Service Science Research Articles

Factors associated with time to relapse in pulmonary tuberculosis patients using penalized Cox models.

Pulmonary tuberculosis (TB) is a contagious bacterial infection caused by Mycobacterium tuberculosis that primarily affects the lungs. Despite advances in treatment, TB remains a major public health challenge, particularly in developing countries. This retrospective cohort study aimed to identify factors that influence the time to relapse in patients with pulmonary tuberculosis. All smear-positive pulmonary tuberculosis patients (1548 patients) whose data were recorded in the tuberculosis registration system of Golestan University of Medical Sciences and Health Services from March 2014 to March 2019, and followed up until February 2021. To analyze the data, we applied LASSO, MCP, and SCAD penalized Cox models. Based on the AIC and BIC criteria, the MCP penalized model was better than the LASSO and SCAD penalized models. The variables of age at diagnosis (> 35 vs. 35, HR = 2.77), marital status (married vs. single, HR = 8.49), chronic renal failure (Yes vs. No, HR = 5.36), and pre-treatment smear test results (+ 1 vs. 1-9Basil, HR = 0.65 and + 2 vs. 1-9Basil, HR = 0.96) influenced time to relapse according to the MCP penalized Cox regression model. Health care systems should focus on identification of factors that influence time to relapse and developing interventions to reduce relapse rates.

The Responsibilities of the Forensic Specialist in the Criminal Process: Problems and Regulatory Solutions

The present work deals with the problem of the activities carried out by the forensic science specialist in the process of the crime investigation. The author pays a great attention to the analysis of the responsibilities of the specialist, which are stipulated in the processual-criminal law and the departmental normative acts of the Forensic Science Service. Arguments are brought in favour of the necessity to eliminate some contradictory processual provisions as well as the necessity to specify and complete the directives that regulate the daily activity of the forensic science specialists.

Improvizing West Java MSMEs Using Quality Service Gaps Model

This study aims to understand the challenges and opportunities for the development of Micro, Small and Medium Enterprises (MSMEs) in West Java. With a very large number, MSMEs in West Java have great potential to drive economic growth. However, various obstacles such as access to capital, information, and technology are still an obstacle. This research proposes the application of the Service Science framework to map the MSME ecosystem and identify opportunities for service innovation. Thus, it is expected to increase the competitiveness of MSMEs and make a greater contribution to the regional economy. This research reveals that MSMEs in West Java face significant constraints in terms of access to capital, information, and technology. Through in-depth interviews with 8 MSME owners, this research aims to understand in-depth the challenges and opportunities faced by micro, small and medium enterprises. Thematic analysis of the interview data identified a gap between the ideal conditions that MSMEs desire and the actual conditions they experience. Using the Service Quality Gap Model, this study created four action plans to improve MSMEs in West Java. By addressing the identified gaps and encouraging collaboration between MSMEs, government, academia and industry, the Sadulur platform can catalyze the sustainable growth and development of MSMEs in West Java. These gaps, which we refer to as 'customer gaps', are manifested in four main themes: 1) the potential for MSMEs to create innovative products more easily, 2) the need to develop a strong business foundation and build sustainable brand value, 3) the importance of improving business processes and management to increase efficiency, and 4) the need to build good relationships with external parties to expand networks and business opportunities. These findings form the basis for formulating an action plan to improve the quality of services provided to MSMEs.

Regional Workforce Dynamics in West Virginia: Insights from Shift-Share and Location Quotient Analysis

West Virginia, home to approximately 1.77 million residents, has been grappling with significant economic challenges characterized by persistent poverty and sluggish growth. Despite ongoing development efforts, the state’s Gross State Product (GSP) has seen only a modest increase of 0.1% over the past five years, reaching USD 71.7 billion, while the unemployment rate remains at 4.0%. The annualized employment growth rate of 0.7% lags behind the national average, and only about 54% of West Virginia’s adult population is either employed or actively seeking employment, resulting in one of the lowest labor force participation rates in the nation. In contrast, certain industrial sectors, such as healthcare, social assistance, retail trade, and accommodation and food services, have shown intermittent growth at the county and regional levels. To explore the unique characteristics and significance of these regions in relation to employment growth, this study examines regional employment patterns in West Virginia from 2001 to 2020, focusing on the main regions of the state: Metro Valley, Mid-Ohio Valley, New River/Greenbrier Valley, Mountain Lakes, and Potomac Highlands. Utilizing shift-share and location quotient (LQ) analyses, this research identifies the sectors driving regional employment and assesses their performance. Key findings reveal strong sectoral performance in mining, manufacturing, and finance in the Mid-Ohio Valley; wholesale trade, transportation, and utilities in the Metro Valley; agriculture and administrative services in the New River/Greenbrier Valley; agriculture and manufacturing in the Potomac Highlands; and scientific services, healthcare, and utilities in the Mountain Lakes region. Based on these insights, this study recommends targeted policy interventions to address regional disparities, enhance sectors with significant short- and long-term benefits, and foster balanced economic development across the state.

Co-developing frameworks towards environmentally directed pharmaceutical prescribing in Scotland – A mixed methods study

The presence of human pharmaceuticals in the aquatic environment is recognised internationally as an important public health and environmental issue. In Scotland, healthcare sustainability targets call for improvements to medicine prescribing and use to reduce healthcare's impact on the environment. This proof-of-concept study aimed to develop a framework on the environmental impact of pharmaceuticals to use as a knowledge support tool for healthcare professionals, focussing on pharmaceutical pollution. Nominal Group Technique was applied to achieve consensus on pharmaceuticals and modelling factors for the framework, working with a panel of cross-sector stakeholders. Bayesian Belief Network modelling was applied to predict the environmental impact (calculated from hazard and exposure factors) of selected pharmaceuticals, with Scotland-wide mapping for visualisation in freshwater catchments. The model calculated the pollution risk score of the individual pharmaceuticals, using the ratio of prescribed mass vs. mass that would not exceed the predicted no-effect concentration in the freshwater environment. The pharmaceuticals exhibited different risk patterns, and spatial variation of risk was evident (generally related to population density), with the most catchments predicted to exceed the pollution risk score for clarithromycin (probability >80 % in 35 of 40 modelled catchments). Simulated risk scores were compared against observed risk calculated as the ratio of measured environmental concentrations from national regulatory and research monitoring and predicted no-effect concentrations. The model generally overpredicted risk, likely due to missing factors (e.g. solid-phase sorption, temporal variation), low spatial resolution, and low temporal resolution of the monitoring data. This work demonstrates a novel, trans-disciplinary approach to develop tools aiding collation and integration of environmental information into healthcare decision-making, through application of public health, environmental science, and health services research methods. Future work will refine the framework with additional clinical and environmental factors to improve model performance, and develop electronic interfaces to communicate environmental information to healthcare professionals.

A bottom-up nationwide analysis of sectoral land use reveals spatial heterogeneity across the United States

The high degree of urbanization and economic development in the United States has intensified competition for land resources, leading to land use conflicts and environmental challenges. Addressing these issues first requires an exploration of high-resolution, sector-specific land use patterns. However, existing land classification studies rarely provide spatially explicit data on urban land use across all sectors at a national level. This study aims to fill this gap by analyzing land use areas across various economic sectors in the United States, particularly focusing on urban impervious surfaces. Using a bottom-up approach, we created a full-sector land use inventory, integrating Points of Interest (POI) data, road networks, building characteristics, and geographic information processing techniques. Our primary innovation lies in the development of a spatially explicit database that details sector-specific land use areas nationwide. On this robust foundation, we further explored the heterogeneity of sectoral land use eco-efficiency (SLUEE) among different sectors and states, providing supplementary insights into spatial disparities in urban land use. Our findings reveal significant spatial heterogeneity, with service sectors dominating land use and exhibiting higher SLUEE compared to goods-producing industries. Key sectors such as Professional, Scientific, and Technical Services (441064.58 ha), and Administrative and Support Services (420148.34 ha) are prominent across states according to land use area, reflecting the country's service-oriented economy. Additionally, regional disparities in SLUEE are evident, with jurisdictions like Washington D.C., New York, and California demonstrating more efficient land use. Compared with traditional land use evaluations, our model effectively offers higher spatial resolution, down to the census block level, to sectoral land use evaluation. Building on this robust database, our SLUEE analysis has uncovered notable heterogeneity between sectors and states, offering new insights into cross-sectoral and inter-state land use dynamics that can inform and promote sustainable urban planning.

Everything, everywhere, and all at once: A blueprint for supra-organization of core facilities.

Core facilities are crucial for cutting-edge scientific research in academic institutions, yet they place a significant financial burden on budgets. The viability of these facilities can be improved through cross-institutional collaborations, although initiating and sustaining such partnerships poses challenges. Insights from Israel's recent nationwide organization of core facilities could offer valuable lessons for fostering similar cooperation elsewhere. Despite the chronic shortfall in public research funding, Israeli research institutions were slow to fully embrace infrastructure sharing. This gap led to the creation of the Israel Research Core Facilities (IRCF) in 2022, which linked core facilities across the country through a bottom-up approach. IRCF facilitated the formation of numerous specialized nation-wide networks for intellectual exchange, and supported training workshops and meetings aimed at core technology providers. These initiatives serve dual purposes: they ensure the ongoing advancement of technological capabilities across facilities, regardless of their size or location, and they strengthen the commitment to the IRCF mission by motivating the maintenance of the IRCF database. As a result, a model of "capacity sharing" emerged, connecting all of Israel's core facility centers. This model enhances infrastructure use, supports strategic planning, and fosters growth. With over 450 core experts offering over 1100 scientific services consolidated into a publicly accessible database, IRCF supports research in universities, hospitals, government, and industry. This strategy could act as a model for creating regional core facility organizations to elevate research quality and ensure efficient infrastructure development.

Investigating the Challenges of Infertility Treatment Development in Centers of Iran University of Medical Sciences and Health Services

Investigating the Challenges of Infertility Treatment Development in Centers of Iran University of Medical Sciences and Health Services

Editorial: Web3 and service science: perfectly aligned to maximize the values of all stakeholders in the digital economy

Editorial: Web3 and service science: perfectly aligned to maximize the values of all stakeholders in the digital economy

Effect of Periodontal Treatment in Patients with Periodontitis and Diabetes: Review of Systematic Reviews with Meta-Analyses in the Last Five Years.

Periodontitis is a chronic infectious-inflammatory pathology, with a high prevalence, which destroys the dental support and, if left untreated, leads to tooth loss. It is associated with other pathologies, particularly diabetes mellitus. Our objective was to conduct a review of systematic reviews with meta-analyses to determine the evidence for periodontal treatment on periodontitis and diabetes. Second, we assessed the risk of bias and methodological quality using the AMSTAR-2 and ROBIS tools. We performed bibliographic searches in PubMed/Medline, Embase, Cochrane Central, Dentistry & Oral Sciences Source databases and in the Web of Science (WOS) scientific information service to identify systematic reviews with meta-analyses from the last five years. Eighteen studies that met the inclusion criteria and evaluated 16,247 subjects were included. The most studied parameters were probing pocket depth, clinical attachment level, bleeding on probing and the glycated hemoglobin. Most of the included meta-analyses evaluated adult patients with periodontitis and type 2 diabetes mellitus (T2DM). Most of the meta-analyses considered and assessed by AMSTAR-2 showed significant methodological errors. The risk of bias was the domain with the worst assessment with the ROBIS tool. Despite the weaknesses of the included meta-analyses in terms of methodological quality and the risk of bias, periodontal treatment and DM treatment appear to contribute to improved clinical outcomes in a bidirectional manner between periodontitis and DM.

ANTI-CANCEROUS POTENTIAL OF POLYSACCHARIDES DERIVED FROM WHEAT CELL CULTURE

There is a global need to discover effective anti-cancerous compounds from natural sources. Cultivated wheat cells can be a valuable source of non-toxic or low toxic plant-derived polysaccharides. In this study we evaluated the antitumor ability of seven fractions of wheat cell culture polysaccharides (WCCPSs) in the HCT-116 colon cancer cell line. Almost all (6/7) fractions had an inhibitory effect on the proliferation of colon cancer cells, and two fractions (A-b and A-f) had considerable therapeutic indexes. The WCCPS fractions induced cell cycle arrest in the G1 phase and induced different rates of apoptosis (<48%). Transmission and scanning electron microscopy revealed that WCCPS fractions caused apoptotic changes in the nucleus and cytoplasm, including damage to mitochondria and external morphological signs of apoptosis. In addition, the WCCPSs induced an increase in the levels of Bax, cytochrome c, caspases 8 and 3, indicating that cell death was assessed through intrinsic and extrinsic pathways of apoptosis. Furthermore, some fractions caused a significant decrease of c-Myc, b-catenin, NFkB2 and HCAM (CD 44) levels, indicating enhanced cell differentiation. Thus, for the first time, our results provide a proof of concept of the anti-cancer capacity of WCCPS fractions in colorectal cancer. This research was supported by the FEDER Operational Program 2020/Junta de Andalucía-Consejería de Economía y Conocimiento/ Project (B-CTS-562-UGR20) and the Chair “Doctors Galera-Requena in cancer stem cell research” (CMC-CTS963); Erasmus+ Mobility Program; “Bolashak” Presidential Scholarship of the Republic of Kazakhstan for scientific work abroad; Scottish Government’s Rural and Environment Science and Analytical Services (RESAS) division.

Roadmap for Linking Registry Data with Health Services Data to Support Evidence-Informed Decision-Making.

ApproachAs part of a learning period to optimize the use of RWE for decision-making for drugs for rare diseases, the [organization name removed to allow for blind review] conducted an environmental scan to map real-world data in patient registries. Over 400 patient registries were identified, signaling the potential wealth of untapped information to support decision-making by linking registry data with health services data. To better understand the challenges faced by registry holders hoping to link registry data with health services data sources available in Canada, a series of interviews were conducted with several Canadian rare disease registries. In addition, a literature review was completed, and Canadian experts in epidemiology, privacy, record linkage, registry science, and health services research were consulted to inform the development of a roadmap to meet various stakeholder needs. ResultsThe resulting roadmap consists of 8 specific steps covering topics related to registry purpose, informed consent, ethical approval, participant privacy, governance, data linkability, participant identifiability and jurisdictional requirements. ConclusionThe roadmap is currently undergoing pilot testing by a pan-Canadian rare disease registry. A final [organization name] report and an accompanying roadmap in a checklist format to facilitate implementation will be finalized, disseminated across key stakeholders, and made publicly available. ImplicationsWhile developed for registries, the roadmap applies to the linkage of clinical trial or cohort study data, or other systematically gathered patient-level data to health services data.

Designing and delivering climate training for natural resource managers: Increasing climate literacy and action through education and engagement

AbstractResponding to climate impacts and expanding adaptation efforts necessitates getting the right knowledge and tools in the hands of land managers and decision‐makers. In 2022–2023, several regional US Geological Survey Climate Adaptation Science Centers partnered with the US Fish and Wildlife Service (FWS) Science Applications Program on the first targeted climate training series designed for the FWS Grassland Ecosystem Team. This training spanned multiple months and formats with self‐paced virtual lessons, webinars, and an in‐person workshop. As the FWS Grassland Ecosystem Team is tasked with conservation planning for grassland birds and other species, the focus of the workshop was an interactive collaborative activity incorporating species adaptive capacity assessments, future climate projections, and adaptation menus into the decision‐making process. Herein, we describe the methods used to design and deliver the training series, as well as lessons learned for future climate literacy programs aimed at natural resource managers.

Rethinking service blueprint for digital coopetition: A new framework for networked collaboration

This study adapts traditional service blueprint methodologies for technology-driven coopetition networks, where companies simultaneously collaborate and compete. Integrating insights from service science, we developed an enhanced service blueprint framework with three key components: the cyber frontstage Lane for digital interactions, the physical backstage Lane for physical operations, and the support stage lane for supporting processes. Empirical validation in the Portuguese stone sector demonstrated the framework’s effectiveness in identifying network dysfunctions and its ease of use for industry professionals. Feedback highlights its relevance in capturing the complexities of modern digital coopetition and managing interactions and resources. This research underscores the necessity of updating service blueprint methods to optimize service delivery and value co-creation in digitally evolving sectors.

Health Infrastructures in India with Special Reference to MSME Sector - An Assessment

The healthcare enterprise consists of each the general public and business sectors and consists of scientific tourism, hospitals, fitness insurance, scientific equipment, and outsourcing. The creation of healthcare products, inclusive of scientific equipment, instruments, and services, in addition to for biotechnology and diagnostic laboratories via way of means of Indian Startups affords an answer within side the shape of healthcare services and products and quickens technological innovation to face up to international competition. The National Health Policy, which changed into posted in 2017 to construct the fitness care infrastructure, and the Pradhan Mantra Ayushman Bharat understand the significance of pharmaceutical agencies for enhancing healthcare. The pinnacle 20 markets for scientific gadgets are closely encouraged with the aid of using the scientific tool sector. MSME makes up 6.11% of the GDP from manufacturing, 24.63% of the GDP from services, and 45% of the whole exports. According to the Medical Tourism Index (MIT) for 2020–21, scientific era in India is predicted to attain US $50 billion with the aid of using 2025 and is now positioned 10th. Out of forty six international locations, India`s healthcare marketplace is predicted to attain US$372 billion with the aid of using 2022.usedsecondary data in this paper for discussed Health infrastructures and evaluate role of Health facilities and problems in Health sector in India by secondary source.

ASSESSMENT OF THE IMPACT OF FINANCIAL AND NON-FINANCIAL INSTRUMENTS ON EQUITY AND CASH FLOWS AS THE BASIS FOR DECISION-MAKING TO INCREASE ENTERPRISE MARKET CAPITALIZATION

The market capitalization of an enterprise is one of the key indicators that characterize the degree of influence of financial and non-financial instruments on its volumes and dynamics. Establishing the relationship between such instruments and metrics of equity and cash flows best outlines the plane of their direct impact on stimulating market capitalization and implementing effective management measures in the context of optimizing the use of equity and cash flows. The purpose of the study is to establish how the impact of indicators of financial and non-financial instruments on equity and cash flows forms an appropriate basis for making managerial decisions to increase the market capitalization of enterprises. As a result of the study, the toolkit for increasing the market capitalization of the enterprise from the standpoint of its grouping in terms of financial and non-financial plane was clarified. It was found that among the 36 analyzed indicators of the impact on equity and cash flows of the studied machine-building enterprises in Ukraine during the period 2010-2021, the most significant are bank lending, investment and technical metals, research and development costs, foreign scientific and technical services received, production investments, work-in-progress, and accounts payable for products, goods, and services. The results were transformed into a model of ranked instruments for stimulating the market capitalization of machine-building enterprises, which demonstrates the degree and directions of the influence of indicators of financial and non-financial instruments on the dynamics of equity and cash flows, which ensures the formation of an information database for making decisions on the further use of such instruments. The structuring of the toolkit serves as the basis for forming a system of management decisions containing practical recommendations within each group of instruments aimed at optimizing market capitalization through increased equity and cash flows of the enterprise. The obtained results will be beneficial to financial analysts of enterprises in preparing databases for making financial and non-financial decisions.

Pre-mixed small engine fuels (SEFs): Ignitable liquid analysis, canine detection, and a discussion of formulation changes

A variety of types and brands of pre-mixed small engine fuels (SEFs) were analyzed by gas chromatography-mass spectrometry (GC–MS) to determine their ignitable liquid composition. Additionally, many of these brands and fuel mixes were tested six years apart, first in 2018 and again in 2024, to determine if any formulation changes had occurred. All tested products were comprised of a range of isoparaffinic content, and most also contained at least one aromatic compound. One product marketed as a fuel treatment to fix ethanol-related issues contained 2-butoxyethanol. To determine Bureau of Alcohol, Tobacco, Firearms and Explosives (ATF) ignitable liquid detection canine (ILDC) response to the specific combination of ignitable liquids in these products, ILDC teams searched representative samples of the SEFs with no detection difficulty shown for the vast majority of these products. Reporting the ignitable liquid classification of SEFs would be dependent upon individual forensic science service provider (FSSP) protocols and the appearance of the ignitable liquid in casework data. The classification possibilities for these mixtures are discussed, including a case example of data resembling an SEF.

'A symbiosis in the sense of improving patient benefit'

'Implementation science and health services research must come together even more closely at their intersection and work together more than before.' This is the plea of Prof Dr Juliane Köberlein-Neu, holder of the Chair of Health Services Research and Health Economic Evaluation at the University of Wuppertal and Congress President of the 23rd German Congress for Health Services Research. Professor Köberlein-Neu explains the congress title 'Implementation knowledge creates innovative care' in the cover interview with 'Monitor Versorgungsforschung' and talks about what she hopes to see from both scientific disciplines in the future.

Implementation Science of Integrating Pre-Exposure Prophylaxis in Pharmacist-Led Services in the United States.

Racial inequities in HIV in the United States (US) are pervasive. Pre-exposure prophylaxis (PrEP) is one of the most effectiveyet underutilized HIV prevention strategies, and stark inequities in PrEP uptake exist. Lack of access to PrEP clinics is a majorbarrier to access that could be overcome by integrating pharmacists into the provision of PrEP services including prescribingand dispensing. A number of reviews have shown promise in folding pharmacies into the expansion of PrEP services, but this review extends those by examining the implementation science evidence of pharmacist-led PrEP services in the US. We reviewed literature over the past five years of the implementation science of pharmacist PrEP services (2018-2023) and present seminal findings in this area. Only two studies are anchored within an implementation science framework despite all studies assessing common implementation science constructs. Overwhelming evidence supports feasibility and adoption of PrEP services in pharmacies yet gaps in workflow integration, scalability and sustainability exist. Continuing to build the implementation science evidence of pharmacy-based PrEP services is critical to standardize our measures across varying contexts and inform policy efforts that support pharmacy-based PrEP services.

Concept analysis of patient journey disruptions: the obstacle of integrated care

PurposeThis article aims to clarify the concepts used to understand, analyze and improve a patient’s progress through a health service system. A patient pathway describes plans and intentions. Within it, we distinguish between the clinical pathway of decisions and interventions and the care pathway of supportive activities. As a patient pathway is implemented, it turns into a patient journey of what is done, what happens to a patient’s medical condition and what is experienced and felt. We introduce “patient journey disruption” (PJD) as a concept describing the events that need to be prevented from happening to accomplish integrated, coordinated and seamless care.Design/methodology/approachThe method used in this paper is concept analysis. First, an expert steering group worked to refine the concept of PJDs; second, an analysis of similar concepts from related fields was done to root the concept into existing theories, and third, semi-structured interviews with professionals and patients were done to test the concept of PJDs in the home care context.FindingsPJDs are agency-based harmful events in the execution of the care pathway that deviate the patient journey from what can be reasonably expected. PJDs are management failures, which is why they should be studied by healthcare operations management (HOM) and service science scholars with the intention to find ways to prevent them from happening.Research limitations/implicationsThis study has limitations, including presenting conceptual ideas and preliminary results that are only indicative.Practical implicationsWe believe that the introduction of the concept of PJDs into the literature provides a new, systematic way of approaching the different shortcomings in our healthcare production systems. Moreover, by systematically identifying different PJDs, interventions can be designed and targeted more appropriately.Originality/valueManagerial challenges regarding healthcare processes have been studied but have not been well defined. The concept of PJDs is an original, well-thought-out definition.