Database Search Research Articles

Human oral microbiome as forensic biomarkers for individual identification: A systematic review

: The oral microbiome is a promising and novel source of biomarkers for forensic identification. It offers distinct signatures that may differentiate individuals, sparking new avenues of research and discovery.: This systematic review is meticulously designed to comprehensively consolidate current research on oral microbiome signatures in forensic contexts, leaving no stone unturned in our quest for knowledge. It focuses explicitly on microbial diversity, community structure, and specific taxa as potential markers for individual identification.s: To identify relevant studies published between 2014 and 2024, a comprehensive search of major scientific databases was conducted. Inclusion criteria encompassed peer-reviewed articles investigating oral microbiome diversity and specific microbial markers relevant to forensic individual identification. These studies were employed to evaluate the reliability and consistency of these biomarkers across diverse populations and environmental conditions.: The review included 13 studies that met the criteria, revealing significant associations between specific oral microbial taxa and individual identification. This systematic review highlighted consistent discriminatory power and stability of microbial signatures across varied populations.: Oral microbiome analysis is promising to enhance forensic investigations by providing unique biomarkers for individual identification. However, challenges such as standardization of microbiome studies and influences of environmental factors on microbiome underscore the need for further research to validate and effectively implement oral microbiome data in forensic practice.

Nutritional benefits of camel milk in autism-A mini-review

Camels are essential livestock for milk, meat, and transportation, particularly in arid regions.Camel's milk is a staple diet worldwide due to its nutritional value, including lactoferrin, calcium, vitamins, peptides, zinc, and polyunsaturated fatty acids (PFA). It has therapeutic properties like anti-diabetic, bactericidal, anticarcinogenic, and anti-hypertensive effects. Camel's milk also increases carbohydrate metabolism, curing gastrointestinal disorders due to polyunsaturated fatty acids, vitamins, and anti-inflammatory proteins. Its low fat and cholesterol levels, vitamins, minerals, and insulin content make it a critical source of insulin, potentially helping treat diabetes. This review article mainly emphasized the maximum nutritional benefit of camel milk consumption by children or adults suffering from autism spectrum disorders (ASD) after going through extensive reviews of published articles. This article was conducted based on searches in open-source databases like Google Scholar, Embase, DOAJ, PubMed, etc., using specific keywords such as ‘camel milk,’ ‘camel milk benefit,’ ‘camel milk future,’ etc.Camel's milk has been found beneficial for individuals with autism spectrum disorders in India, but further scientific research is needed to comprehend its nutritional and physiological benefits fully.

Traumatic posterior atlantoaxial dislocation without an associated fracture: a PRISMA-compliant case-based systematic review and meta-analysis.

Traumatic posterior atlantoaxial dislocation (TPAD) without an associated fracture is a rare and challenging spinal injury. This PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses)-compliant case-based systematic review and meta-analysis aimed to comprehensively explore TPAD, covering clinical presentation, diagnosis, treatment, and clinical and radiological outcomes. Following the presentation of a case of TPAD without an associated fracture, we conducted a systematic search of electronic databases, including Scopus, PubMed, and Web of Science, from inception through October 2023, without language restrictions. Cases involving dislocations due to congenital anomalies or inflammatory processes were excluded. The search yielded 31 eligible cases of TPAD without an associated fracture. The majority (81%) of the cases were males, with traffic accidents being the leading cause (87%). Notably, 52% of the cases presented without any neurological deficits. Regarding treatment approaches, 23% of the cases were managed through closed reduction alone, 32% required fusion following closed reduction, and 45% underwent open reduction and fusion. A time delay exceeding 7.5 days was associated with a significantly higher risk of closed reduction failure (odds ratio, 56.463; p =0.011). This review identified key management strategies for TRAD without fracture, informed by the available evidence. Optimal management entails prompt closed reduction under C-arm while monitoring neurological status once hemodynamic stability is achieved. Surgical fusion is indicated for cases with magnetic resonance imaging-confirmed transverse ligament rupture or residual instability. If closed reduction fails, open reduction and fusion should be carried out. Posterior C1-C2 screws fixation is the preferred fusion technique, providing high levels of safety and biomechanical stability.

Harm reduction for perinatal cannabis use: protocol for a scoping review of clinical practices

IntroductionThe American College of Obstetricians and Gynaecologists recommends against cannabis use during pregnancy and lactation (‘perinatal cannabis use’) given its association with negative parent–child health outcomes. However, cannabis is becoming...

Cross-Sectional Survey Analysis of Institutional Research Partnerships in Complementary and Integrative Health: Identifying Barriers and Facilitators.

Objective: Collaboration between complementary and integrative health (CIH) institutions and research-intensive (R1) institutions has been successfully undertaken in the United States, resulting in federally funded research projects, educational programs, and faculty development. The aim of this cross-sectional survey study was to explore the barriers and facilitators to establishing and maintaining such collaborative partnerships. Methods: A 32-question survey was sent to participants recruited through author contacts and resources, literature review, and database searches. Participants were required to be researchers and affiliates who attempted, completed, or had current collaborative endeavors involving CIH and R1 institutions. Data were collected in the research electronic data capture (REDCap) system and descriptive quantitative and qualitative data analysis was undertaken. Results: A total of 26 unique entries were included in the final data analysis; four of which were paired entries (one from an R1 institution and one from a CIH institution) to make up two dyad data collections. Eighty-one percent of the participants had senior leadership roles at CIH institutions representing five CIH disciplines-East Asian medicine (acupuncture and Traditional Chinese Medicine), chiropractic medicine, massage therapy, naturopathy, and yoga. Collaborative research projects were often (>38%) in response to specific project funding mechanisms. Over 60% of the collaborations also included educational activities and faculty development. Collaborations resulted in multiple different types of benefits to both institutions but were not without associated challenges. Conclusion: Collaborations between R1 and CIH institutions can be cooperative, productive, and mutually beneficial. Funding mechanisms supporting R1 and CIH collaboration increase CIH research productivity as well as the development of innovative research methodology to study the real-world practice of CIH therapies, whole systems, and whole person health. CIH researchers would greatly benefit from such funding, allowing access to research infrastructure, professional development, and the provision of protected time to conduct research.

Sustainability of Interprofessional Education: Protocol for a Scoping Review.

Interprofessional education (IPE) is an approach that can improve health care quality, contribute to the qualification of health care professionals, and train undergraduate students. Although this strategy has made significant progress in the last decade, integration, sustainability, and institutional growth are still priorities worldwide. Thus, maintaining strategies is essential for their full development and evolution. This study aimed to identify discussions about the sustainability of IPE and map its actions or strategies (or both). The scoping review will follow the Joanna Briggs Institute methodology. This scoping review protocol follows the JBI Reviewers' Manual, with 6 stages: identifying the research question; identifying relevant studies; study selection; data extraction and coding; analysis and interpretation of results; and consultation with stakeholders. Two independent and blind reviewers will evaluate and select studies available in English, Portuguese, and Spanish based on the eligibility criteria. Searches will be conducted on LILACS, Embase, Scopus, PubMed/MEDLINE, ERIC, Web of Science, CINAHL, Google Scholar databases; ProQuest Dissertations & Theses Global, and Brazilian Digital Library of Theses and Dissertations. The main research question is as follows: What have been the sustainability strategies for IPE actions? This scoping review will incorporate studies (empirical or theoretical-reflective) that address strategies or actions (or both) for IPE sustainability. They must present a quantitative, qualitative, or mixed methods approach and be available in full text. Data on strategies or actions for IPE sustainability will be extracted and inserted into a spreadsheet for analysis. Quantitative data will be analyzed using descriptive statistics, while qualitative analysis will identify meanings and patterns through thematic analysis. Thus, the aim is to present the compiled findings in tables and charts. The database search was conducted on March 22, 2024. In April and May 2024, duplicate studies were excluded. From July to November 2024, study selection will be carried out. In December 2024, data extraction and tabulation will take place, as well as consultation with stakeholders. The aim is to publish the results in scientific journals in January 2025. This protocol will guide this scoping review to identify discussions on the sustainability of IPE and map its actions or strategies (or both); summarize the definitions and institutions that develop or promote IPE; and present the main recommendations for the area under study. Additionally, possible research gaps can be identified to guide future studies. This review will shed light on existing knowledge gaps and the current state of research, which could provide support for future research, programs, and policy responses to foster collaboration and interprofessional practice and, consequently, improve the quality of user care. This information will be useful in supporting decision-making by government officials, managers, teachers, facilitators, and students in the implementation, maintenance, and development of IPE. Open Science Framework 5VNJS; https://osf.io/5vnjs/. DERR1-10.2196/60763.

Medicinal Plants as A Natural Immunity Booster Against Covid 19: A Review

Medicinal plants have long been valued for their therapeutic properties, especially in boosting immune function. This review explores the role of medicinal plants in enhancing immunity during the COVID-19 pandemic, with an emphasis on plants known for their bioactive compounds and health benefits. A thorough search of online databases resulted in the identification of 115 published articles from 2020 to 2024, which led to the selection of 50 plants commonly used for immune support. Plants include Garlic, Ashwagandha, Neem,Turmeric, Guduchi, Holy Basil, Amla, Aloe Vera, Black Cardamom, Cinnamon, Pomegranate, Guava, Moringa, Black Cumin, Lemon, Lemongrass, Papaya, Green Tea and others. These plants contain bioactive compounds such as flavonoids, alkaloids, and terpenoids, which are believed to possess immune-boosting, anti-inflammatory, and antiviral properties. Garlic, Turmeric, and Ashwagandha are particularly noted for combating oxidative stress and supporting immune function, while Gurjo, Neem, and Amla are valued for their detoxifying and anti-inflammatory effects. These plants, traditionally used during viral infections like the flu and COVID-19, represent a fusion of ancient cultural wisdom and modern scientific research.Future research should focus on clinical validation and pharmacological studies to better understand the efficacy of these plants in immune modulation.

Smoking-Related Tear Film Abnormalities and Dry Eye Disease: A Meta-Analysis

Dry eye disease (DED) is a prevalent ocular condition characterized by tear film instability and ocular surface inflammation. Smoking has been identified as a potential risk factor for DED, but the impact of different smoking modalities (active, passive, and e-cigarette) on tear film and DED remains unclear. This meta-analysis aimed to evaluate the association between various forms of smoking and tear film abnormalities leading to DED. A systematic search of PubMed, Embase, and Cochrane Library databases was conducted for studies published between 2013 and 2024 investigating the effects of active smoking, passive smoking, and e-cigarette use on tear film parameters and DED diagnosis. Data extracted included tear film break-up time (TBUT), Schirmer's test results, tear osmolarity, and DED diagnostic criteria. Pooled effect estimates were calculated using random-effects models. Eight studies met the inclusion criteria, comprising 4 on active smoking, 2 on passive smoking, and 2 on e-cigarette use. Active smoking was significantly associated with reduced TBUT (standardized mean difference [SMD] = -2.87; 95% CI: -3.12 to -2.62; p<0.00001), lower Schirmer's test scores (SMD = -2.79; 95% CI: -3.23 to -2.35; p<0.00001), and increased tear osmolarity (SMD = 12.55; 95% CI: 8.17 to 16.93; p<0.00001). Passive smoking and e-cigarettes showed a similar trend but with less pronounced effects. In conclusion, this meta-analysis provides evidence that active smoking significantly impairs tear film stability and contributes to DED. Passive smoking may also have detrimental effects, while the impact of e-cigarettes requires further investigation. These findings underscore the importance of smoking cessation in DED management and public health strategies for eye health.

Evaluation of thyroid function tests among children with neurological disorders

BackgroundThyroid hormones (THs) are essential for brain development. Numerous studies have identified significant links between thyroid dysfunction and cognitive function. However, research on the significance and necessity of thyroid function tests in diagnosis of neurological disorders is limited and subject to controversy.MethodsOur study employed a combination of meta-analysis and case-control design. For the meta-analysis, we conducted a systematic search of online databases for studies that compared thyroid function tests in children with neurological disorders to controls. In our case-control study, we recruited a total of 11836 children, comprising 7035 cases and 4801 healthy controls. Wilcoxon Rank Sum Test was used to determine characteristics of thyroid function between the cases and healthy controls. In order to exclude the false discovery rate (FDR), the Benjamini-Hochberg (BH) procedure is applied.ResultsA total of 12 relevant literature sources were included in the meta-analysis. Compared with controls, free thyroxine (FT4) levels were significantly decreased in neurological disorders in meta-analysis (MD = -0.29, 95% CI: -0.50 to -0.09), whereas thyroid-stimulating hormone (TSH) levels showed no significant difference (MD = -0.07, 95% CI: -0.36 to 0.21). In our case-control study, levels of free thyroxine (FT4), total triiodothyronine (TT3), total thyroxine (TT4), and anti-thyroglobulin antibodies (TG-Ab) were notably reduced among individuals with neurological disorders, compared with healthy controls (P<0.001, P<0.001, P=0.036, P=0.006). However, thyroid-stimulating hormone (TSH) levels did not show any statistically significant differences among the cases and controls.ConclusionsOur research demonstrates that, in comparison to controls, children with neurological disorders exhibited a significant decrease in FT4 levels, while TSH levels remained unchanged. This finding provides a reference for potential serum marker of neurological disorders in children. Replication in future studies with the assessment of THs is needed to determine whether thyroid function should be included as a routine screening in these children.

Incentives for pregnant mothers during antenatal care for better maternal and neonatal health outcomes in low and middle income countries: A Systematic Review and Meta-Analysis

Background Universal access to maternal, newborn, and child healthcare is essential for achieving Sustainable Development Goal 3, but the effectiveness of various incentive-based programs for pregnant mothers in low- and middle-income countries (LMICs) remains uncertain. Objective of this systematic review was to determine if incentive-based interventions influenced maternal and neonatal health outcomes. Methods We conducted a search in various databases from inception. All incentive-based interventional studies conducted on pregnant women in LMICs were included. Evidence from the included trials was synthesized using risk ratios (RRs) to compare the outcomes between groups receiving incentives and not receiving incentives. The meta-analysis was conducted using random-effects model. We assessed the quality of the included studies using the Cochrane Risk of Bias 2.0 tool and reviewed the collected data to determine its suitability for meta-analysis. This study is registered in PROSPERO (CRD42021247681). Results Of the 3,897 records that were identified, 11 met eligibility criteria, all of which exhibited varying degrees of risk of bias, ranging from high to some concerns. Analysis of maternal outcomes across studies revealed no significant differences in the likelihood of delivering at a healthcare facility (RR 1.13, 95% CI: 0.86 to 1.47) and in frequency of prenatal care (RR 0.99, 95% CI: 0.88 to 1.12) between intervention and control groups. However, high levels of statistical heterogeneity were observed for both outcomes indicating variability among study results. Similarly, analysis of tetanus vaccine coverage showed no significant difference between groups (RR 1.00, 95% CI: 0.92 to 1.08), with moderate statistical heterogeneity observed. Conclusion The maternal and neonatal outcomes examined in this review did not have any significant differences in intervention group when compared to the control group. The interventions to address maternal health concerns need to follow a multifactorial approach. There is a need for extensive primary research studies in the future.

Polygenic Risk Score Implementation into Clinical Practice for Primary Prevention of Cardiometabolic Disease

Background: Cardiovascular disease is a leading cause of mortality globally and a major contributor to disability. Traditional risk factors, as initially established in the FRAMINGHAM study, have helped to stratify populations and identify patients for early intervention. Incorporating genetic factors enhances risk stratification tools, enabling the earlier identification of individuals at increased risk and facilitating more targeted and effective risk factor modifications. While monogenic risk variants are present in a minority of the population, polygenic risk scores (PRS) are collections of multiple single-nucleotide variants that collectively provide summative risk and capture a more accurate risk score for a greater number of people. PRS have demonstrated clear utility in cardiometabolic diseases by predicting onset, progression, and therapeutic response. Methods: A structured and exploratory hybrid search strategy was employed, combining keyword-based database searches and supplementary techniques to comprehensively synthesize the literature on PRS implementation in clinical practice. Discussion: A comprehensive overview of PRS in cardiometabolic diseases and their potential avenues for integration into primary care is discussed. First, we examine the implementation of genetic screening, risk communication, and intervention strategies through the lens of the American Heart Association’s implementation criteria, focusing on their efficacy, minimization of harm, and logistical considerations. Then, we explores how the varied perceptions of patients and practitioners towards PRS can influence both adoption and utilization. Lastly, we addresses the need for the development of clear guidelines and regulations to support this process, ensuring PRS integration is both scientifically sound and ethically responsible. Future directions: Initiatives aimed at advancing personalized approaches to disease prevention will enhance health outcomes. Developing guidelines for the responsible use of PRS by establishing benefits, while mitigating risk, will a key factor in implementation for clinical utility. Conclusions: For integration into clinical practice, we must address both patient and provider concerns and experience. Standardized guidelines and training will help to effectively implement PRS into clinical practice. Developing these resources will be essential for PRS to fulfill its potential in personalized, patient-centered care.

Phytochemicals in the treatment of patients with depression: a systemic review

BackgroundDepression is a complex mental disease whose incidence increases every year; 300 million people worldwide currently suffer from it. Women are more likely to suffer from depression, twice the rate as men. It is one of the few illnesses that can lead to suicide, which makes it very dangerous – currently, 700,000 people die from suicide and it is the 4th most common cause of death in people aged 15-29. The treatment strategies for depression is a big challenge for physicians, pharmacists, scientists and classic remedies cause many side effects. Therefore, natural phytotherapy with herbs can prove to be a good solution. Phytotherapy is a popular treatment method used for centuries in Chinese medicine or Ayurveda.Materials and methodsThe study conducted a comprehensive database search PubMed, ClinicalKey and MedNar covered the years 2015 - 2024 to provide the most up-to-date data. 13 randomized controlled trials and 1 meta – analysis were included in the systematic review.ResultsMany plants show anti-inflammatory, antioxidant and cognitive enhancing effects, which are particularly important in depression. In the treatment of depression, plants such as Crocus sativus L. stigma, Lavandula angustifolia, Hypericum perforatum L. and Curcuma longa L. have proven to be effective. They show good effectiveness in human studies and alleviate the symptoms of depression. Herbal products can support classical pharmacotherapy, but this requires further research. Non-commercial clinical trials in the future should provide answers to research questions: at what stage of treatment of patients with MDD will the use of phytochemicals be most appropriate in terms of therapy efficacy and safety for the patient.ConclusionsCrocus sativus L. stigma, Lavandula angustifolia, Hypericum perforatum L. and Curcuma longa L. in modern medicine can help improve the well-being of patients with depression. The use of herbs as an intervention was associated with a decrease in the concentration of proinflammatory cytokines and an overall improvement in the mood of patients. Further research should be undertaken into combining both therapies in order to improve patients’ quality of life and reduce treatment costs.

Are trauma-related beliefs associated with psychosis symptoms? A systematic review and meta-analysis.

Trauma-related beliefs are theorized to contribute to the development and maintenance of psychosis symptoms. However, the evidence for this proposal has yet to be systematically reviewed. This article is the first to synthesize and meta-analyze studies examining associations between trauma-related beliefs and psychosis symptoms, including hallucinations, delusions, paranoia, and negative symptoms. A systematic database search of Medline, PsychINFO, Embase, Web of Science, CINHAL, and Cochrane identified a total of 15 articles that met the inclusion criteria for systematic review and 11 articles which met the inclusion criteria for meta-analysis. Separate random-effects meta-analyses were conducted for each psychosis symptom. Meta-analytic findings demonstrated a small to moderate association between trauma-related beliefs and hallucination severity (k = 7, r = 0.25, 95% CI 0.10-0.39), a moderate to large association with delusion severity (k = 8, r = 0.43, 95% CI 0.31-0.54), and large association with paranoia severity (k = 4, r = 0.58, 95% CI 0.49-0.66). Narrative synthesis findings indicate that evidence for an association between negative symptoms and trauma-related beliefs was inconclusive. The meta-analytic findings provide support for an association between trauma-related beliefs and positive psychosis symptoms. This provides evidence suggesting trauma therapies for psychosis that target these beliefs may improve distressing psychosis. However, further research adopting longitudinal designs and controlling for confounders is required to better establish causality, including mediation analysis of therapy trials.

The therapeutic potential of exercise in post-traumatic stress disorder and its underlying mechanisms: A living systematic review of human and non-human studies

Background Exercise for post-traumatic stress disorder (PTSD) is a potentially effective adjunct to psychotherapy. However, the biopsychosocial mechanisms of exercise are not well understood. This co-produced living systematic review synthesizes evidence from human and non-human studies. Methods We Included controlled human and non-human studies involving searches of multiple electronic databases (until 31.10.23). Records were screened, extracted, assessed for risk of bias, and reconciled by two independent reviewers. The primary outcome for human studies was PTSD symptom severity, while outcomes of interest for non-human studies included freezing behaviour, fear memory, fear generalization, startle response, and locomotion. Data were synthesised with random-effects meta-analysis. Results Eleven human studies met the eligibility criteria. Overall, exercise was not associated with symptom severity improvement compared to control (standardized mean difference [SMD] -0.08, 95% confidence interval [CI] -0.24 to 0.07; 8 studies, one at low risk of bias). High-intensity exercise reduced PTSD symptoms scores more than moderate-intensity exercise. There was insufficient data to examine the effects of exercise on functional impairment, PTSD symptom clusters, and PTSD remission. Only three studies, all at high risk of bias, examined mechanisms of exercise with inconclusive results. Exercise was associated with improvement in all behavioural outcomes, including locomotor activity (SMD 1.30, 95% CI 0.74 to 1.87, 14 studies), and changes in several neurobiological markers, including increase in brain-derived neurotrophic factor (SMD 1.79, 95% CI 0.56 to 3.01). Conclusions While non-human studies provide compelling evidence for the beneficial effects of exercise, human trials do not. Evidence from non-human studies suggest that exercise might increase the levels of brain-derived neurotrophic factor, enhance cognitive appraisal, and improve perceived exertion. Overall, the paucity of data on the effectiveness of exercise in PTSD and mechanisms of action underscore the need for rigorous trials. Registration The protocol was registered with PROSPERO (ID:453615; 22.08.2023).

Unlocking the Potential: How Flavonoids Affect Angiogenesis, Oxidative Stress, Inflammation, Proliferation, Invasion, and Alter Receptor Interactions in Endometriosis

ABSTRACTEndometriosis, though not classified as a carcinogenic condition, shares features such as oxidative stress, migration, invasion, angiogenesis, and inflammation with tumor cells. This study aims to review the effects of flavonoids on these processes and their molecular mechanisms in preventing and treating endometriosis. A comprehensive review was conducted, involving a literature search in online databases using keywords like “endometriosis,” “endometrioma,” and “flavonoid.” Two authors screened the literature based on predefined criteria, and the selected studies were summarized in a structured data extraction table. Studies reviewed showed that various flavonoids impact key processes in endometriosis, including angiogenesis, inflammation, oxidative stress, and invasiveness. Flavonoids such as 2′,7'‐dichlorodihydrofluorescein diacetate (H2DCF‐DA), naringenin, apigenin, myricetin, 5,7‐dimethoxyflavone (DMF), chrysin, and 6,8‐diprenylorobol were found to induce oxidative stress. Xanthohumol, isoliquiritigenin, and luteolin demonstrated effects on angiogenesis. Apigenin, isoliquiritigenin, and luteolin exhibited anti‐inflammatory properties. Additionally, 3,6‐dihydroxyflavone, isoliquiritigenin, and naringenin displayed anti‐invasive activities. Flavonoid–receptor interactions further enhance their therapeutic potential in endometriosis management. Flavonoids such as nobiletin, chrysin, and daidzein modulate PPARγ and PPARα, reducing inflammation, promoting apoptosis, and improving lipid metabolism. These interactions regulate critical pathways in angiogenesis and immune responses. Additionally, flavonoids impact the aryl hydrocarbon receptor (AhR), with compounds like resveratrol inhibiting cell proliferation and cholesterol biosynthesis, further suppressing lesion growth. The ability of flavonoids like quercetin and kaempferol to antagonize NR4A1 leads to reduced cell proliferation and oxidative stress in endometriotic tissues. These findings offer insights into the mechanisms through which specific flavonoids modulate angiogenesis, inflammation, oxidative stress, and invasiveness in endometriosis. By targeting receptors such as PPARs, AhR, and NR4A1, flavonoids demonstrate the capacity to modulate both metabolic and inflammatory pathways, offering a multifaceted approach to managing endometriosis. Flavonoids can selectively target pathophysiologic molecules and pathways implicated in the condition. Consequently, leveraging the therapeutic attributes of flavonoids could lead to novel strategies for managing endometriosis.

Experience of patients and healthcare practitioners with interdisciplinary care in immune-mediated inflammatory diseases with skin manifestations: A systematic scoping review.

Immune-mediated inflammatory diseases with skin manifestations (skIMIDs) may affect multiple organs. Interdisciplinary care (IC) can overcome the fragmented knowledge used in the management of skIMIDs. In skIMIDs-care, patient and healthcare practitioner (HCP) satisfaction with IC is unknown. Yet, patient experience influences adherence and medical outcomes. Moreover, HCP experience influences professional satisfaction, perception of care quality and autonomy. Thus, measuring patient and HCP experience can identify areas for improvement in care delivery. The aim of this scoping review was to gather evidence on patient- and HCP perceptions on skIMID-IC and their measurement. We systematically searched on 30 August 2023 PubMed/EMBASE/Cinahl/Web of Science. Eligible studies had to address explicitly experience of IC by patients or HCPs. A conceptional synthesis appraised how experiences were measured and IC was perceived by patients and HCPs. The database search resulted in 21 eligible studies. Fourteen described positive patient and HCP experiences with a specific IC programme. These studies were heterogenous on the levels of IC models, medical conditions, measurement methods and outcomes. Despite that patients and HCPs rated such tailored IC models positively, seven studies on a geographically broader region reported less satisfaction with IC. A conceptual analysis identified domains deemed as important regarding IC: 'general satisfaction', 'patient-HCP interaction', 'information', 'functioning of IC', 'benefits of IC'. For patients, 'access to care' and 'disease management' were added. For HCPs 'illness perception' was deemed relevant. The heterogeneous way in how IC experience is captured hinders strong conclusions, which mandates the development of standardized analysis tools. Experience with IC in skIMIDs strongly depends on the context of the provided IC and patient experience seems to be better in local IC programmes than systems rolled out in larger geographical regions. Future need is to develop a core IC outcome set including medical outcomes, process indicators, financial indicators, plus patient and HCP care experience measures.

Evaluation Methods, Indicators, and Outcomes in Learning Health Systems: Protocol for a Jurisdictional Scan.

In learning health systems (LHSs), real-time evidence, informatics, patient-provider partnerships and experiences, and organizational culture are combined to conduct "learning cycles" that support improvements in care. Although the concept of LHSs is fairly well established in the literature, evaluation methods, mechanisms, and indicators are less consistently described. Furthermore, LHSs often use "usual care" or "status quo" as a benchmark for comparing new approaches to care, but disentangling usual care from multifarious care modalities found across settings is challenging. There is a need to identify which evaluation methods are used within LHSs, describe how LHS growth and maturity are conceptualized, and determine what tools and measures are being used to evaluate LHSs at the system level. This study aimed to (1) identify international examples of LHSs and describe their evaluation approaches, frameworks, indicators, and outcomes; and (2) describe common characteristics, emphases, assumptions, or challenges in establishing counterfactuals in LHSs. A jurisdictional scan, which is a method used to explore, understand, and assess how problems have been framed by others in a given field, will be conducted according to modified PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. LHSs will be identified through a search of peer-reviewed and gray literature using Ovid MEDLINE, EBSCO CINAHL, Ovid Embase, Clarivate Web of Science, PubMed non-MEDLINE databases, and the web. We will describe evaluation approaches used both at the LHS learning cycle and system levels. To gain a comprehensive understanding of each LHS, including details specific to evaluation, self-identified LHSs will be included if they are described according to at least 4 of 11 prespecified criteria (core functionalities, analytics, use of evidence, co-design or implementation, evaluation, change management or governance structures, data sharing, knowledge sharing, training or capacity building, equity, and sustainability). Search results will be screened, extracted, and analyzed to inform a descriptive review pertaining to our main objectives. Evaluation methods and approaches, both within learning cycles and at the system level, as well as frameworks, indicators, and target outcomes, will be identified and summarized descriptively. Across evaluations, common challenges, assumptions, contextual factors, and mechanisms will be described. As of October 2024, the database searches described above yielded 3503 citations after duplicate removal. Full-text screening of 117 articles is complete, and 49 articles are under analysis. Results are expected in early 2025. This research will characterize the current landscape of LHS evaluation approaches and provide a foundation for developing consistent and scalable metrics of LHS growth, maturity, and success. This work will also serve to identify opportunities for improving the alignment of current evaluation approaches and metrics with population health needs, community priorities, equity, and health system strategic aims. Open Science Framework b5u7e; https://osf.io/b5u7e. DERR1-10.2196/57929.

Interventions to Enhance Facility Deliveries in Low- and Middle-Income Countries: A Scoping Review.

The objectives of this review were to identify and map evidence of interventions to enhance facility deliveries in low- and middle-income countries (LMICs). A search for all relevant existing reports in the literature was conducted in December 2020 using the following online bibliographic databases: PubMed, EMBASE, and CENTRAL. A manual search of the reference lists of relevant systematic reviews and all identified studies was performed to identify additional studies. Two reviewers independently screened the titles and abstracts of the retrieved studies, and then screened the full text identified as inclusion in the initial screening. The search of electronic databases and hand searching identified a total of 6682 articles. A total of 40 reports were identified for full-text review, and 31 reports were excluded. Finally, nine trials were included in the scoping review, and a total of 29,892 women were included in this review. Of nine trials, one was conducted in Nepal, and the other eight trials were performed in Africa: Kenya, Uganda, Nigeria, Tanzania, and Zambia. Our review found the following effective interventions to enhance facility deliveries: group antenatal care (ANC), birth plans, full vouchers, conditional cash transfers (CCTs), non-monetary incentives, and short message service (SMS). Women who received group ANC, promotion of birth plans, full vouchers, CCTs, non-monetary incentives, and SMS were significantly more likely to deliver at a facility.

Impact of internet addiction and gaming disorder on body weight in children and adolescents: A systematic review.

Internet use and gaming have increased in daily life. Internet addiction has not been recognised in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition or 11th Revision of International Classification of Diseases despite gaming addiction having been listed since 2013. Previous studies have shown an association between internet use and weight gain or disordered eating patterns in the general population, however none have addressed this association in a paediatric population. The aim of this study is to investigate the relationship between internet addiction or gaming addiction and weight in children and adolescents under 18 years of age. A systematic search of electronic databases was conducted, and articles were screened for relevance. The Joanna Briggs Institute (JBI) 3critical appraisal tool was used to assess quality of studies. Due to heterogeneity of the studies, a meta-analysis could not be performed, thus a narrative summary was performed with the results summarised and tabulated. Of 8114 initial articles identified, we included 14 studies. The review produced inconsistent results, with three of the 14 studies demonstrating no statistically significant relationship between internet and/or gaming addiction and obesity. The remaining 11 studies showed a statistically significant positive association. One study demonstrated that those who are underweight as well as overweight and obese were more likely to have problematic internet use. Four articles demonstrated increased rates of poor nutritional habits, poor eating patterns and weight control behaviour in children and adolescents with internet addiction or gaming disorder. Another study showed no statistically significant association between internet addiction and disordered eating or eating disorder. Most of the available studies revealed increased rates of obesity in children and adolescents with internet addiction or gaming disorder, with poor patterns of eating. Clearer definitions and consistent use of terminology are required to enable more robust research in this field.

Effectiveness of Mind-Body Interventions Delivered by Nurses in Improving Psychological Well-being and Surgical Recovery: A Meta-Analysis

Surgical patients often experience psychological distress that can hinder their recovery. Mind-body interventions (MBIs) delivered by nurses, such as guided imagery and mindfulness exercises, may improve psychological well-being and surgical recovery. This meta-analysis examined the effectiveness of nurse-delivered MBIs on adult surgical patients. A systematic search of PubMed, CINAHL, PsycINFO, and Cochrane Library databases was conducted from January 2013 to November 2024. Randomized controlled trials (RCTs) examining the effects of nurse-delivered MBIs on adult surgical patients were included. Primary outcomes were anxiety, depression, and pain. Secondary outcomes included length of hospital stay, postoperative complications, and medication usage. Random-effects models were used to calculate pooled effect sizes (Hedges' g). Six RCTs met the inclusion criteria, comprising 785 participants. Meta-analysis revealed that nurse-delivered MBIs significantly reduced anxiety (g = -4.09, 95% CI [-6.25, -1.93], p = 0.0002) and depression (g = -3.40, 95% CI [-4.96, -1.85], p < 0.00001) compared to standard care. Significant reductions in postoperative pain (g = -1.77, 95% CI [-2.10, -1.44], p < 0.00001) were also observed. No significant differences were found for length of hospital stay or postoperative complications. In conclusion, nurse-delivered MBIs effectively improve psychological well-being and reduce postoperative pain in adult surgical patients, supporting their integration into routine surgical care.