Literature Search Engines Research Articles

West African Medicinal Plant Substances and Molecules Activities Against Viral Hepatitis B and Hepatocellular Carcinoma.

Chronic hepatitis B virus (HBV) infection remains a major global public health problem with devastating consequences, such as hepatocellular carcinoma. Currently, approved treatments are limited to interferon and nucleoside/nucleotide analogues for chronic hepatitis B and chemotherapy, radiotherapy, and surgery for cancer. Both treatments have their limitations, making complete cure an elusive goal. Therefore, the identification of new therapeutic targets using medicinal plants and the development of new antiviral and anticancer strategies are of utmost importance. The aim of this review is to identify from the literature the substances and molecules of West African flora involved in the fight against chronic hepatitis B and liver cancer and to provide a summary of their mechanisms of action. Pubmed, HAL open science, and Google Scholar literature search engines were used to identify medicinal plants and molecules from the West African flora. Among West African countries, Gambia and Niger had the highest prevalence of hepatitis B virus infection, and 09 West African countries had high rates of liver cancer. A number of studies carried out in Mali, Benin, Senegal, and Burkina Faso enabled us to list anti-HBV and anticancer plants, as well as a number of molecules isolated from plants found in West African regions. By offering a glimpse into the world of anti-HBV and anticancer molecules from West Africa, this review provides valuable information to support the future development of herbal antiviral and anticancer drugs.

Cryoablation in Chronic Pain Management: A Narrative Review

Abstract Cryoneurolysis is a technique of applying extreme cold temperatures to specific sensory nerves, causing a prolonged period of loss of conduction through that nerve. This technique has found widespread application in the field of interventional pain medicine in a variety of conditions including chronic postsurgical pain, phantom limb pain (PLP), and cancer pain. Its use in chronic pain states has been aided further by the advent of handheld cryoneurolysis devices and the widespread use of ultrasonographic imaging to guide and target nerves accurately. Chronic pain states – chronic knee pain from osteoarthritis, refractory PLP, temporomandibular disorders, cervicogenic headaches, low back pain, different peripheral neuropathies, and metastatic bone tumor pain – are some of the conditions where cryoneurolysis has been proven to benefit patients in cases where the symptoms were refractory to other conventionally used modalities. Chronic pain is a complex and multifaceted condition and hence requires a variety of individualized treatment approaches. Current research on this treatment method for chronic pain indicates that it carries low risk and, when used correctly, offers extended pain relief without causing motor function loss. This narrative review includes all types of scientific studies, published between 2010 and 2023, which were selected using a specific set of keywords through two different literature search engines. In conclusion, it explains how cryoneurolysis works to provide long-term pain relief and summarizes the latest evidence supporting its use in chronic pain management.

Natural Products for Preventing and Managing Anthracycline-Induced Cardiotoxicity: A Comprehensive Review.

Doxorubicin (DOX) is an anthracycline anticancer agent that is highly effective in the treatment of solid tumors. Given the multiplicity of mechanisms involved in doxorubicin-induced cardiotoxicity, it is difficult to identify a precise molecular target for toxicity. The findings of a literature review suggest that natural products may offer cardioprotective benefits against doxorubicin-induced cardiotoxicity, both in vitro and in vivo. However, further confirmatory studies are required to substantiate this claim. It is of the utmost importance to direct greater attention towards the intricate signaling networks that are of paramount importance for the survival and dysfunction of cardiomyocytes. Notwithstanding encouraging progress made in preclinical studies of natural products for the prevention of DOX-induced cardiotoxicity, these have not yet been translated for clinical use. One of the most significant obstacles hindering the development of cardioprotective adjuvants based on natural products is the lack of adequate bioavailability in humans. This review presents an overview of current knowledge on doxorubicin DOX-induced cardiotoxicity, with a focus on the potential benefits of natural compounds and herbal preparations in preventing this adverse effect. As literature search engines, the browsers in the Scopus, PubMed, Web of Science databases and the ClinicalTrials.gov register were used.

LITERATURE REVIEW ON THE EFFECTIVE USE OF GOOGLE SITE AS AN INTERACTIVE MEDIUM IN ISLAMIC EDUCATION LEARNING

Abstract The current rapid advancement of technology has significantly impacted various aspects of life, including the field of education. This research aims to analyze the use of Google Sites as a medium to enhance student learning outcomes. The method employed is qualitative research with a literature review approach or System Literature Review (SLR). This study aims to compare existing theories with previous theories in the research literature. The literature sources used are derived from research results or studies published in scientific articles, with articles sourced from electronic literature search engines such as Mendeley and Google Scholar. The results of the study indicate that the use of Google Sites as a learning medium in the era of technological advancement can improve student learning outcomes

Potential of Chlorogenic Acid in the Management of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): Animal Studies and Clinical Trials-A Narrative Review.

Chlorogenic acid (CGA) is a natural polyphenol found in coffee, tea, vegetables, and fruits. It exhibits strong antioxidant activity and possesses several other biological properties, including anti-inflammatory effects, antimicrobial activity, and insulin-sensitizing properties. Moreover, it may improve lipid and glucose metabolism. This review summarizes the available information on the therapeutic effect of CGA in metabolic dysfunction-associated steatotic liver disease (MASLD). As the literature search engine, the browsers in the PubMed, Scopus, Web of Science databases, and ClinicalTrials.gov register were used. Animal trials and clinical studies suggest that CGA has promising therapeutic potential in treating MASLD and hepatic steatosis. Its mechanisms of action include antioxidant, anti-inflammatory, and anti-apoptotic effects via the activation of the Nrf2 signaling pathway and the inhibition of the TLR4/NF-κB signaling cascade. Furthermore, the alleviation of liver disease by CGA also involves other important molecules such as AMPK and important physiological processes such as the intestinal barrier and gut microbiota. Nevertheless, the specific target cell and key molecule to which CGA is directed remain unidentified and require further study.

Exploring gender differences in pharmacokinetics of central nervous system related medicines based on a systematic review approach.

Due to the inevitable differences in physiological and/or genetic factors between genders, the possibility that differences in pharmacokinetics between genders may occur when exposed to the same dose of the same drug is subject to reasonable inference and suspicion. Nevertheless, a significant number of medicines still rely on empirical usage and uniform clinical application without consideration of inter-individual diversity factors. In particular, in the pharmacokinetic diversity of medicines related to central nervous system (CNS) activity, consideration of gender factors and access to comparative analysis are very limited. The purpose of this study was to conduct an integrated analysis and review of differences in pharmacokinetics between genders that have not been specifically reported to date for medicines related to CNS effects, which are a group of drugs with relatively significant concerns about systemic side effects. This study was accessible through extensive data collection and analyzes using a web-based scientific literature search engine of pharmacokinetic results of CNS-related drugs performed on humans, taking gender into account. As a result, significant differences in pharmacokinetics between genders were identified for many drugs related to CNS. And most of the pharmacokinetic differences between genders suggested a higher in vivo exposure in females. This study suggests that consideration of gender factors cannot be ignored and will be an important point of interest in the precision medicine application of CNS-related medicines.

Health Information Technology 기반 국내외 의료용 마약류 모니터링 시스템 비교 분석

This study was conducted to propose ways to improve the domestic system based on a comparative analysis of domestic and foreign Health Information Technology (HIT) system using cases to prevent misuse and abuse of controlled substances. Korea, the United States, and Australia were selected as the countries to be investigated as representative examples of nationwide use of HIT. Literature data was collected from the official website of the system operating organization and major literature databases and search engines such as Pubmed and Google Scholar using the name of each country's HIT system as a keyword. We focused on analyzing the purpose of system operation, target drugs, information collection method, system operation method, and compensation to system users. Korea’s Narcotics Information Management System (NIMS) is the only system that can track the serial numbers of controlled substances in connection with prescription and dispensing records, and is designed and operated with a focus on regulatory purposes to improve legal compliance. NIMS had a relatively long reporting cycle, so there were limitations in checking the latest controlled substances prescription and dispensing records. It was also the only system in which pharmacists did not have the authority and role to check and monitor prescription records. In order to effectively prevent misuse and abuse of controlled substances, the reporting cycle must be shortened by switching to a real-time monitoring system including nonreimbursement medications. In addition, there is a need to guarantee pharmacists the authority to request prescription records before dispensing and the roles that accompany this.

Harnessing Artificial Intelligence for Enhanced Efficiency in Academic Writing and Research

In the recent past, there has been a surge in the use of artificial intelligence (AI) in the development of smart technologies for the purpose of improving efficiency in writing academic papers and conducting researches. However, the potential of using AI in the improvement of scholarly processes has not been optimally realized due to low awareness and visibility of the tool among the users. In this respect, this paper aims to describe the following tools of AI which can be applied in the research process including literature search and manuscript preparation. To assess the AI technology, the current literature in form of case studies was reviewed and this included the automated literature search engines, citation management software, natural language processing tools and data analysis tools. It also reveals that AI approaches can also help in decreasing the amount of time spent in article and data search, citation, citation management, and even in the generation of quality publications. This essay also examines the ethical issues of using artificial intelligence in research and any bias that may be present. In conclusion, it is necessary to underline that AI can be useful in improving the results of learning processes. But it is crucial that the researchers are trained well and are put in a position to doubt the outcome produced by the AI. Thus, the purpose of the paper is to discuss how AI is being used in academia at the moment and what could be done to expand its use in the future.

Touching Reduces Pain and Stress: A Narrative Review

This narrative review involved entering the terms touching, massage, pain and stress on PubMed and PsycINFO literature search engines. The search yielded 47 studies that are summarized here. The prevalence of touching has varied widely across cultures from a low of 57% in China to a high of 100% in Austria. Touching has been more prevalent in relationships with partners and children and was more diverse in warmer, less conservative and religious countries and among younger, female and liberal people. The three predominant forms of touching that appear in this literature include handholding primarily for painful conditions, hugging (embracing) for stressful conditions and massaging for both painful and stressful conditions. Other less prevalent literature addresses the effects of COVID-19 on touching, touching by robots, and negative reactions to touching. Unlike earlier literature, most of the researchers have either measured or theorized underlying brain pathways for touching reducing pain and stress. Most of this research has been conducted in the laboratory as opposed to being naturalistic, so it is not clear how generalizable the data are to lifelike situations.

Effect of Physical Exercise On Heart Failure Patients

The incidence of heart failure is a health problem that often occurs in society. Globally it reaches more than 23 million patients worldwide and is expected to grow to 46% by 2030. Patients with heart failure characterized by low activity tolerance, low quality of live, increased mortality and re-hospitalization, and increased treatment cost. Heart failure patients experience shortness of breath, fatigue, anxiety. Where the signs and symptoms of heart failure are chronic and progressive. The writing method uses the PRISMA literature review method, via the remote-lib.ui.ac.id database which facilities a literature search engine and is linked to various scientific publications such as Scopus, ProQuest, Clinical Key for Nursing, PubMed with several keywords, (HFrEF OR (Heart Failure)) AND (physical exercise) AND (Physical capacity). From the first search we get 1512 articles, then selected to become 7 articles with cardiovascular restrictions, last 5 years, nursing, English. Activity management in Heart failure is an important intervention to provide, both while in the treatment room and as self-management and self-care. Non-pharmacological and pharmacological nursing management as a way to improve self-care and self-management in heart failure patients is important to provide because it can increase the achievement of treatment goals.

A Review of Antidepressant Effects and Mechanisms of Three Common Herbal Medicines: Panax ginseng, Bupleurum chinense, and Gastrodia elata.

Major depressive disorder (MDD) has been reported to affect an increasing number of individuals due to the modern lifestyle. Because of its complicated mechanisms and recurrent attacks, MDD is considered a refractory chronic disease. Although the mainstream therapy for MDD is chemical drugs, they are not a panacea for MDD because of their expensiveness, associated serious adverse reactions, and endless treatment courses. Hence, we studied three kinds of herbal medicines, namely, Panax ginseng C.A. Mey (PGM), Bupleurum chinense DC (BCD), and Gastrodia elata Blume (GEB), and reviewed the mechanisms underlying their antidepressant properties to provide a reference for the development of antidepressants and clinical medications. An extensive range of medicinal, clinical, and chemistry databases and search engines were used for our literature search. We searched the literature using certain web literature search engines, including Google Scholar, PubMed, Science Direct, CNKI (China National Knowledge Infrastructure), and Web of Science. Experimental research found that active compounds of these three medicines exhibited good antidepressant effects in vivo and in vitro. Clinical investigations revealed that single or combined treatment of these medicines improved certain depressive symptoms. Antidepressant mechanisms are summarized based on this research. The antidepressant mechanism of these three medicines includes but is not limited to ameliorating inflammation within the brain, reversing the hypothalamic-pituitary adrenal axis (HPA) system hyperfunction, inhibiting monoamine neurotransmitters reuptake, anti-neuron apoptosis and preventing neurotoxicity, and regulating depressive-related pathways such as the BDNF pathway and the PI3K/Akt/mTOR pathway.

Sotagliflozin vs Dapagliflozin: A Systematic Review Comparing Cardiovascular Mortality.

After the debut of the results of the effect of Sotagliflozin on Cardiovascular Events in Patients with Type 2 Diabetes Post Worsening Heart Failure (SOLOIST-WHF) and Sotagliflozin in Patients With Chronic Kidney Disease and Type 2 Diabetes (SCORED) trials at the American Heart Association's 2020 Scientific session, sotagliflozin became the first drug andthe third sodium glucose co-transporter-2 (SGLT-2) inhibitor to be approved for heart failure (HF) across the spectrum of ejection fraction (EF). In light of this recent major U.S. Food and Drug Administration (FDA) approval of sotagliflozin, we conducted a systematic review to compare the cardiovascular mortality rates between sotagliflozin and dapagliflozin in patients with HF. To find relevant articles, we extensively searched major research literature databases and search engines such as PubMed, MEDLINE, PubMed Central, Google Scholar, Embase, and Cochrane Library. We compared the results of significant trials involving sotagliflozin with the trials studying dapagliflozin to provide comprehensive mortality results of both drugs. The results showed that the timely initiation of sotagliflozin in HF cases significantly reduces cardiovascular mortality, hospitalizations, and urgent HF visits. Comparative trials with dapagliflozin indicate enhanced mortality reduction associated with greater initial symptom burden. The results of these major trials cannot be overlooked due to the large size of the combined trials, the randomized design, and the high standards with which they were conducted. The pathophysiology behind the cardioprotection offered by these agents is complex and multifactorial, but it is believed that due to the diuretic-like function, SGLT-2 inhibitors reduce glycemic-related toxicity, promote ketogenesis, and exert antihypertrophic, antifibrotic, and anti-remodeling properties. The benefits of dapagliflozin on cardiovascular death and worsening HFin patients with mildly reduced or preserved EFappeared especially pronounced in those with a greater degree of symptomatic impairment at baseline. Sotagliflozin led to a rise in the count of days patients were alive and not hospitalized (DAOH), which offers an extra patient-centered measure to assess the impact of the disease burden. The data in our article will help future researchers conduct large-scale trials with sotagliflozin to identify and implement it in the treatment of patients with HF as a mortality-reducing drug and to improve the quality of life for patients with HF.

Comparing the Safety and Efficacy of Proton Pump Inhibitors and Histamine-2 Receptor Antagonists in the Management of Patients With Peptic Ulcer Disease: A Systematic Review.

Peptic ulcer disease (PUD) refers to the occurrence of an open erosion in the inner lining of the stomach, duodenum, or sometimes lower esophagus. Treatments like proton pump inhibitors (PPIs) or histamine 2 receptor antagonists (H2RAs) are available on the market to efficiently treat the break in the mucosal lining. However, there is little evidence about the effects of the medication on the type and location of the ulcer and the epigastric pain caused by disintegration and increased acidity in the stomach. Given the above, we conducted a systematic review comparing the safety and efficacy of PPIs and H2RAs in various ulcer locations (gastric, duodenal, and pre-pyloric) and the effect of prolonging the treatment with the same medication or changing into a drug from another class in treatment-resistant ulcers. We employed major research literature databases and search engines such as PubMed, Medical Literature Analysis and Retrieval System Online (MEDLINE), Science Direct, and Google Scholar to find relevant articles. After a thorough screening, a quality check using various tools, and applying filters that suited our eligibility criteria, we identified eight articles, of which five were random clinical trials (RCTs), two review articles, and one meta-analysis. This study compares the different side effects of PPIs and H2RAs. Most studies concluded that omeprazole is superior in healing ulcers and bringing pain relief and that patients resistant to H2RAs can be treated better when switched to a PPI. This study also discusses the adverse effects of chronic use, such as diarrhea, constipation, headaches, and gastrointestinal infections. Patients on long-term PPI therapy are required to take calcium supplements to prevent the risk of fractures in older adults. Regarding long-term outcomes, PPIs remain the mainstay of treatment for peptic ulcer disease, based on the papers we reviewed.

Impact of adapting paediatric intensive care units for adult care during the COVID-19 pandemic: a scoping review

ObjectivesThe objectives were to categorise the evidence, map out the existing studies and explore what was known about the organisation of paediatric intensive care units (PICUs) during the first 18...

From the international tobacco control arena to the local context: a qualitative study on the tobacco advertising, promotion and sponsorship legislative environment in Sudan and the challenges characterising it

ObjectivesThe aim of the study was to assess the Sudanese tobacco advertising, promotion and sponsorship (TAPS) legislative environment and the challenges characterising it. We formulated three research questions: What is...

Estimation of rumen undegradable starch from chemical composition in the feeds of ruminants

In ruminant diets, rumen undegradable starch (RUS) contributes to maintaining rumen health by maximizing post-ruminal starch absorption. This present study aimed to estimate dietary RUS values from their chemical composition. The database was developed from some literature search engines and obtained 41 studies from 17 references. The chemical composition of ash, dry matter (DM), neutral detergent fiber (NDF), acid detergent lignin (ADL), acid detergent fiber (ADF), crude protein (CP), ether extract (EE), organic matter (OM), starch, and rumen undegradable starch (RUS) was included into the database. Pearson correlation analysis was employed in order to establish the relationship between chemical composition with RUS of feedstuff. The chemical composition with significant correlation (P<0.05) was used to estimate RUS using multiple linear regression. The RUS estimate equation was validated by calculating the root mean square error (RMSE) and plotting the RUS estimated and observed. As a result, RUS was significantly correlated with CP, NDF, ADF, and starch. The equation for estimate RUS was: RUS = 29.814 – 3.148 CP – 0.208 NDF – 0.396 ADF + 0.418 Starch. It is concluded that rumen undegradable starch (RUS) can be accurately estimated from the chemical composition of feedstuff.

Achieving a tobacco-free Bangladesh by 2040: a qualitative analysis of the tobacco advertising environment and prohibitions in Bangladesh

ObjectivesThis paper explores the Bangladeshi tobacco advertising, promotion and sponsorship (TAPS) legislative environment, to highlight any potential policy loopholes and to facilitate the identification of additional provisions for inclusion. The...

Assessing the use of supplementary materials to improve genomic variant discovery

The curation of genomic variants requires collecting evidence not only in variant knowledge bases but also in the literature. However, some variants result in no match when searched in the scientific literature. Indeed, it has been reported that a significant subset of information related to genomic variants are not reported in the full text, but only in the supplementary materials associated with a publication. In the study, we present an evaluation of the use of supplementary data (SD) to improve the retrieval of relevant scientific publications for variant curation. Our experiments show that searching SD enables to significantly increase the volume of documents retrieved for a variant, thus reducing by ∼63% the number of variants for which no match is found in the scientific literature. SD thus represent a paramount source of information for curating variants of unknown significance and should receive more attention by global research infrastructures, which maintain literature search engines. Database URL https://www.expasy.org/resources/variomes.

Vitamin C Administration in Breast Cancer After Surgery Treatment : A Review

Introduction : Breast cancer is still the most common type of cancer, and surgery is still an alternative available. Postoperative care for breast cancer is an action that must be evaluated from a variety of perspectives. Methods : The information retrieval feature of the PubMed and Cambridge Core literature search engines was used to find review of literature articles for this journal. The periodicals on which the literature was predicated were obtained. Result Vitamin C has various functions in cases of breast cancer. A special review in this paper is in terms of wound healing and anti-pain modulation in postoperative breast cancer. The existence of this is considered significant and can be used as postoperative therapy. Conclusion : Vitamin C involvement in postoperative therapy for breast cancer is expected to have benefits in terms of wound healing as well as modulation of anti-pain interventions. Furthermore, vitamin C therapy is not permitted as an adjunctive treatment or to lower the risk of breast cancer or to inhibit post-surgical complications within those cases.

Immune cells and associated molecular markers in dermal fibrosis with focus on raised cutaneous scars.

Raised dermal scars including hypertrophic, and keloid scars as well as scalp-associated fibrosing Folliculitis Keloidalis Nuchae (FKN) are a group of fibrotic raised dermal lesions that mostly occur following cutaneous injury. They are characterized by increased extracellular matrix (ECM) deposition, primarily excessive collagen type 1 production by hyperproliferative fibroblasts. The extent of ECM deposition is thought to be proportional to the severity of local skin inflammation leading to excessive fibrosis of the dermis. Due to a lack of suitable study models, therapy for raised dermal scars remains ill-defined. Immune cells and their associated markers have been strongly associated with dermal fibrosis. Therefore, modulation of the immune system and use of anti-inflammatory cytokines are of potential interest in the management of dermal fibrosis. In this review, we will discuss the importance of immune factors in the pathogenesis of raised dermal scarring. The aim here is to provide an up-to-date comprehensive review of the literature, from PubMed, Scopus, and other relevant search engines in order to describe the known immunological factors associated with raised dermal scarring. The importance of immune cells including mast cells, macrophages, lymphocytes, and relevant molecules such as cytokines, chemokines, and growth factors, antibodies, transcription factors, and other immune-associated molecules as well as tissue lymphoid aggregates identified within raised dermal scars will be presented. A growing body of evidence points to a shift from proinflammatory Th1 response to regulatory/anti-inflammatory Th2 response being associated with the development of fibrogenesis in raised dermal scarring. In summary, a better understanding of immune cells and associated molecular markers in dermal fibrosis will likely enable future development of potential immune-modulated therapeutic, diagnostic, and theranostic targets in raised dermal scarring.