Sarcomatoid Carcinoma Presenting Research Articles

Pulmonary Sarcomatoid Carcinoma Presenting as Massive Pleural Effusion

Pulmonary Sarcomatoid Carcinoma Presenting as Massive Pleural Effusion

Recurrence of pulmonary sarcomatoid carcinoma presenting as haemothorax: a case report

Pulmonary sarcomatoid carcinoma (PSC) is a rare and highly invasive malignant tumour. It has similar clinical manifestations and imaging features to ordinary lung cancer. This current case report describes a 65-year-old male patient who had a mass in the apicoposterior segment of the left upper lobe with haemoptysis. Imaging studies revealed a central parenchymal mass surrounded by areas of ground-glass opacity, strongly indicating the presence of a pulmonary malignancy. Intraoperatively, the tumour was discovered to have invaded the chest wall and exhibited a significant propensity for bleeding. Consequently, a left upper lobe resection accompanied by extensive pleural debridement were performed. Subsequent postoperative histopathological examination confirmed the diagnosis of PSC. Unfortunately, 1 month after the surgery, the patient presented with left-sided haemothorax. Despite employing various haemostatic interventions, the patient eventually succumbed to haemorrhagic shock. This study provides a treatment strategy reference for patients with PSC presenting as haemothorax.

Sarcomatoid carcinoma metastasis to bone marrow with unknown primary

Sarcomatoid carcinoma presenting as bone marrow metastasis with unknown primary is a rare entity. Usually patients present with widespread symptoms of extensive disease process. In the present case patient was evaluated for anemia and a subsequent bone marrow examination showed metastatic malignancy. All complimentary diagnostic tests were performed, Immunohistochemistry of bone marrow biopsy revealing presence of epithelia differentiation lineage markers with mesenchymal lineage markers also although routine biopsy showed only subtle mesenchymal component. The patient was referred to higher cancer centre and despite of elaborate laboratory work up including PET scan the primary origin of metastatic sarcomatoid carcinoma remained undetermined as patient unfortunately passed away within 10 days.

Metastatic pulmonary sarcomatoid carcinoma presenting in an infant

Abstract Pulmonary sarcomatoid carcinoma is a rare subtype of non-small cell lung cancer typically seen in elderly male patients, accounting for 0.1–0.4% of all lung cancers [1]. We present a case report of a 3-month old boy diagnosed with pulmonary sarcomatoid carcinoma after presenting to the emergency department with respiratory distress. This is the first reported case of pulmonary sarcomatoid carcinoma presenting in an infant.

Sarcomatoid carcinoma presenting as cancers of unknown primary: a clinicopathological portrait

BackgroundSarcomatoid carcinoma of unknown primary (SCUP) is a rare entity of either poorly differentiated carcinoma with sarcoma-like differentiation or a true mixed lineage neoplasm. Limited data regarding clinicopathological profile and management exists.MethodsWe retrospectively reviewed the MD Anderson Cancer of Unknown Primary database and tumor registry to identify 48 SCUP patients between 2001 and 2017. Patient characteristics, pathology, molecular diagnostics, treatments, and outcomes were obtained. Kaplan-Meier method was used to estimate overall survival (OS) and compared using log rank test.ResultsMedian age at diagnosis was 59 years (range 27–86). Majority of patients were female (58%) and presented with ≥3 metastatic sites (52%), commonly lymph node (50%), bone (42%), lung (27%), and liver (21%). First line treatment included chemotherapy (35%), surgery (27%), and radiation (24%). Gemcitabine and docetaxel (18%) was the most common chemotherapy regimen. Median OS for entire cohort was 11 months (95% CI: 5.6 to 16.4). Poor performance status (PS), > 1 metastatic site, elevated lactate dehydrogenase (LDH), and high neutrophil-to-lymphocyte ratio (NLR) were significantly associated with worse OS on univariate analyses. On multivariate analyses, poor PS (HR 8.7; 95%CI: 3.0–25.0; p < 0.001) and high NLR (HR 3.4; 95%CI: 1.3–8.8; p = 0.011) emerged as independent prognostic factors for OS.ConclusionsSCUP is a rare presentation with an aggressive clinical course and limited survival. Diagnosis is difficult to make and requires careful review and synthesis of histology, immunohistochemistry, and molecular diagnostics. Chemotherapy resistance remains a challenge. Early mutational profiling is warranted, and clinical trial participation should be encouraged for this subset.

Clinicopathologic features and survival outcomes of sarcomatoid carcinoma presenting as cancer of unknown primary.

e23565Background: Sarcomatoid carcinoma is a rare histologic subtype of cancer of unknown primary (SCUP) characterized by poorly differentiated carcinoma with a component of sarcoma-like differenti...

Pulmonary sarcomatoid carcinoma presenting as a necrotizing cavitary lung lesion: diagnostic dilemma

Pulmonary sarcomatoid carcinoma presenting as a necrotizing cavitary lung lesion: diagnostic dilemma