To evaluate the impact of fluid resistance on the performance of tubular indirect evaporative coolers (TIECs), a mathematical model of secondary air channel resistance was developed. An experimental setup was created to study the effects of factors such as secondary air flow rate and water spray flow rate on R2 under actual conditions. The model used the same conditions to analyze how factors like air flow, water flow, and droplet size influenced R2. The relationship between R2 and wet-bulb effectiveness (εwb) was also examined experimentally. The data from the experiments were compared to the model's predictions, showing a maximum relative error of 10 %, confirming the model's accuracy. It was found that R2 and secondary air flow rate (V2) are positively correlated, and εwb increases with R2. The experiments yielded secondary air resistances ranging from a minimum of 548.2 Pa to a maximum of 554.26 Pa. These results are valuable for selecting appropriate fans for the secondary air channel. Additionally, simulations were conducted to predict and calculate energy losses in the secondary air channel under real working conditions, providing a useful basis for future fan selection.