The seakeeping behaviour can be severely affected by the coupling between sloshing and ship motions in waves. The sloshing behaviour of liquid-loaded ships in bi-directional waves differs significantly from that in uni-directional waves. Given that ships operate in short-crested or multi-directional waves during their whole service period, it is significant to gain a deeper understanding of the effect of wave directionality on the coupling between sloshing and ship motions. In this study, a KRISO container ship (KCS) model with type-B liquefied natural gas (LNG) cargo tanks is adopted for coupling analysis. The 2D long-crested regular wave is adopted as an uni-directional wave, and three dimensional (3-D) cross wave is adopted as a bi-directional wave. The computational fluid dynamics (CFD) method is applied for the sloshing and seakeeping simulation of the ship model in different wave fields. The differences in wave elevation, sloshing forces, and coupling effects between ship motions and sloshing are studied in these two wave fields by adjusting control parameters such as ship heading angle and filling ratio. The comparative results indicate that sloshing behaviour and coupled motion responses in cross waves should be paid enough attention during ship design and evaluation.