In this study, we aim to determine post-pandemic level of secondary traumatic stress and the associated factors among healthcare workers practicing in the Western province of Saudi Arabia. Healthcare workers practicing at public health sector of the Western province of Saudi Arabia. Received Web-based Self-administered questionnaire, assessing post-pandemic Secondary Traumatic Stress (STS), using Secondary Traumatic Stress Scale (STSS). A total of 380 responses received. Logistic regression analysis identified significant predictors of secondary traumatic stress (STS). Females had a significantly higher likelihood of experiencing STS (OR=2.425, p<0.001). Doctors were significantly more likely to experience STS compared to other specialties (OR=2.863, p=0.016). Participants sleeping 7hours were associated with a lower likelihood of STS (OR=0.427, p=0.016), while sleeping 6hours showed a trend towards lower STS but was not statistically significant (p=0.068). Participants aged 50 and above were significantly less likely to experience STS (OR=0.275, p=0.021). Lastly, Saudi nationals were significantly more likely to experience STS compared to non-Saudis (OR=2.717, p=0.014). Female healthcare workers, doctors, and those younger than 50 years old were all found to be at a significantly higher risk of STS. Interestingly, sleep duration emerged as a potential protective factor, with those sleeping 7hours exhibiting a lower risk of STS. Finally, the analysis revealed a higher prevalence of STS among Saudi nationals compared to non-Saudis.