This study was aimed to investigate the psychological mechanisms underlying non-suicidal self-injurious behavior. For this purpose, we hypothesized that dysfunctional child modes act as a psychological mechanism to influence the relationship between negative parent-child relationships in childhood and current cognitions (catastrophizing), emotions (emotional dysregulation and depression), and behaviors (non-suicidal self-injurious behaviors). A sample of 430 college students (male 97, female 333) with experience of non-suicidal self-injurious behavior was selected to test the multi-mediation effects of child schema mode (angry, impulsive), catastrophizing, emotional dysregulation, and depression on the relationship between negative parent-child relationships in childhood and non-suicidal self-injury. As a result of structural equation modeling analysis, it was found that negative parent-child relationships in childhood directly influenced child schema mode, catastrophizing, depression, and non-suicidal self-injurious behaviors. In addition, it was found that negative parent-child relationships in childhood were dually mediated by child schema mode and depression and child schema mode and emotional dysregulation. The present study highlights the mediating role of child schema modes as a psychological mechanism underlying the relationship between negative parent-child relationships in childhood and non-suicidal self-injurious behavior. Based on these findings, the usefulness and direction of schema therapy interventions in the field of non-suicidal self-injury counseling are discussed.