A toxic, fright-producing chemical, 4-aminopyridine, was tested for alleviating damage by redwinged blackbirds (Agelaius phoeniceus) to ripening corn in Brown County, South Dakota. The treatment reduced losses by about 7() percent in 8 contiguous sections colntaining 1,013 acres of corn. Numbers of blackbirds using the treated area fell sharply during a 5-day period after treatment began and remained at a low level for the remainder of the damage season. The technique was highly specific for blackbirds. Although pheasants (Phasianus colchicus) were abundant, there was no evidence that any were affected, and mortality among other species of birds was negligible. Blackbirds, principally red-winged blac3<birds, damage ripening corn in many areas of the United States and create a need for an effective, safe, and economical means of controlling damage. Many techniques have been tried, some providing a degree of relief ( Neff 194S, Neff and Meanley 1957, Bird and Smith 1963), but, for the effort expended, most have failed to give the protection desired. Since 1, the Denver Wildlife Research Center has investigated methods of controlling blackbird damage to ripening field corn at Sand Lake National Wildlife Refuge, South Dakota ( De Grazio 1964 ) . From 1961 to 1963, we detennined that redwings destroyed an average of about 3 bushels of com per acre in a 94-section survey area surrounding the marshes of this refuge. In 1962 and 1963 experiments, we sprayed partially husked ears of standing corn with a chemical frightening agent, 4-aminopyridine. Some species of birds affected with 4aminopyridine emit distress cries and perform aerial distress displays, and a few affected individuals often frighten the other 1 Deceased. birds in the floek and cause thenr to leave. Although this chemieal was first synthesized by Koenigs and Gredner ( 1931), its unique aetion on birds was discovered by Goodhue et al. (l964), and its utility for controlling damage by birds in some situations was demonstrated by Goodhue and Baumgartner (1965s, b). In redwings, we found that a lethal dose of 4-aminopyridine was necessary to produee distress behavior. The acute oral LD50, as well as the dose necessary tol produce distress in 50 percent of the birds, was 2.4 mg/kg (95 pereent eonfidence limits, 1.5-3.8 mg/kg). At this level, distress usually began about 15 minutes after dosing and lasted for about 20 to 30 minutes. Our studies in 1963 indieated the eonditions for using 4-aminopyridine sprays effectively, the number of treatments necessary to provide proteetion during the damage season, and the number of treated ears required per aere. These investigations showed that the feedingl habits of blackbirds could be disrupted after they had beeome established in a field, and that a field could be protected even though only a few birds were affeeted. Often, a few