There is no financial information to disclose. Bone grafting can fail in scaphoid non-unions, generally due to unfavorable local conditions, perfectible surgery or poor patient compliance. With added devascularization, bone loss and demotivation, it may seem unsafe to repeat a similar procedure. This series of 48 iterative scaphoid bone grafts shows it is possible to obtain an 82% healing rate, even in these difficult conditions. The series is part of a prospective global single-operator series of 366 scaphoid non-unions grafted between 1991 and 2015. Twenty-four patients were operated elsewhere, 24 were personal failures. The series includes 45 male and 3 female patients, average age 29. The average delay from fracture to first graft was 5,6 years, between grafts was 8 months. Thirteen patients were smokers, 7 stopped during healing. Eight were on workers compensation. Pre-operative grip strength was 45% of contralateral, ROM 66%, pain was estimated 4,5/10. The initial fracture was situated in the proximal third 9 times, middle third 38 times, and distally in 1 patient. Thirty-two patients had no degenerative changes, 11 presented radio-scaphoid lesions at various stages, and 5 had radio-and intra-carpal involvement. The first graft was non-vascularized in all but one case. The second was an iterative illiac graft in 11 cases, a vascularized anterior radius graft in 29 cases, a microsurgical femoral condyle graft in 10 cases. (Two patients were grafted a third time.) All patients had clinical and x-ray follow-up ( average 6,2 years, 4-260 months). Forty-one patients (82%) had healed, confirmed by CT scan when in doubt. There were no infections nor cases of RSD, 12 hardware removals and minor bone trimmings. None of the 7 failures requested a salvage procedure. In successful grafts, pain was down to 1,5/10, strength was 75% of contralateral, ROM unchanged. Average DISI measured 9 degrees. Bone fusion was shown to halt most degenerative changes. Compared to our main cohort of bone grafts for scaphoid non-union, this series of 48 patients included more males, who were initially stiffer, more painful and smoked more frequently. These secondary grafts gave a lower success rate (82 instead of 93%) with less post-operative ROM, less strength but the same pain relief, when union was achieved. •The study illustrates some of the causes for failure in scaphoid healing and shows the importance of vascularized bone grafts, free if necessary, when re-operating failed scaphoid non-unions.•Faced with persistant scaphoid non-union, repeated bone grafting seems a good alternative to salvage procedures in most patients.