Developmental Research Articles

Psychological impact of the covid -19 pandemic on school age children

Introduction: The psychological impact of the COVID-19 pandemic on the general population has been widely studied. However, few studies have been carried out on children, even though they are experiencing a difficult situation and major stress that may expose them to significant psychological suffering. We are interested in how children perceive these emotional changes during the confinement associated with the COVID-19 pandemic. The aim is to understand the impact of the pandemic and containment on children. To do this, we assessed the prevalence of depression, anxiety and perceived post-traumatic stress in school-age children, looking for factors associated with these psychopathological dimensions with a view to better management and intervention to reduce the possible negative effects of this situation. Methodology: This is a cross-sectional study based on gathering information from all primary school pupils in Fez, who responded freely and voluntarily. The study was carried out over a period of two months, from June 2020 to August 2020, using an online self-questionnaire and psychometric evaluation scales: QIPS, CDI, CRIES-13. Results: 330 students met our inclusion criteria. The mean age of our participants was 8.68 ± 1.94 years, with a minimum of 6 years and a maximum of 12 years. There was a slight female predominance, with 168 girls (50.9%) and 162 boys (49.1%). Most of the pupils (95.2%) lived in urban areas, 92.7% of the children had married parents, and 64.5% of our participants had parents with a university education. Almost half of the children had a family income of more than Dhs10,000 per month. Only 2.1% of the children had a psychiatric history, 16.7% of the children had a history of somatic illness, 22.1% of the participants had a family psychiatric history, 11.2% of our participants had experienced a stressful event in their lives and 22.1% had parents who had previously experienced a stressful event. Evaluation of the CRIES-13 scale showed that 39.4% had a positive score of over 30 in favour of significant symptoms of post-traumatic stress disorder, a probable depressive state (CDI score>15) was revealed in 26.1% of the children, and with regard to anxiety disorder, the mean score in our sample was 32.27 (±8.147) with a median of 29. The analytical study showed a statically significant relationship between certain socio-demographic characteristics, namely: parents' low level of education, living with divorced parents, low monthly family income and negative psychological impact during the pandemic. On the other hand, female gender was correlated with the occurrence of anxiety. Our study also revealed other correlations, notably between the presence of a personal history of psychiatric or somatic illness and the occurrence of depression, family psychiatric history, and the experience of a stressful event by the child and parents were factors strongly associated with the three psychological disorders studied. Factors related to the child's lifestyle, such as the practice of physical activity at home, a daily study period of less than 2 hours, and dissatisfaction with distance learning, were associated with psychological distress during confinement. In addition, certain personality traits seemed to be implicated in the worsening of this condition during confinement: the presence of a relative with covid-19, the child's knowledge of the pandemic, and the fear that the pandemic would continue. Conclusion: The COVID-19 pandemic has had a severe impact on the general public, particularly children, psychological interventions identifying and targeting children at risk are urgently needed, and future studies are warranted to design and evaluate the effectiveness of interventions.

Nutritional status, dietary habits, and their relation to cognitive functions: A cross-sectional study among the school aged (8-14 years) children of Bangladesh.

Limited research addressed links between nutritional status, dietary habits, and cognitive functions in young children. This study assessed the status of cognitive functions and their association with nutritional status and dietary habits of school age children of Bangladesh. This cross-sectional multi-centre study was conducted on 776 participants in 11 conveniently selected educational institutions. A printed questionnaire with three sections (Section 1: background information, section 2: PedsQL™ Cognitive Functioning Scale, and section 3: semi-quantitative food-frequency questionnaire) was utilized for the data collection purpose. Sections 1 and 3 were self-reported by parents, and trained volunteers completed section 2 in-person along with the anthropometric measurements. Statistical analyses were done in Stata (v.16). Mean with standard deviation and frequencies with percentages were used to summarize quantitative and qualitative variables, respectively. Pearson's chi-square test and Spearman's rank correlation coefficient were used to explore bivariate relationships. The mean age of the participants was 12.02±1.88 years, and the majority (67%) were females. The prevalence of poor cognitive function was 46.52%, and among them, 66.02% were females. In terms of body mass index (BMI), 22.44% possessed normal weight, 17.51% were overweight, and 5.19% were obese. This study found a statistically significant relationship between BMI and cognitive functions. Furthermore, different dietary components (e.g., protein, carbohydrate, fat, fiber, iron, magnesium) showed a significant (p<0.05 for all) weak positive correlation with cognitive function. BMI and dietary habits were associated with the cognitive function of young children in Bangladesh. Although the cross-sectional design of the study precludes causal relationships from being determined, the study finding deserves further examination via longitudinal research.

Эмпирическое исследование особенностей координационных функций у слабослышащих детей младшего школьного возраста

&lt;p&gt;The article examines the features of coordination functions (static, dynamic, spatial, object and symbolic coordination) in hearing-impaired children of primary school age from the perspective of N.A. Bernstein`s psychophysiological movement theory. According to this theory, there are five levels of the movement construction system: the level of static coordination (A), the level of dynamic coordination (B), the level of spatial coordination (C), the level of object coordination (D) and the level of symbolic coordination (E). 60 respondents took part in the study. 30 hearing-impaired primary schoolchildren (7&amp;ndash;11 years old) with sensorineural hearing loss (13 girls and 17 boys) were included in the experimental group, and 30 primary schoolchildren (7&amp;ndash;11 years old) without hearing impairment formed the control group (16 girls and 14 boys). The parameters of coordination functions were assessed using neuropsychological tests. A comparative analysis of the development of coordination functions in children from the experimental and control groups revealed a decrease in their dynamic characteristics such as pace and accuracy, which confirms the insufficiency of all these levels of movement organization in children of primary school age with sensorineural hearing loss, compared to children without hearing impairments.&lt;/p&gt;

Sensitive periods of flexibility development at school age

The objective is to identify sensitive periods for the accentuated development of flexibility of schoolchildren. Methods: the scientific research was conducted on the basis of 60 schools in the city of Kirov, in Russia from September 14, 2022 to May 22, 2023. The pedagogical experiment involved 1,217 children (579 boys and 638 girls) from grades 1 to 11 of secondary school number 60 Kirov, Russia. Each lesson in the discipline "Physical education" lasted 40 minutes and took place 3 times a week. All students were engaged in the usual physical education program at school. All students took the tests at the beginning and at the end of the school year. The level of flexibility development was determined by the test "Leaning forward from a standing position on a gymnastic bench." Excel was used to process the results of the study, the Biostatistics-2022 program determined the reliability of the results of the T-Student study. Results: After the end of the study, the average indicators in each age group increased during the academic year. In the indicators of boys from the beginning to the end of the study, there was a significant and significant increase in flexibility indicators in the second grade (+15%), in the third grade (+17%) and in the fourth grade (+15%). In girls, a significant increase in the value is noted in the third grade (+16%), fifth grade (+14%) and sixth grade (+15%). In other age periods, there is not a significant increase in flexibility indicators (p&gt;0.05). Conclusion: As a result of this large-scale study, it can be argued that the targeted development of flexibility should be in boys aged 8 to 11 years, and in girls aged 9-10 years, 11-12 years and 12-13 years. Keywords: Physical exercises, Joint mobility, Muscle stretching, Physical education.

Learning at a distance: recognising remote tutoring as a career

Remote Education Tutors (RETs) enact crucial roles in Australian distance schooling, by living with families who reside in geographically isolated locations and supporting their school age children’s learning. As part of a larger research project, this paper presents a study of four RETs derived from semi-structured interviews conducted in their respective home schoolrooms. Informed conceptually by Bronfenbrenner’s socio-ecological systems theory (1979, 1986), the thematic analysis generated four substantive themes related to the participants’ lives and work: pedagogical competencies; healthy relational dynamics; optimism with a solution focus; and substantive occupation. More broadly, the RETs contribute indispensably to the educational success and the lifestyle sustainability of the school age children with whom they work, yet currently there is no formal recognition of that contribution, just as there is no viable career pathway for RETs seeking to become qualified teachers. Accordingly, they are as occupationally invisible as the remote living families whom they serve.

Reproducibility between preschool and school-age Social Responsiveness Scale forms in the Environmental influences on Child Health Outcomes program.

Evidence suggests core autism trait consistency in older children, but development of these traits is variable in early childhood. The Social Responsiveness Scale (SRS) measures autism-related traits and broader autism phenotype, with two age-dependent forms in childhood (preschool, 2.5-4.5 years; school age, 4-18 years). Score consistency has been observed within forms, though reliability across forms has not been evaluated. Using data from the Environmental Influences on Child Health Outcomes (ECHO) program (n = 853), preschool, and school-age SRS scores were collected via maternal report when children were an average of 3.0 and 5.8 years, respectively. We compared reproducibility of SRS total scores (T-scores) and agreement above a clinically meaningful cutoff (T-scores ≥ 60) and examined predictors of discordance in cutoff scores across forms. Participant scores across forms were similar (mean difference: 3.3 points; standard deviation: 7), though preschool scores were on average lower than school-age scores. Most children (88%) were classified below the cutoff on both forms, and overall concordance was high (92%). However, discordance was higher in cohorts following younger siblings of autistic children (16%). Proportions of children with an autism diagnoses were also higher among those with discordant scores (27%) than among those with concordant scores (4%). Our findings indicate SRS scores are broadly reproducible across preschool and school-age forms, particularly for capturing broader, nonclinical traits, but also suggest that greater variability of autism-related traits in preschool-age children may reduce reliability with later school-age scores for those in the clinical range.

Testing the reported long-term advantages of protein-fortified human milk in very low birth weight neonates

Preterm infants are at-risk for extrauterine growth restriction and downward percentile-crossing between birth and discharge. Increased energy and protein intake through fortification of human milk during the first weeks of life has been associated with improved short-term growth and better developmental outcomes. The aim of this study was to evaluate whether these benefits persist up to children school age. The study was designed as an observational study. During hospitalization, 22 very low birth weight preterm infants were fed with increasing protein fortification of human milk (protein supplemented group, PSG). As a control group (CG), 11 preterm infants were fed with standard nutrition regimen. At children school age (9–11 years), we assessed anthropometric data (weight, height, BMI), global health (renal function), and specific psychological outcomes (Child Behavior Checklist 6–18). A global homogeneity between CG and PSG groups emerged: we found no significant differences in weight, height, and BMI, nor in internalizing symptom outcomes (all ps &amp;gt; 0.05). However, mothers reported significantly higher externalizing symptoms for the PSG infants compared to CG infants. Therefore, neonatal enteral protein supplementation in very low birth weight preterm infants leads to no positive nor adverse consequences in long-term assessment, suggesting that benefits are restricted to the neonatal term and first years of age.

Children with developmental coordination disorders: a review of approaches to assessment and intervention

Developmental Coordination Disorder (DCD) is a neurodevelopmental disorder characterized by deficits in motor skills, with gross and fine motor dysfunction being the main symptom. This condition greatly impairs children’s daily life, learning, and social interaction. Symptoms typically appear during preschool or school age, and if left untreated, they can persist into adulthood. Thus, early assessment and intervention are crucial to improve the prognosis. This study aims to review the existing literature on DCD, providing a comprehensive overview of the assessment for children with DCD in terms of body functions and structures, activities and participation, and environmental factors within the framework of the International Classification of Functioning, Disability, and Health - Children and Youth (ICF-CY). Additionally, specific rehabilitation interventions will be described, offering valuable insights for the clinical assessment and intervention of children with DCD.

Hermeneutic Phenomenological Study of Nepalese Migrant Worker's Families from Communication Perspective

This research study is conducted to explore the role of intrapersonal communication on human development of international migrant workers' left behind family (IMWLF). It considers these left behind families to have difficult life conditions due to the separation with their family members. It includes the experience of migrant workers' left behind son, daughter and spouses. Study has explored the variation in qualitative experience in this life condition due to their gender identity. Major focus is on human physiological, psychological, emotional, cognitive, intellectual and spiritual development. Hermeneutic phenomenological qualitative study is conducted through an in-depth interview of 4 participants from international migrant workers' left behind families based on interpretive research philosophy in a cross-sectional time frame on inductive approach. Inductive approach is implied to see the individual development within a wider area of human development. Major finding of this study is that family separation caused by migrant working has highly impacted their human development in various spheres as in studied variables such as physiological, psychological, emotional, cognitive, intellectual and spiritual level. Positive intrapersonal communication skills enhancement is explored as needed for intervention for the qualitative human development of these research participants in specific and in general of international migrant workers left behind families in Nepal.

Cardiac development demystified by use of the HDBR atlas.

Much has been learned over the last half century regarding the molecular and genetic changes that take place during cardiac development. As yet, however, these advances have not been translated into knowledge regarding the marked changes that take place in the anatomical arrangements of the different cardiac components. As such, therefore, many aspects of cardiac development are still described on the basis of speculation rather than evidence. In this review, we show how controversial aspects of development can readily be arbitrated by the interested spectator by taking advantage of the material now gathered together in the Human Developmental Biology Resource; HDBR. We use the material to demonstrate the changes taking place during the formation of the ventricular loop, the expansion of the atrioventricular canal, the incorporation of the systemic venous sinus, the formation of the pulmonary vein, the process of atrial septation, the remodelling of the pharyngeal arches, the major changes occurring during formation of the outflow tract, the closure of the embryonic interventricular communication, and the formation of the ventricular walls. We suggest that access to the resource makes it possible for the interested observer to arbitrate, for themselves, the ongoing controversies that continue to plague the understanding of cardiac development.

Indoor air pollution: an Italian Knowledge, Attitude and Practice (KAP) study among the general population.

Indoor air pollution negatively affects population health and the national health services in terms of socio-economic costs. The presence of indoor pollutants depends a lot on lifestyles. The aim of this work is to evaluate knowledge, daily habits and the preventive behaviors in order to contrast the effects on health caused by indoor pollutants. The study was conducted through the administration of questionnaires to the population resident in the metropolitan city of Messina (Italy), asking about sociodemographic characteristics, knowledge, daily habits and preventive behaviors. The questionnaire was filled by 894 subjects (46.8% M; 53.2% F). Regarding knowledge, 66.8% had heard of indoor air pollution and 94.9% knew what the most common indoor pollutants are; regarding daily habits they often aired out the house (91.9% in the morning and 71.4% after cleaning), 24.8% were smokers and 36.7 of them smoked indoors; regarding preventive behaviors, 41.6% chose the cleaning products based on habit and only 32.9% bought plants able to purify environments. Although the analyzed population had adequate knowledge of indoor air pollution, this did not strongly impact on the adoption of healthy lifestyles. Therefore, it becomes necessary to intervene on a social level with environmental education activities, starting from school age.

АЛГОРИТМ – МЕТОДИЧЕСКАЯ ПОДГОТОВКА БУДУЩИХ УЧИТЕЛЕЙ НАЧАЛЬНЫХ КЛАССОВ В ОБУЧЕНИИ НАЧАЛЬНОМУ ЕСТЕСТВОЗНАНИЮ

The article “Algorithm - methodological training of future primary school teachers in teaching primary natural science” is devoted to the urgent problem of teacher training in teaching primary natural science at school for children of primary school age. The authors of the work conducted a study of teaching methods in the process of teaching primary science in primary schools, necessary for the methodological training of school teachers. A detailed analysis of teaching methods made it possible to identify the shortcomings and advantages of the analyzed methods and showed the possibility of their improvement through a successful combination of various methods in the course of teaching primary science to children of primary school age. The authors of the article, using their own examples, convincingly proved the effectiveness of a combination of traditional and innovative teaching methods. In addition to traditional teaching methods such as conversation, story, explanation, practical methods, in modern conditions of informatisation of society, methods such as the use of audio and video films and the use of the latest computer systems play an important role in the methodological training of future primary school teachers in teaching primary science.

Multiple endocrine neoplasia type 2B diagnosed after small intestinal volvulus with progressive megacolon in an adolescent.

Multiple endocrine neoplasia type 2B is a rare autosomal dominant disease characterized by the presence of medullary thyroid carcinoma, pheochromocytoma, Marfan-like fatigue, a peculiar face with thickening of the lips, mucosal neuromas on the lips and tongue, and gastrointestinal phenomena. Most patients harbor pathological variants of the RET gene. Herein, we present the first case of a 14year-old boy who experienced small intestinal volvulus along with a megacolon, and he was diagnosed with multiple endocrine neoplasia type 2B. The patient complained of constipation since he was 2years old and slowly progressive abdominal distension at school age. At 14years of age, he presented with remarkable megacolon mimicking Hirschsprung's disease and complicated with small intestinal volvulus. The volvulus was successfully repaired, and the particularly dilated transverse colon was resected following a rectal biopsy. Histopathological evaluation of the resected transverse colon revealed to be compatible with ganglioneuromatosis. After emergency surgery, the patient was diagnosed with multiple endocrine neoplasia type 2B with medullary thyroid carcinoma, and a de novo variant of RET was confirmed. Gastroenterologists should consider it when treating patients with constipation, especially those with megacolon. Therefore, timely diagnosis may lead to appropriate treatment of medullary thyroid carcinoma and improve mortality.

Association between preterm infant body composition in the first 3months of life and preschool age: a cohort study.

Compared with full-term infants, preterm infants have fat-free mass deficit in the first months of life, which increases the risk of metabolic diseases in the future. In this cohort of children born under 32-week gestational age or less than 1500g, we aimed to evaluate the associations of body composition at term equivalent age and in the first 3months of life with fat-free mass and fat mass percentage at 4 to 7years of life. Body composition assessments by air displacement plethysmography and anthropometry were performed at term, at 3months of corrected age, and at 4 to 7years of age. Multiple linear regression analysis was used to observe the associations between body composition at these ages. At term, fat mass percentage showed a negative association and fat-free mass a positive association with fat-free mass at 4 to 7years. The fat-free mass at 3months and the gain in fat-free mass between term and 3months showed positive associations with fat-free mass at 4 to 7years. Conclusion: Body composition at preschool age is associated with fat-free mass in the first 3months of life, a sensitive period for the risk of metabolic diseases. What is Known: • Preterm infants have a deficit in fat-free mass and high adiposity at term equivalent age compared to full-term infants. • Fat-free mass reflects metabolic capacity throughout life and therefore is considered a protective factor against the risk of metabolic syndrome. What is New: •Fat-free mass gain in the first 3months of corrected age is associated with fat-free mass at preschool and school ages. •The first 3months of life is a sensitive period to the risk of metabolic diseases.

워킹맘의 평가염려 완벽주의와 직무소진의 관계

Objectives This study aimed to examine whether mindfulness mediates the relationship between evaluative con-cern perfectionism and job burnout among working moms Methods For the research, an online survey was conducted with full-time working mothers with children under elementary school age, addressing evaluative concern perfectionism, job burnout, and mindfulness. A total of 250 responses were analyzed using SPSS 27.0 and AMOS 27.0. Results The analysis revealed significant correlations among the key variables. Additionally, mindfulness was found to partially mediate the relationship between evaluative concern perfectionism and job burnout among working moms. The individual trait of evaluative concern perfectionism corresponds to job demands leading to burnout, and in such cases, mindfulness appears to play a role in mitigating maladaptive influences as a job resource. Conclusions This implies that mindfulness, serving as a personality factor and a cognitive-behavioral intervention focus, plays a crucial role in addressing job burnout among working moms who exhibit perfectionistic tendencies. Finally, the implications and limitations of this study were discussed.

Sexual Dimorphism of Elastic Fibers in Prenatal Lung Mice

Scientific data has revealed the existence of lung gender differences and therefore sparked a renewed interest in understanding the underlying mechanisms and their effect in the healthy lung development and/or in pathological conditions. Elastic fibers have an important role in lung development during pre and post-natal stages, because a well-developed pulmonary elastic fibers favour pre-natal lung maturation and enhance alveolarization. Sexual differences studies on lung elastic fibers content are focused essentially on the post-natal stage, with scarce data on pre-natal lung development. Using an experimental mice model, we developed this research work to study gender differences in the lungs elastic fibers during gestational days E15-E19, using image analysis and elastin HPLC methodologies. Our results show significant sexual dimorphism in lung elastin and elastic fibers content pre-natal stage, which is more evident in the last two gestational days (E18 and E19). Female’s mice have more elastin and elastic fibers which could mean that the elastogenesis process begins earlier than males. These results are an important contributes to understand the underlying factors involved in physiology and lung development sexual difference.

Neurodevelopmental outcomes and occupational participation of preterm children at school age: a scoping review

Preterm children may experience major challenges that affect their occupational participation and daily functioning, especially at school age. This scoping review aims to examining and synthesizing the available literature about adverse neurodevelopmental outcomes and occupational participation restrictions of preterm children born &lt; 37 weeks of gestation. The MEDLINE, Science Direct, CINAHL databases were searched from January 2013 to December 2023, for published cohort studies that assessed the neurodevelopmental outcomes and occupational participation of school-aged preterm children, compared to full-term born peers. Out of 6631 identified articles, 13 studies met the inclusion criteria and involved 958 preterm children, aged 6-10 years old. Studies included in the current scoping review reported adverse neurodevelopmental outcomes, such as cognitive impairment, executive function and sensory processing deficits, emotional and behavioral problems, language and visual perception difficulties, as well as occupational participation restrictions, like feeding difficulties, academic challenges and peer relationship problems. Findings suggest that neurodevelopmental deficits and occupational participation restrictions, especially in extremely preterm children, not only exist in early childhood but persist during school age. Future research should focus on exploring potential differences or patterns in neurodevelopmental outcomes and occupational participation between preterm groups with different gestational age ranges.

Trajectories of Perceived Parental Psychological Control and the Longitudinal Associations with Chinese Adolescents' School Adjustment across High School Years.

Past research supports the detrimental effects of parental psychological control on adolescent school adjustment in both emotional and academic domains. However, how psychological control changes during adolescence, and how such developmental course is related to adolescent psychological well-being and academic functioning are unclear. The direction of effects between parenting and child behaviors is also inconclusive. This 3-year longitudinal study addressed these research gaps by using five waves of survey data on 710 Chinese adolescents of high school ages (Mean age at T1 = 15.54 years, SD = 0.45, 50% males). Using latent growth curve models and latent class growth analysis, the majority of adolescents (about 63%) reported gradual increases of parental psychological control in the first 2 years of high school but a slight decline afterwards, while the other 37% perceived low and stable levels. Results from parallel latent growth modeling suggested that trajectories of psychological control were positively related to developmental trends of internalizing problems (i.e., depression and anxiety) and maladaptive academic functioning, but negatively associated with the trajectory of adaptive academic functioning, as indexed by intercept-intercept and slope-slope associations. The random-intercept cross-lagged models further revealed that psychological control was predictive of adolescent anxiety and lower adaptive academic functioning, and bidirectionally associated with maladaptive academic-related beliefs and behaviors at the within-person level. Taken together, these findings highlight the crucial role of parental psychological control on adolescent school adjustment in the Chinese cultural context and support the reciprocal model of parent-child interactions.

The Long-term Effect of Cantonese Usage under the Dominance of Mandarin on Academic Performance

Researches on the effect of bilingualism/diglossia on academic performance conclude disparately yet converge on the children of early school age. This research aims to figure out the longer-term influence of Cantonese usage on academic performance by conducting a large sample survey and the Chinese reading literacy assessment of PISA 2018 on 100 young citizens aged 18 to 25 in Guangdong province. In addition to reconfirming the vastness of Cantonese-Mandarin bilinguals in Guangdong province, China, The Language History Questionnaire 3 detected a categorically strong dominance of Mandarin in the Cantonese districts of Guangdong. Nevertheless, it is still not suggested that the Guangdong parents preclude Cantonese from family language planning out of worry about the childrens academic performance, drawing on the result that no negative effect of Cantonese usage was found in the correlation test.

Complete Blood Count Reference Intervals for Children Aged Less Than 1 to 12 Years in the Northern Region of Ghana.

Reliable laboratory diagnostic results are key for evaluating and improving children's health. To interpret these results, child-specific reference intervals (RIs), which account for constant biological changes and physiological development with sex and age, are required, as recommended by the Clinical and Laboratory Standards Institute (CLSI). This study presents age- and sex-specific reference intervals for complete blood count (CBC) parameters in children (<1-12 years old) in the Northern Region of Ghana. In this cross-sectional study, 600 healthy children from randomly sampled schools in Tamale (the Northern Region) were recruited and screened. Data from 388 eligible children were used to nonparametrically determine the reference intervals of CBC parameters at the 2.5th and 97.5th percentiles. The CBC reference intervals were compared for variations in sex and age groups using the Wilcoxon rank-sum test. There were no statistically significant differences in most CBC parameters by sex (RBC, Hb, HCT, MCH, RDW (CV/SD), WBC, LYM#, MON#(%) NEU#(%), EOS#(%), and BAS#(%); p > 0.05) and age group (RBC, MCV, RDW (CV/SD), WBC, LYM#, MON#(%) NEU#(%), EOS#(%), and BAS%; p > 0.05). However, there were observable differences between this locally established CBC reference interval and that used for children at Tamale Teaching Hospital (manufacturer's RIs). This study emphasises the importance of determining reference intervals representative of the local child population and incorporating them into the current reporting system of laboratories in the Northern Region to ensure the provision of effective and efficient healthcare services.