Abstract At present, the “source-load interaction” distribution network operation mode has gradually replaced the “source-load operation” mode. The uncertainty and volatility of the distribution system have been enhanced, the controllability has been weakened, the voltage fluctuations have been frequent, and the power quality has been decreased. Voltage regulation is crucial to fully absorbing new energy generation and improving the operation safety of the active distribution network. To solve the problem of real-time control of distribution networks, this paper proposes a distributed voltage control method of active distribution networks with global sensitivity, establishes a distributed communication mechanism, and builds a distributed forward push-back communication rule to transfer power and voltage information between nodes. The global sensitivity of voltage, active power, and reactive power is used for real-time, independent, and effective control of multiple devices at each node, and the distributed control process is simulated according to actual production conditions. Furthermore, the centralized and decentralized real-time voltage control methods are proposed, and the centralized and distributed methods are implemented in medium voltage primary distribution network (MVPN) and low voltage secondary distribution network (LVSN), respectively, to play the advantages of high computing efficiency and fast control response. Based on model predictive control (MPC), intra-day rolling time scale voltage regulation is constructed, and second-level control is used to adapt the MPC results, finally promoting the optimal scheduling and rapid response of various controllable flexible resources in the multi-level active distribution network.