Gangrene Of Scrotum Research Articles

Safety assessment of dapagliflozin: Real-world adverse event analysis based on the FAERS database from 2012 to 2023

BackgroundDapagliflozin possesses the capacity to cure a wide range of diseases, however, there are many adverse events (AEs) that have not yet been acknowledged or recorded. AimSafety assessment of dapagliflozin based on the Food and Drug Administration Adverse Event Reporting System (FAERS) database, to explore differences between the reported AEs to provide a overview of the safety profile of dapagliflozin. MethodsWe extracted data from the United States FAERS database, including from the fourth quarter of 2012 to the third quarter of 2023. Reporting odds ratio (ROR), proportional reporting ratio (PRR), Bayesian confidence propagation neural network (BCPNN), and empirical Bayesian geometric average (EBGM) were used to evaluate the relationship between dapagliflozin and its associated AEs. ResultsA total of 13,593,946 case reports were gathered from the Food and Drug Administration Adverse Event Reporting System database for this investigation. Among these, there were 44,506 episodes of adverse events that were associated with dapagliflozin. Included in the analysis were 341 preferred words and 2 system organ classes that showed statistical significance according to all four methods simultaneously. The system organ classes encompassed illnesses related to metabolism and nutrition, as well as problems affecting the renal and urinary systems. PT levels were screened for adverse drug reaction signals including scrotal gangrene, scrotal cellulitis, perineal cellulitis, diabetic ketoacidosis, and pancreatitis. ConclusionThe majority of our findings aligned with the specification, however, certain novel indicators of AEs such as acute pancreatitis were not accounted for. The analysis of the AE signals may provide support for clinical monitoring and risk identification of dapagliflozin. Due to the inherent limitations of FAERS data, well-designed studies are required to demonstrate the safety of dapagliflozin.

(280) Second Stage Surgery After Ring Flap Metoidioplasty: Technique and Outcomes

Abstract Introduction Metoidioplasty is an option for creation of external male-appearing genitalia in transmasculine individuals. Many individuals report good sensory, functional, and aesthetic outcomes following single-stage metoidioplasty with urethral lengthening and scrotoplasty. However, an average of 12% of patients require a second-stage surgery to improve aesthetic appearance, place testicular implants, address complications, and maximally lengthen the neophallus. These procedures are risky to perform at the time of initial metoidioplasty as this may disrupt the vascular supply to the neoscrotum via the anterior branches of the external pudendal artery. We report outcomes of second-stage ring-flap labial metoidioplasty involving monsplasty, upper labia majora dermatolipectomy, and scrotoplasty with testicular implant insertion. Objective Transmasculine individuals who have had metoidioplasty with rotational advancement labia majora flap and (Ghent style) scrotoplasty often desire monsplasty, upper labia majora tissue resection, and testis implant insertion to optimize aesthetics, reduce dysphoria and improve voiding function. We describe our technique and surgical outcomes with dermatolipectomy of the mons pubis (monsplasty) and upper labia majora with simultaneous testis implant insertion. Methods We retrospectively reviewed the outcomes of ring flap metoidioplasty patients who underwent second stage surgery involving monsplasty and upper labia majora dermatolipectomy, and testis implant insertion. Monsplasty is performed by excising excess skin and adipose tissue to better expose the penis and lift the genitals. Upper labia majora tissue is subsequently resected, followed by development of pockets into each hemiscrotum inferiorly. Silicone carving implants are then individually sized and inserted to serve as testicular prostheses. Results From November 2017 to January 2022, 13 patients underwent second stage metoidioplasty and scrotoplasty with testis implant insertion. Mean follow-up was 22 months. Monsplasty was not desired/necessary in two (15%) patients. Implant malposition occurred in one (7.7%) patient, and one (7.7%) patient was unhappy with the overall aesthetics prompting him to seek a second opinion. To date, no surgical revision was desired nor performed. There were no wound or implant infections, and no scrotal necrosis. Conclusions Monsplasty and upper labia majora dermatolipectomy with simultaneous testis implant insertion is a safe and reliable combination of surgeries after metoidioplasty with Ghent style scrotoplasty. Disclosure No

Fournier’s gangrene reconstruction: A 10-year retrospective analysis of practice at Guys and St Thomas’s NHS Foundation Trust

Fournier's gangrene is a rare and potentially fatal condition that affects the external genitalia and perineum as a necrotizing soft-tissue infection. It is equally prevalent in men and women and although there are many ways to manage the condition, it must be done so effectively because there is a chance that life-threatening complications could develop. This retrospective study set out to fill any knowledge gaps, compare reconstructive options to those described in the literature, and promote reflection on current management. Between January 2010 and January 2020, all perineal debridement operation notes were examined. The primary conclusions were that a large majority of defects could be repaired using split skin grafts to reduce surgical time and donor site morbidity. To avoid secondary contracture and the need for revision surgery, full-thickness skin grafts should be used whenever possible to treat penile defects.

Response Guided Slow Infusion of Albumin, Vasoconstrictors and Furosemide Improves Ascites Mobilization and Survival in Acute on Chronic Liver Failure: A Proof-of-Concept Study.

Background and AimsAcute-on-chronic liver failure (ACLF) with increasing organ failure is associated with poor outcomes. Severely deranged systemic hemodynamics and decreased effective arterial blood volume contribute to tissue damage and organ failure. Response-guided therapy with albumin, vasoconstrictors, and furosemide may help overcome effective hypovolemia, improve diuresis and impact survival.MethodsIn the observation cohort, 230 patients with ACLF (CANONIC criteria) with ascites (≥Grade II) and ACLF ≥Grade I were enrolled. A total of 136 patients (GROUP I) received response-guided (urine sodium >80mmol/day) slow albumin-furosemide infusion ± terlipressin (SAFI ± T), while 94 patients (GROUP II) received standard medical therapy. Twenty-eight-day survival, ascites mobilization (nil or grade 1), and adverse events were noted. In another mechanistic cohort (n = 40), laboratory evidences for improvement in various pathophysiological alterations; gut permeability, endotoxemia, cytokine storm, neutrophil dysfunction, and hemodynamic alterations following SAFI ± T/Noradrenaline (NAdr) were evaluated.ResultsAge, gender, CLIF-C-ACLF, SOFA and MELD scores, ACLF grades and urine sodium were not different between the two groups in the observation cohort. Ascites was mobilized in 102/136 in GROUP I (SAFI ± T) and 23/94 in GROUP II (p < 0.05). Twenty-eight-day survival was significantly higher in GROUP I = 103/136 (75.7%) vs GROUP II = 50/94 (53.2%), (P = <0.001). All those who were unable to reach urine sodium >80 mmol/day died. Four patients in GROUP I developed scrotal gangrene. In the mechanistic cohort, 72% of patients survived with significant improvement in gut permeability, endotoxemia, serum cytokines, neutrophil dysfunction, and hemodynamic alterations.ConclusionAscitic fluid mobilization by response-guided SAFI ± T/NAdr therapy improves survival by improving splanchnic and systemic hemodynamics, decreasing gut congestion, gut permeability, and endotoxemia, improving neutrophil functions, and reducing pro-inflammatory cytokines in circulation.

Fournier’s gangrene: the current state of the problem and our treatment experience

The OBJECTIVE of the study was to analyze the results of treatment of patients with lightning scrotal gangrene (Fournier’s gangrene).METHODS AND MATERIAL. The work is based on the analysis of the results of treatment of 31 patients with Fournier’s gangrene aged 32 to 82 years. In 19 (61.3 %) patients, the most probable nosological causes of Fournier’s gangrene were diseases of the anorectal zone, in 10 – pathology of the urogenital sphere. In 2 patients, Fournier’s gangrene developed as a result of a closed injury (1) and a gunshot wound (1) of the perineum and scrotum. A limited (slowly progressing) form of the disease was observed in 18 (58.1 %) patients, a common form with a lightning (9) and rapidly progressing (4) course – in 13 (41.9 %). 6 (19.3 %) patients suffered from diabetes mellitus of varying severity. In all patients, the clinical manifestations of the disease and laboratory parameters were characterized by the phenomena of generalized surgical infection with signs of systemic inflammatory response syndrome and endotoxicosis. In 93.5 % of patients, causative microflora was represented by various associations of both facultative-anaerobic and obligateaerobic gram-negative and obligate-facultative anaerobic gram-positive microorganisms. The growth of anaerobic gramnegative non-clostridial flora was also obtained.RESULTS. Out of 31 patients, 6 (19.3 %) patients died who had a common form of FG with a lightning and rapidly progressing clinical course in the format of systemic inflammatory response syndrome and systemic endotoxicosis with an outcome in organ-system dysfunction. The causes of death were: septic shock (in 1), progressive systemic endotoxicosis (sepsis) with the outcome of multiple organ failure (in 3) and pulmonary embolism (in 2).CONCLUSION. Multidisciplinary approach to solving organizational and therapeutic and tactical tasks with the participation of doctors of related specialties, active surgical tactics in the format of «aggressive surgery», providing for the widest possible excision of necrotic and non-viable tissues, performed in combination with programmed (stage-by-stage) sanitation necrectomy, pathogenetically justified correction of violations of the homeostasis system, rational antibacterial therapy, a comprehensive system of local wound treatment and plastic replacement of lost integumentary tissues are priority ways to optimize the results of treatment of patients with Fournier’s gangrene.

Paratesticular Embryonal Rhabdomyosarcoma (RMSE-PT): A Case Study in the Surgery Department of the Regional Hospital of Ziguinchor (Senegal)

<i>Introduction:</i> Paratesticular embryonal rhabdomyosarcoma (RMSE-PT) is a rare and aggressive malignant mesenchymal tumor developed at the expense of connective tissue, representing approximately 7% of all rhabdomyosarcomas. Embryonic and alveolar histological types are most common in children, the pleomorphic type occurs exclusively in adults, and the prognosis is poor. The treatment method consists of tumor resection surgery, radiotherapy, and/or adjuvant chemotherapy. Here, we report a case of paratesticular embryonal rhabdomyosarcoma in a 3-year-old child. Through this observation, we discuss the diagnostic and therapeutic. <i>Methods:</i> In this report, our patient was a 3-year-old child with a large, painless right purse that had evolved over four months and was gradually increasing in volume. Physical examination detected a right scrotal mass, hard, painless, necrotic, suggestive of gangrene, while the left testicle was palpated at the bottom of the bursa, of normal appearance. The diagnosis revealed scrotal gangrene. <i>Results:</i> During the surgery, a large inguinoscrotal tumor was realized, and the realization of a right orchidectomy by the scrotal way with complete excision and dissection of an inguinal lymph node was finally made. The tumor markers (beta-human chorionic gonadotropin and alpha-fetoprotein) were negative, except for lactate dehydrogenase (LDH), which was increased. The surgical specimen's immunohistochemistry revealed an embryonic rhabdomyosarcoma invading the spermatic cord. The ultrasound revealed a tumor mass in the right testis. Computed tomography performed one month after surgery was normal. <i>Conclusions:</i> The care is multidisciplinary, combining surgery, polychemotherapy, and radiotherapy. The rarity of the clinical and the delay in diagnosis were the aggravating factors in the prognosis of our patient.

Scrotal Necrosis Following Heated Intra-peritoneal Chemotherapy: Case Report and Review of the Literature

Scrotal necrosis is a rare occurrence that is scarcely reported among patients having undergone heated intra-peritoneal chemotherapy (HIPEC) procedures. Due to anatomic factors and the thermally enhanced cytotoxicity of chemotherapeutic agents, this complication can have debilitating post-operative effects. We herein highlight the presentation of scrotal necrosis in a patient who underwent HIPEC procedure for peritoneal metastasis secondary to colorectal carcinoma, and how it contrasts to previously documented cases of a similar nature. Furthermore, we describe a successful management strategy that consisted of conservative measures followed by surgical debridement and primary repair, and enabled the patient to experience significant functional and cosmetic improvement.

Postless Hip Traction Table for Combined Femoral and Pelvic Fractures

In multiple injured patients, the association of femoral and pelvic fractures is not uncommon. Femoral reduction and fixation in those patients may be performed with a traction table and a perineal post, but it may result in various groin-related complications, including the displacement of the pubic rami, pudendal nerve neurapraxias, vaginal tears, and scrotal necrosis. The aim of this study was to describe a technique for femur fracture distraction without the use of a perineal post in patients with pelvic trauma. Here, we describe the technical details and 5 cases of femoral fracture associated with pelvic fractures treated with a postless distraction technique. Our preliminary results using this technique show a sufficient distraction to allow reduction and internal fixation of the femoral fracture with a standard femoral nail.

ADVERSE REACTIONS ASSOCIATED WITH A NON-SURGICAL CHEMICAL STERILANT IN FOUR DOGS

Chemical sterilization is an alternative method to traditional surgical castration for means of canine population control. Zinc gluconate neutralized with arginine is an easy and cost-effective intratesticular chemical sterilant for use in male dogs. Rare adverse reactions have been reported and include scrotal ulceration, scrotal necrosis, testicular necrosis and orchitis. Here we present four additional cases of adverse reactions following administration of zinc gluconate neutralized with arginine that include ulcerative scrotal dermatitis, testicular necrosis, orchitis and vasculitis.

Successful treatment following early recognition of a case of Fournier\u2019s scrotal gangrene after a perianal abscess debridement: a case report

BackgroundFournier’s gangrene is an acute surgical emergency characterized by high mortality rates ranging from approximately 13% to 45%. Therefore, aggressive multidisciplinary management is necessary.Case presentationA 29-year-old Asian man who had undergone surgical debridement at another hospital to treat a perianal abscess 5 days earlier was admitted to our hospital for severe scrotal and perianal pain, swelling, and high fever. A physical examination revealed a perianal abscess. Furthermore, the scrotum was gangrenous and exhibited extensive cellulitis in the perineum and bilateral inguinal area. Crepitations between the skin and fascia were palpable. A diagnosis of Fournier’s gangrene was made. The patient was treated with immediate surgical debridement under general anesthesia. He received broad-spectrum antibiotics, and debridement was repeated until the wound exhibited healthy granulation. Because both testes were severely exposed, they were transpositioned back into the scrotum 1 week after surgery. The patient was discharged on the 11th postoperative day.ConclusionsThe mainstay of treatment for Fournier’s gangrene should include fluid resuscitation, broad-spectrum antibiotic therapy, intensive care, nutritional support, and early aggressive surgical debridement of all necrotic tissue.

Lambeau fascio-cutané de la face interne de la cuisse dans la reconstruction des pertes de substances périnéo-scrotales

Perineal and scrotal gangrene is an acute, severe and rapidly extensive disease. The treatment of the acute phase often causes a loss of extended substance (A, B) which often poses problems in secondary reconstruction. Thus different types of treatment may be proposed: the controlled healing, skin transplant, burying the testes, and locoregional flaps which may be fasciocutaneous or musculocutaneous. We report the case of a patient with loss of scrotal substance whose cover was done by a fasciocutaneous flap of the inner thigh. The patient, aged 70 years, without pathological antecedents underwent surgery for Fournier gangrene of the scrotum. After treating the acute phase with left orchiectomy, the patient showed a defect in scrotal substance (A, B) and in the underside of the penis whose reconstruction was performed by a fasciocutaneous flap of the inner thigh. Post-operative suites were simple, and the patient was very satisfied with the result. The fasciocutaneous flap of the inner thigh is an ideal flap for reconstruction of perineal and scrotal substances loss, it is vascularized by branches of the pudendal artery, it is simple, easy to perform, very reliable with satisfactory aesthetic results (C). It allows the use of a skin paddle measuring 9 × 20 cm, but it requires a second withdrawal intervention (D).

Hip Distraction Without a Perineal Post: A Prospective Study of 1000 Hip Arthroscopy Cases

Background: Hip arthroscopy has traditionally been performed with a perineal post, resulting in various groin-related complications, including pudendal nerve neurapraxias, vaginal tears, and scrotal necrosis. Purpose: To assess the safety of a technique for hip distraction without the use of a perineal post. Study Design: Case series; Level of evidence, 4. Methods: We prospectively analyzed a consecutive cohort of 1000 hips presenting to a dedicated hip preservation clinic; all patients had hip pain and were subsequently treated with hip arthroscopy. Demographic variables, hip pathology, and lateral center edge angle were recorded for each case. In the operating room, the patient’s feet were placed in traction boots in a specifically designed distraction setup, and the operative table was placed in varying degrees of Trendelenburg. With this technique, enough resistance is created by gravity and friction between the patient’s body and the bed to allow for successful hip distraction without the need for a perineal post. In a subset of 309 hips (n = 281 patients), the degrees of Trendelenburg as well as the distraction force were analyzed. Results: The mean ± SD Trendelenburg angle used among the subset of 309 hips was 11° ± 2°. The mean initial distraction force necessary was 90 ± 28 lb, which decreased to 65 ± 24 lb by 30 minutes after traction initiation (P < .0001). The most important variables in determining initial force for this cohort of patients were, in order of magnitude, sex (P < .0001), weight (P < .0001), and lateral center edge angle (P < .01). No groin-related complications occurred among the entire cohort of patients, including soft tissue or nerve-related complications. The rate of deep venous thrombosis was 2 in 1000. Conclusion: The use of the Trendelenburg position and a specially designed distraction setup during hip arthroscopy allows for safe hip distraction without a perineal post, thereby eliminating groin-related soft tissue and nerve complications. Certain patient variables can be used to estimate the required distraction force and inclination angle with this method.

Infected Vaginal Hydrocele Due to a Septic Puncture-Aspiration: A Series of Seven Cases Collected at Yalgado Ouedraogo Teaching Hospital of Ouagadougou

Objective: To describe diagnostic and therapeutic outcomes of infected vaginal hydrocele.Material and Methods: This is a retrospective descriptive study over a period of two years from June 2013 to May 2015 at the urological emergency department of Yalgado Ouedraogo University Hospital (CHU-YO). Results: We collected seven cases during the period of study. The average age of patients was 35 years. Two patients (2/7) were from urban and five from rural areas. Five patients (5/7) were married and two (2/7) unmarried. Six patients (6/7) were farmers and one (1/7) was civil servent. Clinical examination findings were dominated by bilateral painful scrotal swelling and fever in all cases, a scrotal necrosis in two cases. The dominant indication of the punctureaspiration was discomfort during sexual intercourse (5/7). At the opening of the scrotum purulent fluid was aspirated in all cases, and we performed a unilateral orchidectomy in two cases. A hydrocelectomy was performed in all cases. The postoperative evolution was simple in all patients. Conclusion: The puncture-aspiration must be avoided because the risk of infection and the high recurrence rate.

Abstract 181: Kawasaki Disease in Children Six Months and Below - Clinical Experience from Chandigarh, North India

Kawasaki disease (KD) is a medium vessel vasculitis of childhood. Clinical presentation in infancy is often characterized by paucity of symptoms. We report our experience of managing 15 children with KD aged 6 months and below at the Advanced Pediatrics Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India. To the best of our knowledge there are no data on this aspect of KD from any developing country. Objective: To describe the clinical and laboratory profile of children with KD aged 6 months and below in our cohort Methods: Records of Pediatric Rheumatology Clinic from 1994 - 2014 were analyzed. Fifteen of the 415 children with KD, diagnosed on the basis of American Heart Association criteria, were aged 6 months and below. Fourteen children were given intravenous immunoglobulin and 3 also received infliximab. Results: Incomplete KD was present in 13 children (87%). Mucosal changes were present in 11 (73%); extremity changes in 10 (66%); rash in 9 (60%); conjunctival injection in 8 (53%) and lymphadenopathy in 3 (20%) children. Irritability at presentation was noted in 13 (87%); 4 (26%) had respiratory symptoms and 2 (13%) children had BCG scar reactivation. Eleven patients were diagnosed beyond day 10 of illness. Of 12 patients, in whom C-reactive protein was estimated, 11 had raised levels. Thrombocytopenia was seen in 3 patients - one of these developed scrotal gangrene. Coronary artery abnormalities were present in 5 (33%) patients. Two children died from disease related complications - one of these had giant coronary artery aneurysm. Conclusions: Incomplete forms of KD are commonly seen in children below 6 months of age. This may result in delayed diagnosis.

Reconstruction of Scrotal and Perineal Defects in Fournier’s Gangrene

Fournier’s gangrene described in 1883 by Jean Alfred Fournier, still poses ethiopathogenic, evolutive and therapeutic problems. This is a therapeutic emergency; early diagnosis, medical and surgical treatments contribute to reducing mortality rate. Tissue defect engendered by infection and/or by its excision requires morphological and functional reconstruction. The choice of the reconstruction technique depends on several parameters: early or delayed coverage, the size of the defect, the local capital skin and the patient’s general condition. Through this study involving 95 cases of scrotal and perineal gangrene treated at the National Center of Burns and Plastic Surgery of Ibn Rochd University Hospital of Casablanca over a period of 10 years (2004-2014), we report our approach in the surgical management of defect secondary to Fournier’s gangrene.

Scrotal necrosis to total de-gloving injury of the male genitalia: an experience from Sub-Saharan Africa

Two patients with very different aetiologies of their genital injuries are presented: one lost his scrotal skin as a result of Fournier&amp;rsquo;s gangrene, the other experienced complete denudation of scrotal and penile skin plus the amputation of his glans penis through an agricultural machinery. The placement of denuded gonads in thigh pouches and delayed skin grafting provide safe treatment options in a low budget setting of a Sub-Saharan country.

Juvenile gangrenous vasculitis of the scrotum: an exceptional cause of scrotal ulcers

ejd.2012.1804 Auteur(s) : Teresa Pinto-Almeida teresap.almeida@hotmail.com, Aristoteles Rosmaninho, Ines Lobo, Rosario Alves, Manuela Selores Department of Dermatology, Hospital de Santo Antonio Rua D. Manuel II, s/n 4100 Porto, Portugal Juvenile gangrenous vasculitis of the scrotum (JGVS) is a particular form of scrotal gangrene that has been rarely reported since its first description in 1973 [1]. The authors present a case of this exceedingly rare entity. A 32 year-old man presented with [...]

Role of Hyperbaric Oxygen Therapy in Management of Complicated Case of Fournier Gangrene to Improve Patient Outcome

Fournier’s Gangrene is a life threatening urosurgical emergency and a synergistic gangrene of scrotum. It is a rapidly progressive & devastating form of necrotising fasciitis of perinal, perineum and genital area associated with high mortality and morbidity. Radical surgical debridement, broad spectrum antibiotics, negative pressure wound dressings and hyperbaric oxygen therapy are considered to be the cornerstone of treatment and contribute to improved outcomes. We present a case of Fournier Gangrene in a 57 Year old male patient complicated by presence of rare multiple microbial which was successfully managed with early diagnosis, prompt measures and use of hyperbaric oxygen.

Chryseomonas luteola bacteremia in a patient with left pyocele testis with Fournier′s scrotal gangrene

phenotypic characters, including the presence of multi-trichous flagella and single polar flagellum in bio groups Ve-1 and Ve-2, respectively. The CDC groups Ve-1 and Ve-2 are named as Chryseomonas luteola and Flavimonas orrhyzihabitans, respectively. The CDC group Ve-1 is placed under the Pseudomonas stutzeri group in compliance with the colony characters as they form dry and wrinkled colonies. Based on the phylogenetic relationship studies, it was found that Chryseomonas luteola and Flavimonas orrhyzihabitans are junior subjective synonyms of Pseudomonas species. [2] Chryseomonas luteola is an aerobic, Gram-negative, motile rod found in the environment as saprophytes. It was previously named as Pseudomonas luteola and CDC group Ve-1 and was placed under the Pseudomonas stutzeri group based on 16S rRNA analysis. The infections caused by Chryseomonas luteola include bacteremia, pneumonia, biliary tract infections, surgical wound infections, abscesses, peritonitis, subdural empyema and infections associated with the presence of prosthetic devices. We report a case of bacteremia caused by Chryseomonas luteola in a patient with pyocoele testis with Fournier’s scrotal gangrene. CASE REPORT

Fournier’s gangrene: Is it scrotal gangrene?

Fournier's gangrene was originally described as scrotal gangrene in young males. Today, it is generally accepted as synergistic necrotizing fasciitis of perineal, genital, or perianal regions, and the epidemiologic data have changed. However, there are still limited data about females due to the lack of female patients, even in large case series. A retrospective review of the medical records of all patients who received surgery for emergency conditions over the past 22 years was performed to identify patients with Fournier's gangrene. Data from these patients were then reviewed to determine the age, gender, etiology, causative bacteria, predisposing factors, treatment modalities, length of hospital stay, and morbidity and mortality rates associated with Fournier's gangrene. Data were evaluated using multivariate analyses. Sixty-five patients (20 female) were identified with the diagnosis of Fournier's gangrene. The mean age was 50.8 years. The most common etiology was hemorrhoidectomy in male and perianal abscess in female patients. The most commonly isolated microorganism in both male and female patients was Escherichia coli. Twenty-nine patients had diabetes mellitus, which was the most common predisposing factor. Mean hospitalization time was 24.4 days and the overall mortality was 27.70%. Fournier's gangrene is still an important disease with high mortality rates in spite of the developments in intensive care units and new-generation antibiotics. It seems that there are no major differences between male and female patients in the characteristics of the condition.