Secondary Types Research Articles

Are socioeconomic composition effects on student achievement less relevant after de-tracking reforms in Germany?

Recent de-tracking reforms in some German federal states converted or merged the two lower track secondary school types into a comprehensive one, where students can achieve all school-leaving qualifications. The goals of the reforms were to facilitate desegregation of students from different socioeconomic backgrounds and to reduce educational disparities. We investigated whether socioeconomic composition (SEC) and SEC effects have, in fact, changed with the de-tracking reforms. Moreover, we examined whether a possible increase in students' educational expectations of achieving the general qualification for university entrance contributes to the intended reduction of SEC effects. We used data from two representative large-scale assessment studies carried out in 2009 and 2015 covering the period of reforms. The SEC changed in non-academic school types. SEC effects on students' reading achievement tended to decrease, but are still significant in the comprehensive schools. The level of students’ educational expectations did not mediate the SEC effects.

Advancing Micro Plastic Analysis: A Comprehensive Review of Detection and Characterization Techniques

This review paper critically evaluates the current state of micro plastic detection and characterization methods, highlighting the significant environmental and health risks posed by microplastics. Microplastics, categorized into primary and secondary types, are ubiquitous in various ecosystems, raising concerns about their impacts on aquatic life and human health. The paper discusses the diverse characteristics of microplastics and the challenges associated with their detection in complex environmental matrices. An overview of existing detection methods, including visual identification, spectroscopic techniques, and emerging technologies such as automated imaging and machine learning, is provided. Additionally, the review addresses the environmental fate and transport of microplastics, their interactions with biota, and the socio-economic implications of pollution. Emphasizing the need for standardized methodologies and innovative solutions, the paper calls for enhanced public awareness and policy initiatives to mitigate the pervasive threat of microplastics, thereby contributing to global environmental sustainability efforts.

A comparative study of GPT-4o and human ophthalmologists in glaucoma diagnosis

Artificial intelligence (AI), particularly large language models like GPT-4o, holds promise for enhancing diagnostic accuracy in healthcare. This study evaluates the diagnostic performance of GPT-4o compared to human ophthalmologists in glaucoma cases. A prospective, observational study was conducted at a tertiary care ophthalmology center. Twenty-six glaucoma cases, including both primary and secondary types, were selected from publicly available databases and institutional records. The cases were analyzed by GPT-4o and three ophthalmologists with varying levels of experience. The accuracy and completeness of primary and differential diagnoses were assessed using 10-point and 6-point Likert scales, respectively. Statistical analyses were performed using nonparametric methods, including the Kruskal–Wallis and Mann–Whitney U tests. GPT-4o was significantly less accurate in primary diagnosis compared to human ophthalmologists. Specifically, GPT-4o achieved a mean score of 5.500 (p < 0.001) compared to Doctor C, who had the highest score of 8.038 (p < 0.001). Completeness scores for GPT-4o 3.077 (p < 0.001) were also lower than Doctor B, who had the lowest score of 3.615 (p < 0.001) among human ophthalmologists. However, for differential diagnosis, GPT-4o (7.577) showed comparable accuracy to Doctor A (7.615) and Doctor C (7.673) (p < 0.0001) while achieving the highest completeness score (4.096), outperforming Doctor C (3.846), Doctor A (2.923), and Doctor B (2.808) (p < 0.0001). AI, including GPT-4o, is currently not an acceptable standalone method for diagnosing glaucoma due to its lower accuracy compared to human clinicians. These findings suggest that GPT-4o could serve as a valuable adjunct in clinical practice, particularly in complex cases, but should not replace human expertise, especially for initial diagnoses. Future improvements in AI models could enhance their utility in ophthalmology.

Implementation of Income Tax on Third Party Services at PT. Taspen (Persero) Manado

Tax provisions for third-party services in Indonesia are regulated by various tax regulations, including the Income Tax Act. The main points highlighted in this study include Articles 21, 23, and Article 4(2) on Income Tax. This study aims to investigate and examine how income tax is applied to third party service fees. This study was conducted in PT. Taspen (Persero) in Manado. This study used primary and secondary data types using a qualitative method of descriptive analysis. The results show that PT has high income tax on third-party services. Taspen targets Articles 21, 23 and Article 4(2) of the Income Tax Act. The calculations and deductions adhere to current regulations, with withholding rates of 2.5% and 5% for Article 21, 2% for Article 23, and 10% for Article 4, paragraph 2.

Analisis Tingkat Kesejahteraan Rumah Tangga Petani Padi di Desa Cadaskertajaya Kecamatan Telagasari Kabupaten Karawang

Agricultural development in rural areas not only increases production, but also increases people's income, opens up more job opportunities, and improves welfare. This research aims to analyze farmer household income, farmer household expenditure, and the level of welfare of rice farmer households in Cadaskertajaya Village, Telagasari District, Karawang Regency. The research method used is Mix Method, with primary and secondary data types. Primary data was collected through interviews using questionnaires from 47 rice farmers. Secondary data was obtained from the Central Statistics Agency, Karawang Regency Agricultural Service, Cadaskertajaya Village, and other institutions. Samples were taken using the proportional random sampling method, with the criteria being farmer owners and farm workers. Data analysis uses the Directorate of Land Use's criteria poverty line for household income, the Sayogyo criteria poverty line for household expenditure, and welfare indicators from BPS. The research results show that the average household income of rice farmers in Cadaskertajaya Village is IDR 34,582,351.69 per year and IDR 8,124,446.81 per capita per year. The household expenditure of rice farmers is IDR 25,380,255.32 per year and IDR 8,413,937.59 per capita per year. Based on the poverty line criteria of the Directorate of Land Use, 53.19% of farmers are not poor, and according to the Sayogyo criteria, 82.61% are not poor. The welfare level is calculated using 11 indicators from BPS, with the highest score being 33 and the lowest score being 27, which is still included in the high welfare category.

The Effect of Psychoeducation on Fear of Childbirth: A Literature Review

Purpose : The aim of this study is to investigate the contribution of psycoeducation to reduce FOC among primigravida and nulligravida mothers between 2015 and 2023. A literature review study was conducted to explore the effects of psychoeducation on pregnancy anxiety. Method : Systematically reviewed studies between 2015 and 2023, the researchers searched a total of 10 studies. This review uses search research from Pubmed, Science Direct and Google Scholar as sources. Result : This study found variations between primary and secondary types of fear of childbirth (FOC). A woman who experiences primary FOC, also known as childbirth anxiety (Primigravida), is newly pregnant and about to give birth for the first time. Secondary fear of childbirth is caused by trauma or a painful birth event (Nulligravida). Pharmacological and non-medical treatments such as psychoeducation were improved to relieve during labour anxiety, confidence during labour, reduction of depressive symptoms, and decrease in caesarean delivery rates. Conclusion: Psychoeducation conducted by midwives can reduce the fear of facing labour experienced by pregnant women.

PENGARUH PERKEMBANGAN TEKNOLOGI, KUALITAS SDM, PERTUMBUHAN EKONOMI, DAN INVESTASI TERHADAP TPT

Unemployment is a macro problem that grows due to the imbalance between economic growth and increased employment. East Java Province made various efforts to reduce the open unemployment rate. To overcome the unemployment problem in East Java, several indicators are of concern to be studied, namely technological development, quality of human resources (HR), economic growth, and investment in 2015-2022. The purpose of this study is to findout the factors that can affect TPT in East Java. This study uses panel data, through classical assumption tests to hypothesis tests, with secondary data types coming from the official website of BPS (Central Statistics Agency). The estimation results suggest that technological developments, the quality of human resources, and investment tend to increase the number of TPT in East Java. Meanwhile, economic growth tends to reduce the TPT figure in East Java. This research can be a learning material about unemployment.

DDX3X dynamics, glioblastoma's genetic landscape, therapeutic advances, and autophagic interplay.

Glioblastoma is one of the most aggressive and deadly forms of cancer, posing significant challenges for the medical community. This review focuses on key aspects of Glioblastoma, including its genetic differences between primary and secondary types. Temozolomide is a major first-line treatment for Glioblastoma, and this article explores its development, how it works, and the issue of resistance that limits its effectiveness, prompting the need for new treatment strategies. Gene expression profiling has greatly advanced cancer research by revealing the molecular mechanisms of tumors, which is essential for creating targeted therapies for Glioblastoma. One important protein in this context is DDX3X, which plays various roles in cancer, sometimes promoting it or otherwise suppressing it. Additionally, autophagy, a process that maintains cellular balance, has complex implications in cancer treatment. Understanding autophagy helps to identify resistance mechanisms and potential treatments, with Chloroquine showing promise in treating Glioblastoma. This review covers the interplay between Glioblastoma, DDX3X, and autophagy, highlighting the challenges and potential strategies in treating this severe disease.

Mayer-Rokitansky-Küster-Hauser Syndrome: A Case of Primary Amenorrhoea and Diagnostic Approach

Background: Amenorrhoea, defined as the absence of menstruation, can be classified into primary and secondary types. Primary amenorrhoea is diagnosed when menstruation has not occurred by age 15 or within three years of breast development. Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is a rare cause of primary amenorrhoea characterized by uterovaginal aplasia in women with a normal 46, XX karyotype and secondary sexual characteristics. This case report discusses a 15-year-old girl diagnosed with MRKH syndrome after a thorough diagnostic workup. Methods: A detailed diagnostic evaluation was conducted, including physical examination, imaging (ultrasonography and MRI), hormonal testing, and chromosomal analysis. The patient presented with primary amenorrhoea and no family history of related conditions. Ultrasound and MRI confirmed the absence of a uterus and non-visualization of the ovaries. Hormonal tests were within normal ranges, and chromosomal analysis revealed a 46, XX karyotype. Results: The diagnostic workup confirmed an atrophic uterus with small bilateral ovaries and no functional endometrial tissue. Mayer-Rokitansky-Küster-Hauser syndrome was diagnosed. The patient was counseled regarding surgical options, including neovaginoplasty, to create a functional vaginal canal for sexual intercourse. Conclusion: MRKH syndrome, though rare, is an important consideration in cases of primary amenorrhoea. Timely diagnosis through imaging and chromosomal analysis is crucial for appropriate management. Psychological counseling and surgical options such as neovaginoplasty can significantly improve the quality of life for affected individuals, particularly regarding sexual health and reproductive possibilities. Addressing the psychological burden associated with infertility is also critical to patient care.

Recommended guidelines for screening for underlying malignancy in extramammary Paget's disease based on anatomic subtype

IntroductionExtramammary Paget’s disease (EMPD) may be associated with an underlying internal adenocarcinoma, referred to as secondary EMPD. Differences in this association by EMPD anatomic subtype and implications for screening are not fully understood. ObjectiveDefine the rates of secondary EMPD and types of associated adenocarcinomas by EMPD anatomic subtype and propose a screening algorithm for underlying adenocarcinoma. MethodsSystematic literature review of EMPD (January 1990- November 2022). One hundred twenty-two studies met the inclusion criteria. A multidisciplinary expert panel reviewed the recommendation statements on adenocarcinoma screening. ResultsPerianal EMPD was associated with a high rate of underlying adenocarcinoma (25%, primarily colorectal) compared with penoscrotal and vulvar EMPD (6% each, primarily of genitourinary origin). Thorough screening in perianal EMPD includes a colonoscopy, urine cytology, and computed tomography (CT) of the chest, abdomen and pelvis. Cost-conscious screening tests in low-risk penoscrotal disease include urine cytology, heme-occult test, and prostate-specific antigen test (especially if under 70 years of age). For low-risk vulvar EMPD, urine cytology and mammography are recommended. EMPD with high-risk features may warrant more sensitive organ-specific testing. LimitationsSelection bias; retrospective data without systematic follow-up. ConclusionsScreening for underlying adenocarcinoma in EMPD should be guided by anatomic location.

Evaluation of Landslide Hazards Using the Landslide Possibility Index: The Influence of the Exposed Rocks on Landslides in Kirkuk-Koysinjaq Main Road, Northern Iraq

Landslides on slopes occur for various reasons and lead to significant economic losses, adverse influences on the environment, and fatal accidents. The newly constructed road within mountainous areas between the Shewan area and the Taq Taq district linking Kirkuk Governorate to Koysinjaq city experiences annual landslides. This paper aims to use the Landslide Possibility Index (LPI) system to evaluate the stability of slopes, identify the factors that control potential landslides and their severity, as well as the extent and scope of the risks to which slope faces are exposed. Four stations were chosen, data were collected, aerial photographs were studied, and detailed fieldwork was conducted to measure the ten LPI system parameters. The results show that the studied stations varied in failure possibilities, hazard zones, and categories, and that one of the main reasons for the slope failures in the study area is improper road cuttings with a steep angle to the slopes. There is clear control of the exposed rocks on the failures in the studied stations. The severe weathering of the claystone layers within the Bai Hassan Formation triggers secondary types of failures, which are governed by bottom weathering mechanism. Factors like failure to construct sewers or channels to drain rainwater, lack of ditches on the two side of the road, and the absence of fall-preventing techniques and slope stabilization solutions worsen the situation and escalate the hazard of failures.

Neurological Aspects of Sarcopenia: A Comprehensive Update on Pathophysiology, Diagnosis, and Therapeutic Advances

Sarcopenia is an age-related disorder characterized by progressive and generalized loss of skeletal muscle tissue. This condition affects approximately 9.9-40.4% of older adults, 2-34% of outpatients, and about 56% of hospitalized patients. Sarcopenia is classified into primary and secondary types, with primary sarcopenia resulting from the natural aging process and secondary sarcopenia caused by various factors such as sedentary lifestyle, disease, and nutrition. The pathophysiology of sarcopenia involves cellular mechanisms, including genetic alterations, telomere erosion, and proteostasis disruption. Mitochondrial dysfunction, epigenetic modifications, and metabolic factors also contribute to the condition. Neurological aspects, such as motor neuron loss and sodium channel dysfunction, play a crucial role in the development of sarcopenia. Prevention and treatment strategies include exercise interventions, nutritional strategies, and pharmacological interventions. Vitamin D supplementation, testosterone replacement therapy, and selective androgen receptor modulators (SARMs) are among the treatments explored. However, these treatments come with potential

Exploring Thinopyrum spp. Group 7 Chromosome Introgressions to Improve Durum Wheat Performance under Intense Daytime and Night-Time Heat Stress at Anthesis.

Durum wheat (DW) is one of the major crops grown in the Mediterranean area, a climate-vulnerable region where the increase in day/night (d/n) temperature is severely threatening DW yield stability. In order to improve DW heat tolerance, the introgression of chromosomal segments derived from the wild gene pool is a promising strategy. Here, four DW-Thinopyrum spp. near-isogenic recombinant lines (NIRLs) were assessed for their physiological response and productive performance after intense heat stress (IH, 37/27 °C d/n) had been applied for 3 days at anthesis. The NIRLs included two primary types (R5, R112), carriers (+) of a differently sized Th. ponticum 7el1L segment on the DW 7AL arm, and two corresponding secondary types (R69-9/R5, R69-9/R112), possessing a Th. elongatum 7EL segment distally inserted into the 7el1L ones. Their response to the IH stress was compared to that of corresponding non-carrier sib lines (-) and the heat-tolerant cv. Margherita. Overall, the R112+, R69-9/R5+ and R69-9/R112+ NIRLs exhibited a tolerant behaviour towards the applied stress, standing out for the maintenance of leaf relative water content but also for the accumulation of proline and soluble sugars in the flag leaf and the preservation of photosynthetic efficiency. As a result, all the above three NIRLs (R112+ > R69-9/R5+ > R69-9/R112+) displayed good yield stability under the IH, also in comparison with cv. Margherita. R112+ particularly relied on the strength of spike fertility/grain number traits, while R69-9/R5+ benefited from efficient compensation by the grain weight increase. This work largely confirmed and further substantiated the value of exploiting the wild germplasm of Thinopyrum species as a useful source for the improvement of DW tolerance to even extreme abiotic stress conditions, such as the severe heat treatment throughout day- and night-time applied here.

Histological differences related to autophagy in the minor salivary gland between primary and secondary types of Sjögren’s syndrome

Some forms of Sjögren’s syndrome (SS) follow a clinical course accompanied by systemic symptoms caused by lymphocyte infiltration and proliferation in the liver, kidneys, and other organs. To better understand the clinical outcomes of SS, here we used minor salivary gland tissues from patients and examine their molecular, biological, and pathological characteristics. A retrospective study was performed, combining clinical data and formalin-fixed paraffin-embedded (FFPE) samples from female patients over 60 years of age who underwent biopsies at Okayama University Hospital. We employed direct digital RNA counting with nCounter® and multiplex immunofluorescence analysis with a PhenoCycler™ on the labial gland biopsies. We compared FFPE samples from SS patients who presented with other connective tissue diseases (secondary SS) with those from stable SS patients with symptoms restricted to the exocrine glands (primary SS). Secondary SS tissues showed enhanced epithelial damage and lymphocytic infiltration accompanied by elevated expression of autophagy marker genes in the immune cells of the labial glands. The close intercellular distance between helper T cells and B cells positive for autophagy-associated molecules suggests accelerated autophagy in these lymphocytes and potential B cell activation by helper T cells. These findings indicate that examination of FFPE samples from labial gland biopsies can be an effective tool for evaluating molecular histological differences between secondary and primary SS through multiplexed analysis of gene expression and tissue imaging.

Assessing driver distraction from in-vehicle information system: an on-road study exploring the effects of input modalities and secondary task types

In-vehicle information system (IVIS) use is prevalent among young adults. However, their interaction with IVIS needs to be better understood. Therefore, an on-road study aims to explore the effects of input modalities and secondary task types on young drivers' secondary task performance, driving performance, and visual glance behavior. A 2 × 4 within-subject design was undertaken. The independent variables are input modalities (auditory-speech and visual-manual) and secondary task types (calls, music, navigation, and radio). The dependent variables include secondary task performance (task completion time, number of errors, and SUS), driving performance (average speed, number of lane departure warnings, and NASA-TLX), and visual glance behavior (average glance duration, number of glances, total glance duration, and number of glances over 1.6 s). The statistical analysis result showed that the main effect of input modalities is significant, with more distraction during visual-manual than auditory-speech. The main impact of secondary task types was also substantial across most metrics, aside from average speed and average glance duration. Navigation and music were the most distracting, followed by calls, and radio came in last. The distracting effect of input modalities is relatively stable and generally not moderated by the secondary task types, except radio tasks. The findings practically benefit the driver-friendly human–machine interface design, preventing IVIS-related distraction.

Public Behavior and Emotion Correlation Mining Driven by Aspect From News Corpus.

Emotion motivates behavior. Investigating the correlation between behavior and emotion, an often overlooked perspective, plays a significant role in uncovering the underlying motives behind behaviors and the intrinsic cause-effects of social events. This article proposes a methodology for mining the correlation between public behavior and emotion using daily news data. Initially, aspect-emotion-reaction (A-E-R) triplets are extracted and generalized, encompassing both explicit and implicit patterns. Then, a knowledge representation model based on hypothetical context (KRHC) with a self-reflection mechanism is proposed to uncover implicit relationships between emotion and behavior through attention mechanisms. By combining rule-based methods for explicit relationships and deep learning for implicit ones, an understanding of emotion-behavior patterns is achieved. In this study, the behaviors are divided into three categories of prosocial, antisocial, and normal behaviors with ten secondary types. Seven categories of emotions are adopted. The proposed deep learning model KRHC is validated on A-E-R datasets and public KINSHIP datasets. The experiment results are concluded; for example, when "fear", "sad", and "surprise" emotions appear, it drives behavior "panic" with most probability. These findings could provide insights for both human-computer interaction and public safety management applications.

Determinants of housing demands and residential rent costs in an emerging city in Southern Nigeria

Housing is vital to human experience. It is the basis and foci of daily activities. In Asaba, a strategically located, fast-growing metropolis, city officials are confronted by myriads of urban planning issues, one of which is provision of urban housing. This study attempted to identify the determinants of housing demands and costs of residential rents within the city (Asaba). In this study, the ex-post facto and survey designs were deployed. The data for the study comprised of the primary (questionnaire data) and secondary (historical housing data) types. For effective questionnaire administration, the study area was stratified into high, medium and low income areas. The Analysis of Variance (ANOVA) and the Spearman's rank correlation coefficient were deployed for data analyses. The results indicated that the key determinants of residential housing demand and costs were ease of access to public transport (69 %), nearness to security formations (80 %) and higher demand for houses in supply (75.8 %); and the Spearman's rank correlation showed that these factors were significant at P < 0.05. Other factors such as availability of electricity and access to water supply were not significant determinants of choice of housing at P > 0.05. This is due to the fact that the whole region lacks adequate electricity supply and water is self-harnessed through boreholes. ANOVA showed that there was a significant temporal variation in the cost of residential housing rents at p<0.05 (F-69.03; sig 0.000). Consequently, this study recommends that there is need for the decentralisation of the city; which should be realised by an efficient development of the suburbs to high standards that would meet the requirements of prospective renters. Policy development and establishment of basic facilities in the suburbs, would help actualise this decentralization. Also, collaboration between government and private developers could yield more supply in the housing stuck, consequently reducing costs of housing.

Experimental research on biogenic methane generation pathway and microflora constraints based on in-situ gas-water-microbe

Biogenic coalbed methane (CBM), generated through the biodegradation process of coal organic matter, is a relatively clean and environment-friendly unconventional natural gas resource. To investigate the differences in microbial communities (bacteria and archaea) as well as their environmental influencing factors between the Permian Shanxi Formation (P1s) and Taiyuan Formation (P1t), we systematically collected in-situ CBM samples along with coalbed water and microbial samples from a representative biogenic CBM field – the Baode block locked in the Ordos basin in China. The relative content of biogenic CBM was quantitatively calculated while analyzing gas composition, stable isotope, ion content, and high-throughput sequencing analysis to discuss the generation pathway for biogenic CBM and environmental control factors affecting microbial community structure. The results indicate that P1s and P1t are mixed with early thermogenic gas and secondary biogenic gas genetic types within their respective CBMs. The average proportion for biogenic gas within current coal seams is approximately 62.24 % for P1s, while it reaches around 64.37 % for P1t. Water quality type primarily consists of Na-HCO3 type with total dissolved solids (TDS) measuring at approximately 1015.86 mg/L for P1s, whereas P1t exhibits Na-Ca-HCO3-Cl water type with TDS content reaching about 2314.85 mg/L. Combining dominant Methanobacterium species, along with Δ13C(CO2-CH4) ratios and δD(CH4) versus δD(H2O) indexes, represents the biogenic CBM primarily generated through the hydrogenotrophic methanogenesis pathway. The in-situ bacterial communities of P1s are mainly influenced by Ni, pH, and TDS. The archaeal communities exhibit higher sensitivity to environmental factors (such as Co, pH, Ni, and dissolved organic carbon) than bacteria. These findings hold significant implications for understanding the generation process of biogenic CBM in middle and low-rank coal areas.

Dog and owner demographics impact dietary choices in Dog Aging Project cohort.

To describe the demographic factors of owners and their dogs associated with owner feeding choices and the regularity with which those diets were fed to a US-based population of dogs. This cross-sectional analysis examined 40,367 initial survey responses from US dog owners participating in the Dog Aging Project. The surveys were collected from January 2, 2020, to December 31, 2022, and included primary and secondary diet component types and dog and owner demographic variables. Each demographic variable was compared across diet type choices with a χ2 test of independence. Most owners (82%) fed a commercially prepared extruded dry diet (kibble) as the primary diet component. Most owners (89%) reported that they fed their dogs a consistent diet over time. Owner demographic factors (income, education level) were less correlated with difference in diet choices than dog demographic factors (size, neuter status, purebred status, activity level), but owner age did correlate with choice: younger owners tended to feed kibble more compared to older owners. Home-cooked diets were most often consumed by small (< 30-lb) dogs, purebred dogs in poorer health status, and dogs with owners aged 45 years or older. Raw diets were more commonly fed to purebred, intact, and highly active dogs. Ten percent of service dogs were reportedly fed a raw diet of some sort. Demographic variables are associated with statistically significant differences in diet types selected. Nutrition studies examining health outcomes associated with the feeding of different diet types should account for these factors during design or analysis in order to avoid bias. An epidemiological tool, the directed acyclic graph, is presented. This information will help clinicians in their discussions with clients about pet nutrition.

Determination of the immune response type in measles patients of different ages from a high-incidence area

According to the WHO data, the incidence of measles is now in the cyclic increase phase. The non-vaccinated subjects, like as persons who have previously received one or two doses of measles vaccine are involved in the epidemic process. The purpose of our study was to determine the immunological pattern in the groups of measles patients of different age in areas with high incidence of infection. To determine the immune response type in measles patients, qualitative and quantitative indices of IgM and IgG were used, detected by the following ELISA test-systems: VectoMeasles-IgM (JSC “Vector-Best”, Russia); Anti-Measles Viruses ELISA (IgG) and Avidity Anti-Measles Viruses ELISA IgG (Euroimmun, Germany). The serological study of 1893 patient allowed to determine the primary and secondary types of immune response. In 72.64% of the patients with primary immune response, the serum samples contained low-avidity IgG at a concentration of 0.45 (0.22- 0.74) IU/mL. In the group with a secondary immune response, high-avidity antibodies were detected at a concentration of 24.28 (21.59-27.4) IU/mL. The antibody levels in secondary type of response was 54-fold higher than IgG values in the first group (p 0.05). In the group with primary immune response, the ratio of children ( 1 to 14 years) and adults (18 to 70 years old) was almost the same (49.6% and 47.56%). Appropriate values for children and adult cohorts with a secondary immune response were 2.12% and 96.53%, respectively (p 0.05). Among 46 teenagers (15-17 years old), 84.8% responded with a primary immune response to the measles virus. Thus, in the area with high-incidence of measles among patients of different age, the primary-type immune response was determined in 72.64%, and secondary-type, in 27.36%. We have found that in the patients with a secondary type of immune response group, the proportion of children and teenagers was 27.8 times lower than among adults, thus indicating to high efficiency of vaccination in pediatric population. At the same time, the results of studies among measles patients with primary-type immune response, both children and adults, suggest some “gaps” in the vaccine prevention program.