Seawater reverse osmosis (SWRO) technology has been universally adopted because of its high efficiency, economic benefits, easy maintenance, and high-pressure seawater pump (HPSP) and energy recovery device (ERD) are essential components, which determine the specific energy consumption of SWRO system. However, it is still unclear about energy dissipation mechanism and mixing characteristics from the perspective of system. For that, this thesis proposes a novel system-level Computational Fluid Dynamics (CFD) model considering all interfaces in HPSP and integrated energy recovery and pressure boost device (IERPBD). To profoundly investigate the system performance under various operating conditions, the pressure and composition distribution, power loss of each interface and mixing rate are numerically calculated and analyzed. Additionally, experiment of the effect of temperature on SWRO system performance is conducted to practically verify the proposed model, which indicates that the presented model could precisely reflect the energy dissipation and mixing characteristics. Besides, it is advised that the rotating speed of HPSP and IERPBD should not be set too high which could increase the mixing rate and energy consumption, and higher temperature might lower the quality of produced freshwater. This study offers a feasible way to reveal the energy dissipation mechanism of SWRO desalination system.