Max Score Research Articles

Optimising children's movement assessment batteries through application of motivational and attentional manipulations

An external focus of attention, enhanced expectancies, and autonomy support (i.e., OPTIMAL factors) are key factors to optimise motor performance and uncover latent movement capabilities. However, research on the combination of OPTIMAL factors, particularly in children's dynamic movement settings is limited. Therefore, this study examined the combined effects of OPTIMAL factors on children's performance on a dynamic movement assessment battery, hypothesising higher performance scores in the optimised version of the assessment battery versus standardised version of the assessment. Forty-nine children (15 boys, 34 girls; mean age 10.61 ± 1.38 years) completed the Dragon Challenge (DC) dynamic movement assessment battery. Performance was measured via a summation of movement process (technique), outcome, and time-to-completion scores (max score N = 54) with higher scores representing better performance. Participants completed a standardised and an optimised version of the DC in a counterbalanced fashion. For the latter, DC protocols were optimised via the provision of choice (autonomy support); external focus instructions augmented by simple knowledge statement, positive feedback and promotion of a growth mindset (Enhanced expectancies). Results indicate that motor performance (DC score) was better in the optimised (M = 31.08 ± 6.66) vs. standardised (M = 29.04 ± 5.88). The findings indicate that the combination of OPTIMAL factors can improve children's motor performance in dynamic movement settings and that standardised motor assessment may not reveal children's true movement capabilities.

Quality of life and adherence to healthy lifestyle factors among breast cancer survivors in Cyprus

Abstract Breast cancer is a prevalent disease for women globally, with rising survival rates highlighting the need to address the breast cancer survivors’ (BCS) quality of Life (QoL). Furthermore, adherence to a healthy lifestyle is associated with decreased mortality in BCS. Mapping the Lifestyle Medicine pillars and the World Cancer Research Fund/American Institute for Cancer Research recommendations identifies 7 healthy lifestyle components: weight management, physical activity, healthy eating, restorative sleep, avoidance of risky substances, positive social connections and stress management. This study examines adherence to these healthy lifestyle components and QoL among BCS. A cross-sectional study conducted in 2022-23 recruited primary adult BCS from the Bank of Cyprus Oncology Centre. Participants completed a survey assessing self-reported QoL and adherence to the aforementioned 7 healthy lifestyle components, through validated questionnaires. Out of 349 BCS approached, 272 were included in the final analysis. Mean age and time since main treatment completion were 51 (SD: 7.4) and 3.6 (SD: 2.5) years respectively. Amongst study participants 58% were classified as bad sleepers, 53.3% were overweight or obese, 23% were stressed, 78% reported to have moderate/high physical activity, and 60% adhered to the Mediterranean diet. Regarding substance use, 16% were current smokers, and 18% were hazardous drinkers. Median score for social support was 75 (IQR: 53-97; max score=100) and for QoL was 67 (IQR: 50-97; max score:100). BCS in Cyprus generally exhibit moderate adherence to the Mediterranean diet, engage in fairly active lifestyles and enjoy high levels of social support and QoL. On the other hand, a substantial proportion smoke or drink, are overweight or obese, are stressed and have poor sleep quality. Targeted interventions to increase the adherence of breast cancer survivors to the 7 healthy lifestyle components are required. Key messages • Overall variability exists in the adherence to healthy lifestyle components among BCS in Cyprus. • This population can benefit from intervention targeting sleep, stress and weight management.

Early wave reflection of carotid artery is associated with 18F-FDG PET hypometabolism in Alzheimer's brain areas of cognitively normal adults.

Arterial stiffening likely plays a role in Alzheimer disease (AD) pathogenesis. The current study investigated whether inter-individual variations in arterial stiffness and pressure wave parameters were associated with 18F-FDG positron emission tomography (PET) metabolism in AD-associated brain areas throughout adulthood, independently of age and before the onset of any neuropsychological disorders. A prospective, large age-range population of 67 patients (17 young, 16 middle-aged, and 34 older adults; 37 women) underwent a: brain 18F-FDG PET, blood pressure recording, and carotid/femoral pulse wave-based measurements, including the time-to-peak of the reflected backward carotid pulse wave (bT), on the same day. Multivariable and quantitative voxel-to-voxel analyses (P-voxel < 0.005, corrected for cluster volumes) were conducted to assess associations between vascular parameters and 18F-FDG PET metabolism in AD-associated brain areas. In the multivariable analysis, only increased age and decreased bT were independently associated with the decline of metabolic activity in AD-associated brain areas (P < 0.001). In the voxel-to-voxel analysis with age as a covariate, bT was strongly associated with the metabolic activity of 40 clusters in AD-associated brain areas (clusters cumulative volume: 63 cm3; T score max: 5.7). In a large age-range population of adult patients, who are still unaffected by neuropsychological disorders, an early reflected arterial pressure wave, as evidenced by a decreased bT value, is strongly associated with hypometabolic activity of AD-associated brain areas, independently of age.

Sharma's risk assessment score as a decision making tool to decide between total hip arthroplasty or hemiarthroplasty as a treatment option for elderly patients with fracture neck of femur. A prospective observational study

PurposeThe decision to do a total hip arthroplasty (THA) or a hemiarthroplasty (HA) in an elderly with a fracture neck of femur (FNOF) is commonly based upon the surgeon's preference, pre-anesthetic fitness, hospital setup, and intensive care backup. The author devised a Sharma's risk assessment score (SRAS), based upon all the common factors that affect the surgical outcomes following FNOF in the elderly, to help orthopedic surgeons decide between THA or HA as a treatment for FNOF. Material & methodsIt was a prospective observational study conducted in a tertiary-level institute. SRAS is based upon 10 parameters with each parameter having a max score of 4 and a minimum score of 1. So the maximum score a patient can score is 40 and the minimum a patient can score is 10. It was hypothesized that a patient with FNOF with a preop SRAS score >20 if subjected to a (HA) and a patient with a preop SRAS score ≤ 20 if subjected to a (THA) would have better outcomes and low complication rates. Out of Eighty-eight patients with FNOF, 7 were lost to follow-up. The remaining 81 patients with FNOF were prospectively followed between May 2018 and May 2022 and segregated into two groups THA (n = 47) and HA(n = 34) based on the SRAS. ResultsThe average length of follow-up was 2.6 years (6 months–4 years). The average SRAS was an average 25.7(21–32) in the HA group and 16.2 (11–20) in the THA group. Complications were seen in 12.7 % of the THA group and 17.6 % of the HA group. We had a 2.1 % 90-day mortality in the THA group and a 2.9 % 90-day mortality in the HA group. One year mortality in THA was 2.1 % and it was increased to 5.8 % in the HA group. ConclusionSRAS is a useful decision-making tool that would guide surgeons to decide between THA or HA as a treatment option for elderly FNOF and would help minimize post-operative complications and reduce mortality. Level 3 studyProspective observational study.

Cohort profile: the CARTaGENE Cohort Nutrition Study (Quebec, Canada)

PurposeTo address emerging nutritional epidemiological research questions, data from contemporary cohorts are needed. CARTaGENE is the largest ongoing prospective cohort study of men and women in Québec, Canada. Dietary information...

Isolation of Trichoderma strains from rhizospheric soil and assessment of their potential for biofertilizer from freshwater aquaculture pond sediment

Abstract. Thi QVC, Nhan TH, Hung NVK, Thuy NP. 2024. Isolation of Trichoderma strains from rhizospheric soil and assessment of their potential for biofertilizer from freshwater aquaculture pond sediment. Biodiversitas 25: 2866-2876. Trichoderma spp. are filamentous fungi found in almost all soils and can synthesize massive quantities of cellulase enzymes which can simply break down cellulose polysaccharides. Freshwater water aquaculture pond sediment has caused some environmental pollution which is required to be properly dealt with. The objective of this study was to isolate Trichoderma strains from rhizosphere soil and to evaluate their potential for biofertilizer from freshwater aquaculture pond sediments. Twenty-six strains of Trichoderma spp. were isolated from soil. The Carboxymethyl Cellulose (CMC) degrading ability of the S25 strain was extremely strong, with a halo diameter zone measuring 8.9±3.8 cm. According to the BLAST result, there was 99.11% similarity between S25 strains and Trichoderma asperelloides, with a max score of 1011 and an E-value of 0.0. The T. asperelloides S25 was selected for bioproduct production. The use of T. asperelloides S25 bioproduct passively enhanced the efficient decomposition of organic fertilizers. After just 30 days of incubation, total organic matter content was ? 30% and material had a spongy, soft, and brown-black in color. According to the Government of Vietnam’s Decree No. 14/2019/ND-CP on fertilizer management, dated September 14, 2019, all treatments were chosen for the production of granular bio-compost. These findings highlight the potential of bioproduct T. asperelloides S25 for sustainable aquaculture practices and organic waste management.

Chilean children's adherence to sustainable healthy diets and its associations with sociodemographic and anthropometric factors: a cross-sectional study.

To describe adherence to sustainable healthy diets among a sample of 958 Chilean pre-schoolers (3-6years) and explore associations between adherence and child and maternal sociodemographic and anthropometric characteristics. Children's adherence to sustainable healthy diets was calculated from single multiple-pass 24-h dietary recalls using the Planetary Health Diet Index for children and adolescents (PHDI-C). Higher PHDI-C scores (max score = 150 points) represent greater adherence. Adjusted linear regression models were fitted to explore associations between PHDI-C scores and child and maternal characteristics. Children obtained low total PHDI-C scores (median 50.0 [IQR 39.5-59.8] points). This resulted from low consumption of nuts & peanuts, legumes, vegetables, whole cereals, and vegetable oils; a lack of balance between dark green and red & orange vegetables, inadequate consumption of tubers & potatoes and eggs & white meats, and excess consumption of dairy products, palm oil, red meats, and added sugars. Mean PHDI-C total score was significantly higher (50.6 [95%CI 49.6, 51.7] vs 47.3 [95%CI 45.0, 49.5]) among children whose mothers were ≥ 25years compared to those with younger mothers. Positive associations were observed between scores for fruits and maternal education, vegetables and maternal age, added sugars and child weight status, while negative associations were observed between fruits and child age, and vegetable oils and maternal education. Scores for dairy products PHDI-C component were lower among girls. Adherence to sustainable healthy diets was low among this sample of Chilean children and was significantly associated with maternal age, being lower among children whose mothers were younger.

Performance of an artificial intelligence/machine learning model designed to identify hospitalized patients with cancer who could benefit from timely specialized palliative care delivery.

1559 Background: Timely access to specialty Palliative Care (SPC) services provides significant benefits to hospitalized patients with cancer, including improvements in quality of life. However, many patients with cancer who could benefit from SPC suffer from lack of timely referral or do not receive SPC services. A previously published trial of an artificial intelligence/machine learning (AI/ML) model to predict need for SPC at Mayo Clinic increased timely SPC consultation of hospitalized patients overall. We sought to review the performance of this algorithm in patients with cancer across an expanded hospitalized population. Methods: The study population consisted of all patients admitted into a Mayo Clinic hospital in Minnesota, Wisconsin, Arizona and Florida between January 2020 and September 2023. Due to the size of the cohort a case-control sample of three controls for every case was created. Patients were considered to be a patient with cancer if they had at least one billing diagnosis up to 1 year prior to their index hospitalization from any of the 5 HCC categories denoting cancer: Metastatic Cancer and Acute Leukemia (HCC 8); Lung and Other Severe Cancers (HCC 9); Lymphoma and Other Cancers (HCC 10); Colorectal, Bladder, and Other Cancers (HCC 11); and Breast, Prostate, and Other Cancers and Tumors (HCC 12). The training data set consisted of 107,076 patient encounters with a total of 8,355,090 time periods of constant risk. An AI/ML model using gradient boosting methods which contained 269 variables (both static and time-varying) of various classes with SPC consultation treated as a time-to-event outcome was trained. Results: Due to the longitudinal nature of the prediction, performance was assessed using the max score AUC (using the max score a patient received during a given encounter prior to an event or discharge) to produce the AUC. The model had an overall AUC of 0.932 (0.929, 0.935 – 95% CI). We saw a decrease in performance of the AI/ML model in the Oncology population with an overall performance of 0.818 (0.806, 0.83). Some of the most influential variables were previous SPC visit, age, metastatic disease, acute leukemia diagnosis, and pain scores. Conclusions: An AI/ML model can effectively predict the need for an inpatient PC consult in a population of hospitalized patients with cancer. [Table: see text]

Long-term effects of abatacept on atherosclerosis and arthritis in older vs. younger patients with rheumatoid arthritis: 3-year results of a prospective, multicenter, observational study

BackgroundWe aimed to reveal the effect of abatacept (ABT) on atherosclerosis in rheumatoid arthritis (RA) patients, 3-year efficacy for arthritis, and safety in a population of older vs. younger patients.MethodsIn this open-label, prospective, observational study, patients were stratified into four groups: younger (20–64 years old) and older (≥ 65 years) patients taking ABT (AY and AO) and conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) (CY and CO). Primary endpoints were change from baseline in mean intima-media thickness (IMT) of the common carotid artery, IMT max (bulbus, bifurcation, and internal and common carotid artery), and plaque score at Week 156. Disease activity, retention rate, and adverse effects were also evaluated.ResultsThe ABT group (AY + AO) tended to have smaller increases in mean IMT, max IMT, and plaque score than the csDMARD group (CY + CO) at Week 156, although the differences between groups were not statistically significant. Multivariate analysis showed significantly lower increases in plaque score with ABT than with csDMARDs, only when considering disease activity at 156 weeks (p = 0.0303). Proportions of patients with good or good/moderate European League Against Rheumatism response were higher in the ABT group, without significant difference between older and younger patients. No significant differences were observed in ABT retention rates between older and younger patients. Serious adverse effects, especially infection, tended to be more frequent with ABT than with csDMARDs, although no significant differences were found.ConclusionsABT may decelerate atherosclerosis progression and may be useful for patients with high risk of cardiovascular disease, such as older patients.Trial registration number:UMIN000014913.

Wings of Knowledge: Navigating Learner Confidence and Cognitive Load in Avian Radiography with a Low Fidelity Model.

In veterinary first opinion practice, radiography is an important diagnostic tool for avian patients. Teaching of such diagnostic skills to learners is usually conducted using teaching models in clinical skills laboratories. The aim of this work is to evaluate the impact of using a teaching model for avian radiography positioning by measuring learner's cognitive load, confidence, satisfaction, and assessing learning by OSCE assessment. An avian radiography positioning model was created and evaluated with pre- and post-Likert questions on confidence, a pre and post 9-point cognitive load scale, an OSCE assessment (max score = 20), and post Likert questions on satisfaction. Thirty-two undergraduate veterinary medicine and veterinary nursing students participated in the study. The results showed the cognitive load of participants was high and did not change with the use of a physical model (p = .882). Participants exhibited increased confidence in avian radiography positioning (pre; M = 2, post; M = 4, p < .001) and expressed high overall satisfaction with the model (x̄ = 4.6, no negative or neutral Likert responses). The OSCE results demonstrated a higher pass rate mean (82%) for the positioning tasks compared to the collimation and centering tasks (53%). Overall, the model was well received by learners with increased confidence and a satisfactory learning experience in a clinical skill for exotics species. These findings suggest the avian radiography positioning model is an effective model to train students to position avian patients for radiography.

Initial evaluation of the TALES (technology and literacy engagement after stroke) programme targeting functional literacy and social engagement in people with aphasia after stroke

ABSTRACT Background and aims Literacy skills are typically affected in people with stroke aphasia, leading to reduced engagement in functional everyday reading/writing tasks, such as email/messaging via social media. The aim of this study was to investigate the outcomes of the TALES (Technology And Literacy Engagement after Stroke) programme, a group-based online literacy-focused programme for people with aphasia after stroke. This first evaluation of this programme aimed to examine outcomes related to feasibility, changes in language, literacy and self-ratings of communication skills. Methods Five participants with aphasia were assessed on a range of outcome measures relating to language and self-perception of communication skills. These were: the Western Aphasia Battery-Revised (WAB-R; (Kertesz, 2007)), literacy subtests from the Psycholinguistic Assessment of Language Processing in Aphasia (PALPA; (Kay et al., 1996)) and the Communication Outcomes after Stroke (COAST; (Long et al., 2008)). TALES consisted of a weekly group online session, 1:1 supported telehealth reading/writing practice and regular messaging via email. Results and main contribution From a descriptive statistics perspective, the mean gains across the cohort were 7.94 (from 84.24 to 92.18) on the WAB AQ (aphasia quotient), 8.92 (from 81.18 to 90.10) on the WAB LQ (language quotient). Additionally, there was a change in the mean scores for PALPA subtests (31, 37 and 40) observed between the pre-treatment assessment and post-treatment assessment. Finally, the mean score increased by 8.8 (from 49.40 to 58.20) on the COAST (max score = 80). Results indicated gains in literacy and communication measures as well as changes to self-rating of communication reflecting changes in communication confidence. Conclusions Mindful of the threats to the internal validity inherent in the study design, the reported online therapy can overcome barriers such as distance and mobility limitations and may provide greater accessibility to therapy for individuals with aphasia. TALES was a low-therapist-input yet reasonably intensive treatment approach which embedded language practice immediately in functional use through the social group format and personally-relevant written communication. Implications The TALES programme meets many neuroscience principles of neurorehabilitation including “use it or lose it”, salience and transference. Future research may usefully investigate the contribution of the group format versus the functional literacy components towards these potentially promising early data.

Cultural adaptation and reliability testing of the Chinese version of evidence-based practice knowledge assessment in nursing: A cross-sectional study

ObjectiveThe EKAN is a reliable and validated tool for objectively measuring the evidence-based practice (EBP) knowledge of nurses. Thus, we set out to translate and culturally modify the Evidence-Based Practice Knowledge Assessment in Nursing (EKAN), and then evaluate its validity and reliability among Chinese practicing nurses. MethodsThis cross-sectional study consisted of two phases. The first phase involved translating the EKAN into Chinese (EKAN-Chinese), using a process of forward translation, back translation, review, cultural adjustment as well as a pilot study. The second phase aimed to assess the psychometric properties of the EKAN-Chinese and establish a baseline measure of EBP knowledge among 120 nurses from a large general hospital in Beijing, China. Data were collected from August to November 2022 and analyzed with Rasch software. This study was reported using the cross-sectional STROBE checklist. ResultsThe newly translated, EKAN-Chinese was pilot-tested after slight modification of four items without altering the intended meaning. The outfit unweighted mean square was 1.03 (SD = −0.13), the infit weighted mean square was 1.00 (−0.17), and the mean difficulty index ranged from −3.43 to 2.85 according to validity indices. The results of the reliability indices revealed low person reliability (0.49), high item reliability (0.96), moderate person separation index (0.99), and sufficient item separation index (4.71). The mean EKAN-Chinese sum score was 9.8 (max score = 20, SD = 2.9). ConclusionThe newly translated EKAN-Chinese showed sufficient psychometric evidence to support use in practicing Chinese nurses. The EKAN-Chinese can be used by nurse leaders in China as a potential screening tool to 1) objectively identify nurses who need educational training in evidence-based nursing practice, and 2) gauge the effectiveness of education and training programs to improve EBP knowledge and ultimately, evidence-based care.

Reliability of VPA Learning Over Repeat Exposures Across an Extended Interval Using Automated Remote Method

AbstractBackgroundThe current study examined the test‐retest reliability of a newly developed Learning Over Repeat Exposures (LORE) paradigm using Verbal Paired‐Associates. This LORE paradigm involves the acquisition of a set of 8 verbal paired associates over a 5‐day “burst”. In this investigation, two bursts, separated by a nine‐month interval, were compared to assess the stability of novel learning outcome measures, such as the learning slope (between day 1 and the day of max performance) and first overnight forgetting.MethodAn opportunistically recruited sample of 14 participants (out of an initial pilot study of N = 20) completed the VPA‐LORE task using the Cambridge Cognition ‘NeuroVocalix’ platform, which employs text‐to‐speech and automated speech recognition technology to remotely administer and score the task, enabling its potential use at scale. The task structure consists of an immediate recall following presentation on the first day of a burst, and a single recall attempt followed by a presentation on subsequent days. As with the pilot study, neither floor nor ceiling effects were observed, and performance was in the expected range.ResultThe observed moderate to strong correlations between the two bursts revealed good reliability for the measures examined: learning slope from day 1 to day of max score, r s = .815, first day immediate recall, r s = .736, max pairs learned, r s = .707, and day 1 forgetting r s = .702. In total, participants missed only a few visits, with six missing sessions out of a total of 140 sessions, representing 4.3% of all sessions. The retention of 14 participants from the original pilot study also highlights the feasibility and acceptability of this method.ConclusionThese results suggest that the VPA‐LORE paradigm, delivered via the NeuroVocalix platform, is a stable and reliable assessment tool even when considering extended intervals between bursts and accounting for missing data. The novel learning measures derived from the VPA‐LORE paradigm provide valuable insights into learning processes and could further enhance cognitive assessment. Future research could explore the applicability of the paradigm for clinical populations and longitudinal studies in cognitive assessment.

Knowledge, Attitudes, and Willingness of Healthcare Workers in Iraq's Kurdistan Region to Vaccinate against Human Monkeypox: A Nationwide Cross-Sectional Study.

Although human monkeypox infections had not been recorded in the Kurdistan region of Iraq as of August 2023, the rapid growth of cases worldwide and the detection of monkeypox in neighboring Middle Eastern nations call for careful planning and timely response measures. Educating and empowering frontline healthcare workers (HCWs) so that they can act to curb the spread of monkeypox infections are core elements of primary prevention and protecting public health. Therefore, this study aimed to assess HCWs' knowledge and attitudes about monkeypox and their willingness to vaccinate against monkeypox. By employing a convenience sampling method, an online survey was disseminated via Google Forms between 1 November 2022 and 15 January 2023. The researchers utilized regression analyses to ascertain the factors associated with the three parameters: knowledge, attitude, and the willingness to vaccinate. A total of 637 HCWs were included in the analysis (ages ranged between 21 and 51 years). The mean overall scores were 8.18 of a max score of 16 (SD 3.37), 3.4 of 5 (SD 1.37), and 2.41 of 5 (SD 1.25) for knowledge, attitude, and willingness to vaccinate, respectively. A multivariate logistic regression analysis demonstrated that HCWs who had heard about monkeypox before 2022 rather than later had a higher level of knowledge (AOR: 4.85; 95% CI: 2.81-8.36; p < 0.001). In addition, those who had newly joined the workforce or had less than 1 year experience in practice had more positive attitudes about curbing monkeypox (AOR: 0.35; 95% CI: 0.20-0.59; p < 0.01) than those who practiced for longer. No significant predictors of willingness to vaccinate against monkeypox were identified. The research revealed that HCWs exhibited a relatively low level of monkeypox knowledge. They also had poor attitudes towards monkeypox vaccination and were therefore reluctant to receive the vaccines. Imparting knowledge about the infectious disease can cultivate better awareness and attitudes among HCWs as to their roles in mitigating the spread of an epidemic in the foreseeable future.

Pengaruh Model Teams Games Tournament (TGT) terhadap Motivasi Belajar Matematika Berdasarkan Gender Siswa Sekolah Dasar

The background of this research is that students are less motivated in learning and do not understand mathematical concepts. The problem in this research is limited to the lack of student motivation in the mathematics learning process and the Teams Games Tournament (TGT) type cooperative learning model is rarely applied in the mathematics learning process. The aim of this research is to determine the effect of the Teams Games Tournament (TGT) model on elementary school students' motivation to learn mathematics based on gender. The research method used in this research is quantitative methods. This type of research uses a quasi-experimental method (Quasy Experiment). The research was carried out at SDN 091482 Kasindir, Jorlang Hataran District, Simalungun Regency from September 4 to September 9 2023 in the odd semester of the 2023/2024 academic year. Based on the results of descriptive analysis data obtained from the students' learning motivation progress scores that were tested, in the male initial questionnaire, the average questionnaire score was 38.67, the standard deviation was 1,231, the maximum score was 41, and the minimum score was 36. Initial questionnaire women obtained an average score from the questionnaire results of 39.92, a standard deviation of 1,256, a max score of 43, and a minimum score of 38. Meanwhile, in the final questionnaire for men, the average score of the questionnaire results was 39.83, the standard deviation was 1,337, the The maximum value is 42, and the minimum value is 38. And in the final questionnaire for women, the average value of the questionnaire results was 40.54, the standard deviation was 1,330, the maximum value was 42, and the minimum value was 38. Based on the results of this research, the author put forward suggestions namely, 1). Students are expected to always be active and pay attention to the teacher's explanations during the learning process. 2). For all teachers, they must always innovate and be able to adapt to be able to use various learning methods so that students do not get bored easily in the learning process.

In silico study of new carbonic anhydrase inhibitor derivatives bearing 1, 3, 4-Oxadiazole moiety with promising anti-cancer activity.

Objectives: Molecular docking simulations were performed to assess the theoretical binding affinities of six (6) compounds created where they are derivatives having 1,3,4, oxadiazole moiety, and their target was cancer and Human carbonic anhydrase IX (PDB code: 6U4T). Using ChemDraw Ultra 12.0, the molecular structure was meticulously sketched. Molecular Operating environment software was used to verify the developed compounds by looking at their S. score and Rmsd values. Promising activity was seen with these proteins from the theoretically generated compounds, which exhibited strong binding contacts with the receptor active pocket.&#x0D; &#x0D; Methods: Chemically by joining together several oxadiazole derivatives, sulfanilamide analogues (IVa-IVd) may be created in the lab. Molecular docking and ligand/receptor priming by MOE software.&#x0D; Results: Acetazolamide was selected because it had the same pharmacophore as the sulfanilamide group, and cisplatin was used in clinical trials for cancer therapy. IVc and IVa yielded max score and irrevocable relationship compared with acetazolamide and cisplatin.&#x0D; Conclusion: The MOE docking results validated the potent anticancer activity, the identified compounds showing good binding affinity with target proteins relative to the reference drugs (Acetazolamide and cisplatin). The most effective anticancer compounds were IVc and IVa, which yielded a maximum score with a Rmsd of less than 2, the MOE docking results were able prove this.&#x0D; Compounds IVc and IVa exhibited the greatest cytotoxic impact of the synthetic compounds against MCF7, and all four synthesized compounds showed a superior safety profile than the standards in MCF10a.

Parental imprinting

Abstract Background Parental identity formation is rooted in childhood experiences and internalised relationships with one's family. The present study aims to investigate the possible correlations between the outcomes of experienced motherhood and the woman's internalised parenting style. Methods A retrospective observational study was conducted on an Italian sample of mothers enrolled through an online questionnaire administered from July to September 2022. The Parental Bonding Instrument was used, consisting of 25 items, 12 of which refer to caring (max score 36) and 13 to overprotectiveness (max score 39). From the combination of the scores calculated for the two dimensions, four possible patterns of maternal parenting style can be obtained (affectionate bonding, optimal parenting, controlling without affection, negligent parenting). Results The sample consisted of 1828 mothers (average age 38). Our sample shows that 15.54% of the women have a mother with an affectionate bond, 32% an optimal mother, 36.54% a controlling mother without affection and 15.92% a neglectful mother. Those who have an affectionate mother have a lower likelihood of developing depression (OR:0.6;C.I.:0.4-0.9).Those who have an optimal mother have a higher likelihood of breastfeeding (OR:1.3;C.I. 1.1-1.7).Those with a controlling mother without affection have a higher probability of suffering from anxiety (OR:1.4;C.I.:1.2-1.7).Those with a controlling mother without affection have a higher probability of suffering from depression (OR:1. 7;C.I.:1.3-2.1).Those with a neglectful mother have a higher probability of suffering from anxiety (OR:1.3;C.I.:1.1-1.7).Those with a neglectful mother have a higher probability of developing depression (OR:1.7;C.I.:1.3-2.3). Conclusions Our data shows the existence of a statistically strong correlation between the variables related to the psycho-emotional sphere and the four attachment patterns. Key messages • The parental imprint received has repercussions on various aspects related to one's motherhood and influences its events and outcomes. • Mental health is also influenced by the parental imprint.

SAT615 Long-term Effects Of Transsphenoidal Surgery On Headache In Patients With Pituitary Tumors - A Prospective Study

Abstract Disclosure: V. Hantelius: None. O. Ragnarsson: None. G. Johannsson: None. E. Thurin: None. T. Skoglund: None. T. Hallen: None. Objective: Headache is a common symptom in patients with non-functioning pituitary adenomas (NFPA). The aim of this study was to analyze the long-term effect of transsphenoidal surgery (TSS) on disabling headache in patients with NFPA and to investigate possible predictive factors for headache relief following TSS. Methods: This was a prospective study of 101 patients with NFPA who underwent TSS between September 2015 to December 2021. Headache was assessed preoperatively and 12 months postoperatively with The Migraine Disability Assessment (MIDAS) questionnaire. MIDAS measures the impact of headache on the everyday life during the last 3 months and assess the headache frequency and intensity. Results: Of 101 patients, 27 (27%) experienced disabling headache preoperatively. In these 27 patients, the median (interquartile range) total MIDAS total score improved from 60 (19-140) to 10 (0-49) (p=0.004; max score 270), headache frequency decreased from 45 (25-83) to 6 (3-36) days per 90 days (p=0.002), and headache intensity decreased from 5 (4-7) to 4 (2-7) (p=0.016; on a scale 0-10 at 12 months after surgery. Overall, 18 of 27 patients (67%) had a clinically relevant improvement of their headache, 4 (15%) had a clinically relevant deterioration and 5 (19%) had no clinically relevant change at one year after surgery. No clinical factors that predicted postoperative headache relief were identified. Conclusions: Our study supports that transsphenoidal surgery achieves clinically significant and long-lasting improvement of disabling headache in patients with NFPA. Presentation: Saturday, June 17, 2023

Profil Kebugaran Jasmani Aspek Daya Tahan Vo2max Siswa SD Negeri 27 Bengkulu Tengah

ABSTRACT The purpose of study was to determine the physical fitness profile of the VO2 Max endurance aspect of the students of SD Negeri 27 Bengkulu Tengah. This type of research was descriptive qualitative research. The research subjects were students in grades III, IV, V and VI of SD Negeri 27 Bengkulu Tengah. To analyze the file , the researcher used the multi fitness test (MFT)VO2 Max instrument (arrival back and forth 20 meters). The results of file analysis obtained 21 (29.16%) male students with a value score of VO2 Max &lt;25 with a very bad category, 33 (45 ,83%) of male students with a value score of VO2 Max 25.0 - 33.7 category with a poor category, 17 (23.61%) male students with a value score of VO2 Max 33.8 - 42.5 in the medium category, 1 (1.38% )of male students with a value score of VO2 Max 42.6 was in the good category and 0 (0%) no male students in the very good category. The average V02max of male students was at a value score of VO2 Max 28.91 with a poor category. Mean while, female students found 52 (72.22% ) female students with a value score of VO2 Max &lt;25 in the very bad category, 19 (26.38% ) female students with a value score of VO2 Max score 25.0 - 33.7 with bad category, 1(38% ) female student with a value score of VO2 Max 33.8 - 42.5 in the medium category, 0 (0%) no female students in the good category and 0 (0%) no female students in the very good category. The average V02max of female students was at a value of 24,23 with a very poor category. The average results of physical fitness aspects of endurance VO2 Max students of SD Negeri 27 Bengkulu Tengah were at a value of 26,57 with a bad category. Keywords: Physical Fitness, students of SD Negeri 27 Bengkulu Tengah, Aspects of Endurance VO2 Max

Family Engagement in the Adult Cardiac Intensive Care Unit: A Survey of Family Engagement Practices in the Cardiac Critical Care Trials Network.

Cardiovascular and critical care professional societies recommend incorporating family engagement practices into routine clinical care. However, little is known about current family engagement practices in contemporary cardiac intensive care units (CICUs). We implemented a validated 12-item family engagement practice survey among site investigators participating in the Critical Care Cardiology Trials Network, a collaborative network of CICUs in North America. The survey includes 9 items assessing specific engagement practices, 1 item about other family-centered care practices, and 2 open-ended questions on strategies and barriers concerning family engagement practice. We developed an engagement practice score by assigning 1 point for each family engagement practice partially or fully adopted at each site (max score 9). We assessed for relationships between the engagement practice score and CICU demographics. All sites (N=39; 100%) completed the survey. The most common family engagement practices were open visitation (95%), information and support to families (85%), structured care conferences (n=82%), and family participation in rounds (77%). The median engagement practice score was 5 (interquartile range, 4). There were no differences in engagement practice scores by geographic region or CICU type. The most commonly used strategies to promote family engagement were family presence during rounds (41%), communication (28%), and family meetings (28%). The most common barriers to family engagement were COVID-related visitation policies (38%) and resource limitations (13%). Family engagement practices are routinely performed in many CICUs; however, considerable variability exists. There is a need for strategies to address the variability of family engagement practices in CICUs.