 24-hour ABP profile and, consequently, interpretation and applicability of results. Third, although a continuous relation emerged in most studies between ABP and cardiovascular risk, several investigators tried to define clinical categories based on arbitrary thresholds of ABP. Although such categories are potentially useful to make diagnostic and therapeutic decisions in clinical practice, their prognostic role requires confirmation from large and independent cohort …

Anomeric Specificity of the Stimulatory Effect ofd-Glucose on d-Fructose Phosphorylation by Human Liver Glucokinase

D-Glucose was recently reported to stimulate d-fructose phosphorylation by human B-cell glucokinase. The present study aims at investigating the anomeric specificity of such a positive cooperativity. The alpha-anomer of D-glucose was found to increase much more markedly than beta-D-glucose the phosphorylation of D-fructose by human liver glucokinase. Such an anomeric preference diminished at high concentrations of the D-glucose anomers, i.e. when the effect of the aldohexose upon d-fructose phosphorylation became progressively less marked. A comparison between the effects of the two anomers of D-glucose and those of equilibrated D-glucose upon D-fructose phosphorylation by human liver glucokinase indicated that the results obtained with the equilibrated aldohexose were not significantly different from those expected from the combined effects of each anomers of D-glucose. In isolated rat islets incubated for 60 min at 4 degrees C, alpha-D-glucose (5.6 mm), but not beta-D-glucose (also 5.6 mm), augmented significantly the conversion of D-[U-(14)C]fructose (5.0 mm) to acidic radioactive metabolites. Likewise, in islets prelabeled with (45)Ca and perifused at 37 degrees C, D-fructose (20.0 mm) augmented (45)Ca efflux and provoked a biphasic stimulation of insulin release from islets exposed to alpha-D-glucose (5.6 mm), while inhibiting (45)Ca efflux and causing only a sluggish and modest increase in insulin output from islets exposed to beta-D-glucose (also 5.6 mm). The enhancing action of D-glucose upon D-fructose phosphorylation by glucokinase thus displays an obvious anomeric preference for alpha-D-glucose, and such an anomeric specificity remains operative in intact pancreatic islets.

A Five-Year Experience of a Short Stay Observation Unit in Saudi Arabia

A Five-Year Experience of a Short Stay Observation Unit in Saudi Arabia

Preface

This twelfth volume of Annual Review of Heat Transfer marks the beginning of an expanded editorial team that is committed to maintaining the fine tradition of this series by providing improved and timely communications on new and important developments in the field of heat transfer. The theory and practice of heat transfer have been significantly broadened in recent years, particularly in biomedical engineering and biotechnology, micro- and nano-technologies, energy-efficient processes and systems, and in materials technologies such as laser and plasma processing. While continuing to feature advancements in the fundamentals of heat transfer, the editors will give special attention to presenting state-of-the-art reviews on topics of interest in such rapidly evolving areas of technology. The present volume starts with a review of the advances and challenges in micro and miniaturized heat pipes, which are being used for heat dissipation in many modern communication and computing systems. The second article deals with heat transfer in low energy plasmas used for microelectronic manufacturing, while the third article reviews heat transfer and phase-change during high-power, pulsed laser ablation of metals, as in thin film deposition, micro-machining and the synthesis of nanomaterials. Processing of thermoplastic, matrix composite materials, which involves complex, multi-scale heat and mass transfer, is considered in the fourth article, the next two articles deal with heat transfer in crystal growth, a precursor for electronic and opto-electronic device fabrication. The first of these articles treats convective instabilities under various growth conditions, while the second article considers the effects of an applied magnetic field on growth phenomena, associated hydrodynamics and the control of flow instability. The last article of this volume reviews the fundamentals of interferometric tomography and application of the technique to three-dimensional temperature measurement. The editors would like to thank the participating authors for their valuable contributions, to Begell House for editorial assistance, to Nancy Hughes of UC Berkeley and Alina Stroia of SUNY Stony Brook for their secretarial help, and to the thermal science and processing community for their continued support and input.

Proximity of two oppositely oriented reentrant loops in the glutamate transporter GLT-1 identified by paired cysteine mutagenesis.

Sodium- and potassium-coupled transporters clear the excitatory neurotransmitter glutamate from the synaptic cleft. Their function is essential for effective glutamatergic neurotransmission. Glutamate transporters have an unusual topology, containing eight membrane-spanning domains and two reentrant loops of opposite orientation. We have introduced pairwise cysteine substitutions in several structural elements of the GLT-1 transporter. A complete inhibition of transport by Cu(II)(1,10-phenanthroline)(3) is observed in the double mutants A412C/V427C and A364C/S440C, but not in the corresponding single mutants. No inhibition is observed in more then 20 other double cysteine mutants. The Cu(II)(1,10-phenanthroline)(3) inhibition can be partly prevented by the nontransportable glutamate analogue dihydrokainate. Treatment with dithiothreitol restores much of the transport activity. Moreover, micromolar concentrations of cadmium ions reversibly inhibit transport catalyzed by A412C/V427C and A364C/S440C double mutants, but not by the corresponding single mutants. Inhibition by Cu(II)(1,10-phenanthroline)(3) and by cadmium is only observed when the cysteine pairs are introduced in the same polypeptide. Therefore, in both cases the proximity appears to be intra- rather than intermolecular. Positions 364 and 440 are located on reentrant loop I and II, respectively. Our results suggest that these two loops, previously shown to be essential for glutamate transport, come in close proximity.

Pre-anesthetic assessment clinics in Ontario.

To survey the provision of pre-anesthetic assessment clinics in hospitals in Ontario during the summer of 1997. Mail survey questionnaire of all 300 hospitals in Ontario. Replies were received from 260 hospitals (86.7%) of which 131 provide anesthesia. Of these, 86% are community and 14% teaching hospitals. Regular clinics are held in 63% of these hospitals, most commonly daily. As to location, 73% are held in the outpatient department. Written guidelines detailing which patients should be referred are issued by 77% of departments. The attending surgeon is the most common source of referral (64%). Referred patients are most commonly seen by a nurse (52%) who decides on onward referral to an anesthesiologist. Services generating the most referrals are general surgery (83%), orthopedics (64%) and obstetrics/gynecology (49%). In 47% of hospitals 10-50 patients are seen per month and they travel most commonly up to 100 km. The average "no show" rate is 6.2%. Only 36% of departments assess patients the same day as seen by the surgeon. On attending the clinic, 51% can see an internist the same day in contrast to 30% being able to see a cardiologist. Pre-admission testing is available to 97% on the same day. Direct funding is available for the nurse (87%), physician (1%) and secretarial help (43%). Remuneration of the anesthesiologist is fee for service (99%) and sessional (1%). Pre-anesthetic assessment clinics are common in Ontario. More development is required to enable patients to receive all aspects of their preoperative assessment during one visit.

Rate of psychiatric illness 1 year after traumatic brain injury.

Neurobehavioral symptoms are not uncommon after a traumatic brain injury. However, psychiatric syndromes per se have rarely been studied in patients with such an injury. The purpose of this study was to evaluate the type and extent of psychiatric syndromes in patients with traumatic brain injury. One hundred ninety-six hospitalized adults were studied 1 year after a traumatic brain injury with the use of a two-stage psychiatric diagnostic procedure. Psychiatric diagnoses were made according to ICD-10 criteria on the basis of data from the Schedules for Clinical Assessment in Neuropsychiatry interview. Of 164 patients interviewed, 30 (18.3%) had an ICD-10 diagnosis of a psychiatric illness. Among the 120 patients who were 18-64 years old, 21.7% had a psychiatric illness, compared with 16.4% in a study of the general population. A depressive illness was present in 13.9% of the traumatic brain injury patients, compared with 2.1% of the general population, and panic disorder was present in 9.0%, compared with 0.8% of the general population. In comparison with the general population, a higher proportion of adult patients had developed psychiatric illnesses 1 year after a traumatic brain injury; the rates of depressive episode and panic disorder were significantly higher in the study group. A history of psychiatric illness, an unfavorable global outcome according to the Glasgow Outcome Scale, a lower score on the Mini-Mental State examination, and fewer years of formal education seemed to be important risk factors in the development of a psychiatric illness. Compensation claims, however, were not associated with the rate of psychiatric illness.

Ehrlich's Ascites Fluid Adsorbed Over Protein a Containing Staphylococcus Aureus Cowan I Produces Inhibition of Tumor Growth

Our earlier studies have shown that removal of various blocking factors from the sera of tumor-bearing animals and humans by adsorption over heat-attenuated and formalin-fixed-Staphylococcus aureus Cowan I (SAC) containing Protein A (PA) causes antitumor immune response. It was also shown that this procedure caused regression of a wide variety of established animal and human tumors. In the present investigation, the therapeutic potential of inoculation of ascites fluid adsorbed in vitro over non-viable SAC containing PA has been demonstrated in Ehrlich’ s ascites tumor (EAT) in mouse. The antitumor effect was evident by a significant decrease in body weight (p > 0.001) as well as significant reduction in viability of ascites tumor cells(p > 0.001) in peritoneal cavity. However, some of the responding animals died earlier than controls, this may be due to the toxicity associated with therapy. The toxic effects were evident in decreased contents of glutathione, and increased activity of glutathione-S-transferase, decreased activity of microsomal enzymes and also in an early death of some of tumor regressed animals. The probable causes of toxicity of the therapy and prospects of reversing these toxic effects are discussed.The authors thankfully acknowledge the critical review of the manuscript by Dr. P.N. Viswanathan, Head, Ecotoxicology Laboratory, ITRC. The technical and secretarial help of Mr. Ram Vimal and Mr. A. Sharma is also thankfully acknowledged. One of the authors (ASV) is thankful to the Council of Scientific and Industrial Research (CS1R), India, for the award of junior research fellowship to him.

Memory Piece: Editing ESC, 1985–1989

MemoryTiece: •Editing ESC,1985-1989 ROWLAND MCMASTER University ofAlberta G o r d o n M o y les a n d I t o o k o v e r the editing of English Studies in Canada in 1985, but our experience with it stretched back to its beginnings. We had been in on the creation. By the time we became Secretary-Treasurer and President of ACCUTE, which was then known as ACUTE, in 1972, much groundwork for the journal had already been laid. Commit­ tees chaired by Professors Gerald McCaughey and Paul Fleck had examined all practical matters to do with a journal and prepared a brief to the Canada Council (these were the days before SSHRCC) showing the need for such a journal, its objec­ tives, and what it would cost. It was our business, then, to see that the Association’s wishes were carried out. The names of an Editor and of members ofan Editorial Board had to be sub­ mitted to the Canada Council by 1 October 1973. Paul Fleck’s committee worked expeditiously to come up with suggestions and prepare the application to the Council. And in a room at the Park Plaza Hotel in Toronto, the Executive held a lively meeting to discuss the results. From my office in Edmonton, I subsequently called Lauriat Lane Jr. at the University of New Brunswick to ask if he would take on the task of being Editor. And to our great good fortune, he agreed. He then put together a first-rate editorial team with James Woodfield as Managing Editor. At the 1974 Annual General Meeting, we were able to report to the membership ofACCUTE that the Canada Council had given a full grant to the Association’s new journal, which was to be called English Studies in Canada. Lauriat Lane was an admirable editor. He managed the journal with talent and aplomb, and I personally had good rea­ son to appreciate both the management and the talent. The ESC 25 (1999): 131-35 ESC 25, 1999 ACCUTE Executive occasionallyhonouredscholarswhohad made outstanding contributions to the profession, and someone had the good idea that it would be appropriate to accompany the honour with a biographical essay in ESC. I was asked to write the piece on F.E.L. Priestley. I did it as well as I could, and I submitted it to Laxry Lane. A short while later he phoned me and said, in effect, “it’s a pretty good essay but what would you say to moving the section on such a page to the end.” He was dead right. The essay now ended with personality and style. There was a good editor at work. When, after two terms in which the journal solidly estab­ lished itself as the major Canadian journal in English studies, the New Brunswick team was ready to hand over to someone else, the Chairman of my Department, David Jackel, called me one evening to say ACCUTE was looking for a new Editor. I allowed as how I knew that. He then said, “Why don’t you apply?” I said that I would think it over. My first move was to call Gordon Moyles with whom I had worked so well in the past to see if he would join me in this venture. We had tri­ umphed over difficulties before. I knew I could rely on Gordon, and our general outlooks blended happily. A pair of obsessivecompulsives , weboth liked to arrive at airports early—my wife, on the other hand, always chooses to board a train, a bus, or a plane with insouciance just as the doors are closing. She does have other virtues innumerable. But I digress. Gordon agreed to be Managing Editor if ACCUTE accepted our proposal. We then negotiated with the Chairofthe Department, whocame up trumps, as he very helpfully provided such essentials as space, a degree of secretarial help, and a number of graduate research assistants. The University’s administration also contributed a small but welcome amount of money. With these things as­ sured, and a potential Editorial team assembled, we then made our application to the ACCUTE Executive, and eventually the Executive approved. We took...

Calumenin, a Ca2+-binding protein retained in the endoplasmic reticulum with a novel carboxyl-terminal sequence, HDEF.

We have identified and characterized a cDNA encoding a novel Ca2+-binding protein named calumenin from mouse heart by the signal sequence trap method. The deduced amino acid sequence (315 residues) of calumenin contains an amino-terminal signal sequence and six Ca2+-binding (EF-hand) motifs and shows homology with reticulocalbin, Erc-55, and Cab45. These proteins seem to form a new subset of the EF-hand protein family expressed in the lumen of the endoplasmic reticulum (ER) and Golgi apparatus. Purified calumenin had Ca2+-binding ability. The carboxyl-terminal tetrapeptide His-Asp-Glu-Phe was shown to be responsible for retention of calumenin in ER by the retention assay, immunostaining with a confocal laser microscope, and the deglycosylation assay. This is the first report indicating that the Phe residue is included in the ER retention signal. Calumenin is expressed most strongly in heart of adult and 18.5-day embryos. The calumenin gene (Calu) was mapped at the proximal portion of mouse chromosome 7.

Is My Book Idea Sellable? Writing the Book Proposal

Follow up on your book idea with a prospectus. Allow yourself to dream about what the book will look like and share these details with a publisher. We can tell you how well the book fits our needs.

A study of the quality of university life: SUNY at Buffalo

A Q. of L. questionnaire was sent to all 1375 faculty members at SUNY Buffalo. Each was asked to judge the level of satisfaction and importance of 123 elements of campus life. The study created a complex evaluation of the University (services, offices, functions, attitudes) intended to guide future policy. The study was well received; it has guided policy and the Faculty Senate requested that it be repeated in 3 to 5 years. The quality of campus life was generally perceived to be better in the professional schools than in the core arts and sciences faculties. Librarians had especially low morale and Q. of L. Monetary and institutional barriers that frustrated faculty members in trying to fulfill their professional obligations to their own high standards were the major factors detracting from Q. of L. (lack of secretarial help, little travel money, bureaucratic red tape, etc.). This methodology would easily be transferable to other campuses. Studies conducted elsewhere would provide a basis for comparison that would enlarge our ability to assess professionally our universities and help guide their future development.