Screen Shots Research Articles

Amplicon-based long-read sequencing is useful for confirming zygosity of DSG2 variants associated with Japanese ARVC

Abstract Background Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited cardiomyopathy mainly caused by desmosomal gene variants. Previously, we reported that DSG2 variants were the most common in 153 Japanese ARVC probands (DSG2 multiple, n=62 and single, n=4; PKP2, n=28; others, n=7). Among the multiple DSG2 variant carriers, 22 probands were compound heterozygous carriers, and 25 were homozygous, which were confirmed by genetic testing for family members (Figure A). On the other hand, 88% of their family members with single DSG2 variant carriers were not diagnosed with ARVC, which meant that recessive DSG2 variants were the major cause of ARVC in Japan. However, zygosities in remaining 15 probands with multiple DSG2 variants were unknown due to the lack of genome data from their parents. Purpose This study aimed to clarify the zygosities of multiple DSG2 variants using amplicon-based long-read sequencing. Methods Genomic DNA was extracted from whole blood using standard protocols. The range containing multiple variants was amplified by long-range PCR. Sequencing libraries were prepared using ONT Ligation Sequencing Kit. Each library was loaded onto a flow cell for sequencing on ONT GridION Mk1 running MinKNOW control software. FASTQ files were aligned to hg38 using minimap2. Variants were called using Clair3 and phased using WhatsHap. Integrative Genomics Viewer (IGV) was used for visualization of the phased variants. Results We successfully phased all the multiple DSG2 variants found in the 15 proband. A typical result of amplicon-based LRS was shown in Figure B. It was IGV screen shot of reads at DSG2 containing c.874C>T (p.R292C) and c.1481A>C (p.D494A). The reads colored in red belonged to one haplotype, while the ones in blue belonged to the other. Each of the two variants was on different color reads, indicating they were compound heterozygous variants. Using LRS, we confirmed all the 15 probands had compound heterozygous variants in DSG2. Overall, the 62 probands (40.5%) with DSG2 variants were recessive variant carriers (Figure A). Conclusions Japanese ARVC was mainly caused by autosomal recessive variants in DSG2. Clarifying the zygosity of causative variants is crucial for the diagnosis in recessive diseases including Japanese ARVC. Amplicon-based LRS was helpful for phasing the multiple DSG2 variants directly without genetic testing of the parents.Figure AFigure B

GENERATION Z’S LINGOS ON TIKTOK: ANALYSIS OF EMERGING LINGUISTIC STRUCTURES

The internet is an environment where users display the prowess in language and all forms of semiotic resources for different forms of communication. The current study examines Generation Z’s use of language in order to highlight the emerging forms of language structures on TikTok, as a result of the innate ability of humans to create new forms, mostly in verbal communication. The research questions are: What are the forms of construction of Generation Z’s lingo on TikTok? What semantic peculiarities are Generation Z’s lingo on TikTok characterized by? The premise of this study is that, Generation Z’s creative use of language on TikTok, shows the innate ability of humans to create new forms, and adapt to the affordances of new platforms in using language for communication. Crystal’s (2005) propositions concerning Internet Linguistics— the Stylistic perspective is applied in this study. Fifty Tik Tok videos were downloaded from the TikTok platform, some of the videos had the same lingos, in which case only one of such videos was chosen. Seventeen videos were used, each video was played; the part of the video that had the Generation Z’s word(s) was screen shot and used as the data for the analysis. In all, seventeen images were used. Findings show that the Generation Z’s lingo is replete with: acronyms used as full words in speech, combination of words and image in speech, the use of neologisms, esoteric words, and laconic structures. Some words and phrases have new meanings in addition to their previous meanings; all these show a new variety of the English language. The study recommends that language users should deploy the affordance of new internet platforms to freely express themselves, in doing so, naturally, new varieties will spring up and widen the lexicon of the English language.

NARRATIVE BUILDING THROUGH MEMES ON RAPE AND HARASSMENT VICTIMS: A MULTIMODAL DISCOURSE ANALYSIS

The social media memes on rape and harassment victim in Pakistan create verbal and semiotic sexual violence for the victims along with their online supporters. Online misogyny is online abuse against women and girls that is rooted in a hatred and mistrust of women which seeks to silence the victims of rape and harassment, further reinforce gender inequalities. This research explored the role of linguistic and semiotic choices made by social media users to create social media memes serving victim blaming, victim silencing and revealing the diseased cognitive structures of such netizens (internet users) in the virtual world. The research is based on five social media memes on the most talked about cases of rape and harassment in the online world. The researcher selected those rape and harassment cases on which there were at least 25-50 memes. The present study data was taken from Facebook and Twitter in the form of screen shots of the memes. The data was analyzed at two level Micro-Discourse Analysis and Macro-Discourse Analysis. The research findings explored the triangular relationship between linguistic, social and cognitive structures. Thus, the social media memes revealed the cognitive structures of the meme creators through their linguistic as well as semiotic choices.

Simulation and Modelling of Pre-emptive Priority CPU Scheduling Algorithm

A model is a representation of an idea, thing or object in a simplified form. Model contains information about a system that is created with the aim of studying the actual system. Simulation is an imitation of system using a computer model. In this journal simulation is done by using OS-SIM, an operating system simulator. Process scheduling in an important part in operating systems. Several scheduling algorithms exist in the field. Shortest job first, round robin, first come first serve, priority and all of their variants. In this journal discussion about pre-emptive priority scheduling algorithm is presented thoroughly. Pre-emptive priority scheduling algorithm is an algorithm based on priority. The higher the number of the priority, the higher the priority. Five processes are available and given. Each with burst time, priority and different arrival times. Simulation and modelling with OS-SIM are discussed to understand this algorithm more easily. Some statistics numbers in the system are calculated automatically by the OS-SIM. Some screen shot pictures of the simulator are given to describe the model. It is concluded that for these processes the average turnaround time is 42/5 = 8.4 ms and for average waiting time is 28/5=5.6 ms and the total burst time is 14 ms.

AAPM WGPE report 394: Simulated error training for the physics plan and chart review.

Simulated error training is a method to practice error detection in situations where the occurrence of error is low. Such is the case for the physics plan and chart review where a physicist may check several plans before encountering a significant problem. By simulating potentially hazardous errors, physicists can become familiar with how they manifest and learn from mistakes made during a simulated plan review. The purpose of this project was to develop a series of training datasets that allows medical physicists and trainees to practice plan and chart reviews in a way that is familiar and accessible, and to provide exposure to the various failure modes (FMs) encountered in clinical scenarios. A series of training datasets have been developed that include a variety of embedded errors based on the risk-assessment performed by American Association of Physicists in Medicine (AAPM) Task Group 275 for the physics plan and chart review. The training datasets comprise documentation, screen shots, and digital content derived from common treatment planning and radiation oncology information systems and are available via the Cloud-based platform ProKnow. Overall, 20 datasets have been created incorporating various software systems (Mosaiq, ARIA, Eclipse, RayStation, Pinnacle) and delivery techniques. A total of 110 errors representing 50 different FMs were embedded with the 20 datasets. The project was piloted at the 2021 AAPM Annual Meeting in a workshop where participants had the opportunity to review cases and answer survey questions related to errors they detected and their perception of the project's efficacy. In general, attendees detected higher-priority FMs at a higher rate, though no correlation was found between detection rate and the detectability of the FMs. Familiarity with a given system appeared to play a role in detecting errors, specifically when related to missing information at different locations within a given software system. Overall, 96% of respondents either agreed or strongly agreed that the ProKnow portal and training datasets were effective as a training tool, and 75% of respondents agreed or strongly agreed that they planned to use the tool at their local institution. The datasets and digital platform provide a standardized and accessible tool for training, performance assessment, and continuing education regarding the physics plan and chart review. Work is ongoing to expand the project to include more modalities, radiation oncology treatment planning and information systems, and FMs based on emerging techniques such as auto-contouring and auto-planning.

IJCM_112A: Impact of competitive spirit on weight, waist circumference and HbA1c among the followers of Dixit Lifestyle participating in 90 Days weightloss and Diabetes Reversal Challenge

Background: Author has initiated World free of obesity and diabetes campaign since 2013. This lifestyle suggests taking only two meals in a day and go for any cardio exercise for 45 minutes at a stretch every day. This lifestyle is showing great results in weight loss and diabetes prevention/remission. Through the campaign 90 days weight loss and diabetes reversal challenge was organized from 1t August to 31st October 2023. Objectives: 1) To find out the effect of competitive spirit on weight and waist circumference among the participants 2) To find out the effect of competitive spirit on HbA1c and doses of diabetes medicines Methodology: Through messages on social media people were informed about the 90 days weight loss and diabetes reversal challenge. To join the challenge it was mandatory to submit there latest HbA1c and fasting insulin report, weight (Kg) and waist circumference (cm). Participants were categorized and added to non diabetic, prediabetic and diabetic WhatsApp groups having senior coordinators who monitored their progress. Members had to post screen shot of daily exercise and photo of daily meals. Weekly quizzes and various competitions were organized. Members filled daily google form and progress tracker at the end challenge with all parameters. Results: Out of 648 members 544 submitted all data at the end of three months which included 68 non diabetics, 253 prediabetics and 223 diabetics. Average weight loss was 4.12 Kg and waist circumference loss was 2.29 inches. Average HbA1c reduction was 0.428 gm%. 80 diabetics converted to prediabetic status and 10 to non diabetic status. 53 prediabetics became non diabetics. In 44 diabetics medicines were reduced and in 16 they were stopped. Conclusion: Competitive spirit while following Dixit Lifestyle has shown great results as regards weight loss, inch loss and HbA1c reduction.

Bahrun Naim’s Hacking Manifesto: How A Historical Model of Cyber Threat Mischaracterization Helps Us Diffuse a Dead Cyberterrorist Influencer

The late Bahrun Naim is generally considered one of the most recognizable names of historical Indonesian cyber terrorist actors, where he continues to be characterized as a “computer guru” and hacker who supported Indonesian extremist and Islamic State hacking. This paper is the first reexamination of Naim’s lengthy e-book manifesto chapters on hacking, finding that most of the tutorial demonstrations on hacking tools readers might believe Naim performed were screen shots of other online content that Naim appeared to have plagiarized. This practitioner’s paper suggests that Naim is a historical model of cyber threat mischaracterization, questioning who Naim was signaling with his hacking manifesto and why so many audiences including cyber threat analysts may have been influenced by reports on him. This paper evaluates Naim’s native and researched technical knowledge based on his manifesto, suggesting the perception of Naim’s native technical knowledge may have been embellished. This paper offers a conceptual interdisciplinary model for practitioners and researchers evaluating cyberterrorists’ technical pedigrees and social environments. This model can also be applied to countering the range of cyber warfare including narrative warfare conducted by cyberterrorists, often revealing shortcomings in the mythos of cyberterrorists’ influence and technical skills.

Screen Shots: State Violence on Camera in Israel and Palestine by Rebecca L. Stein (review)

Screen Shots: State Violence on Camera in Israel and Palestine by Rebecca L. Stein (review)

The English Register in Social Media Instagram

This research entitled "English Register in Instagram Social Media". This research is conducted with the aim at identifying and mapping the use of English registers in social media Instagram and specifically is to find out the function of the usage of those registers. This research is a-qualitative descriptive research. The method applied for this research is observation method with note-taking and screen shot technique. To answer the formulated problems, this research applied register theory from Halliday (1994).

Preface

The title of the ConferenceXXII Conference of PhD Students and Young Scientists “Interdisciplinary topics in mining and geology”The location and the date of the conference virtual event – online conference, June 29th to July 1st, 2022 in Wrocław, Poland XXIInd Conference of PhD Students and Young Scientists “Interdisciplinary topics in mining and geology” continues a series of events that started in 2000 at Wrocław University of Science and Technology. Scientific programme of the Conference focuses on four thematic panels:1. Mining Engineering: sustainable development, digitalisation in mining, problems of securing, protecting and using remnants of old mining works, underground mining, opencast mining, mineral processing, waste management, mining machinery, mine transport, economics in mining, mining aeronautics, ventilation and air conditioning in mines,2. Earth and Space Sciences: geology, hydrogeology, environmental protection, extraterrestrial resources, groundwater and medicinal waters, engineering and environmental protection, geotourism,3. Geoengineering: environmental protection, applied geotechnics, rock and soil mechanics, geohazards,4. Geoinformation: mining geodesy, GIS, photogrammetry and remote sensing, geodata modeling and analysis.The XXII Conference of PhD Students and Young Scientists was held as a virtual event, that is as a virtual, online conference in real-time. The reason why the Organizing Committee decided to change the traditional formula of the event to online formula was related to the concern for the health of the participants due to the COVID-19 epidemic.The XXII Conference of PhD Students and Young Scientists took place from June 29th to July 1st, 2022 in Wroclaw, Poland. That is the organizers worked and managed the event from the Wrocław University of Science and Technology Geocentre building. Because the conference focused on four thematic panels, four different special opening lectures were delivered by wellknown scientists- Professor Jan Zalasiewicz (University of Leicester, England)- Associate Professor Artur Krawczyk (AGH University of Science and Technology, Poland)- Professor Biljana Kovacević-Zelić (University of Zagreb, Croatia)- Assistant Professor Eduard Kan (Tashkent Institute of Irrigation and Agricultural Mechanizations Engineers, Uzbekistan).The Conference was divided into 8 oral sessions (with 33 presentations) and 1 poster session (with 33 posters). The amount of time provided to one presentation was 15 minutes, after presentation there was 5 minutes available for discussion. The poster session was available throughout the event, and the posters were available for online viewing on the Conference’s website with the possibility of make discussion and ask questions in real time via zoom meeting application as well. Every day of the Conference one “virtual coffee break” was devoted for discussion between participants and question and answer session for the Organizers.There were 96 registered participants from 13 countries. The online XXII Conference of PhD Students and Young Scientists was conducted using the Zoom meeting platform with commemorative screen shots taken. By tradition two competitions, for the best oral presentation and for the best poster were held. The award for the best oral presentation was given ex aequo to Julia Tiganj (TH Georg Agricola University of Applied Sciences, Germany) for the presentation entitled Post-mining goes international: hurdles to climate neutrality using the example of China and Oksana Khomiak, Jörg Benndorf (TU Bergakademie Freiberg, Germany) for the presentation entitled Spectral analysis of ore hyperspectral images at different stages of the mining value chain, whereas the best poster was awarded to Adam Wróblewski, Jacek Wodecki, Paweł Trybała, Radosław Zimroz (Wrocław University of Science and technology, Poland) for the poster entitled Large underground structures geometry evaluation based on point cloud data analysis.List of Scientific Committee, Organizing Committee, Editorial Team are available in this pdf.

Stylistic Features of Internet Relay Chat IRC as a Medium of Computer-Mediated Communication

This study is a quantitative-qualitative, descriptive study in one of the mediums of computer-mediated communication, CMC. It attempts to investigate some stylistic features in the medium of Internet Relay Chat IRC that are used by online chatters. The data of this study are gathered from open access chatrooms through screen shots. The number of screen shots that are used in the analyses is (30) screen shots. The findings reveal that chat systems allow chatters to use different stylistic features such as graphic features, orthographic features, discourse features, flaming, spamming, spoofing, trolling, and lurking. The most frequent features are orthographic features such as “abbreviation, acronyms and punctuation”. These features are widely used in internet relay chat to save time, effort and as economy expressions.

Investigating Cyberbullying in Electronic Communication: A Descriptive Study

Cyberbullying is widely used nowadays in electronic communication. It takes different forms, and it is considered a serious problem that faces all communities. Therefore, the current study is an attempt to discover cyberbullying with its types found in one type of electronic communication, “Facebook”. The data are as type of screenshots and collected from an archived formal page on Facebook called “BBC News”. The data of the study encompass (10 comments) samples “screen shots” from different posts on “BBC News”. The analyses reveal “four” different types of cyberbullying which are employed in the data. The types are flaming, which is a reply directed towards other people’s comments; rumour spreading which is directed towards the posts or the channel; trolling, which is directed towards a specific post or the topic of discussion; and tagging, which occurs by making tags to other people with their usernames. Thus, cyberspace creates new different social environments that allow different online users from all over the world to contribute to electronic communication and cause many forms of cyberbullying.

Social media engagement, perceptions of social media costs and benefits, and well-being in college student-athletes

Objective: The present study investigated the association between social media engagement and factors related to well-being (e.g., depression, anxiety, sleep, loneliness, self-esteem). Participants: A sample of 1120 college student-athletes (338 males, 777 females, 5 identified as non-binary) from nine universities participated in this study. Method: Data were collected through self-report measures and screen shots of participants’ screen time in the previous week. Results: Overall screen time taken from devices was not associated with self-reported well-being, whereas use of social media during daily activities was related to worse well-being across domains (e.g., lower self-esteem, higher fear of missing out, stress, anxiety, depression). In addition, student-athlete perceptions that social media interfere with their lives were related to worse well-being. Conclusions: The implications of these findings, including the possibility of using protective behavioral strategies (PBS) to reduce negative impacts of social media in college students, are discussed.

Reconceptualizing semiotic resources in the eco-social system of an online language tutoring course

ABSTRACT Translanguaging and trans-semiotizing research has problematized the static view of language and argued that meaning making is a dynamic, material, social, and historical process across multiple timescales in complex eco-social systems. The second author proposed the concept of trans-semiotizing as an alternative lens to study language teaching and learning. In this autoethnographic study, the dynamic processes of online language learning and teaching are examined by analysing the semiotic resources, trans-semiotic practices, and the coordination of different semiotic resources. To capture such dynamic processes and the semiotic resources involved, the first author setup multiple cameras and used screen recording to document my teaching. Data include recordings of my computer screens, video recordings of my physical environment, facial expressions, body movements, screen shots of my social media posts, and my teaching notes. We draw on Lemke’s dynamic eco-social system concept to discuss how semiotic resources are used in online language teaching and learning across different timescales.

Rebecca L. Stein, Screen Shots: State Violence on Camera in Israel and Palestine

Rebecca L. Stein, <i>Screen Shots: State Violence on Camera in Israel and Palestine</i>

Stein, Rebecca L. 2021. Screen Shots: State Violence on Camera in Israel and Palestine. Stanford University Press.

AbstractScreen Shots takes an ethnographic approach to explore the visual history of the Israeli military occupation of Palestinian territories and the different roles photography played within the decades‐long conflict. Choosing to forgo the usual route of exploring the impact of photos on social activism, the author focused instead on how easily images can be utilized as tools of colonialism supporting the occupation; a unique viewpoint offering readers a more comprehensive understanding of the function of photography as a political placeholder in modern age. Although Screen Shots attempts to showcase a solid overview of the Palestinian‐Israeli conflict through images for over more than two decades, it still comes short in terms of balance in revealing real‐life experiences of snapping photos for political purposes from both sides.

Automated Reinforcement Management System (ARMS): focused phase I provider feedback

BackgroundAlcohol use increases risk for morbidity and mortality and is associated with over 3 million annual deaths worldwide. Contingency Management (CM) is one of the most effective interventions for substance use disorders, and has recently been coupled with technologies to promote novel treatments for alcohol use disorders (AUD). Leveraging these technological advances, we are developing the Automated Reinforcement Management System (ARMS), an integrated CM system designed to enable CM treatment as a component of a digital therapeutic or adjunct therapy remotely to anyone with a smartphone.ObjectiveTo collect detailed provider feedback on ARMS and determine the need for modifications to make the system most feasible, acceptable, and useful to providers.MethodsSeven providers completed one-hour structured interviews/focus groups wherein we described the ARMS system and its application to clinical care. Providers viewed screen shots of the ARMS provider facing and patient facing systems. Providers gave feedback on their current AUD treatment practices, preferences for the functionality and appearance of the system, preferences for receipt of information on their patients, why they and their patients would or would not use the system, suggestions for improvement, and the proposed intervention overall. To analyze the qualitative data gathered, we used a qualitative descriptive approach with content analysis methods.ResultsThe overarching theme of Individualized Treatment emerged throughout the interviews. This sentiment supports use of ARMS, as it is intended to supplement provider communication and intervention as an adjunctive and customizable tool with the ability to reach rural patients, not a stand-alone option. Themes of Accountability and Objective Assessment arose during discussions of why people would use the system. Themes within provider obstacles included, Information Overload and Clinical Relevance, and in patient obstacles, Sustained Engagement and Security Concerns. Two themes emerged regarding suggestions for improvement: Increasing Accessibility and Bi-directional Communication.DiscussionThemes from provider input are being used to modify ARMS to make it more user friendly, time saving, and relevant to treatment of AUD. If successful, ARMS will provide effective, individualized-digital therapeutic for those needing adjunctive treatment or those living in rural remote areas needing better connected care.

«КОНСЕРВАТИВНАЯ ДЕМОКРАТИЯ» КАК ВАРИАНТ ПОЛИТИЧЕСКОГО КОНСЕРВАТИЗМА

The article describes the conservative discourse in modern Russia, focused on finding an adequate conservative model for the country, taking place from 2014 to 2022 on the virtual platform - ‘Russian idea’. The article uses extensive materials of the web-site, with focus on the position of the project manager Boris Mezhuyev, one of the most famous inspirers of the conservative turn. Relying on the ideas of Vadim Tsymbursky, Mezhuyev builds an independent line of conservative discourse, taking into account current situation. The project managed to include many representatives of different backgrounds and views, which allowed Boris Mezhuyev to form his concept of “conservative democracy” taking into account different positions. The formation of the concept is based on the Mezhuyev’s desire to combine theory and practice, including the conservative bias of the United Russia Party, and to do so based on what they see as the main values of conservatism as a political ideology. The change in the political situation on February 24, 2022 caused Mezhuyev's decision to close the project. We believe that this experience is useful for Political Science, especially since the life of virtual platforms can be short, so it is necessary to carry out their scientific screen shot.

A developmental study of expressing simultaneous events in film-based narratives

This study examines the expression of simultaneity in the film-based oral narratives of 100 English monolinguals in the following three age groups: preschoolers (4–6 years), school-aged children (7–10 years), and adults (19–48 years). Participants told a story of what happened in the film, in an off-line task, to an interviewer who had not seen the film. The film was rich in simultaneous events at various sites through the episodic structure. Focus was on quantitative and qualitative aspects of simultaneity, from the perspective of forms and functions. Quantitative results showed very little simultaneity at preschool and almost similar expression at school age and adulthood. Qualitative analyses revealed that perceptual, semantic, and discourse factors affected the profiles of development. Preschool children expressed local simultaneity between situations in adjacent clauses, more frequently between unbounded situations that are implicitly simultaneous. Besides, they tended to express more simultaneity in scenes that were perceived in a single screen shot. From age 7, children became more able to express simultaneity across larger stretches of the text, covering a wider scope on situations on parallel timelines. Top-down knowledge of narrative organization guided older narrators to take temporal perspectives that go beyond the semantic properties of events, giving way to discourse-motivated simultaneity where causality plays a substantial role. Language forms to express simultaneity showed a long developmental route – through verb semantic and tense-aspect alternations as the widest, basic usage to specific lexical forms like conjunctions (e.g. while), adverbs (e.g. meanwhile), and more sophisticated syntactic configurations. The form-function analyses enabled an exploration of the cognitive and language abilities in the production of simultaneous relations under the constraints of narrative discourse organization. The study reinforced the results of previous developmental studies of temporality, shedding further light on the relatively unexplored topic of simultaneity expression.

Implementation of documented and written informed consent for clinical trials of communicable diseases: Lessons learned, barriers, solutions, future directions identified during the conduct of a COVID-19 clinical trial

Background and objectiveThe communicable nature of many infectious diseases, including SARS-CoV-2, creates challenges for implementing and obtaining regulatory-compliant written informed consent. The goal of this project was to identify and evaluate processes that address these barriers while maintaining clinical and research staff safety. MethodsWe reviewed Federal Drug Administration (FDA), World Health Organization (WHO), and VA Office of Research and Development (ORD) guidance about informed consent during the COVID-19 pandemic, and identified and pilot-tested several mechanisms for obtaining regulatory-compliant consent during our COVID-19 therapeutics clinical trial. ResultsSeveral processes were identified. These included a standard face-to-face consent with a plan for maintaining a paper copy of the signed consent form, a phone or video chat consent process that included taking a picture of the signed consent form or a screen shot of the signed document during a video chat, integration of the consent forms into software embedded within the electronic health record, and secure software programs with electronic signature. These processes are FDA-compliant but time-intensive, often requiring four or more hours of coordination between the clinical team, research staff, patients, and legally authorized representatives. ConclusionsFuture studies could evaluate how to improve efficiency, and whether some elements of the consenting process, such as the requirement for documented written signed consent, rather than a witnessed oral consent, is an acceptable standard for research participants with communicable diseases.