Scorpion Bite Research Articles

Protective effect of Tecoma stans (L.) Juss.ex Kunth in CFA-induced arthritic rats

Ethnopharmacological relevanceTecoma stans (L.) Juss.ex Kunth (Bignoniaceae) is mainly found in tropical and subtropical regions of Africa and Asia. The leaves, flowers, roots, and bark are used to treat various aliments includes, skin infections, kidney problems, intestinal disorders, jaundice, toothaches, joint pain and repair cracked bones, antidotes for snake, scorpion, and rat bites. Aim of the studyThe objective of the study is to assess the anti-arthritic properties of T. stans leaf using Complete Freund's adjuvant (CFA)-induced rat. Materials and methodThe ethanol extract of T. stans leaf (ETSL) was subjected toGas Chromatography-Mass Spectrometry (GC-MS) and Liquid Chromatography-Mass Spectrometry (LC-MS) analysis for the identification of potential bioactive. The anti-arthritic activity was carried out by administering CFA (0.1 ml) into the sub-plantar surface of the right hind paw. The experimental animals were treated with indomethacin (10 mg/kg) and ETSL (250, 500 mg/kg) once a day orally for fourteen days. The arthritic parameters and hematological and biochemical parameters were evaluated using standard kit reagents. The levels of pro-inflammatory cytokines and inflammatory mediators were measured in blood serum. Antioxidant parameters were assessed in homogenized liver and joint tissues. Radiological and histopathological analysis of joint was performed. A computational molecular docking investigation of the phytoconstituents was conducted against COX-2, IL-1β, IL-6, and TNF-α receptors. ResultsThe ETSL at 500 mg/kg demonstrated significant (p < 0.01) restoration of arthritic parameters, hematological and biochemical indices and oxidative stress in CFA-induced rats which was further supported by radiological histological examination. In addition, there was significant (p < 0.05) reduction observed in pro-inflammatory cytokines, inflammatory mediators and up-regulation of anti-inflammatory cytokines in the treated group. Verbascoside was found to exhibit better biding affinities −10.4, −7.4, −7 and −6.2 kcal/mol against COX-2, IL-1β, TNF-α, and IL-6 respectively, confirmed through in silico study. ConclusionsThe observed outcome suggests that ETSL at a dosage of 500 mg/kg demonstrated notable anti-arthritic effects by suppressing pro-inflammatory cytokines and oxidative stress biomarkers. This effect could potentially be attributed to the presence of bioactive verbascoside identified in the LC-MS analysis.

Do Previous Multiple Scorpion Bites Produce Resistance to Local Anesthetics Administered Via Repeated Subarachnoid and Epidural Blocks? A Case Report and Review of Available Evidence

Introduction: Failure to achieve a subarachnoid block, even after a second attempt, and the inability to activate epidural analgesia, despite a properly placed catheter, can be both frustrating and perplexing. This case presents a situation where these incidents occurred, and two well-conducted attempts at a subarachnoid block and a properly placed epidural catheter block were unable to produce surgical anesthesia. Case Presentation: A 55-year-old female, classified as American Society of Anesthesiologists (ASA) grade II, was scheduled for a total abdominal hysterectomy with bilateral salpingo-oophorectomy. After adequate pre-operative preparation, an epidural catheter was inserted on the morning of surgery, followed by a subarachnoid block with all the proper precautions, which completely failed. After waiting for 10 minutes, the epidural block was activated with a local anesthetic mixture. To our surprise, it also did not produce any desirable effect, so the subarachnoid block was repeated, which again failed to produce any clinical block. Consequently, the surgery had to be conducted under balanced general anesthesia. Recalling previous experience and evidence, a history of scorpion bites was elicited. The patient had a history of multiple encounters (five) and was from a geographical area known to be endemic for scorpions. Conclusions: This case represents another instance of developing resistance to the effects of local anesthetics after exposure to scorpion venom. We believe there is a strong correlation between previous scorpion bites, the number of bites, and the duration between the most recent bite and the development of resistance to local anesthetic agents (LAAs). From a detailed search, it was evident that enough clinical evidence has emerged to irrefutably support this proposal.

A comprehensive review on pharmacological, phytochemical and anticancer potential of Tragia species

Genus Tragia is a member of Euphorbiaceae family and is frequently found in tropical environments. There are more than 150 species in Tragia. Tragia plant is widely distributed in India and East Africa peninsula. Tragia has been designated for multiple medicinal properties including anti-bacterial, anti-inflammatory, anti-fungal, reproductive, diarrhoea, scorpion bite, whooping cough, diabetes etc. These are few medicinal benefits of Tragia. Tragia is also used in ethno medical research. Tragia involucrata, Tragia spathulata, Tragia benthamii, Tragia pluknetii, Tragia urens, Tragia nepetifolia and Tragia urticifolia are the principal species being researched worldwide. By the conventional wisdom, Tragia would be a component in siddha and ayurvedic medicine. Pharmacologically, many phytochemicals including lignans, alkaloids, flavonoids, terpenoids and phenolic substances, have been linked to these characteristics. The combined effects of these phytoconstituents greatly enhance their potential as medicinal agents. Moreover, this review discusses the challenges and future prospects in harnessing the full therapeutic potential of Tragia species. Issues such as standardization of extracts, elucidation of specific active compounds and clinical translation are addressed, highlighting areas that require further research.

Scorpion Bite Mimicking Acute Coronary Syndrome/Myocarditis Later Detected to Have Preexcitation Syndrome—A Case Report and Review of Literature

Abstract Introduction: Scorpion sting-induced myocarditis is a strange and potentially life-threatening problem that merits careful clinical consideration and management. Case Details: Our case, a young male presented with history of scorpion bite over left foot sole associated with local burning an itching with subsequent development of systemic symptoms. The patient received supportive care, including pain management, fluid resuscitation, and close cardiac monitoring. Given the severity of the myocardial involvement, specific interventions targeting the venom’s impact on the heart were initiated. The patient showed significant improvement in symptoms and cardiac function with the implemented management strategies. We present a case report of a patient who suffered myocarditis following a scorpion sting, emphasizing the distinctive clinical features, diagnostic dilemma, and successful management. This case highlights the importance of heightened awareness among healthcare providers when faced with scorpion envenomation, particularly in regions where such encounters are prevalent. Conclusion: This case report contributes to the limited literature on scorpion bite-induced myocarditis, shedding light on the diagnostic intricacies and successful management.

Into the Venomous Abyss: Unveiling Rare Complications Following Scorpion Bites

Scorpion bites are common in India. Usually harmless, some scorpion bites do develop serious systemic complications such as myocardial infarction, pulmonary oedema, myocarditis, cerebrovascular accidents. These complications are rare and seldom reported. First is a case of acute myocarditis and pulmonary oedema following scorpion bite; second is a case of acute haemorrhagic stroke and tachyarrhythmia following scorpion bite. The authors report these two cases of fatal complications of scorpion sting that illustrates the brief review of literature on its clinical presentation and emergency resuscitation.

Effect of Champakadi Agad in the Management of Shitapitta w.s.r. to Urticaria - A case study

Introduction: Shitapitta is a skin ailment that was first reported in Madhava Nidan which can be correlated to urticaria. It is a disorder characterized by symptoms comparable to Insect and scorpion bite, such as wheals resembling those from a wasp sting, itching, pain, fever, and burning feeling. Champakadi Agad is one of the Ayurveda formulations listed in Chapter 37/71-72 of Ashtanga Hridaya Uttarasthana by Acharya Vagbhata. Agadas are used to cure a variety of toxic conditions. Aims: To study the effect of Champakadi agad for local as well as internal use in case of Shitapitta. Case Report: This article is a case study about a 24 yrs old female patient who came to the OPD of Panchakarma Dept of Dr. D. Y. Patil College and hospital, Pimpri, Pune complaining of itchy skin, raised reddish bumps over the skin along with burning and pricing pain over her both palms and cheeks. She was treated with Champakadi Agad’s Local application for 30 days. Results after 30 days was found satisfactory. With no negative side effects, the therapy methods significantly reduced the disease's indications and symptoms. Discussion:This is a case study based on the management of Shitapitta (Urticaria). This study established the role of Champakadi Agad in the treatment of Shitapitta (Urticaria). Conclusion:The treatment of Shitapitta by Ayurvedic measures has been thoroughly examined and discussed here. Her progression is also shown here, step by step. This case study will encourage further research and aid in the development of an ayurvedic treatment protocol for Shitapitta (Urticaria).

Traditional utilization of bamboo in the Central Siwalik region, Nepal.

Bamboo are the fastest growing perennial woody grasses that have versatile applications. Most of the local people inhabiting the riverine area of the Siwalik region of Nepal rely on bamboo products for economic benefits and medicinal uses. Our objective was to identify the diversity of bamboo species, their ethnomedicinal practices, and economic and ecological importance. Data were collected by direct observation, key informant interviews, participatory rural appraisal, inventory technique, focus group discussions, and a household survey using semi-structured and structured questionnaires. We recorded four genera and nine species of bamboo, of which eight species have been used for agriculture, five for medicine, four for construction, food, fodder, artifacts and religious purpose, three for river embankment, and two for ornamental purpose. As the local people in the study area were deprived of medical facilities, using traditional herbal medicine to cure various diseases was a common practice. The inhabitants responded that they use bamboo-based primary ethnomedicinal care even against snake and scorpion bites. Similarly, they use bamboo young culm for reducing body weight and control diabetes. The value of the informant consensus factor was found to be maximum for the bamboo against snake and scorpion bites (1.0) and minimum for weight loss (0.81). This study concludes that the traditional utilization of all kinds of bamboo in the region is vast despite their less diversity. The recorded bamboo species are used not only for food and fodder but also in preparing artifacts, soil nutrients restoration in the fallow land, construction materials for the rural people, river embankments, and religious and spiritual purposes. Therefore, if grown on a large scale, bamboo can provide sustainable benefits for the local users and ecological aspects. Bambusa tulda and Dendrocalamus strictus have a broad spectrum of pharmacological agents. Considering the multifaceted application of bamboo in the Siwalik area, it is worthwhile to encourage the local people to bamboo plantation, which would contribute to supplement their household requirements and be one of the alternative livelihood options.

Agriculture-Related Occupational Hazards Reporting to Health Facility in Tribal Area: A Retrospective Record-Based Observational Study

Abstract Introduction: India being a country of agriculture, most of its population is engaged in agriculture-based activities in a varied manner either directly or indirectly. This sector of activity being most unorganized, very little attention has been given to the occupational health problems of these workers. Objectives: To evaluate the socioeconomic profile of agriculture-related occupational health hazards like physical, chemical, biological, mechanical, respiratory, and dermatological, agriculture-related occupational health hazards. Materials and Methods: The present study was a retrospective record-based observational study conducted in 3 health centers (2 PHCs and 01 Tertiary care Health center) of tribal area of western Maharashtra over a period of 12 months with a sample size of 274 cases. Results: We found an increased incidence of occupational hazards among males of age group 21–60 years and illiterate individuals mainly during rainy and winter seasons. Out of the 274 cases, 22.99% were illiterate. Biological occupational hazards were the most prevalent form of occupational hazard contributing 81.02% of total cases, the majority of cases (64%) arising due to snake bites followed by scorpion bites (19%). Of total 274 cases of occupational hazards 10.21% cases were of mechanical hazards and 6.93% cases of chemical hazards. Another prevalent factor associated was addiction to some substances like alcohol or tobacco in about 74% of cases. This suggests that addiction may be one of the important contributory factors related to occupational hazards. Conclusion: There is high burden of agricultural related occupational hazard especially the biological hazard and addictions like substance abuse may be a contributory factor for mechanical injury as well as biological hazard. We Suggest ways to minimize incidences of occupational hazards which may include Awareness and education to target population about various hazards and their prevention, Periodic medical examination based on hazard. Vocational training and rehabilitation may also be given due attention by health policymakers and government at all levels.

Extração e quantificação de anticorpos entivenenos em ovos de galinha contra veneno de escorpião

ABSTRACT: Avian-derived IgY is thought to be the best therapy for scorpion bites concerning low-level side effects. The present study analyzed a hypothesis about the neutralization of scorpion venom Androcotonus australis through antibodies produced in the egg yolks of chickens. The venom used for inoculation was obtained from Androctonus australis (yellow fat-tailed scorpion) from southern Punjab, Pakistan. The lethal dose of LD50 against scorpion venom was calculated in chickens and mice. Safe doses were given to egg-laying chickens to produce IgY antibodies. The antivenom IgY antibodies were extracted from the egg yolks of immunized chicken using the polyethylene glycol (PEG) method. Moreover, IgY was confirmed through sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and the Ouchterlony double immunodiffusion assay test. The antibody titers were evaluated by the enzyme-linked immunosorbent assay (ELISA). The neutralisation capacity of extracted anti-scorpion antibodies was tested on mice. The calculated LD50 of scorpion venom for chicken and mice was 4 mg/kg and 2.5 mg/kg, respectively. SDS-PAGE and Ouchterlony double immunodiffusion confirmed the presence of IgY against scorpion venom. The maximum titer value of specific IgY produced against scorpion venom was 3.5 ug/ml. A concentration of 220 ul/LD50 was effective to neutralize 1 mg of scorpion venom. It is suggested that IgY obtained from egg yolks is safe against targeted venom and can be used as an effective alternative to equine IgG antibodies against scorpion envenoming.

Subarachnoid hemorrhage following scorpion bite: case report

Scorpion stings are life threatening and toxicological emergencies with systemic effects caused by autonomic nervous system damage. Subarachnoid hemorrhage (SAH) is extremely rare complication of scorpion sting. In this report, we present an unusual case of a 62-year-old male patient with scorpion sting who developed a complication of SAH. A high index of suspicion is vital for earlydiagnosis and prompt management of the complication because it is as a life-threatening emergency for patients presenting with hemorrhagic stroke.

A Review on Pharmacological and Therapeutic Aspect of Shirishadi Agada w.s.r. Vishachikitsa

In Agadtantra many Jangam (animal poison) and Sthawar visha (plant poisoning) are described and in treatment of Visha many Agada are described. Agad means drug or formulation of drug which act against poisons or neutralize the poisoning effects. Keet visha (insect bite) is one of the common poisoning in Jangam visha. In Ayurvedic Samhitas many Agada formulations are described in treatment of Keet visha. Shirishadi Agada is mentioned in treatment of Keet visha (insect bite), Sarp (snake bite), Luta (spider), Mushak (rat poison) and Vruschik visha (scorpion bite) in Ashtang hridayam in Uttarsthana. Shirishadi Agad is herbal formulation contains Shirish, Pippali and Arka. This review is for collective information about therapeutic and pharmacological action of Shirishadi Agada.

The Effect of Neutrophil/Lymphocyte Ratio and Mean Platelet Volume on the use of Antivenom in Snake Bites and Scorpion Stings

Objective: We evaluated the distribution, use of antivenom, treatments applied during the follow-ups, and effects on the use of NLR and MPV antivenom in cases of snake bites and scorpion stings followed in the paediatric intensive care unit (PICU) and the effects of these cases on the length of stay in the intensive care unit and hospital. &#x0D; Materials and Methods: Demographic characteristics of the patients followed in the PICU and the severity of their clinical findings at admission, antivenom use after snake and scorpion bites were retrospectively examined from the clinical course in the hospital automation system and archived file records.&#x0D; Results: Of 38 patients who were followed up in the PICU for snake and scorpion bites, half were followed up for snake bites and half for scorpion bites. Antivenom treatment was applied according to the clinical stage. There was a positive correlation between antivenom-administered patients and NLR (p

Epidemiologic profile of scorpion sting accidents in the duodecennial between 2011 and 2022 in the southeastern region of Brazil

Scorpion sting accidents have a significant impact in Brazil, leading to increased hospitalizations and healthcare costs, especially in regions with high scorpion populations. The present study aimed to perform an epidemiological analysis of these accidents in Southeastern Brazil. It is an epidemiological, ecological, and mixed-design study. The methodological strategy involved the analysis of epidemiological bulletins provided by the Sistema de Informação de Agravos de Notificação (Sinan) from 2011 to 2022. The data revealed that 613,385 cases of accidental scorpion bites were reported. Minas Gerais had the highest number of cases (50.44%). Males, Caucasians, between 20 and 59 years old, with a low level of education, are the most affected. Victims sought medical attention within 3 hours of the bite, and 27.34% were on the fingers. About 89.7% of the cases were classified as mild, 95.33% were cured, and 0.78% died from the reported disease. The results highlight the urgent need for targeted prevention strategies, improved medical management, and community awareness campaigns to reduce the impact of scorpion stings in the southeastern region of Brazil.

Scorpion Envenomation: The Cause of Inadequate Subarachnoid Block - A Case Series

Background: Failure of neuraxial or regional anaesthesia can result from factors such as drug errors, technical inefficiencies, and poor patient positioning. While these causes are well-known, resistance to local anaesthetic action due to mutations in sodium channels or scorpion sting is a lesser-known contributor to block failure. In India, a tropical country with a significant number of patients presenting for surgical procedures, a history of scorpion bites is not uncommon. Case: We observed seven cases of failed regional anesthesia who had history of scorpion sting. All the patients received intrathecal bupivacaine by experienced anesthesiologists, of seven patients five patients did not develop sensory or motor block. One patient had delayed successful subarachnoid block after second attempt and one patient had successful block at first attempt. Conclusion: Our observations revealed instances of failed spinal blocks, despite adequate drug dosages and experienced anesthesiologists performing the procedures, in patients with a history of scorpion envenomation. Accordingly, our study concludes that obtaining a thorough scorpion sting history during pre-anesthesia check-ups, particularly in endemic areas, can effectively prevent unnecessary repeated pinpricks, escalating dosages, patient and surgeon discomfort, and skepticism towards the skills of anesthesiologists.

Occurrence of scorpion sting and associated factors in a highly marginalized municipality in Guerrero, Mexico: A cross-sectional study.

Scorpion sting is a neglected public health problem, despite a global estimate of 1.2 million scorpion stings and some 3,250 deaths annually. This cross-sectional study estimates the occurrence of scorpion stings and identifies associated factors in seven communities in the highly marginalized municipality of Chilapa, in the Mexican state of Guerrero. After informed consent, 1,144 households provided information on 4,985 residents. The questionnaire collated sociodemographic data, characteristics of the dwelling, efforts to avoid scorpion stings, and individual information of scorpion stings suffered in the last year. Cluster-adjusted (acl), bivariate and multivariate analysis relied on the Mantel-Haenszel procedure. The overall period prevalence of scorpion stings in the year prior to the study was 4.4% (218/4985), 5.4% in men (126/2320), and 3.5% in women (92/2665), p<0.01. The majority occurred at home 68.3% (149/218), followed by agricultural fields 26.6% (58/218), street 2.8% (6/218), and work 2.3% (5/218). Factors associated with scorpion sting were carrying firewood (OR 2.1; CI95%acl 1.40-3.09), keeping free-range hens around of the home (OR 1.9; CI95%acl 1.19-2.85), residing in a rural area (OR 1.7; CI95%acl 1.04-2.78), being male (OR 1.6; CI95%acl 1.18-2.28), and helping with housework (OR 1.6; CI95%acl 1.04-2.40). This study confirms scorpion bites are a public health problem in these marginalized communities in Guerrero State, with risk factors related to living conditions and the work process at home and in the fields. Almost all risk factors identified could be reduced with low-cost interventions implemented by the communities themselves.

Management of scorpion bite through Ayurveda: A case report

Abstract: Agadatantra, the branch of toxicology in Ayurveda, refers to various methods of eliminating toxins from the body that arises from animate, inanimate, and artificial poisons. Scorpion stings are a serious health concern in rural areas. In Agadatantra, the symptoms of scorpion sting are explained under Vrischika visha (~scorpion venom poisoning). The main characteristics of scorpion venom poisoning are Vahnivat dahanam (~burning sensation like fire), Kshipram urdhvarohanam (~quick spreading in an upward direction), Danshe ruja tishthati (~pain remains at bite site), Sadyah ati ruk (~instant severe pain), Danshashyavata (~brownish discoloration of bite site), and Dansha toda (~ pricking type of pain at bite site). This is a case report of a 24-year-old male, who had an episode of Vrischika damsha (~scorpion bite) and presented to the outpatient department with complaints of severe edema, pain and redness, and itching. The first line of management for scorpion stings is typically symptomatic including strong analgesics, which can be systemic (opiates or paracetamol) or localized (such as a cold compress). Antivenom is the specific treatment for scorpion envenomation that is used in conjunction with supportive measures. In Ayurveda classics, Hinguadi gulika is one of the formulations mentioned in Vrischikavisha prakarana, which has been referred to as the most potent Lepana (~anointment) for scorpion venom poisoning. In comparison to existing conventional treatment modalities, Hinguadi gulika lepana is a very simple and very cost-effective procedure. Hinguadi gulika was given in combination with Kulakadi kashaya which is widely practiced in all Visha (~poison) conditions. In the present case, Hinguadi gulika and Kulakadi kashayam have shown assuring results in the management of acute scorpion envenomation.

Scorpion bite and failed spinal anesthesia: is ropivacaine the answer?

Scorpion bite and failed spinal anesthesia: is ropivacaine the answer?

Posterior Reversible Encephalopathy after Scorpion Envenomation, Two Cases with Review of the Literature

Posterior reversible encephalopathy (PRES) is a clinico radiological syndrome, which manifests itself by headaches, confusion, consciousness disorders or during a sudden rise in blood pressure but can be seen in other circumstances, such as during an immune reaction or a systemic infection. Its mechanism is explained by a lesion of the blood-brain barrier leading to a reversible vasogenic edema. The scarcity of sympathetic innervation of the posterior cerebral territories explains its usual localization. We report two cases of a 5 and 18 years old girl who presented with tonic-clonic seizures following a scorpion bite. An emergency brain MRI was performed, showing bilateral signal abnormalities of the posterior cortico-subcortical territories and basal ganglia, compatible with an atypical PRES syndrome. The diagnosis of PRES syndrome complicating a scorpion bite was retained.

Safety Evaluation of Rock Hyrax (Procavia capensis) Hyraceum: Oral Toxicity Study in Rats

Urine from domestic animals has traditionally been used to treat multiple human diseases. Rock hyrax hyraceum (RHH) is a dark brown resin-like substance made up of accumulated feces and urine of rock hyraxes, used in traditional African medicine to treat snake and scorpion bites, as well as colic, hysteria, epilepsy, and Parkinson’s disease. As there is no scientific backing for the utilization of hyrax hyraceum, there is an urgent need to establish its safety as a medicine. Furthermore, toxicity evaluation facilitates the identification of factors for clinical surveillance of the potential side effects, as well as the estimation of a preliminary hygienic dose level and dosing frequency range for human clinical trials. The safety of RHH was assessed by administering 2.5 and 5 gm/kg doses of hyraceum crystals dissolved in de-ionized water and administered to rats orally. We evaluated the acute toxicity profile, as well as the effect of RHH on liver and kidney function and histopathological investigations. The results of this investigation showed that consuming RHH does not have any hazardous effects on liver and kidney function and histopathological investigations. Drinking RHH did not cause toxicity. These findings are consistent with those of previous studies of drinking cows and camel urine. We encourage more research on hyraceum composition in relation to rock hyrax habitat areas and eating patterns, as we believe it will help us understand why people practice drinking hyraceum as a medicine.

EFFECT OF PREVIOUS SCORPION BITE ON THE EFFICACY OF INTRATHECALLY ADMINISTERED LEVOBUPIVACAINE IN SUBARACHNOID BLOCK

Objectives: Local anesthetics administered by spinal anesthesia acts through sodium channels. Mutations of sodium channels may be responsible for resistance to local anesthetic agents. The scorpion venom contains neurotoxins that block the sodium channels. In view of the high prevalence of scorpion stings in our region and observation of failure of spinal anesthesia in patients with a history of scorpion stings in routine practice, the present study is planned. Methods: Forty patients of the American Society of Anesthesiologists Grade I or II who were undergoing infraumbilical surgery were divided into two groups as S (patients with h/o scorpion bite) and C (patients with no such history). The subarachnoid block was given with 3.2 ml of injection Levobupivacaine 0.5% heavy using 26 gauzes Quincke spinal needle. A blind observer recorded a sensory block using a needle prick and a motor block using the Bromage scale. Onset of sensory and motorized block, time to peak of sensory, and motor block and its relation to number of scorpion bites were observed in both the groups. Results: The onset of sensory (2.61±1.68 mins) and motor blockade (2.91±1.80 mins) was significantly delayed in Group S (p=0.010 and 0.004, respectively). Time to peak of sensory and motor blockade was also prolonged in Group S (6.45±2.83 mins and 7.8±3.95 mins) compared to Group C (3.60±0.84 mins and 4.56±1.30 mins) which was statistically significant (p&lt;0.05). Patients who had previous scorpion bites (Group S) had a significant failure rate of spinal anesthesia compared to the control group. Conclusion: In this study, it was observed that the patients with scorpion bites had a significant failure rate of spinal anesthesia, suggesting probable resistance to the local anesthetic agents.