Score Research Articles

Cetirizine modifies quality of life and symptoms in children with seasonal allergic rhinitis: a pilot study.

Background and aim:Seasonal allergic rhinitis (SAR) is a common disease in childhood that is characterized by bothersome symptoms and impaired quality of life (QoL). As histamine is the pivotal pathogenic mediator in SAR, antihistamines are the first-line option in the treatment. Cetirizine is a well-known effective antihistamine. This real-life pilot study aimed to investigate the effectiveness of a 4-week continuous cetirizine treatment in a group of Italian children with SAR.Methods:Total symptom score (TSS) and the Pediatric Rhinoconjunctivitis Quality of Life Questionnaire (PRQLQ) were assessed at baseline and the end of the treatment.Results:Cetirizine significantly improved QoL (in all domains) and symptom severity (p<0.001 for both).Conclusions:The present preliminary study showed that a 4-week cetirizine treatment was able to improve QoL significantly. Cetirizine treatment also significantly reduced symptom severity in Italian children with SAR and was safe.

MENINGKATKAN HASIL BELAJAR KOORDINASI GERAK MELALUI MODEL KOOPERATIF

This study aims to improve learning outcomes motion coordination through the cooperative model of students of class III Elementary School No. 18 / IX Muaro 2018/2019 academic year the research method is classroom action research, consists of two cycles each cycle carried out 3 times a meeting, each cycle consisting of planning, action, observation and reflection, The research subjects were 26 students in class III, 13 male and 13 female students, data collection techniques are observation, and formative tests, data analysis is comparing the average score, the successful evaluation is KKM of 68 individuals and 80% classical, The results showed that the pre-cycle completeness of three students or by 12% increased to 14 students or by 54% in the first cycle and increased again to 22 or by 85% in the second cycle, Observation of teacher activity by 68% in the category of "Good" increased to 83% in the category of "Very Good" Observation of student activity by 60% in the category of "Good" increased to 83% in the category of "Very good" therefore, it can be concluded that the cooperative model improves learning outcomes for the coordination of class III motion elementary school number 18 / IX Muaro Jambi in 2018/2019 academic year.

MiR-199a modulates autophagy and inflammation in rats with cerebral infarction via regulating mTOR expression.

The aim of this study was to investigate the roles of micro ribonucleic acid (miR)-199a in rats with cerebral infarction by regulating mammalian target of rapamycin (mTOR). A total of 36 Sprague-Dawley rats were randomly assigned into three groups, including: sham group (n=12), model group (n=12) and miR-199a mimics group (n=12). In sham group internal and external carotid arteries were exposed. The ischemia-reperfusion model was successfully established using suture embolization in the other two groups. After modeling, rats in sham group and model group were intraperitoneally injected with normal saline. However, rats in miR-199a mimics group were injected with miR-199a mimics. Following intervention for 3 d, sampling was conducted. Neurological deficit was evaluated in rats based on the Zea-Longa scoring system. Hematoxylin-eosin (HE) staining was performed to observe neuronal morphology. The expression of mTOR was detected using immunohistochemistry, and the relative expression level of tau protein was determined via Western blotting (WB). Besides, the messenger RNA (mRNA) expressions of mTOR and tau were detected by quantitative Polymerase Chain Reaction (qPCR). Finally, inflammatory factor content was measured through enzyme-linked immunosorbent assay (ELISA). Model group and miR-199a mimics group exhibited a substantially higher Zea-Longa score than sham group (p<0.05). Compared with model group, the Zea-Longa score rose prominently in miR-199a mimics group (p<0.05). According to the results of HE staining, the structure of neurons in sham group was clear and intact, while the structure of neurons in model group was disordered. Meanwhile, neuronal morphology in miR-199a mimics group was significantly worse than that in model group (p<0.05). Immunohistochemistry results demonstrated that the positive expression level of mTOR was considerably upregulated in both model group and miR-199a mimics group in comparison with sham group (p<0.05). Moreover, its positive expression level in miR-199a mimics group was markedly higher that in model group (p<0.05). Based on the results of WB, model and miR-199a mimics groups exhibited a remarkably higher relative expression level of tau protein than sham group (p<0.05). However, the relative expression level of tau protein in miR-199a mimics group was prominently higher than that in model group (p<0.05). QPCR results manifested that the relative mRNA expression levels of mTOR and tau in model group and miR-199a mimics group were dramatically higher than those in sham group (p<0.05). Compared with those in model group, the relative mRNA expression levels of mTOR and tau increased significantly in miR-199a mimics group (p<0.05). ELISA results revealed that model group and miR-199a mimics group had prominently higher content of inflammatory factors than sham group (p<0.05). In addition, content of inflammatory factors in miR-199a mimics group was considerably higher than that in model group (p<0.05). MiR-199a modulates mTOR expression to exert important regulatory effects on the autophagy and inflammation in rats with cerebral infarction.

Mediating effects of anxiety and depression on social support and suicidal ideation among rural middle school students in Sichuan

Objective To explore the relationships among social support, depression, anxiety and suicide ideation among middle school students in rural areas of south Sichuan Province so as to provide a scientific basis for promoting middle school students’ mental health and reducing suicide ideation. Methods A sum of 2 217 students of grade 7 and 10 from 2 township middle schools in mountainous areas of Zizhong County, Sichuan Province, were investigated by means of typical sampling and cluster random sampling. Social Support Rating Scale (SSRS), Self-rating Scale for Depression (SDS), Self-rating Anxiety Scale (SAS) and Self-compiled adolescent health questionnaire were used to measure suicidal ideation, and structural equation model was used for statistical analysis. Results The depression score of middle school students was (13.51±12.57), and the self-rating scale for Depression score of girls was (14.61±12.67), higher than that of boys (12.24±12.34). The SSRS score of Social Support Rating Scale of junior high school students was (35.49±5.88), which was higher than that of senior high school students (34.70±5.43), and the differences were of statistical significance ( t = 4.46, 2.67, P <0.05). The results of structural equation model showed that depression and anxiety directly affected suicidal ideation, and the standardized effects were respectively 0.11 (95% CI = 0.06–0.16) and 0.09 (95% CI =0.05–0.14). Depression and anxiety were the intermediate variables in the relationship between social support and suicidal ideation, and the mediating effects were respectively −0.46 (95% CI = −0.51– –0.41) and −0.21 (95% CI = −0.27– –0.16). Studying period could play a mediating role in the indirect effect made by social support on suicide ideation through anxiety. Conclusion Anxiety and depression have significant mediating effect on the relationship between social support and suicidal ideation among middle school students in rural areas of south Sichuan province. Anxiety and depression intervention are important measures to reduce suicide ideation among low social supporters. 【摘要】 目的 探讨农村中学生社会支持、抑郁、焦虑及自杀意念的关系, 为促进中学生心理健康、降低自杀意念提 供科学依据。 方法 采用典型抽样和整群随机抽样相结合的方法对四川省资中县山区的 2 所乡镇中学共 2 217 名初一和 髙一全部学生展开为期 3 年的追踪调査。使用社会支持评定量表 (Social Support Rating Scale, SSRS)、抑郁自评量表 (Self- rating Depression Scale, SDS)、焦虑自评量表 (Self-rating Anxiety Scale, SAS)、自编自杀意念的条目进行调査, 通过构建一般 及群组分析的结构方程模型探讨变量间的关系。 结果 中学生抑郁得分为 (13.51±12.57) 分, 女生抑郁得分为 (14.61± 12.67) 分, 男生为 (12.24±12.34) 分; 初中生社会支持得分为 (35.49±5.88) 分, 髙中生为 (34.70±5.43) 分, 差异均有统计学意 义 ( t 值分别为 4.46, 2.67, P 值均<0.05)。抑郁、焦虑直接影响自杀意念, 标准化效应分别为0.11 (95% CI = 0.06~0.16)、0.09 (95% CI =0.05~0.14)。抑郁、焦虑是社会支持与自杀意念关系中的中介变量, 中介效应值分别为 −0.46 (95% CI = −0.51~ −0.41)、−0.21 (95% CI = −0.27~−0.16)。学段在社会支持通过焦虑对自杀意念的间接关系中具有调节作用。 结论 农村 中学生焦虑、抑郁在社会支持与自杀意念关系中有中介效应, 焦虑和抑郁干预是在低社会支持者中降低自杀意念的重要 措施。

Expression level of lncRNA PVT1 in serum of patients with coronary atherosclerosis disease and its clinical significance.

The purpose of this study was to detect the expression level of PVT1 in the serum of coronary artery disease (CAD) patients, and to explore the clinical significance of PVT1 in CAD. A total of 200 CAD patients and 200 healthy controls in the same period were included. The serum level of PVT1 in every subject was detected. Then, the correlation between PVT1 level and Gensini score in CAD patients was analyzed by Spearman correlation test. Finally, multivariable Logistic regression test was conducted to assess risk factors influencing coronary atherosclerosis disease. It was found that PVT1 was highly expressed in the serum of CAD patients and its level was correlated with Gensini score (r=0.761, p=0.023). Besides, multivariable Logistic regression test obtained that PVT1 was the risk factor influencing coronary atherosclerosis disease (crude OR = 2.074, 95% CI: 1.642-3.529; adjusted OR = 1.762, 95% CI: 1.382-2.096). Serum level of PVT1 helps to distinguish mild and severe CAD. Meanwhile, PVT1 is an independent risk factor influencing the development of coronary atherosclerosis disease.

Risk of medication errors and nurses' quality of sleep: a national cross-sectional web survey study.

We aimed to evaluate quality of sleep and self-perception risk of medication errors, in a significantly-sized sample of nurses in Italy, using a web survey. An anonymous questionnaire about self-perception of quality of sleep (Pittsburgh Sleep Quality Index - PSQI) and risk of medication errors (based on the 7 R-rule), was made up and delivered by social media, i.e., Facebook and Instagram. Risk of medication errors was intended as near misses, i.e., accidents that do not cause the patient harm. A poor quality of sleep stated by PSQI score >5, was present in 87.9% of subjects and the risk of medication errors during the last shift was reported in 76% of them. However, more than half of nurses' sample (60.1%) reported a good or excellent self-perception quality of sleep. Risk of medication errors was associated with poor quality of sleep and it was independently associated with short resting time after night shift and bad self-perception quality of sleep (OR 3.165, 95% CI 1.468-6.827, p=0.003). Absence of proper resting is crucial on performance even if nurses perceived a good quality sleep. The relationship between shift work, poor sleep quality, and risk of medication errors represents crucial point for all health professionals' community, and web-survey represents a valuable information in order to capture the risk of medication errors. Health care organizations should encourage such a type of research in order to show a more proactive approach towards patient safety.

A Score based Approach to Detect Drowsiness using OpenCV

A Score based Approach to Detect Drowsiness using OpenCV

OPINION MINING OF TWITTER DATA USING MACHINE LEARNING

People express their opinions through social media sites like Twitter, Instagram, and Facebook. Tweets can be used to analyze opinions expressed towards various keywords, which can be anything from the names of products, companies or famous people. Consumers can utilize the insights of analyzed opinions and companies that want to monitor the public sentiment of their brands or any other situation where data on public opinions can be useful. Training data is abundantly available and can be obtained through automated means, we’ve obtained our data from twitter. The goal of our project is to implement the most effective algorithms and compare their accuracy. We use machine learning techniques like Max entropy, Naive Bayes, SVM and DCNN (Deep Convolution Neural Network). The data is analyzed for the presence of emoticons and keywords that either signify positive or negative expression towards the query term by Max, NB, and SVM methods. In DCNN, latent contextual semantics relationships and co-occurrence of statistical characteristics are used to obtain word embeddings between the words. Finally, word embedding is combined with n-grams and a polarity score is issued for the tweets. Our research focuses on comparing the accuracy of these algorithms to determine which are the most effective and accurate.

AKT answer relating to Wells score

AKT answer relating to Wells score

AKT question relating to Wells score

AKT question relating to Wells score

Creating Weighted Score For Estimating Of Interaction's Levels Occurred By Criterions And Specifications Of Examining Questions With Their Different Types

Creating Weighted Score For Estimating Of Interaction's Levels Occurred By Criterions And Specifications Of Examining Questions With Their Different Types

Clinical efficacy of ticagrelor combined with aspirin in patients with coronary heart disease angina pectoris and its effects on NT-ProBNP and CK-MB levels.

This study aims to explore the clinical efficacy of ticagrelor combined with aspirin in patients with coronary heart disease angina pectoris and the effects on N terminal pro B type natriuretic peptide (NT-ProBNP) and creatine kinase-MB (CK-MB) levels. A total of 150 patients with coronary heart disease angina pectoris were prospectively analyzed in this study. These patients were admitted to Huaiyin Hospital of Huai'an City from February 2017 to February 2019. The patients were divided into control group and research group according to different treatment methods. The following indicators before and after treatment were observed: therapeutic efficacy, prevalence of adverse reactions, duration and frequency of angina attack, NT-ProBNP and CK-MB levels. Receiver operating characteristic (ROC) curve was used to analyze the predictive value of NT-ProBNP and CK-MB for the curative effect of coronary heart disease angina pectoris. The total effective rate in the research group was higher than that in the control group (p<0.05). The prevalence of adverse reactions in the research group was lower than that in the control group (p<0.05). The duration and frequency of seizures of the two groups after treatment were lower than those before treatment. The duration and frequency of seizures in the research group were lower than those in the control group (p<0.05). The physiological function, physical pain, vital energy score and general health status in the research group were higher than those in the control group (p<0.05). The NT-ProBNP and CK-MB levels in both groups after treatment were decreased. Ticagrelor combined with aspirin has definite therapeutic effect on patients with coronary heart disease angina pectoris, with low prevalence of adverse reactions. It can significantly reduce the levels of NT-ProBNP and CK-MB, which is worthy of promotion.

A study on two kinds of scoring models in predicting the degree of esophageal varices and bleeding.

This study aims to investigate the value and determine the accuracy of two kinds of scoring models in predicting the degree of esophageal varices (EV) and esophageal variceal bleeding (EVB) in patients with liver cirrhosis (LC). A total of 189 patients with LC, who underwent esophagogastroduodenoscopy (EGD), color Doppler ultrasound (CDU), and computed tomography (CT), were retrospectively analyzed. Then, the routine blood examination, liver function test, M-index of the spleen in CT, EGD, and CDU results were recorded. According to the EGD result, these patients were divided into five groups: varicose bleeding group, severe varices group, moderate varices group, mild varices group, and no varices group. Then, the receiver operating characteristic curves of all predicting parameters studied were respectively drawn, the area under the receiver operating characteristic curves were calculated, and the predictive value of EV and EVB was evaluated. The area under the receiver operating characteristic curve of the VAP score model and Plt/S-D score model was 0.901 and 0.835, respectively. The VAP score model cut-off value of 461.5 for predicting moderate esophageal varices (MoEV), severe esophageal varices (SEV), and EVB has a specificity and sensitivity of 100% and 68.7%, respectively, while the Plt/S-D score model cut-off value of 835.5 for predicting MoEV, SEV, and EVB has a specificity and sensitivity of 95.1% and 58.2%, respectively. These two kinds of scoring models can predict the degree of esophageal varices and bleeding in liver cirrhosis patients and has good predictive accuracy.

Association of major adverse cardiovascular events and cardiac troponin-I levels following percutaneous coronary intervention: a three-year follow-up study at a single center.

Major adverse cardiovascular events occurrences of patients with different cardiac troponin-I (cTnI) levels following percutaneous coronary intervention (PCI) remained controversial. The prognostic relevance and risk factors of PCI-related myocardial infarction (MI) were not very clear as well. Our study included 249 coronary artery disease patients without preoperative cTnI elevation who successfully accepted PCI from 2013 to 2014. A three-year follow-up was conducted for each patient. The patients were divided into PCI-related MI group and non-PCI-related MI group. Risk factors of PCI-related MI were first explored. The occurrence of MACE was recorded. The prognostic relevance between PCI-related MI (PMI) group and non-PCI-related MI group, as well as different postoperative cTnI levels, were compared. Low-density lipoprotein cholesterol (LDL-C), age, Gensini Score, total stent length, and intra-operative complication were found positively correlated with PCI-related MI occurrence, while hemoglobin and prior PCI history were negatively correlated. After 3-year follow-up, the Kaplan-Meier survival curve showed MACE occurrence was significantly increased in PCI-related MI group. Comparing to patients with normal postoperative cTnI, MACE occurrence was increased in patients with a 10×upper limit of normal (ULN)≤cTnI<70×ULN and cTnI≥70×ULN, while there was no difference in patients with 1×ULN≤cTnI<5×ULN and 5×ULN≤cTnI<10×ULN. Cox proportional hazard regression analysis revealed PMI, NT-proBNP, and left ventricular ejection function (LVEF)<50% were positively correlated with MACE occurrence, while maximum inflation pressure and apoA-I were negatively correlated. Prognosis of PCI-related MI was poor, as well as in patients with postoperative cTnI≥10×ULN. Among the risk factors of PMI, LDL-C, age, Gensini Score, total stent length, and intra-operative complication were positively correlated with PCI-related MI occurrence, while hemoglobin and prior PCI history were negatively correlated.

核等值：一种观察分数等值体系

核等值：一种观察分数等值体系

Effects of metformin alone and in combination with spironolactone on hyperandrogenism in polycystic ovarian syndrome

Objective To evaluate the efficacy of combined therapy with metformin and low-dose spironolactone as compared with metformin alone on the clinical and endocrine-metabolic alterations of patients with polycystic ovarian syndrome (PCOS). Background PCOS is the most common endocrinological disorder in reproductive-age women. Thus, at least theoretically, metformin plus spironolactone therapy may be an effective and safe combination for PCOS. Patients and methods A prospective randomized comparative study was carried out on 48 patients with the PCOS in Obstetrics and Gynecology Department, Menoufia University Hospital, and Al-Shohadaa Hospital, Egypt, from the period of May 2016 till January 2018. Detailed history, laboratory investigations, obstetric examination, and follow-up were done. Results Mean hirsutism score and BMI (kg/m2) were 10.8 ± 3.9 and 26.8 ± 2.2, respectively, before treatment, which decreased significantly to 7.6 ± 2.4 and 22.10 ± 1.92, respectively, after 6 months of treatment. Luteinizing hormone, follicle-stimulating hormone, free testosterone, dehydroepiandrosterone sulfate, fasting glucose, fasting insulin, and homeostasis model assessment of insulin resistance were decreased significantly after 6 months of treatment as compared with before treatment among women who received metformin + hypocaloric diet and received metformin + spironolactone + hypocaloric diet before treatment. Free testosterone was decreased in group B (58.2 ± 9.1) more than group A (73.6 ± 12. 9). Conclusion The results confirm the beneficial effects of metformin in patients with PCOS. It also proves that the addition of low-dose spironolactone induces a more marked reduction of clinical and biochemical hyperandrogenism in patients with PCOS present with hyperandrogenic conditions.

The role of preoperative Pentacam in optimizing visual outcome after cataract surgery

Objective To evaluate the role of preoperative Pentacam in optimizing visual outcome after cataract surgery. Background It has been suggested that Pentacam gives comprehensive data about preoperative astigmatism, lens density, and refractive power helping in optimizing the visual outcome after cataract surgery. Patients and methods Preoperatively, the patients were subjected to careful history taking, thorough ocular examination including assessment of manifest refraction, measurement of logMAR uncorrected distance visual acuity, and corrected distance visual acuity, biometry and keratometry with the Intraocular lens (IOL) Master partial coherence interferometry device, corneal topography (Pentacam) and to exclude irregular astigmatism, mean lens density, and cataract grading score were evaluated. Slit lamp examination, dilated funduscopy under pharmacological, intraocular pressure, and Hoffer Q formula was used in eyes with an axial length shorter than 22 mm, and SRK/T formula was used for all other cases. Cataract surgery were performed according to the standard protocols. Postoperative manifest refraction (sphere and cylinder) and visual acuity (uncorrected and corrected) were obtained. Results There was significant improvement of astigmatism postoperatively. Also, there were significant improvements of UCVA and BCVA in postoperative assessment as compared with preoperative evaluation. Conclusion Preoperative Pentacam can help in the improvement of preoperative astigmatism. It also resulted in the improvement of Uncorrected visual acuity (UCVA) and Best corrected visual acuity (BCVA).

Kronik Engelli Bireylerde Ortez Ve Yardımcı Cihaz Memnuniyetinin Araştırılması

Amaç: Bu çalışmanın amacı ortez/yardımcı cihaz tavsiye edilen kronik engelli bireylerin ortez kullanım memnuniyetlerinin araştırılması. Bununla birlikte tanı grupları ve serebral palsili bireylerin motor fonksiyon seviyeleri ile ortez kullanım memnuniyeti arasında ilişki olup olmadığının araştırılmasıdır. Gereç ve Yöntem: Çalışmaya 105 kronik engelli birey (64 serebral palsili, 13 spina bifida, 14 musküler distrofi ve 14 farklı nörolojik tanılı birey) ve aileleri dahil edildi. Yardımcı cihaz/ortez kullanımı, günlük kullanma süreleri ve eğer ortezlerini kullanmıyorlarsa nedenleri sorgulandı. Bireylerin ortez kullanım memnuniyetleri araştırmacılar tarafından literatüre dayanarak oluşturulmuş Ortez Kullanım Memnuniyet Anketi ile değerlendirildi. Bulgular: Serebral palsili bireylerin motor fonksiyon düzeyleri ile ortez kullanım memnuniyeti arasında ilişki olmadığı bulundu (p=0.779). Ortez Kullanım Memnuniyet Anketi toplam skoru ve günlük ortez kullanma süreleri arasında pozitif yönlü zayıf bir ilişki saptandı (r=0.242, p=0.015). Ortez Kullanım Memnuniyet Anketi toplam skoru ve ne kadar zamandır ortez kullanıldığına ait veriler arasında bir ilişki bulunmadı (p=0.811). Engelli bireylerin tanılarının (p=0.23) ve cihaz/ortez tipinin ortez kullanma memnuniyeti skorları ile ilişkili olmadığı saptandı (p=0.97). Sonuç: Sonuç olarak, kronik engelli bireylerde ortez/yardımcı cihaz günlük kullanım süresi arttıkça kullanım memnuniyetinin arttığı ve cihaz/ortez tipinin ortez kullanma memnuniyeti ile ilşkili olmadığı gözlemlendi. Ayrıca serebral palsili, spina bifida, musküler distrofi ve diğer tanı gruplarının ortez memnuniyetlerinin benzer olduğu görüldü.

Efeito do treinamento de força sobre a aptidão física em pós - bariátricos: revisão sistemática

Introdução: A cirurgia bariátrica tem efeito na redução de peso. O exercício físico apresenta relação positiva sobre os aspectos fisiológicos para indivíduos pós-bariátricos. No entanto, o efeito do treinamento de força e sua aplicação no pós-operatório permanecem obscuros.&#x0D; Objetivo: O presente estudo objetivou realizar uma revisão sistemática dos efeitos do treinamento de força sobre os aspectos fisiológicos em indivíduos pós-bariátricos.&#x0D; Métodos: Uma pesquisa foi conduzida em bases de dados, seguindo em conformidade com os critérios do PRISMA. Os estudos incluídos foram avaliados utilizando a escala PEDro. A pontuação do Kappa de Cohen avaliou o nível de concordância.&#x0D; Resultados: Sete estudos foram incluídos na revisão. Os períodos de duração das intervenções e indivíduos avaliados foram homogêneos. Os estudos demonstraram melhoras significativas para as variáveis de aptidão física. No entanto, foram identificadas descrições inconsistentes na sessão de treinamento, dificultando a orientação prática adequada.&#x0D; Conclusão: Os estudos reportaram efeitos positivos sobre as variáveis analisadas.

MiR-195 alleviates ulcerative colitis in rats via MAPK signaling pathway.

To study the effect of micro ribonucleic acid (miR)-195 on the inflammatory response of ulcerative colitis (UC) model rats and to explore its regulatory mechanism, thus providing a new scheme for the clinical treatment of UC. A rat model of UC was prepared by 2, 4, 6-trinitrobenzenesulfonic acid (TNBS)/ethanol assay, and the rats were randomly divided into Control group, Model group, and miR-195 mimic (miR-195 agomir) group. The disease activity index (DAI) in each group was observed. Hematoxylin and eosin (H&E) staining was utilized to detect the pathological changes in the rat colon tissues in each group. The levels of interleukin-6 (IL-6) and IL-1β in the colon tissues of the rats in each group were detected by enzyme-linked immunosorbent assay (ELISA). In addition, the messenger RNA (mRNA) and protein levels of p38 mitogen-activated protein kinase (p38 MAPK) and tumor necrosis factor-alpha (TNF-α) in the colon tissues of each group of rats were examined via Reverse Transcription-Polymerase Chain Reaction (RT-PCR) and Western blotting, respectively. Compared with those in Control group, the rats in Model group had an increased DAI score, severely pathologically damaged colon tissues, raised levels of IL-6 and IL-1β in the colon tissues and significantly elevated mRNA and protein levels of p38 MAPK and TNF-α. In comparison with those in Model group, the DAI score was decreased, the pathological damage to the rat colon tissues was improved, the levels of IL-6 and IL-1β in the rat colon tissues were reduced, and the mRNA and protein levels of p38 MAPK and TNF-α were notably lowered in miR-195 agomir group. MiR-195 mimics can alleviate the pathological damage to the colon and inflammatory responses in UC model rats, and its mechanism may be related to the inhibition on the p38 MAPK signaling pathway.