Secondary Ones Research Articles

Light curve modeling of the eclipsing binary systems V0876 Lyr, V3660 Oph, and V0988 Mon

Abstract Photometric study and light curve modeling for the systems V0876 Lyr, V3660 Oph, and V0988 Mon were carried out by means of their first charge-coupled device observations and the Wilson–Devinney code based on model atmospheres by Kurucz (1993. In: Milone, E. (Ed.), Light curve modeling of eclipsing binary stars. New York: Springer-Verlag. p. 93). The accepted models reveal physical parameters that show that all the primary components of the studied systems are more massive and hotter than the secondary ones. The systems V0876 Lyr and V0988 Mon were classified as over contact, with mass ratios of 0.8940 and 0.3904, respectively, while the system V366Oph was classified as detached, with a mass ratio of 0.1181. The evolutionary state of the system components was investigated, and their spectral types were adopted. Both components of the system V0876 Lyr and secondary components of the systems V3660 Oph and V0988 Mon show lower radii and luminosities than expected for Zero Age Main Sequence (ZAMS). Secondary components of the system, V3660 Oph and V0988 Mon, deviated from ZAMS and the Terminal-age Main Sequence (TAMS) with a higher radius and luminosity than expected for ZAMS and TAMS.

Impact of different P2Y12 inhibitors in acute coronary syndrome patients with severe chronic kidney disease: insights from the CORALYS registry

Abstract Background The impact of the most potent P2Y12i ticagrelor and prasugrel after acute coronary syndrome in patients with chronic kidney disease (CKD) remains unclear. Most evidence on dual antiplatelet therapy (DAPT) comes from real-world study but is limited to glomerular filtration rate (GFR) under 60 ml/min whereas no data are available regarding patients with severe CKD (stages IV-V) Methods Consecutive patients with acute coronary syndrome (ACS) treated with percutaneous coronary intervention (PCI) and severe CKD defined as GFR under 30 ml/min not on dialysis from the CORALYS (Incidence and Predictors of Heart Failure After Acute Coronary Syndrome) registry were included. Incidence of Net Adverse Clinical Events (NACE) defined as major adverse cardiac events (MACE, a composite of cardiovascular death, myocardial infarction and unplanned revascularizations) in addition to major bleedings (classified as BARC scale 3 to 5) was our primary endpoint. Overall MACE and their single components, all bleedings, major bleedings and hospitalizations for heart failure were the secondary ones. Results Of 14699 patients in the CORALYS registry, 257 presented with severe CKD not on dialysis and had available data on antiplatelet regimen at discharge. Patients were divided into two groups according to the type of P2Y12i prescribed at discharge: 193 (75.1%) were given clopidogrel while 64 (24.9%) with ticagrelor or prasugrel. Our populaiton was predominantly male (153, 59.5%) with an average age 75.8 ± 10.9 years old. Average GFR was 21.8 ± 6.3 ml/min. Over a median follow-up of 459 days, Ticagrelor and Prasugrel were associated to lower rates of NACE compared to Clopidogrel (39.9% vs 25.0%, p=0.036). This was mainly driven by an excess of both CV mortality (31.1% vs 6.3%) and myocardial infarction (20.7% vs 9.4%) reported in the clopidogrel group. No difference was reported regarding overall bleeding events (5.7% vs 4.6% with clopidogrel and new P2Y12i respectively, p=0.81) and major bleedings (1.7% vs 4.6% with clopidogrel and new P2Y12i respectively, p=0.15). At multivariate Cox regression analysis DAPT with Ticagrelor/Prasugrel resulted independently associated with a lower risk of NACE (Adj Hr 0.41, 95%CI 0.23-0.74, p=0.003) whereas left main involvement or multivessel coronary disease led to higher risk of NACE (Adj HR 1.96 95%CI 1.21-3.18, p=0.006) Conclusions In ACS patients treated with PCI with severe CKD ticagrelor and prasugrel were associated to lower risk of NACE, MACE, CV death and myocardial infarction compared to clopidogrel. No significative difference was reported in overall and major bleedings despite a relative increase of major bleedings in the group treated with Ticagrelor or Prasugrel.

Experimental Study on LTE Mobile Network Performance Parameters for Controlled Drone Flights

This paper analyzes the quantitative quality parameters of a mobile communication network in a controlled drone logistic use-case scenario. Based on the analysis of standards and recommendations, the values of key performance indicators (KPIs) are set. As the main network-impacting parameters, reference signal received power (RSRP), reference signal received quality (RSRQ), and signal to interference and noise ratio (SINR) were selected. Uplink (UL), downlink (DL), and ping parameters were chosen as the secondary ones, as they indicate the quality of the link depending on primary parameters. The analysis is based on experimental measurements performed using a Latvian mobile operator’s “LMT” JSC infrastructure in a real-life scenario. To evaluate the altitude impact on the selected network parameters, the measurements were performed using a drone as transport for the following altitude values: 40, 60, 90, and 110 m. Network parameter measurements were implemented in automatic mode, allowing switching between LTE4–LTE2 standards, providing the opportunity for more complex analysis. Based on the analysis made, the recommendations for the future mobile networks employed in controlled drone flights should correspond to the following KPI and their values: −100 dBm for RSRP, −16 dB for RSRQ, −5 dB for SINR, 4096 kbps for downlink, 4096 kbps for uplink, and 50 ms for ping. Lastly, recommendations for a network coverage digital twin (DT) model with integrated KPIs are also provided.

Analysis of the outcomes in treatment of ulcerative colitis with acupuncture and moxibustion

To clarify the key outcomes of acupuncture-moxibustion treatment of ulcerative colitis. The clinical randomized controlled trials (RCTs) for ulcerative colitis treated with acupuncture and moxibustion were searched from CNKI, Wanfang, VIP, SinoMed, PubMed, EMbase, Cochrane Library, and Web of Science, from the inception of each database to March 20th, 2023. The basic information of literature, intervention measures and outcome indexes were collected. The selection of primary and secondary outcomes, the use frequency of each index and the combination of them in utility were analyzed; and index domains of acupuncture and moxibustion for ulcerative colitis were summarized. A total of 215 RCTs were included and 54 outcomes were involved, classified into 6 categories, i.e. TCM syndromes, symptoms/physical signs, physical and chemical tests, quality of life, long-term prognosis and safety events. The top 3 outcomes with high use frequency were clinical effect evaluation, adverse reactions of acupuncture and moxibustion and the score of main symptoms. Only 3 articles clearly reported the primary outcome and the secondary ones, 180 articles used two types of outcomes simultaneously, 3 articles clearly described the time points of the observation indexes, and 126 articles determined the sources of the evaluation criteria of therapeutic effect, with 57 criteria involved. At present, the outcomes have not been standardized in RCTs of acupuncture and moxibustion for ulcerative colitis. It needs to clarify the primary one and the secondary ones. The criteria have not been unified for the evaluation of therapeutic effects and there is less consideration on the quality of life in patients, the follow-up visit and safety events. The attention should be paid to develop the outcome set, in which, the endoscopic score is taken as the objective, and the improvements in the symptoms/physical signs and the biochemical examination as the supplementary.

THE EFFECT OF PARTIAL SLIP ON THE SURFACE PRESSURE DISTRIBUTION IN A SLIGHTLY COMPRESIBLE FLOW DEVELOPMENT REGION IN THE BOUNDARY LAYER

The study of laminar incompressible fluid flow in the boundary layer revealed, even earlier, that the condition of complete adhesion of fluid particles to the surface (non-slip condition) of the moving body (half-plane) is not met in the flow development (formation) region. The assumption of constancy of the fluid velocity on the surface of a moving body, hence non-slip, leads, in the flow development region, to the complete absence of the normal component of the velocity field. And this contradicts the very concept of the flow development region, where there should be two velocity components - longitudinal (primary) and normal (secondary) ones. In the previous works of the authors, analytical solutions were obtained for the velocity field in the region of development of incompressible fluid flow in the boundary layer. Since the use of the incompressible fluid flow model is restricted by the Mach number, to further expand the speed range, the problem of the of slightly compressible fluid flow development region in the boundary layer was considered. It is analytically proven that all considerations regarding the impossibility of complete non-slip in the flow development region can be applied to a slightly compressible flow. Slight compressibility at the same time means the subsonic nature of the flow and the neglect of temperature effects due to friction. On the basis of a critical analysis of the existing approaches, which consider the flow of a fluid around a immobile plate in the framework of non-gradient flow (which is just impossible due to the lack of a mechanism for creating the motion of the fluid), it is shown that the system of equations is actually non-closed. For the region of flow development, where the longitudinal pressure gradient is not a constant value, one equation is missing. This equation, as in previous works, is obtained from the necessary condition for the extreme of the fluid rate functional. And although the complete solution for the longitudinal component of the velocity contains four constants of integration, to obtain the asymptotics near the solid surface it is sufficient to know only two quantities - the velocity and its first derivative (gradient). These values, as it turns out from the asymptotic solution, coincide with the case of incompressible flow, which allows us to expand the scope of the previously obtained results for a wider domain of Mach numbers, for example . And such values already correspond to the speeds of modern civil aircraft. The dimensionless distribution of pressure in the slightly compressible flow development region is presented and its significant heterogeneity is shown, which, in turn, indicates the importance of the obtained results.

Catalytic Asymmetric Barbier Reaction of Ketones with Unactivated Alkyl Electrophiles.

The Barbier reaction is a reductive-type addition of an aldehyde or ketone with an organic electrophile in the presence of a terminal metal reductant, providing a straightforward and efficient method for carbon-carbon bond formation. This reaction possesses the advantage of circumventing the preparation of moisture- and air-sensitive organometallic reagents. However, the catalytic Barbier reaction of ketones to construct tetrasubstituted stereogenic centers is largely underdeveloped, despite its great potential for accessing synthetically challenging chiral tertiary alcohol. Particularly, the leveraging of unactivated alkyl electrophiles as coupling components is still rarely exploited. Herein, we disclose a photoredox-assisted cobalt-catalyzed asymmetric alkylative Barbier-type addition reaction of ketones to address the aforementioned challenges, thereby allowing for the construction of highly congested tetrasubstituted carbon centers. The alkyl addition fragments could be either readily accessible unactivated alkyl halides or redox-active esters generated through a decarboxylative pathway. Both types of alkyl electrophiles include primary, secondary, and tertiary ones, thus affording diverse enantioenriched tertiary alcohols with a broad substrate scope. This enantioselective protocol is applied for the expedient synthesis of core structure of Sofdra, a very recent FDA-approved drug in 2024. The newly developed bisoxazolinephosphine (NPN) ligand enables high enantioselectivity in this asymmetric reductive addition process.

Tuberculosis in Aceh Province, Indonesia: a spatial epidemiological study covering the period 2019-2021.

The purpose of this study was to determine whether there were any TB clusters in Aceh Province, Indonesia and their temporal distribution during the period of 2019-2021. A spatial geo-reference was conducted to 290 sub-districts coordinates by geocoding each sub-district's offices. By using SaTScan TM v9.4.4, a retrospective space-time scan statistics analysis based on population data and annual TB incidence was carried out. To determine the regions at high risk of TB, data from 1 January 2019 to 31 December 2021 were evaluated using the Poisson model. The likelihood ratio (LLR) value was utilized to locate the TB clusters based on a total of 999 permutations were performed. A Moran's I analysis (using GeoDa) was chosen for a study of both local and global spatial autocorrelation. The threshold for significance was fixed at 0.05. At the sub-district level, the spatial distribution of TB in Aceh Province from 2019-2021 showed 19 clusters (three most likely and 16 secondary ones), and there was a spatial autocorrelation of TB. The findings can be used to provide thorough knowledge on the spatial pattern of TB occurrence, which is important for designing effective TB interventions.

Social Support at School for Students with Sensory Disabilities.

Social support is the gratification of basic social needs (affection, belonging, esteem or approval, security, identity) through interaction with others. Social support at school allows students to perceive themselves as competent during learning and to enjoy school in general. Little is known about social support at school for students with sensory disabilities. This review aims to synthesize findings from studies examining social support at school for students with hearing and visual impairments. A search of computerized databases was supplemented by a manual search of the bibliographies of the main publications. The synthesis of the literature suggests that all students need adequate support devices in class and properly trained support teachers. However, visually impaired students are more likely to have access to resources compared to those with hearing impairments. Students with visual impairments attending regular schools are more positive about the availability of resources than those with hearing impairments attending special schools. Overall, senior secondary school students indicate higher resource availability than junior secondary school ones. Still, very few studies have investigated social support for students with sensory disabilities. Thus, further research is needed to confirm these results.

Challenging the Albanian E.U. Cybersecurity perspectives

Cybersecurity has emerged as a critical concern on a global scale, and Albania is no exception. This paper delves into Albania’s current cybersecurity challenges, shedding light on existing vulnerabilities and presenting recommendations to enhance the nation’s resilience against cyber threats, considering the country’s E.U. perspectives. The paper explores critical facets of cybersecurity, including the vulnerabilities within the country’s infrastructure, the regulatory framework, and the prevalent skills gap. By addressing these aspects, a comprehensive overview is provided, outlining Albania’s challenges in safeguarding its digital assets. The methodology used in this paper applies a theoretical approach based mainly on qualitative methods using secondary data and information, analyzing, comparing, and evaluating sources coming mainly from secondary sources, national and international ones. Through this method, the paper aims to offer a nuanced understanding of the cybersecurity landscape in Albania and its E.U. challenges regarding cybersecurity perspectives. In summary, this research concludes that by addressing cybersecurity challenges, Albania will be more effectively integrated into the E.U. and the global market economy, benefiting well-being and creating a more secure society.

The Effect Of Interaction Between Non-Performing Loans And Operating Expenses On Capital Adequacy Ratio As Moderated By Return On Equity

This study aims to analyze the effect of interaction between non-performing loans (NPL) and Operating Expenses to Operating Income (OEOI) ratios on capital adequacy ratio (CAR) as moderated by return on equity (ROE). A quantitative approach was used in this research. The data in this research were secondary ones and they were obtained from the annual financial statements for 2018-2020 period from commercial banks listed on Indonesian stock exchange (IDX). As many as 42 commercial banks served as the research population. From this number, using the requirement of having complete financial statements for 2018-2020 period as the criteria, 30 commercial banks were sampled purposively. The data were analyzed using multiple linear regression and moderating regression analysis (MRA). This study found that both NPL and operating expenses had a negative effect on CAR. However, while the former’s effect was significant, that of the latter was not. From the moderation regression analysis, it was revealed that ROE could not moderate the NPL’s effect on CAR, yet it could moderate the impact of OEOI on CAR.

Motion dynamics of two-dimensional fundamental and vortex solitons in the fractional medium with the cubic-quintic nonlinearity

Motion dynamics of two-dimensional fundamental and vortex solitons in the fractional medium with the cubic-quintic nonlinearity

Identifying the role of (dis)inhibition in the vicious cycle of substance use through ecological momentary assessment and resting-state fMRI

Functional inhibition is known to improve treatment outcomes in substance use disorder (SUD), potentially through craving management enabled by underlying cerebral integrity. Whereas treatment is challenged by a multitude of substances that patients often use, no study has yet unraveled if inhibition and related cerebral integrity could prevent relapse from multiples substances, that is, one’s primary drug of choice and secondary ones. Individuals with primary alcohol, cannabis, or tobacco use disorders completed intensive Ecological Momentary Assessment (EMA) coupled with resting-state functional MRI (rs-fMRI) to characterize the extent to which inhibition and cerebral substrates interact with craving and use of primary and any substances. Participants were 64 patients with SUD and 35 healthy controls who completed one week EMA using Smartphones to report 5 times daily their craving intensity and substance use and to complete Stroop inhibition testing twice daily. Subsamples of 40 patients with SUD and 34 control individuals underwent rs-fMRI. Mixed Model Analysis revealed that reported use of any substance by SUD individuals predicted later use of any and primary substance, whereas use of the primary substance only predicted higher use of that same substances. Craving and inhibition level independently predicted later use but did not significantly interact. Preserved inhibition performance additionally influenced use indirectly by mediating the link between subsequent uses and by being linked to rs-fMRI connectivity strength in fronto-frontal and cerebello-occipital connections. As hypothesized, preserved inhibition performance, reinforced by the integrity of inhibitory neurofunctional substrates, may partake in breaking an unhealthy substance use pattern for a primary substance but may not generalize to non-target substances or to craving management.

Computational study on CO2 absorption mechanism and structure–activity relationship of biphasic solvent

The biphasic solvents are conducive to improving the efficiency of CO2 capture and reducing the energy consumption caused by regeneration. This study explored their reaction process at the molecular level based on density functional theory (DFT): selection of diamines such as active amines with distinct amino groups, 1,4-butanediamine (BDA) and N-(2-aminoethyl)ethanolamine (AEEA), and with typical phase separation promoters, 2-(diethylamino)ethanolamine (DEEA), and N,N,N′,N′,N′′-pentamethyldiethylenetriamine (PMDETA). This study systematically explores the potential reaction paths in CO2 capture to quantitatively assesse the structure–activity relationships among different amines in different stages of absorption, the influence of reaction sequence on reaction rates, and further elucidates the characteristics of product formation and its impact on the phase separation process. The results indicated that the zwitterion mechanism is widely applicable and remains the dominant explanation for the biphasic solvent CO2 capture mechanism. The intramolecular proton transfer reaction is the key to influencing the absorption rate of CO2, but in the case of interproton transfer, the rate-determining step needs to be judged in conjunction with the type of amino groups on it. And the amine groups on AEEA react with CO2 in different orders, forming distinct zwitterions that have similar activity in later intramolecular proton transfers. Under the zwitterion mechanism, primary amino groups exhibit stronger proton affinity than secondary ones. In solvents approaching saturation stage, DEEA reacts with AEEA and CO2 earlier than PMDETA. This study reveals the reaction mechanism of biphasic solvents and the key paths in different phases, providing insights for developing new solvents.

Regular, Beating and Dilogarithmic Breathers in Biased Photorefractive Crystals

The propagation of light beams in photovoltaic pyroelectric photorefractive crystals is modelled by a specific generalization of the nonlinear Schrödinger equation (GNLSE). We use a variational approximation (VA) to predict the propagation of solitary-wave inputs in the crystals, finding that the VA equations involve a dilogarithm special function. The VA predicts that solitons and breathers exist, and the Vakhitov–Kolokolov criterion predicts that the solitons are stable solutions. Direct simulations of the underlying GNLSE corroborates the existence of such stable modes. The numerical solutions produce both regular breathers and ones featuring beats (long-period modulations of fast oscillations). In the latter case, the Fourier transform of amplitude oscillations reveals a nearly discrete spectrum characterizing the beats dynamics. Numerical solutions of another type demonstrate the spontaneous splitting of the input pulse in two or several secondary ones.

Recurrence and Survival after Robotic vs. Laparoscopic Liver Resection in Very-Early to Early Stage (BCLC 0-A) Hepatocellular Carcinoma: A Retrospective Cohort Study with Propensity Score Matching

Abstract Background Robotic (RLR) and laparoscopic liver resection (LLR) provide similar short-term outcomes in hepatocellular carcinoma (HCC) of stage BCLC 0-A, but data on recurrence and survival are still lacking in populations with high prevalence of cirrhosis. Aims We investigated the outcomes of RLR vs. LLR for HCC in a cohort with high rate of cirrhosis. The primary endpoint was recurrence-free (RFS) and overall survival (OS); incidence, pattern, and treatment of recurrence were the secondary ones. Methods RLRs and LLRs for HCC of stage BCLC 0-A from two tertiary centers for liver surgery were retrospectively reviewed. Propensity score matching (PSM) was used to mitigate selection bias. Survival was estimated with Kaplan Meier method with Log rank. Results One-hundred-ninety-six patients underwent RLR (n=68) or LLR (n=128) for BCLC 0-A HCC. After 1:1 PSM, two groups (RLR=68; LLR=68) of patients with similar characteristics, liver function and HCC features were obtained: age (median) 71-year-old, males 73.5%, underlying cirrhosis 91.2% (Child A 96.8%, MELD <9 96%), portal hypertension 22.1%, single-HCC 90.4%. At a median follow-up of 29.0 months, 2- and 5-year RFS were 78.0 vs. 59.0% and 54.0 vs. 53.0% (p=0.107), while OS was 97.0 vs. 90.0% and 87.0 vs. 90.0% (p=0.951) for RLR vs. LLR respectively. Incidence of recurrence was similar (35.3 vs. 39.7%; p=0.723) and was mostly within the liver (29.4 vs. 30.9%; p=1.000) or within 2 years after hepatectomy (54.2 vs. 81.5%, p=0.116) in RLR vs. LLRs. Curative-intent treatment of recurrences did not differ (liver transplantation 19.6%, redo-resection 15.7%) except for a tendency to more redo-resections of recurrences after RLR (29.2 vs. 3.7%; p=0.062). Conclusion Oncologic outcomes of RLR were not inferior to those of LLR in selected HCC patients of stage BCLC 0-A with underlying cirrhosis. Both techniques guaranteed similar salvageability at HCC recurrence in our experience.

Influence of Severity and Susceptibility Information Content on Users’ Psychological Response in Emergencies—The Moderating Effect of Regulatory Focus

Information content is crucial for public opinion governance, yet its psychological mechanisms remain unclear. This paper endeavors to bridge this knowledge gap by examining the influence of information content on users’ psychological responses. Drawing insights from the heuristic-systematic model (HSM) and regulatory focus theory, we constructed a novel cognitive and emotional response model. Regression analysis reveals that susceptibility strongly influences primary cognitive responses, while severity affects secondary ones. Susceptibility has a stronger impact on emotional responses than severity. Promotion-focus users are less influenced by severity and susceptibility than prevention-focus users. These results offer valuable insights for emergency management strategies and enhance individuals’ resilience in coping with the psychological toll of emergencies.

Effect of Nucleation Heterogeneity on Mineral Precipitation in Confined Environments

AbstractThe formation of new mineral phases in confined environments, especially in porous media, is crucial for various geological processes like mineralization and diagenesis. The nucleation and precipitation of minerals are initiated at the microscale through fluid‐rock interaction, where dissolution of primary phases leads to supersaturated conditions and nucleation and growth of secondary ones. Previous research has focused primarily on either precipitation or nucleation, without fully exploring their combined impact. Our study introduces a computational framework that integrates classical nucleation theory with the micro‐continuum method. We validated our model by comparing with experiments, and discovered that different surface nucleation rate changes the mode of precipitation from a preferential to uniform precipitate textures. Furthermore, our study uncovered that the conventional deterministic precipitation method tends to underestimate the permeability of the porous matrix. In contrast, the new framework significantly improves model accuracy by incorporating preferential precipitation and heterogeneous nucleation.

On the Theoretically Possible Number of Cases in Natural Language

Introduction. The case, which is a semantic and grammatical category, appears in natural languages in the most unexpected way. A word or phrase that has a substantive unit at its core receives an inflection (internal or external) in one case or another, which can be expressed both explicitly and implicitly, and has a grammatical meaning. In this case, inflection can be accompanied by a preposition that has a lexical meaning. These case indicators, morphological and syntactic, organize the main or secondary substantive part of the sentence, i.e. are related to the category of space. The number of cases today is still the subject of scientific debate. Methodology and sources. The present study is based on analizing the views of various scientists on the category of case, with special attention to the theory of L. Hjelmslev. According to this theory, the maximum possible number of cases in natural language is 216. In order to provide a purely formal calculation of the possible number of cases, which would be at the same time independent on the earlier views, the article represents the substantive part of the sentence as a semifinitive multiplied by a specifier (proto-specifier). These statements are prescribed by the binomiality idea, having been developed since 1993 at ETU. Results and discussion. The generally accepted division of sentence parts into main and secondary ones leads us to dividing all possible cases into direct cases (for subject) and indirect cases (for secondary substantive parts). Thus, the direct case can be obtained by a simple transformation from any indirect case, i.e. the space specifier goes back to the spatial proto-specifier. The space proto-specifier represents external space added to substantive mass. The substantive semifinitive is a substantive mass multiplied by internal space. As the binomiality idea prescribes, substantive masses can be in four states, while substantive semifinitives can be in six states. Thus, the number of possible case forms should be equal to 24. Conclusion. According to classical physics, space is three-dimensional, so grammatical space, both external and internal, should also, obviously, be considered three-dimensional. This means that four states of substantive mass and six states of substantive semifinitives can be in each of the three dimensions. Thus, the maximum possible number of cases may indeed reach 216. It should be noted that L. Hjelmslev derived the number 216 in a completely different way, by dint of much deeper reasoning. In the future, it would be interesting to compare L. Hjelmslev’s binary oppositions with the constituents of substantive parts of sentence.

Safety and efficacy of drug-eluting stents for patients at high risk of bleedings: A network meta-analysis.

Among different coronary stents implanted in High Bleeding Risk (HBR) patients with an indication for short antiplatelet therapy, no comparisons in terms of efficacy have been provided. A Network Meta Analysis was performed including all randomized controlled trials comparing different coronary stents evaluated in HBR patients. Major Adverse Cardiovascular Events (MACEs) as defined by each included trial were the primary end point, whereas TLR (target lesion revascularization), TVR (target vessel revascularization), stent thrombosis and total and major (BARC3-5) bleedings were the secondary ones. A total of four studies (ONYX ONE, LEADERS FREE, SENIOR and HBR in BIO-RESORT) including 6637 patients were analyzed with different kind of stents and dual antiplatelet therapy (DAPT) length (1 or 6 months) on 12 months follow-up. About one-third of these patients were defined HBR due to indication for oral anticoagulation. All drug eluting stents (DESs) reduced risk of MACE compared to Bare Metal Stents (BMSs) when followed by a 1-month DAPT. At SUCRA analysis, Orsiro was the device with the highest probability of performing best. Rates of TLR and TVR were significantly lower when using Resolute Onyx, Synergy and BioFreedom stents in comparison to BMS when followed by 1-month DAPT, with Synergy ranking best. Synergy also showed a significantly lower number of stent thrombosis compared to BMS (RR 0.28, 95%CI 0.06-0.93), while Orsiro and Resolute Integrity showed the highest probability of performing best. In HBRs patients, all DESs were superior to BMSs in terms of efficacy and safety. Among DESs, Orsiro was the one with the highest ranking in terms of MACE, mainly driven by a reduced incidence of repeated revascularization and stent thrombosis.

Copper-Catalyzed Enantioconvergent Radical N-Alkylation of Diverse (Hetero)aromatic Amines.

The 3d transition metal-catalyzed enantioconvergent radical cross-coupling provides a powerful tool for chiral molecule synthesis. In the classic mechanism, the bond formation relies on the interaction between nucleophile-sequestered metal complexes and radicals, limiting the nucleophile scope to sterically uncongested ones. The coupling of sterically congested nucleophiles poses a significant challenge due to difficulties in transmetalation, restricting the reaction generality. Here, we describe a probable outer-sphere nucleophilic attack mechanism that circumvents the challenging transmetalation associated with sterically congested nucleophiles. This strategy enables a general copper-catalyzed enantioconvergent radical N-alkylation of aromatic amines with secondary/tertiary alkyl halides and exhibits catalyst-controlled stereoselectivity. It accommodates diverse aromatic amines, especially bulky secondary and primary ones to deliver value-added chiral amines (>110 examples). It is expected to inspire the coupling of more nucleophiles, particularly challenging sterically congested ones, and accelerate reaction generality.