Electricity is the foundation of the entire national economy, and nuclear power has become an important part of the power system with its unique advantages. The main process of nuclear power is the process of the nuclear fuel cycle, including the source and preparation of nuclear fuel, nuclear power plants and nuclear spent fuel processing. In the whole process, nuclear safety is the top priority and the key to the sustainable development of nuclear power. In this paper, aiming at the objective reality of high security risk and strict security requirements for nuclear fuel storage used in nuclear power, based on the analysis of nuclear fuel radiation characteristics and safety monitoring requirements, a nuclear fuel embedded system is designed from the aspects of system overall, software, hardware, data processing, etc. Security intelligent monitoring system. The system uses MCU as the control core, is equipped with motion detection and electronic seal devices, and realizes alarm functions such as identity authentication, unauthorized movement, and illegal unpacking real-time monitoring. Experiments and use show that the system can be easily integrated, installed and deployed on the nuclear fuel packaging container, and the operation is stable and reliable, which effectively promotes the steady improvement of the operating efficiency and operating quality of the nuclear energy system.