Scopus Databases Research Articles

Behavioral Intentions in Sports Tourism: Meta-Analysis and Structural Equation Modeling

This paper addresses fragmentation in sports tourism research, specifically concerning factors influencing behavioral intentions, focusing on key psychological and situational variables. Through a meta-analysis of 18 studies comprising 14,495 observations, drawn from an initial screening of 967 articles listed in the Scopus database, this study investigates the effects of perceived behavioral control, subjective norms, nostalgia, satisfaction, percieved benefit, and percieved risk, on behavioral intentions among general sport tourists. Two distinct theoretical frameworks were examined to uncover the core drivers of intentions. In the first framework, the analysis revealed that perceived behavioral control (effect size = .58), subjective norms (effect size = .50), and nostalgia (effect size = .43) have a stronger influence on behavioral intentions than attitude or image. This finding suggests that the participatory and socially embedded nature of sport tourism amplifies the impact of practical and social factors. Nostalgia emerged as a particularly strong emotional motivator, as it fosters attachment to past sport experiences and enhances future engagement. Among the components of the Theory of Planned Behavior, perceived behavioral control highlights the significance of practical considerations, such as ease of access and affordability, in shaping tourists’ intentions. The second framework underscored satisfaction as the most influential predictor of behavioral intentions (effect size = .77), consistent with Expectancy-Disconfirmation Theory, where experiences that meet or exceed expectations lead to future engagement. Perceived benefit (effect size = 0.50) also played a significant role, indicating that anticipated rewards, such as enjoyment and social connections, positively affect decision-making. In contrast, perceived risk (effect size = -0.25) showed a negative effect on behavioral intentions, in line with Prospect Theory, which emphasizes how potential losses deter engagement, particularly in unfamiliar or high-risk settings. These findings have practical implications for sport tourism management. Enhancing nostalgia, facilitating easy access, and fostering social connections can significantly boost behavioral intentions. Additionally, strategies that prioritize high-quality experiences to maximize satisfaction, while emphasizing perceived benefits and minimizing perceived risks through transparent safety measures, can further encourage positive engagement. Future research should explore specific conditions, such as familiar destinations, group dynamics, and satisfaction-driven contexts, that might enhance the influence of these key factors.

Review of doxycycline for prophylaxis of sexually transmitted infections

AbstractThe surging rates of STIs necessitate medical practitioners in the appropriate specialties to focus on rapid recognition, treatment and prevention of these conditions. Through both pre‐ and post‐exposure prophylaxis with doxycycline, dermatologists can provide up‐to‐date treatment in the field of venereology. Herein, we review the results of clinical trials in the available literature that investigate doxycycline prophylaxis in the prevention of bacterial STIs. A search was performed using the PubMED and Scopus databases which yielded six clinical trials for our review. Based on the results of these clinical trials, doxycycline prophylaxis offers significant reductions in bacterial STIs, specifically in men who have sex with men (MSM). Additional research is needed in other high‐risk groups, including females. Moreover, additional research is needed to determine the effects of doxycycline prophylaxis on tetracycline resistance in STI‐causing bacteria. As the utilization of doxycycline prophylaxis for STIs becomes more common, it is important that dermatologists become familiar with the data surrounding this prevention regimen and patient populations who may seek to know more about it. More research is needed to determine benefits in other subpopulations, antimicrobial resistance and cost effectiveness.

Adverse Childhood Experiences are associated with Mental Health Problems later in life: An Umbrella Review of Systematic Review and Meta-analysis

Introduction: Evidence suggested a link between early adversity and mental health problems. However, it is unclear how much adverse childhood experiences (ACEs) contribute to mental health problems because researchers have produced inconsistent findings. Therefore, the objective of this umbrella review was to combine the contradictory data regarding the effect of ACEs on the development of mental health problems later in life in the global context. Methods: PubMed, Embase, Scopus, Web of Sciences, Cochrane Database of Systematic Reviews, Scopus, and Google Scholar which reported the effect of ACEs on the development of mental health problems were searched. The quality of the included studies was assessed using the Assessment of Multiple Systematic Reviews (AMSTAR). A weighted inverse variance random-effects model was applied to find the pooled estimates. The subgroup analysis, heterogeneity, publication bias, and sensitivity analysis were also assessed. Results: Forty-three SRM with 14707614 study participants were included. The pooled effect of ACEs on the development of mental health problems later in life in the global context is found to be (AOR=1.66 (1.46, 1.87)). Subgroup analysis based on country revealed (AOR=1.67(1.23, 2.11)) in UK, (AOR=0.61(0.41, 0.81)) in Canada, (AOR=1.55(1.40, 1.69)) in Brazil, (AOR=5.65(4.12, 7.18)) in Ethiopia, (AOR=1.92(1.45, 2.38)) in USA, (AOR=2.30(1.89, 2.72)) in Australia and (AOR=1.66(1.46, 1.87)) in irland. While subgroup analysis based on types of adverse childhood adverse experience: domestic violence ((AOR=4.13(1.96, 6.30)), maltreatment (AOR=1.5(0.79, 2.21)), physical abuse(AOR=1.56(1.43,1.63), sexual abuse (AOR=2.07(1.63, 2.51)), child abuse (AOR=5.66(4.12,7.18)), parental mental health problem (AOR=1.73(1.39,2.08)), bullying (AOR=1.99(1.69, 2.29), neglect(AOR=2.11(1.53,2.69)), and parental divorce (AOR=1.66(1.46,1.87)). Based on the type of mental health problem the pooled effect size is 1.87(1.45, 2.30) for depression and 1.67(1.22, 2.13) for anxiety. Conclusion: This umbrella review revealed that adverse childhood experience is significantly associated (with 66% increased risk) with anxiety and depression later in life in a global context. This association is most noticeable when one is subjected to domestic violence, maltreatment, physical abuse, sexual abuse, child abuse, parental mental health problems, bullying, neglect, and parental divorce. Childhood periods are a critical window of opportunity for reducing the risk of developing mental illness in the future and for implementing intervention measures. Preventing childhood maltreatment and addressing psychiatric risk factors can prevent psychopathology. Longitudinal studies are needed to optimize healthcare responses to ACEs. Increased awareness and public health interventions are needed to prevent childhood adversity and prevent mental problems among these victims. To optimize healthcare responses to unfavorable outcomes of childhood adversities, longitudinal and intervention research findings, more public health initiatives, and awareness are required.

Oral Health Complications of SCUBA Diving

OBJECTIVE This review aims to assess the specific oral health complications associated with SCUBA diving, including barodontalgia, barosinusitis, and temporomandibular joint (TMJ) disorders, and to examine the dental implications of hyperbaric oxygen therapy (HBOT) used in decompression sickness treatment. Additionally, this review identifies gaps in the literature and suggests areas for further research to improve dental care guidelines for divers. MATERIALS AND METHODS A systematic literature search was conducted using PubMed and Scopus databases from 2004 to 2024, focusing on terms such as "barodontalgia," "dental barotrauma," and "diving dentistry." From 77 initial articles, 25 studies were selected based on relevance to pressure-induced oral complications, diving-related barotrauma, and dental management for SCUBA divers. RESULTS The review identifies barodontalgia as a prevalent issue, commonly triggered by untreated caries or defective restorations, with symptoms intensified by pressure changes. TMJ disorders, linked to prolonged clenching on diving mouthpieces, and sinus-related barotrauma also emerged as significant concerns. Preventive measures, including regular dental checkups, use of resin-based cements, and customized mouthpieces, are recommended to reduce risks. Furthermore, the review highlights a need for larger, controlled studies across diverse diver populations to validate current recommendations and develop accessible guidelines, especially for recreational divers who may lack access to specialized dental care.

Two Decades of Board Co-Option Research: A Scoping Review

This study conducts a scoping review of board co-option research published between 2002 and 2023. We examined 30 articles from the Scopus database using a scoping review methodology. Our qualitative analysis provides scholars and practitioners with a comprehensive understanding of the impact of board co-option on firm performance and risk management practices. Additionally, our study contributes to the literature by exploring the theoretical foundations of board co-option analysis, the primary focus of most studies, and potential areas for future research.

Manufacturing

Manufacturing is dedicated to industrial production, in which raw materials are transformed into finished products on a large scale and included in the economy´s secondary sector. The Scopus database was used for the bibliometric analysis, based on the term {manufacturing}. The better result shows in the function of the number of documents produced: year 2023; source Proceedings of SPIE; author Franke J. and Wang, L.; affiliation Ministry of Education of China; country USA; document type article; scientific area engineering and funding support National Natural Science Foundation of China.

The Prevalence of Fluoroquinolone-Resistant E. coli in Animals and Animal Products: A Systematic Review and Meta-Analysis

Background: Biological contamination of foods is a serious problem for human health. Animal and animal products may be contaminated by these biological and chemical contaminants. One of the most important causes of foodborne illness in humans is Escherichia coli. Fluoroquinolones can be used as a suitable treatment for enteric infections in food-producing livestock. We aimed to evaluate the current status of resistance of E. coli strains isolated from animals and animal products to fluoroquinolone in Iran. Methods: A systematic search was conducted using the Web of Science, PubMed, Embase, Google Scholar, and Scopus databases from 2000 to Oct 2020. Nineteen studies were selected based on the inclusion criteria and analysis by Comprehensive Meta-Analysis. Results: Based on the data analysis, The rates of antibiotic resistance in animal strains were as follows: Flumequine (75.1%), Enrofloxacin (55.2%), Danofloxacin (48.1%), Ciprofloxacin (48.4%), and Norfloxacin (52.9%). Next, the rates of quinolone resistance among E. coli strains isolated from animal products were Norfloxacin (45.5%), Ciprofloxacin (44.5%), and Enrofloxacin (60.9%). Based on the funnel plots and Egger's test, there was no significant publication bias. Conclusion: We finally concluded that antibiotic resistance in commensal E. coli is related to the overuse of antibiotics in livestock, especially fluoroquinolones.

Evaluating the effects of exercise protocols in hospitalized onco-hematological patients: a systematic review.

Physical activity is associated with improved functionality, independence and quality of life in cancer patients undergoing active treatment. Exercises can be prescribed to improve patient outcomes. Evaluate the effects of applied exercise protocols on functional capacity, quality of life, fatigue and muscle strength in hospitalized onco-hematological patients compared to conventional treatment. Systematic literature review carried out in PUBMED, EMBASE and Scopus databases with the following descriptors: Hematological neoplasms AND Exercise Therapy AND Hospitalization, in November 2023. Studies with adult inpatients with hematological neoplasms who performed an exercise protocol in the intervention group were included. After applying the eligibility criteria, 9 articles were included in the review, 7 of which were randomized clinical trials and 6 were carried out on transplant patients. The most commonly assessed outcome was functional capacity, followed by muscle strength and quality of life, and ending with an assessment of fatigue. Studies have shown positive results for patients, especially those that combine resistance and aerobic exercise protocols. An exercise protocol for patients with onco-hematological diseases can improve the outcomes analyzed. Aerobic and resistance exercises should be performed, but more studies are needed to assess the time and doses required for each activity.

A Narrative Review on the Conceptual and Methodological Advancements in Digital Disruption: A Way to Improved Quality of Services in Health Care

Background: The adoption and successful implementation of digital health solutions heavily depend on digital health literacy, which is particularly critical in the current COVID-19 era. Low levels of digital health literacy are associated with poor preventative practices, the spread of inaccurate information, vaccine hesitancy, and reduced subjective well-being. Thus, the aim of this review was to highlight areas of current scholarly interest and identify any gaps in the literature regarding conceptual and methodological advancements in digital disruption. Methods: The authors conducted a literature search using the databases Scopus, Embase, Web of Science, PubMed, and Google Scholar, focusing on papers released between 2003 and October 2023. The following keywords were used to conduct a thorough literature search: ((digital health OR digital disruption OR digital dental health)) AND (medical health OR telemedicine)), ((online doctor OR online consultation OR online health app)) AND (COVID-19 OR pandemic)). A total of 1,244 studies were screened, including duplicates and non- English research. After applying inclusion and exclusion criteria, 72 articles were selected for the review. Results: A total of 72 articles were included in this review. The studies discussed the potential reasons for disrupted access to healthcare, which is linked to avoidable hospital admissions. Delayed care due to disruptions can lead to disease progression, the exacerbation of existing conditions, and chronic ambulatory care-sensitive conditions. Digital health innovations were presented as solutions to enhance care, reduce clinical workload, and promote independent living. Conclusions: In conclusion, this narrative review provides a comprehensive overview of the conceptual and methodological advancements in digital technology related to healthcare. It demonstrates the potential of digital technology to revolutionize both medical and dental education.

Prognostic value of circulating tumor DNA in different cancer types detected by ultra-low-pass whole-genome sequencing. A systematic review and patient-level survival data meta-analysis.

Ultra-low-pass whole-genome sequencing (ULP-WGS) (≤0.5× coverage) of plasma cell-free DNA (cfDNA) has emerged as a low-cost promising tool to assess circulating tumor DNA (ctDNA) fraction. This meta-analysis aims to summarize the current findings and comprehensively investigate the prognostic value of baseline ctDNA detected by ULP-WGS in solid tumors. A systematic review was carried out by searching PubMed/MEDLINE and Scopus databases to identify eligible studies conducted between January 2014 and January 2024. Inclusion criteria comprised studies with reported overall survival (OS) and progression-free survival (PFS) outcomes across therapy-naïve patients with different solid tumors. All patients underwent baseline ULP-WGS of plasma cfDNA and were categorized as ctDNA positive (tumor fraction ≥10%) or negative (tumor fraction <10%). A one-stage meta-analysis was performed using patient-level survival data reconstructed from published articles. A Cox proportional hazards model with shared frailty was used to assess the difference in survival between arms. A total of six studies, comprising 620 patients (367 negative ctDNA and 253 positive ctDNA), were included in the OS analysis, while five studies, involving 349 patients (212 negative ctDNA and 137 positive ctDNA), were included in the PFS analysis. The meta-analysis showed that patients with baseline positive ctDNA had a significantly higher risk of death (HR = 2.60, 95% CI: 2.01-3.36) and disease progression (HR = 2.28, 95% CI: 1.71-3.05) compared to those with negative ctDNA. The presence of a positive ctDNA at baseline is associated with increased risk of death and progression in patients with same stage cancer.

Management of Muscle Cramps in Patients With Cirrhosis: A Systematic Review of Randomised Controlled Trials.

Muscle cramps are common in patients with cirrhosis. Despite their prevalence and impact on health-related quality of life, there are no widely used clinical practice guidelines for management of muscle cramps in cirrhosis. The aim of this review was to critically evaluate current evidence regarding treatment of muscle cramps in cirrhosis. A systematic review using PubMed, MEDLINE (Ovid), Embase, and Scopus databases was performed on 30 June by two independent reviewers to identify randomised controlled trials (RCTs) reporting interventions for muscle cramps in cirrhotic patients. Twelve RCTs evaluating 13 distinct interventions were identified. Baclofen, methocarbamol, orphenadrine, and taurine supplementation reduced cramp frequency, severity, and duration when compared to placebo. Human albumin, pregabalin, and quinidine reduced cramp frequency compared to placebo. Pickle juice reduced cramp severity compared to placebo. BCAA supplementation and calcium carbonate were found to reduce cramp frequency compared to baseline. Stretching demonstrated a signal towards reducing cramp severity and frequency, and meditation had a signal towards reducing severity only when compared to baseline. Electro-acupuncture was the only intervention which demonstrated no therapeutic effect. Pregabalin was the only agent associated with significant side effects that limited its use. Methocarbamol, orphenadrine, and taurine supplementation were found in placebo-controlled RCTs to be effective in reducing cramp frequency, severity, and duration in cirrhotic patients. All other interventions reported aside from electro-acupuncture demonstrated a positive impact on cramps. High-quality RCTs are needed to further investigate the use of these treatments in terms of comparative efficacy and safety.

Protein phosphatase 2A inhibitors: a possible pharmacotherapy for benzodiazepine dependence.

Benzodiazepines (BZDs) activate the γ-aminobutyric acid (GABA) subtype A (GABAA) receptors, and thus are widely used medicines for the treatment of anxiety and insomnia. For chronic use, tolerance to BZDs is a major problem. Patients with chronic insomnia that develop tolerance to BZDs lose therapeutic effects but also potentially suffer from BZD dependence resulting in BZD withdrawal. The development of such treatments is important for the appropriate use of BZDs. Research articles regarding investigation of BZD dependencewere searched on PubMed, Embase, and Scopus databases using keywords "benzodiazepine", "dependence", "treatment". When BZDs are taken chronically, continuous GABAA binding results in up-regulation of α-amino-3-hydroxy-5-methyl-4-lisoxazolepropionic acid (AMPA) glutamate receptor function and release of brain-derived neurotrophic factor (BDNF). Released BDNF binds to its specific receptor tropomyosin-related kinase receptor B (TrkB). Enhanced BDNF-TrkB signaling activates protein phosphatase 2A (PP2A). Activated PP2A dephosphorylates GABAA receptors, resulting in the downregulation of the GABAA receptor function. Reduced GABAA receptor function augments long-term potentiation (LTP), AMPA-mediated glutamatergic neuroplasticity, by reducing LTP inhibition by GABAA receptor function. Augmented LTP enhances extreme anxiety, which leads to BZD dependence. Therefore, iInhibiting dephosphorylation of the GABAA receptor by PP2A, PP2A inhibitors could reduce LTP and anxiety, restoring BZD effectiveness and resulting in possible therapeutic effects for BZD dependence.

Total Antioxidant Status in Critically Ill Patients with Traumatic Brain Injury and Secondary Organ Failure—A Systematic Review

Introduction: The available literature indicates that oxidant–antioxidant imbalance plays a significant role in the pathophysiology of traumatic brain injury and the subsequent secondary organ dysfunctions. However, there is a lack of studies summarizing the knowledge in this area, and no clear guidelines exist regarding the use of biomarkers of oxidative stress as diagnostics tools. Methods: The present work aims to provide a systematic review of the literature on the use of total antioxidant capacity (TAC) assays in predicting the outcomes of traumatic brain injury (TBI). A literature search was conducted up to 1 September 2024, according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA 2020) guidelines, using the PubMed and Scopus databases. Based on the inclusion criteria, 24 studies were used for the final review. Results: Promising data indicate that TAC assays are useful in predicting 30-day mortality and neurological outcomes. Moreover, they correlate with radiological findings on CT scans in brain injury and the clinical classifications of injuries, as well as the parameters of organ failure. Conclusions: Total antioxidant capacity assays can be used to assess the extent of brain damage and prognosticate general vital functions. Future experiments should include long-term randomized clinical trials on larger populations of TBI patients.

Development of Learning Models to Enhance Students’ Creative Thinking: A Systematic Literature Review

Creative thinking is an essential component in education that drives innovation, problem-solving, and the development of students’ critical thinking skills. This study aims to review various learning models designed to enhance students’ creative thinking abilities through a systematic literature review (SLR). Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) framework, this research identifies, screens, and evaluates relevant articles from the Scopus database, resulting in eight studies that meet the inclusion criteria. The results indicate that, following innovative learning models such as play-based activities, digital-based virtual classrooms (VCLE), basic movement through play approaches, and project-based mathematics learning are effective in improving creativity, problem-solving, collaboration, and student learning motivation. The integration of technology, STEAM approaches, and creative game design also show positive effects in enhancing students’ creative thinking skills. The higher distribution of research at the tertiary education level highlights the need for greater focus on other educational levels, particularly secondary education, to ensure the benefits of learning innovation are evenly distributed. These findings provide practical implications for educators and policymakers, emphasizing the importance of using innovative teaching methods, integrated technology, and the role of teachers as facilitators to develop a conducive learning environment for student creativity. The study also identifies several limitations, including small trial scales and short research durations, indicating the need for further research with larger scales and longer durations. By continually exploring and developing effective learning models, it is expected that students can achieve their maximum potential in dynamic and diverse learning environments.

The Role of Service Robots in Restaurant Settings: A Meta-Analysis Study on Consumer Behavior and Intentions

The employment of service robots in restaurants has become increasingly common. Previous studies have explored the factors related to the impact of service robots on consumers from multiple perspectives, but this topic still lacks an integrated empirical study to organize and analyze the conclusions of previous studies. This study obtained 46 empirical studies through the WoS and Scopus databases. Based on the conclusions and data of these studies and guided by the SOR theory, a holistic conceptual framework was constructed to describe how service robots affect restaurant consumers. This study tested the conceptual framework of the construct through meta-analysis and verified the moderating role of macro variables such as time and culture. This study not only has theoretical significance for future research but can also provide practical guidance for restaurant managers in the application and deployment of service robots.

Spiritual Intelligence and Spiritual Care in Nursing Practice: A Bibliometric Review

Spiritual intelligence (SI) has recently gained traction in various fields, including nursing. Given the increasing emphasis on patient-centred care and the holistic well-being of patients and nurses, SI is particularly relevant in nursing practice. A bibliometric analysis of recent publications (2014–2024) in the field helps synthesise and evaluate the existing research on SI in the general field of nursing, identify literature gaps, suggest future research directions and raise awareness of the importance of SI in nursing practice. The present study reports bibliometric data (n = 461) from the Scopus database on SI, spiritual quotient and spiritual care in nursing and health care. The data are analysed using MS Excel and VOSviewer software. The publications’ trend analysis revealed a significant increase in SI-related publications since 2015. The study presents top-cited articles. Journal of Religion and Health was found to be a prominent journal with the maximum number of publications, and Sage was found to be the top publisher of journals with articles on SI. Network visualisation reveals central figures such as Wilfred McSherry, Trove Giske, Elizabeth Johnston Taylor, Fiona Timmins, Silvia Caldeira and Linda Ross as key researchers in the field. The United States and Iran have the most substantial connections of authors publishing on SI. This study reveals an increasing interest in SI and care within nursing research, confirming its growing significance in the field. By reporting areas where research on SI in nursing remains underdeveloped, the study paves the way for the development of new or updated curricula in nursing programs. The study can guide faculty development initiatives by highlighting the importance of SI and providing resources for educators to incorporate these concepts into their teaching. This study presents specific research questions to address these knowledge gaps. Future studies which can address these questions will enrich nursing education and practice, leading to improved patient outcomes and enhanced nurse well-being using the full potential of SI in nursing practice.

WOUND MANAGEMENT, HEALING, AND EARLY PROSTHETIC REHABILITATION: PART 1 - A SCOPING REVIEW OF HEALING AND NON-HEALING DEFINITIONS

BACKGROUND: Following lower limb amputation, timely prosthetic fitting enhances mobility and quality of life. However, inconsistent definitions of surgical site healing complicate prosthesis readiness assessment and highlight the need for objective wound management measures. OBJECTIVE: This review aimed to compile definitions of healing and non-healing provided in the literature investigating biomarkers of healing of the tissues and structures found in the residual limbs of adults with amputation. METHODOLOGY: A scoping review was conducted following JBI and PRISMA-ScR guidance. Searches using “biomarkers,” “wound healing,” and “amputation” were performed on May 6, 2023, on Web of Science, Ovid MEDLINE, Ovid Embase, Scopus, Cochrane, PubMed, and CINAHL databases. Inclusion criteria were: 1) References to biomarkers and healing; 2) Residuum tissue healing; 3) Clear methodology with ethical approval; 4) Published from 2017 onwards. Articles were assessed for quality (QualSyst tool) and evidence level (JBI system). FINDINGS: Of 3,306 articles screened, 219 met the inclusion criteria and are reviewed in this article, with 77% rated strong quality. 43% of all included sources did not define healing, while the remainder used specific criteria including epithelialization (14%), wound size reduction (28%), gradings scales (3%), scarring (1%), absence of wound complications (2%), hydroxyproline levels (0.5%), no amputation (0.5%), or neovascularization (0.5%). 84% of included sources did not provide definitions of non-healing. Studies defining non-healing used criteria like wound complications (4%), the need for operative interventions (4%), or lack of wound size reduction (1%). For 10% of included sources, healing and non-healing definitions were considered not applicable given the research content. Total percentages exceed 100% for both healing and non-healing definitions because some sources used two definition classifications, such as epithelialization and wound size reduction. The findings indicate a lack of standardized definitions irrespective of study type. CONCLUSION: This review reveals significant gaps in current definitions of healing and non-healing, often based on superficial assessments that overlook deeper tissue healing and mechanical properties essential for prosthesis use. It emphasizes the need for comprehensive definitions incorporating biomarkers and psychosocial factors to improve wound management and post-amputation recovery. Layman's Abstract After a lower limb amputation, early prosthetic fitting can significantly improve quality of life. However, different definitions of surgical site healing make deciding when a prosthetic can be used difficult. This scoping review collected and compared definitions of healing and non-healing found in research about biological markers (biomarkers) that are used for tracking residual limb healing. On May 6, 2023, searches were conducted using terms like “biomarkers,” “wound healing,” and “amputation” across several databases. Studies were included if they discussed biomarkers, focused on residual limb healing, had clear methods and ethical approval, and were published during or after 2017. Of 3,306 articles screened, 219 met the criteria, with 77% rated as high quality. 43% of the included sources did not define healing. Definitions provided included new skin growth (14%), reduction in wound size (28%), grading scales (3%), scarring (1%), no complications (2%), hydroxyproline levels (0.5%), no need for amputation (0.5%), or new blood vessel formation (0.5%). 84% of sources did not define non-healing, with the remainder based on healing complications (4%), the need for more surgery (4%), or no reduction in wound size (1%). In 10% of included sources healing and non-healing definitions were considered not relevant to their research. Total percentages for healing and non-healing definitions exceeds 100% because some sources used two definitions, for example, new skin growth and reduction in wound size. Overall, the review shows gaps in definitions, many of which are too basic and ignore deeper tissue healing and factors needed for prosthetic use. More thorough definitions that include the physical, mental, and social sides of healing are needed to improve recovery. Article PDF Link: https://jps.library.utoronto.ca/index.php/cpoj/article/view/43715/33312 How To Cite: Williams-Reid H, Johannesson A, Buis A. Wound management, healing, and early prosthetic rehabilitation: Part 1 - A scoping review of healing and non-healing definitions. Canadian Prosthetics &amp; Orthotics Journal. 2024; Volume 7, Issue 2, No.1. https://doi.org/10.33137/cpoj.v7i2.43715 Corresponding Author: Professor Arjan Buis, PhDDepartment of Biomedical Engineering, Faculty of Engineering, University of Strathclyde, Glasgow, Scotland.E-Mail: arjan.buis@strath.ac.ukORCID ID: https://orcid.org/0000-0003-3947-293X

The Role of Cognitive Reserve in Post-Stroke Rehabilitation Outcomes: A Systematic Review

Background/Objectives: Stroke remains a major cause of disability and death, with survivors facing significant physical, cognitive, and emotional challenges. Rehabilitation is crucial for recovery, but outcomes can vary widely. Cognitive reserve (CR) has emerged as a factor influencing these outcomes. This systematic review evaluates the role of CR in post-stroke rehabilitation, examining whether higher CR is associated with better outcomes. Methods: A systematic search of PubMed, Google Scholar, Scopus, and Cochrane Library databases was conducted for studies published between 2004 and 2024. Studies examining social-behavior CR proxies (e.g., education, bilingualism) and their impact on post-stroke outcomes were included. Data were analyzed using descriptive statistics. The study quality was assessed using the Methodological Index for NOn-Randomized Studies (MINORS) scale. Results: Among 3851 articles screened, 27 met the inclusion criteria. Higher education levels, bilingualism, and engagement in cognitively stimulating activities were associated with better cognitive outcomes and functional recovery. Lower socioeconomic status (SES) correlated with poorer outcomes. Early rehabilitation and dynamic CR proxies showed stronger associations with cognitive recovery than static ones. Conclusions: CR may predict post-stroke rehabilitation outcomes, with education, bilingualism, and active engagement in cognitive activities showing potential benefits. Future research should explore CR’s role alongside factors like lesion location and severity in enhancing recovery.

Comprehensive Management of Drunkorexia: A Scoping Review of Influencing Factors and Opportunities for Intervention

Background and objectives: Drunkorexia is a novel alcohol-related disorder prevalent among adolescents and young adults. Extensive research on the causes and their relationship is lacking. Identifying these aspects could improve early detection and management by healthcare professionals. The aim of this review was to identify the influencing factors of drunkorexia in adolescents and young adults, as well as the main opportunities for action by health professionals. Methods: A scoping review was conducted in June and July 2024 using three databases (Pubmed, Scopus, and Web of Science). A search and review protocol were established and registered in PROSPERO. The research questions were formulated in Patient, Concept, Context (PCC) formats for an adequate literature review. Original articles from January 2008 to July 2024 were included. Reviews, meta-analyses, and doctoral theses or academic texts were excluded. In the screening phase, a methodological assessment was conducted using the Joanna Briggs Institute’s (JBI) critical appraisal tools to support study eligibility. Depending on the study design, different checklists were used, and cross-sectional studies that received scores of 4/8 or higher, quasi-experimental designs that obtained 5/9 or higher, and qualitative research that obtained 5/10 or higher were accepted. Results: A total of 1502 studies were initially found. After applying the inclusion/exclusion criteria, 20 studies were selected. Complications of emotion regulation, both positive and negative metacognitive beliefs, inability to effectively manage stress and anxiety, symptoms of post-traumatic stress disorder, self-discipline and self-control, or differences in social expectations are predisposing factors for drunkorexia. The management of malnutrition and dehydration is an opportunity for clinical professionals to address this problem. In addition, mental health issues can provide another opportunity to manage heavy alcohol consumption. Conclusions: Drunkorexia must be recognized as a new disease to be addressed from a multidisciplinary perspective. In this way, increasing research on this trend would support prevention and intervention strategies. The use of digital platforms is essential for raising social awareness of this negative habit.

Advancements in ecological assets and ecological product supply: in-depth insights from Karst World Heritage sites

AbstractEcological assets (EA) are fundamental to the supply of ecological products (EP). They underpin the provision of ecological functions by ecosystems, their existence, and health. However, a comprehensive assessment of EA and the supply of EP remains lacking. This study employs the Systematic Literature Review (SLR) method and identifies 215 relevant articles from the Scopus database. The study: (1) Analyzes selected literature by publication years, research themes, geographical distribution, affiliations, and stages. (2) Summarizes key advances and significant achievements in domestic and international research. (3) Formulates six critical scientific questions and provides recommendations based on the current status and characteristics of EA and the supply of EP in Karst World Heritage (WH) Sites. This study furnishes research insights for practitioners and policymakers in the field, contributing to the sustainable development of ecosystems in Karst WH Sites.