SAS Scores Research Articles

The analysis of the effect of psycho-intervention combined with diazepam on patients with sudden sensorineural hearing loss and anxiety

Objective: To investigate the therapeutic effect of psychological intervention combined with diazepam on sudden hearing loss patients with anxiety. Method: 108 cases of sudden hearing loss patients with anxiety were randomly divided into two groups(n=54 in each group): The control group received routine treatment of sudden hearing loss, the study group was given psychological intervention combined with diazepam tablets(2.5 mg once, twice a day) based on the routine treatment. The hearing and HAMA and SAS scores were reviewed after 10 days of treatment. Result: After 10 days of treatment, the average hearing threshold of patients in the control group and the study group were respectively increased by （19.65±7.89）dB and （26.93±9.04）dB (t=4.54, P=0.006), the HAMA score of two groups were respectively decreased by 4.68 and 10.75（t=9.949, P=0.000）and the SAS score of two groups were respectively decreased by 15.93 and 23.39 (t=6.773, P=0.000), and the total efficiency of hearing of two groups were 61.11% and 77.78% (χ²=4.441, P=0.035),respectively. the differences were statistically significant. Conclusion: Psychological intervention combined with diazepam can relieve anxiety in patients with sudden hearing loss effectively, and play a positive role in the development and prognosis of patients with sudden sensorineural hearing loss.

Effects of psychological crisis intervention in amputation patients with limbs high-voltage burns

Objective To explore the effects of psychological crisis intervention in amputation patients with limbs high-voltage burns. Methods A total of 68 amputation patients with limbs high-voltage burns who were treated in Harbin Fifth Hospital from January 2011 to December 2016 were selected in this study using purposive sampling. The participants were randomly divided into the observation group (n=34) and the control group (n=34) . The control group received routine psychological nursing care while the observation group was given psychological crisis intervention. The Stress Reaction (SR) , SAS, and SDS were used to evaluate the effects of the intervention. Results The observation group had significantly lower scores of SR, SAS, and SDS compared with the control group [ (17.89±3.66) vs. (26.89±3.98) for SR; (42.31±8.48) vs. (50.32±10.25) for SAS; (45.32±8.96) vs. (52.77±11.18) for SDS; (t=17.328, 4.512, 3.581; P<0.05) ]. Conclusions The psychological crisis intervention can effectively improve negative emotions such as anxiety and depression in amputation patients with limbs high-voltage burns. It helps patients to develop positive attitudes towards the reality of amputation. Key words: Burns, electric; Amputation; Psychological crisis intervention

Effect of emotional resilience group training on perceived stress, anxiety and depression in patients with gastrointestinal cancer

Objective To investigate the effect of emotional resilience group training on perceived stress, anxiety and depression in patients with gastrointestinal cancer. Methods 325 cases of patients with gastric cancer were divided into experimental group(n=163) and control group(n=162) by random digital table method.Two groups of patients were treated with chemotherapy and routine treatment and the experimental group was trained once a week for 8 weeks of emotional resilience group training.Chinese version perceived stress(CPSS), SDS and SAS were used to evaluate the effect of intervention before and after intervention. Results After 8 weeks of emotional elastic group training, the CPSS score((39.98±4.82) vs (33.96±5.02)), SAS score((48.83±4.58) vs (42.12±4.01)) and SDS score((49.23±4.12) vs (45.21±3.27)) were lower than those before the intervention(all P<0.05). The difference of CPSS((-6.02±3.74) vs (-0.19±2.78)), SAS((-6.71±3.86) vs (-0.39±5.62)) and SDS((-4.02±2.03) vs (-0.62±2.31)) before and after the intervention of the two groups were statistically significant(t=-9.325, -9.529, -6.132, P<0.01). Conclusion Emotional resilience group training can effectively reduce the level of perceptual stress in patients with gastrointestinal cancer, and improve depression and anxiety. Key words: Gastrointestinal cancer; Anxious; Depression; Perceived Stress

Application of rapid rehabilitation process under multidisciplinary collaboration mode in gynecologic malignancies patients

Objective To discuss the application effects of rapid rehabilitation process under multidisciplinary collaboration mode in gynecologic malignancies patients. Methods A number of 50 gynecologic malignancies patients hospitalized in our hospital from January to December 2015 were assigned as control group and received perioperative routine care. Another 50 gynecologic malignancies patients hospitalized between January and December 2016 were assigned as experimental group and received rapid rehabilitation process under multidisciplinary collaboration mode. The stress response, intestinal peristaltic recovery time, hospitalization time, complications and serum albumin changes of patients were compared between the two groups. Results At 1 h before surgery and 8 h after surgery, heart rate (HR) , systolic blood pressure (SBP) , SAS score of patients in the experimental group were lower than the control group, with statistically significant differences between two groups (P<0.05) . At 2 d and 7 d after surgery, the serum albumin level of patients in the experimental group was higher than the control group. Intestinal peristalsis recovery time and hospital time of patients in the experimental group were significantly shorter than those in the control group (P<0.05) . After the surgery, the incidence of complications of patients in the experimental group was lower than the control group. There were statistically significant difference between two groups (P<0.05) . Conclusions Rapid rehabilitation process under multidisciplinary collaboration mode can effectively alleviate the stress response of gynecological malignant tumor patients, improve the nutritional status of the body, promote postoperative recovery and reduce the incidence of complications, and is worthy of further clinical promotion. Key words: Neoplasms; Gynecology; Multidisciplinary collaboration mode; Rapid rehabilitation process

Effect of staged psychological nursing on the improvement of negative emotion and social support in patients with bone injury caused by traffic accident

Objective To explore the effect of staged psychological nursing on negative emotion and social support in patients with bone injury caused by traffic accident. Methods Totally 80 cases of bone injuries caused by traffic accident from February 2016 to January 2017 were selected as the subjects.The randomized digital table method was used to randomly assign patients and divided into the control group and the observation group according to the principle of random allocation,40 patients in each group.The control group received routine care measures, while the observation group received staged psychological intervention on the basis of nursing care of the patients in the control group.Self-rating Anxiety Scale(SAS),Self-rating Depression Scale(SDS) and Social Support Rating Scale (SSRS) were used to compare the difference between two groups of patients before and after intervention, such as negative emotion and social support. Results The observation group were treated by staged psychological nursing intervention, the SAS and SDS scores were (33.28±4.19),(35.71±5.18) points, which were significantly lower than control group(36.41±4.15),(38.12±5.03) points, the differences were significant(t=6.08, 1.96, P<0.01). The observation group of patients with objective social support,subjective social support and social support scores were (20.17±2.65), (24.81±2.84), (15.83±2.05) points, which were higher than the control group(16.11±2.54), (18.24±2.76), (12.34±2.01) points, the difference were statistically significant(t=7.14, 9.13, 7.32, P<0.05). Conclusions Staged psychological nursing can obviously improve the mental status of patients with fracture caused by car injury,reduce the incidence of depression and anxiety, and promote the recovery of patients.It is worthy of clinical application and promotion. Key words: Nursing care; Fracture; Anxiety; Depression; Social support

The application effect of process nursing intervention in dental restorations of dentition defect

Objective To explore the application effect of process nursing intervention on dental implant restoration. Methods A total of 150 patients with dentition defect treated in our hospital from September 2014 to August 2017 were selected as the research objects and were divided into study group and control group according to the random number table method, 75 cases of each group.The patients of the control group were given routine nursing intervention, and the research group was given process nursing on the basis of nursing in the control group.The success rate, treatment satisfaction, postoperative complications, length of hospital stay and SAS score were compared between the two groups. Results The success rate of dental implant in the study group(96.00%)was significantly higher than that of the control group(90.67%), and the difference between the two groups was statistically significant(P<0.05). The satisfaction degree of the patients in the study group(98.67%) was significantly higher than that of the control group(86.67%), and the difference was statistically significant(P<0.05). The incidence rate of complications of patients in the study group(4.00%) was significantly lower than that of the control group(21.33%), and the difference was statistically significant(P<0.05). The hospitalization time of patients in the study group was significantly lower than that of the control group(21.33%), and the difference was statistically significant(P<0.01). The SAS score of the study group was significantly lower than that of the control group, and the difference was statistically significant(P<0.01). Conclusion The process of nursing intervention can improve the treatment success rate of patients with dentition defect, improve the patient satisfaction, reduce the incidence of complications, reduce the hospitalization time and improve the anxiety of patients, and the effect is good. Key words: Procedural nursing; Dentition defect; Dental implant; Curative effect

Effect of cognitive behavior mental nursing on the anxiety, depression and obtaining social support for the aged extensive burn patients

Objective To investigate the effect of cognitive behavior mental nursing on the anxiety, depression and obtaining social support for the aged extensive burn patients. Methods A total of 100 aged extensive burn patients hospitalized in the department of burn plastic surgery of this hospital were selected from October 2013 to December 2015 as the study objects.In addition, random number method was used to divide them into observation group and control group (50 cases each). The patients of both groups received regular treatment, and the patients of control group received traditional nursing.The patients of observation group received cognitive behavior mental nursing based on traditional nursing.The aged patients of both groups received SAS, SDS, SSRS evaluation compiled by Zung 1 day before nursing and 4 weeks after nursing to compare its score.The nursing satisfaction of patients in both groups were observed and compared. Results After nursing for 4 weeks, the SAS and SDS scores in the observation group were significantly lower than those in the control group, and the differences were statistically significant (P<0.05). The overall scores of SSRS of patients in observation group, burn surface area more than 50.00% and SSRS score of head-face burn patients were significantly higher than the control group, and the differences were statistically significant (P<0.05). The nursing satisfaction that was 96.00% for patients in observation group was significantly higher than it of 76.00% for the patients in control group, and the difference was statistically significant (P<0.01). Conclusions Cognitive behavioral psychological nursing can significantly improve the anxiety and depression of elderly patients with large area burn, enhance their ability to obtain social support, and help to build a harmonious relationship between nurses and patients. Key words: Cognitive behavior; Psychological care; Elderly patients with large area burn; Anxiety; Depression

P.1.003 - Pharmacodynamics and pharmacokinetics related gene polymorphisms affect adverse drug reactions of haloperidol

The antipsychotic action of haloperidol is due to the blockade of D2 receptors in the mesolimbic dopamine pathway, while the adverse drug reactions are associated with striatal D2 receptors blockade. Contradictory data concerning the effects of genetic polymorphisms of genes encoding these receptors and associated structures (catechol-O-Methyltransferase, glycine transporter and gene encoding the density of D2 receptors on the neuronal membrane) [1,2], and also genes encoding the elements of haloperidol biotransformation system on haloperidol metabolism rate as well as plasma drug concentration ratio is described in patients with different genotypes [3,4]. To evaluate the correlation between DRD2, SLC6A3 (DAT) and COMT genetic polymorphisms and to investigate their effect on the development of adverse drug reactions in patients with alcohol use disorder who received haloperidol. The second objective of this study was to investigate the effects of CYP2D6 and CYP3A5 genetic polymorphisms on haloperidol equilibrium concentration in patients with alcohol use disorder. The study included 114 male patients (average age 38.12±9.08; median age 39; LQ 34; UQ 48). Bio-Rad CFX Manager™ software (USA) and "SNP-Screen" sets of "Syntol" (Russia) were used to determine polymorphisms rs4680, rs1800497, rs1124493, rs2242592, rs2298826, and rs2863170. In every “SNP-Screen” set, two allele-specific hybridizations were used, which allowed to determine two alleles of studied polymorphism separately on two fluorescence channels. Genotyping was performed using the allele-specific real-time PCR. CYP2D6 and CYP3A were phenotyped with high-performance liquid chromatography-mass spectrometry using concentration of endogenous substrate of the enzyme and its urinary metabolites (6-hydroxy-1,2,3,4-tetrahydro-beta-carboline(6-HO-THBC) to pinoline ratio [5] for CYP2D6 and 6-beta-hydroxycortisol to cortisol ratio for CYP3A). The equilibrium plasma concentration was determined using LC-MS-MS. Statistical analysis of the results was performed with non-parametric methods using the ”Statsoft Statistica v. 10.0“ (Dell Statistica, Tulsa, OK, USA). The normality of samples distribution was evaluated using W-Shapiro-Wilk test and taken into account when choosing a method. The differences were considered as statistically significant at р<0.05 (power in excess of 80 %). To compare two independent groups Mann-Whitney U test was used. Results of this study detected a statistically significant difference in the adverse drug reactions intensity in patients receiving haloperidol with genotypes 9/10 and 10/10 of polymorphic marker SLC6A3 rs28363170. In patients receiving haloperidol in tablets the increases in the UKU score of 10.99 ± 2.12 (10/10) vs 13.14 ± 2.08 (9/10) (p<0.001) and in the SAS score of 5.17 ± 1.49 (10/10) vs 6.88 ± 1.37 (9/10) (p=0.006) were revealed. The results of this study showed that equilibrium concentration level / dose index depends on CYP2D6 genetic polymorphism (0.19 [0.07; 0.43] vs 0.48 [0.38; 0.55], p=0.012). Polymorphism of the SCL6A3 gene can affect the safety of haloperidol, and that should be taken into account during the choice of drug and its dosage regimen. Also our study demonstrates that CYP2D6 genetic polymorphism (1846G>A) can affect haloperidol concentration levels in patients with alcohol use disorder.

Effects of clinical nursing pathway on postoperative rehabilitation and compliance of parturients undergoing cesarean section

Objective To analyze the effect of clinical nursing pathway on postoperative rehabilitation and compliance of parturients who had undergone cesarean section. Methods A total of 70 parturients who had undergone cesarean section in our hospital from September to December 2016 were selected as the research objects.This study was approved by the ethics committee of the hospital.All these parturients were divided into two groups according to the random table method, with 35 cases in each group.Patients in the control group received routine nursing, whereas those in the observation group was given routine nursing plus clinical nursing pathway.The conditions before and after nursing, cesarean section, compliance to rehabilitation and nursing satisfaction of the parturients in the two groups were compared. Results The SAS and SDS scores of the two groups were not statistically significant (P>0.05) .The SAS and SDS score of the control group were higher than those of the observation group, and the differences were statistically significant (P<0.05). In the control group, the amount of bleeding, postoperative exhaust time, lower bed activity time and lactation time were longer than the observation group, and the difference was statistically significant (P<0.05). In the control group, the recovery compliance and nursing satisfaction were lower than those in the observation group, and the difference was statistically significant (P<0.05). Conclusions Giving clinical care path mode to cesarean delivery puerperae plays an important role in improving postoperative rehabilitation and compliance. Meanwhile, it's conducive to reducing the influence of unhealthy emotion on puerperae, and promoting puerperae to have prognosis recovery, which is worth having popularization for clinical application. Key words: Clinical nursing pathway; Cesarean delivery; Postoperative rehabilitation; Compliance

The Clinical Effects of Psychological Nursing in the Pediatric Intensive Care Unit

Objective: To explore the effects of psychological nursing in the pediatric intensive care unit. Methods: 110 cases of intensive care of children from January 2014 to January 2015 were selected and randomly divided into the observation group (n=55) and the control group (n=55). The children of the control group were given usual nursing care, the patients of the observation group were given psychological nursing. On two groups of patients before and after the intervention of the SAS scores and SDS scores compliance parents care quality satisfaction are compared. Results: Before intervention, theobservation group of patients and the control group of patients with SAS scores and SDS scores difference no statistical significance (P &gt; 0.05), and after the intervention, the observation group patients' scores of SAS and SDS were significantly better than the control group, and the observation group below the control group (P &lt; 0.05). The observation group of compliance rate was 96.36%, and the control group of compliance rate was 69.09%, it below the observation (P&lt;0.05). Parents care quality satisfaction of observation group was obviously better than that of control group with that difference is statistically significant (P&lt;0.05). Conclusion: psychological nursing measures used in pediatric intensive care unit has certain feasibility and is worth popularizing clinically.

High-Flow Nasal Cannula versus Nasal Continuous Positive Airway Pressure for Primary Respiratory Support in Preterm Infants with Respiratory Distress: A Randomized Controlled Trial

Background: Nasal continuous positive airway pressure (nCPAP) is the standard noninvasive respiratory support for newborns with respiratory distress. Evidence for high-flow nasal cannula (HFNC) as an alternative mode of respiratory support is inconclusive. Objective: The aim of this work was to evaluate whether HFNC is not inferior to nCPAP in reducing the need for higher respiratory support in the first 72 h of life when applied as a noninvasive respiratory support mode for preterm neonates with respiratory distress. Methods: Preterm infants (gestation ≥28 weeks and birth weight ≥1,000 g) with respiratory distress were randomized to either HFNC or nCPAP in a non-inferiority trial. Failure of the support mode in the first 72 h after birth was the primary outcome. Infants failing HFNC were rescued either with nCPAP or mechanical ventilation, and those failing nCPAP received mechanical ventilation. Results: During the study period, 139 and 133 infants were randomized to the nCPAP and HFNC groups, respectively. The study was stopped after an interim analysis showed a significant difference (p < 0.001) in the primary outcome between the 2 groups. The treatment failure was significantly higher in the HFNC group (HFNC, n = 35, 26.3%, vs. CPAP, n = 11, 7.9%, risk difference 18.4 percentage points, 95% CI 9.7–27). Among the infants in the HFNC group who had treatment failure (n = 35), 32 were initially rescued with CPAP. The rate of mechanical ventilation in the first 3 and 7 days of life was similar between the 2 groups. Treatment failure was significantly higher in the HFNC group per protocol and also in the subgroups of infants with moderate (Silverman Anderson score, SAS ≤5) or severe respiratory distress (SAS score >5). Conclusions: When comparing HFNC to nCPAP as a primary noninvasive respiratory support in preterm infants with respiratory distress, HFNC is inferior to nCPAP in avoiding the need for a higher mode of respiratory support in the first 72 h of life.

The effects of comprehensive nursing care on anxiety, stress status and satisfaction of emergency surgery patients

Objective To explore the effects of comprehensive nursing care on anxiety, stress status and satisfaction in emergency surgery patients. Methods A total of 240 cases of patients receiving surgical treatment in the hospital from February 2015 to March 2016 were selected as the study subjects, and were randomly divided into the experimental group and the control group, 120 cases of each group.The patients in the control group were given routine operating room nursing, and the experimental group was given comprehensive nursing care on the basis of routine care.The anxiety, stress status and satisfaction of the two groups were compared. Results With regard to the self-rating depression scale comparison of patients in experimental group and control group 2 hours before surgery, the difference had no statistical significance(P>0.05). After surgery, SAS score of patients in experimental group was significantly lower than it of control group, and the difference was statistically significant(P 0.05). With regard to the systolic pressure and diastolic pressure comparison of patients in both groups 2 hours before surgery, the difference had no statistical significance(P>0.05). The systolic pressure and diastolic pressure of patients in experimental group were significantly lower than it of control group, and the difference had statistical significance(P<0.01). The nursing satisfaction of the control group was significantly lower than that in the experimental group, and the difference was statistically significant(P<0.01). Conclusion Comprehensive nursing care in the operating room can help alleviate the anxiety and stress in the operation and improve the patient's satisfaction with nursing. Key words: Operation room; High quality and comprehensive nursing service; Anxiety; Stress state; Degree of satisfaction

Clinical analysis of the application of microsurgical therapy in brain tumor

Objective: To determine the clinical effect of microsurgical therapy in treating brain tumor. Methods: A total of 72 patients with brain tumor who were admitted from May 2015 to June 2017 were employed as subjects and divided into two groups through odd-even method. In the control group (n=36), traditional craniotomy was adopted during treatment, while microsurgical therapy was used in the experimental group (n=36). Upon completion of treatments, the recoveries, life quality scores, SAS scores, SDS scores, and the degrees of satisfaction of the two groups were compared. Results: The experimental group showed more significant results in all parameters tested (all P<0.05) compared with the control group (P<0.05). Conclusions: Microsurgical therapy, if properly applied to brain tumor patients, can remarkably improve the patients’ recovery, life quality, SAS, SDS, and degree of satisfaction toward surgery. Such improvement optimizes the surgical effect, enhances prognosis, and enriches patients’ independence in life.

Effect of smartphone usage on quality of sleep in medical students

Background: Like every other important invention of the technological revolution, smartphones have brought with themselves both comforts and problems. An irrational overuse of smartphones has been described as smartphone addiction. Medical students are highly vulnerable to sleep deprivation, smartphone addiction might further aggravate this problem. Aims and Objectives: The aim of this study was to find out the effect of smartphone addiction on sleep quality among medical students of SKIMS Medical College, Srinagar. Materials and Methods: This cross-sectional study was conducted on 236 medical students from October 2017 to December 2017 using a self-administered questionnaire consisting of three parts sociodemographic characteristics, smartphone addiction scale (SAS-SV), and Pittsburgh sleep quality index (PSQI). Pearson correlation coefficient was used to correlate SAS scores and PQSI scores. Results: The prevalence of smartphone addiction in this study was found out to be 34.4%. 62.7% were poor sleepers as assessed by PQSI scores. There was a positive correlation between overall PQSI scores and SAS scores. In the subgroups, the correlation was significant for males and those residing in the hostel. Correlations were highly significant for younger age group (17–19) and 1st year of study. Conclusion: Excessive use of smartphones is prevalent among medical students and is related to poor sleep quality. This study further brings out the importance of the availability of counseling services to medical students, so that those already addicted can be helped and provided with remedial measures.

Effect of patient support model on the mood, self-efficacy and quality of life of nasopharyngeal carcinoma patients

Objective To explore the effect of patient support model on the emotion and self-efficacy of patients with nasopharyngeal carcinoma (NPC) , so as to summarize the nursing model for NPC patients and improve their quality of life. Methods A sample of 86 NPC patients who admitted from October 2013 to October 2016 for the first time were selected by convenience sampling method and divided into observation group (n=43) and control group (n=43) randomly using the random number table. Both of the groups were given routine nursing care, at the same time, the patients in the observation group were given patient support mode nursing. Patients' mood, self-efficacy, self-management ability and quality of life were compared after two months' intervention. Results After the intervention, the SAS and SDS scores of the two groups were significantly improved than before, and the scores were lower in the observation group than those in the control group, with statistical differences (t=13.648, 25.306; P<0.001) . The level of patients' self-efficacy and self-management ability were improved after the intervention, and the scores of the observation group were higher than those of the control group (t=7.698, 6.838; P<0.001) . SF-36 scores of both groups were better than those before the intervention, and SF-36 score of the observation group was higher than that of the control group (t=10.456, P< 0.001) . Conclusions The patient support model can effectively improve the self-efficacy level of NPC patients for the first hospitalization, improve the negative emotions and improve the quality of life of patients. Key words: Nasopharyngeal neoplasms; Emotion; Patient support model; Self-efficacy

Effect of self-efficacy intervention on pregnancy outcome and psychological status of elderly puerperal

Objective To explore the effect of self efficacy intervention on pregnancy outcome and psychological status of elderly women. Methods From July 2015 to July 2016, 96 cases of elderly puerperal were selected as the research objects. They were randomly divided into control group and observation group, 48 cases in each group. Puerperal in the control group were treated with routine clinical nursing intervention; Puerperal in the observation group received self-efficacy intervention on the basis of routine nursing. The differences of SAS, SDS score, duration of labor, CBSEI-C32, OE-16, EE-16 scale scores, mode of delivery and neonatal outcomes before and after intervention were observed between the two groups. Results After the intervention, the scores of SAS and SDS in the control group and the observation group were significantly lower than those before the intervention (P<0.05) ; The SAS and SDS scores of the observation group were significantly lower than those of the control group (t=6.293, 4.807; P<0.05) ; The proportion of vaginal delivery was higher than that of the control group, and the proportion of cesarean section was lower than that of the control group (χ2=4.165, 7.247; P<0.05) ; After the intervention, the OE-16 score, EE-16 score and CBSEI-C32 score were significantly higher than those before intervention (P<0.05) . Conclusions Self efficacy intervention can significantly reduce the elderly maternal psychological anxiety and depression, improve fetal vaginal delivery rate, reduce the incidence of adverse neonatal outcomes and improve pregnancy outcome. Key words: Pregnancy outcome; Elderly puerperal; Self-efficacy; Psychological status

Efficacy analysis of psychological intervention on the basis of medication for the treatment of moderate-severe persistent allergic rhinitis

Objective:To observe the effect of psychological intervention on the basis of drug therapy for moderate-severe persistent allergic rhinitis.Method:Sixty patients with moderate-severe persistent allergic rhinitis were randomly divided into two groups: control group and study group. The control group was only given pure drug therapy. The study group was given drug treatment and psychological intervention. Both groups were treated for 12 weeks. Before and after the treatment, the patients were graded by SAS, SDS and RQLQ to assess their anxiety and depression, as well as changes in the quality of life. Finally, a statistical analysis was performed.Result:After the treatment, the SAS and SDS scores of the control group and the study group were lower than those scores before treatment, and the difference was statistically significant (P<0.05). The SAS and SDS scores were lower in the study group than in the control group after treatment, and the difference was statistically significant (P<0.05).After the treatment, the scores of RQLQ in the control group and the study group were lower than those scores before treatment. and the difference was statistically significant (P<0.05). After treatment with two regimens, the scores of the sleep, the non-nose/eye symptoms, and the emotion were lower in the study group than those scores in the control group, and the difference was statistically significant (P<0.05).Conclusion:To improve the mental disorder and the quality of life of the moderate-severe persistent allergic rhinitis patients, on the basis of drug treatment along with psychological intervention is more effective than using medical treatment.

Greater Cognitive Deficits with Sleep-disordered Breathing among Individuals with Genetic Susceptibility to Alzheimer Disease. The Multi-Ethnic Study of Atherosclerosis.

There are conflicting findings regarding the link between sleep apnea and cognitive dysfunction. Investigate associations between indicators of sleep-disordered breathing (SDB) and cognitive function in the Multi-Ethnic Study of Atherosclerosis and assess effect modification by the apolipoprotein ε-4 (APOE-ε4) allele. A diverse population (N = 1,752) underwent type 2 in-home polysomnography, which included measurement of percentage sleep time less than 90% oxyhemoglobin saturation (%Sat < 90%) and apnea-hypopnea index (AHI). Epworth Sleepiness Scale score (ESS) and sleep apnea syndrome (SAS; AHI ≥ 5 and ESS > 10) were also analyzed. Cognitive outcomes included the Cognitive Abilities Screening Instrument; Digit Symbol Coding (DSC) test; and Digit Span Tests (DST) Forward and Backward. Participants were 45.4% men, aged 68.1 years (SD, 9.1 yr) with a median AHI of 9.0 and mean ESS of 6.0. Approximately 9.7% had SAS, and 26.8% had at least one copy of the APOE-ε4 allele. In adjusted analyses, a 1-SD increase in %Sat < 90% and ESS score were associated with a poorer attention and memory assessed by the DST Forward score (β = -0.12 [SE, 0.06] and β = -0.13 [SE, 0.06], respectively; P ≤ 0.05). SAS and higher ESS scores were also associated with poorer attention and processing speed as measured by the DSC (β = -0.69 [SE, 0.35] and β = -1.42 [SE, 0.35], respectively; P < 0.05). The presence of APOE-ε4 allele modified the associations of %Sat < 90% with DST forward and of ESS with DSC (Pinteraction ≤ 0.05). Overnight hypoxemia and sleepiness were associated with cognition. The average effect estimates were small, similar to effect estimates for several other individual dementia risk factors. Associations were strongest in APOE-ε4 risk allele carriers. Our results (1) suggest that SDB be considered among a group of modifiable dementia risk factors, and (2) highlight the potential vulnerability of APOE-ε4 risk allele carriers with SDB.

The influence of preventive nursing intervention on negative moods and blood oxygen saturation of patients with cardiovascular disease undergoing painless endoscopy in outpatient clinic

Objective To explore the influence of preventive nursing intervention on negative moods and blood oxygen saturation of patients with cardiovascular disease undergoing painless endoscopy in outpatient clinic. Methods A total of 98 cases of patients with cardiovascular disease to undergo painless endoscopy examination in our hospital were selected as the study objects, and were divided into the observation group and the control group according to the random and equal principle.The control group were given routine nursing intervention, while the observation group were given predictive nursing intervention on the basis of the control group.Negative moods, levels of BP, HR, SpO2 and the incidence rate of complications in the two groups were observed. Results After nursing, the scores of SDS and SAS in the two groups were significantly lower than that before nursing (P 0.05). The scores of SDS and SAS of the control group in examination were significantly higher than those before and after examination (P<0.05), and were significantly higher than those of the observation group, before, in and after examination (P<0.05). The incidence rate of complications was 10.20% of the observation group, significantly lower than that of 26.53% of the control group (P<0.05). Conclusions Predictive nursing intervention can alleviate negative moods of patients with painless endoscopic cardiovascular disease effectively, and maintain the stability of blood oxygen saturation (SpO2). Key words: Predictive nursing intervention; Painless endoscopy; Cardiovascular disease; Negative moods; Blood oxygen saturation

Analysis of anxiety factors and nursing intervention in patients before liver puncture

Objective To investigate the related factors of anxiety in patients undergoing liver puncture, so as to provide better clinical care and psychological intervention for patients to ensure the successful completion of liver puncture. Methods From January 2008 to January 2014, 310 cases of patients from the Third People's Hospital of Shenzhen with liver puncture were selected as the research object. The patients' general condition and self rating Anxiety Scale were investigated. Results The SAS score of the patients who would undergo liver puncture was (47.25±0.44) points, and the incidence of anxiety symptoms was 91.3%. The results of univariate and multivariate analysis showed that the effect of patients with anxiety before liver biopsy can explain the variation of the size of the corresponding factors: whether accompanied by family members, payment methods, awareness of the disease, ear of liver failure, the education level, and gender (β' =0.617, 0.352, 0.114, 0.102, 0.082、0.043; P<0.05) . Conclusions Before the liver puncture, the patients show a state of anxiety. The main factors affecting the anxiety status are whether to have family members, to pay for the disease, to understand the disease, to worry about the failure of liver failure, the degree of education and gender medical staff should provide targeted nursing intervention for patients to alleviate anxiety and promote rehabilitation on the basis of the above factors and the relevant circumstances. Key words: Anxiety; Nursing care; Related factors; Liver biopsy; Liver puncture