Abstract Fluid flow through porous spaces with variable porosity has wide-range applications, notably in biomedical and thermal engineering, where it plays a vital role in comprehending blood flow dynamics within cardiovascular systems, heat transfer and thermal management systems improve efficiency using porous materials with variable porosity. Keeping these important applications in view, in current study blood based hybrid nanofluid flow has considered on a convectively heated sheet. The sheet exhibits the properties of a porous medium with variable porosity and extends in both the x and y directions. Blood has used as base fluid in which the nanoparticles of Cu and CuO have been mixed. Thermal radiation, space-dependent, and thermal-dependent heat sources have been incorporated into the energy equation, while magnetic effects have been integrated into the momentum equations. Dimensionless variables have employed to transform the modeled equations into dimensionless form and facilitating their solution using bvp4c approach. It has concluded in this study that, both the primary and secondary velocities augmented with upsurge in variable porous factor and declined with escalation in stretching ratio, Casson, magnetic and slip factors along x- and y-axes. Thermal distribution has grown up with upsurge in Casson factor, magnetic factor, thermal Biot number and thermal/space dependent heat sources while has retarded with growth in variable porous and stretching ratio factors. The findings of this investigation have been compared with the existing literature, revealing a strong agreement among present and established results that ensured the validation of the model and method used in this work.
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