The formation and evolution of cell physiology in USSR was associated with the academician Platon Kostuk, an outstanding world-renowned scientist. His scientific activity occurred in the second half of 20th century, the period of burst-like progress in electrophysiology that provided a number of remarkable results rewarded with three Novel prizes. In biology of that time, electrophysiology was the only field, wherein methods and approaches were developed for the on-line analysis of physiological processes in cells and tissues. The goal of the given essay is to highlight retrospective aspects of the bioelectricity concept and to characterize the related contribution of the electrophysiological school of P.G. Kostuk to the field.