We have collected 12 kHz SeaBeam bathymetry and 120 kHz DSL‐120 side‐scan sonar and bathymetry data to determine the tectonic and volcanic segmentation along the fastest spreading (∼150 km/Myr) part of the global mid‐ocean ridge system, the southern East Pacific Rise between the Easter and Juan Fernandez microplates. This area is presently reorganizing by large‐scale dueling rift propagation and possible protomicroplate tectonics. Fracture patterns observed in the side‐scan data define structural segmentation scales along these ridge segments. These sometimes, but not always, correlate with linear volcanic systems defining segmentation in the SeaBeam data. Some of the subsegments behave cohesively, with in‐phase tectonic activity, while fundamental discontinuities occur between other subsegments. We also collected hydrothermal plume data using sensors mounted on the DSL‐120 instrument package, as well as CTDO tow‐yos, to determine detailed structural and volcanic controls on the hydrothermal vent pattern observed along 600 km of the Pacific‐Nazca axis. Here we report the first rigorous correlation between coregistered hydrothermal plume and high‐resolution marine geophysical data on similar scales and over multisegment distances. Major plume concentrations were usually found where axial inflation was relatively high and fracture density was relatively low. These correlations suggest that hydrothermal venting is most active where the apparent magmatic budget is greatest, resulting in recent eruptions that have paved over the neovolcanic zone. Areas of voluminous acoustically dark young lava flows produced from recent fissure eruptions correlate with many of the major hydrothermal vent areas. Increased crustal permeability, as gauged by increased fracture density, does not enhance hydrothermal venting in this area. Axial summit troughs and graben are rare, probably because of frequent volcanic resurfacing in this superfast spreading environment, and are not good predictors of hydrothermal activity here. Many of the hydrothermal areas are found in inflated areas near the ends of segments, suggesting that abundant magma is being supplied to these areas.