Sample Acquisition System Research Articles

Accelerating attribute-focused process and product development through the development and deployment of autonomous process analytical technology platform system.

Enabling real-time monitoring and control of the biomanufacturing processes through product quality insights continues to be an area of focus in the biopharmaceutical industry. The goal is to manufacture products with the desired quality attributes. To realize this rigorous attribute-focused Quality by Designapproach, it is critical to support the development of processes that consistently deliver high-quality products and facilitate product commercialization. Time delays associated with offline analytical testing can limit the speed of process development. Thus, developing and deploying analytical technology is necessary to accelerate process development. In this study, we have developed the micro sequential injectionprocess analyzer and the automatic assay preparation platformsystem. These innovations address the unmet need for an automatic, online, real-time sample acquisition and preparation platform system for in-process monitoring, control, and release of biopharmaceuticals. These systems can also be deployed in laboratory areas as an offline analytical system and on the manufacturing floor to enable rapid testing and release of products manufactured in a good manufacturing practiceenvironment.

A fast and robust surface sample acquisition system for a Venus lander

JPL and Honeybee Robotics have designed, built and successfully tested a fast end-to-end sample acquisition and transfer system for the Venusian surface. This full scale prototype system uses a rotary-percussive drill designed to penetrate to a 5 ​cm depth in saddleback basalt in 15 ​min under full Venus surface conditions of 470 ​°C and 92 ​bar pressure and supercritical CO2 atmosphere. The drill features a hollow bit that collects particulate samples created during the drilling process. Sample transfer from drill to lander is done pneumatically using the motive force provided by the high pressure Venus atmosphere to entrain the particles in a high density flow. A cyclone particle separator removes the particles from the flow inside the lander and deposits them into an airlock, while the gas itself flows into a low pressure dump tank. Two samples are provided from the drill, one near the surface and one at 5 ​cm depth. Cross contamination between the near surface and at depth samples is minimized by collecting, but not analyzing, a third sample in between the two primary samples. The airlock is designed to depressurize and cool the particulate samples and then present them to science instruments for composition analysis. The entire drilling and sample transfer process completes in 30 ​min, thereby allowing it to support almost any kind of future short duration Venus lander mission. Results are presented for the first end-to-end drilling and sample transfer experiment conducted in a new specialized test chamber that replicates Venus surface conditions.

In Situ Geochronology for the Next Decade: Mission Designs for the Moon, Mars, and Vesta

Abstract Geochronology is an indispensable tool for reconstructing the geologic history of planets, essential to understanding the formation and evolution of our solar system. Bombardment chronology bounds models of solar system dynamics, as well as the timing of volatile, organic, and siderophile element delivery. Absolute ages of magmatic products provide constraints on the dynamics of magma oceans and crustal formation, as well as the longevity and evolution of interior heat engines and distinct mantle/crustal source regions. Absolute dating also relates habitability markers to the timescale of evolution of life on Earth. However, the number of terrains important to date on worlds of the inner solar system far exceeds our ability to conduct sample return from all of them. In preparation for the upcoming Decadal Survey, our team formulated a set of medium-class (New Frontiers) mission concepts to three different locations (the Moon, Mars, and Vesta) where sites that record solar system bombardment, magmatism, and habitability are uniquely preserved and accessible. We developed a notional payload to directly date planetary surfaces, consisting of two instruments capable of measuring radiometric ages, an imaging spectrometer, optical cameras to provide site geologic context and sample characterization, a trace-element analyzer to augment sample contextualization, and a sample acquisition and handling system. Landers carrying this payload to the Moon, Mars, and Vesta would likely fit into the New Frontiers cost cap in our study (∼$1B). A mission of this type would provide crucial constraints on planetary history while also enabling a broad suite of complementary investigations.

Enhanced health index for power transformers diagnosis

Power Transformers (PTs) failures in electrical networks cause significant expenses for power utilities, making the use of assessment techniques essential to efficiently diagnose and estimate the actual operating conditions of such equipment’s. Efficient diagnoses allow operation management of this chain of assets aiming at the ideal balance among investments, maintenance costs and operation performance. Taking this into account, this paper presents an enhanced diagnostic methodology to estimate the PTs’ health based on simple and low-cost data which can be easily obtained without interrupting the unit's operation. The methodology uses data from oil sample analysis and acquisition systems of available electrical quantities and proposes the creation of a new diagnostic factor to identify the condition of the transformer's solid insulation. The new diagnostic factor is based on the history of the average daily load curve of a PT, allowing the estimation and accounting for the PT insulation degradation “in service”. Thus, the enhanced diagnostic methodology proposed in this work can estimate and update the transformerś health estimation in shorter time intervals than required by conventional Health Index (HI) methodologies and may be an important tool for strategic planning and resource optimization in power systems’ companies. The effectiveness of the proposed diagnostic methodology was assessed considering data from a population of 204 power transformers installed in Brazil and the direct comparison with the maintenance history from the conventional HI diagnostic methodology.

Future space drilling and sample acquisition: A collaborative industry-government workshop

A workshop on Planetary Drilling and Sample Acquisition was held at NASA-Goddard Space Flight Center, its purpose was to bring together the past decade of research and development results to define a framework for consistently and completely describing sample acquisition tasks for future Solar System missions, to survey the current state of knowledge of sample acquisition methods, and for each high priority application of sample acquisition technology, determine what had been demonstrated thus far vs. unaddressed areas. Combining inputs from government, academic and industrial participants, the workshop concluded that drilling missions that go 1-2 m deep (on the Moon, Mars, Europa or small bodies) are now feasible to propose in the 2020s, with potentially-high scientific payoff. Further, in developing complex sample acquisition systems for Solar System targets, the workshop agreed that both chamber tests and field tests at terrestrial analog sites are required. The workshop proposed adding cross-contamination and planetary protection requirements explicitly to instrument and surface mission flight calls, and also to add these as part of the technology readiness evaluation for NASA mission proposals.

Development and testing of a pyro-driven launcher for harpoon-based comet sample acquisition

The CORSAIR (COmet Rendezvous, Sample Acquisition, Investigation, and Return) mission was a proposal for the NASA New Frontiers program. It belongs to the Comet Surface Sample Return mission theme which focuses on acquiring and returning to Earth a macroscopic sample from the surface of a comet nucleus. CORSAIR uses a harpoon-based Sample Acquisition System (SAS) with the spacecraft hovering several meters above the comet surface. This stand-off strategy overcomes disadvantages of other systems such as drills. Since comets are low gravity objects, those techniques would require anchoring before sampling, which is not necessary here. Moreover, the harpoon-based system allows for acquiring several samples from different locations on the comet maximizing the scientific output of the mission.Each SAS assembly consists of a pyro-driven launcher, a Sample Acquisition and Retrieval Projectile (SARP) and a retraction system using a deployable composite boom structure. In order to collect enough cometary material, the launcher has to provide the required kinetic energy to the SARP. Due to high energy densities, pyrotechnically actuated devices ultimately reduce the overall system mass and dimensions. First, the scientific and technological background of the CORSAIR mission is explained. Then, an overview of the development, design and testing of the launcher is given. Finally, the launcher theory is introduced explaining the entire reaction chain: initiation → gas dynamics → SARP motion.

Supercapacitors based driving system for space fast surface sample acquisition system

Supercapacitors based driving system for space fast surface sample acquisition system

Development and characteristics of Mechanical Porous Ambient Comet Simulants as comet surface analogs

Comets are icy remnants of the Solar System formation, and as such contain some of the most primitive volatiles and organic materials. Sampling the surface of a comet is a high priority for the New Frontiers program. Planetary simulants are crucial to the development of adequate in situ instruments and sample acquisition systems. A high-fidelity comet surface simulant has been developed to support hardware design and development for one Comet Surface Sample Return tool, the BiBlade Comet Sampler. Mechanical Porous Ambient Comet Simulants (MPACS) can be manufactured to cover a wide range of desired physical properties, such as density and cone penetration resistance, and exhibit a brittle fracture mode. The structure of the MPACS materials is an aggregated composite structure of weakly-bonded grains of very small size (diameter ≤ 40 μm) that are most relevant to the structure of the surface of a comet nucleus.

Approach to technology prioritization in support of moon initiatives in the framework of ESA exploration technology roadmaps

Exploration technology roadmaps have been developed by ESA in the past few years and the latest edition has been released in 2015. Scope of these technology roadmaps, elaborated in consultation with the different ESA stakeholders (e.g. European Industries and Research Entities), is to provide a powerful tool for strategic, programmatic and technical decisions in support of the European role within an International Space Exploration context. In the context of preparation for possible future European Moon exploration initiatives, the technology roadmaps have been used to highlight the role of technology within Missions, Building Blocks and Operational Capabilities of relevance. In particular, as part of reference missions to the Moon that would fit in the time frame 2020 to 2030, ESA has addressed the definition of lunar surface exploration missions in line with its space exploration strategy, with the common mission goals of returning samples from the Moon and Mars and expanding human presence to these destinations in a step-wise approach. The roadmaps for the procurement of technologies required for the first mission elements of the above strategy have been elaborated through their main building blocks, i.e. Visual navigation, Hazard detection and avoidance; Sample acquisition, processing and containment system; Surface mobility elements; Tele-robotic and autonomous control systems; and Storable propulsion modules and equipment. Technology prioritization methodologies have been developed in support of the ESA Exploration Technology Roadmaps, in order to provide logical and quantitative instruments to verify choices of prioritization that can be carried out based on important, but non-quantitative factors. These methodologies, which are thoroughly described in the first part of the paper, proceed through subsequent steps. First, technology prioritization's criteria are selected; then decision trees are developed to highlight all feasible paths of combination of technology prioritization's criteria and to assess the final achievement of each path, i.e. the cost-effectiveness. The risk associated to each path is also evaluated. In the second part of the paper, these prioritization methodologies have been applied to some of the building blocks of relevance for the mission concepts under evaluation at ESA (such as Tele-robotic and autonomous control systems; Storable propulsion modules and equipment) and the results are presented to highlight the approach for an effective TRL increase. Eventually main conclusions are drawn.

PELS (Planetary Environmental Liquid Simulator): a new type of simulation facility to study extraterrestrial aqueous environments.

Investigations of other planetary bodies, including Mars and icy moons such as Enceladus and Europa, show that they may have hosted aqueous environments in the past and may do so even today. Therefore, a major challenge in astrobiology is to build facilities that will allow us to study the geochemistry and habitability of these extraterrestrial environments. Here, we describe a simulation facility (PELS: Planetary Environmental Liquid Simulator) with the capability for liquid input and output that allows for the study of such environments. The facility, containing six separate sample vessels, allows for statistical replication of samples. Control of pressure, gas composition, UV irradiation conditions, and temperature allows for the precise replication of aqueous conditions, including subzero brines under martian atmospheric conditions. A sample acquisition system allows for the collection of both liquid and solid samples from within the chamber without breaking the atmospheric conditions, enabling detailed studies of the geochemical evolution and habitability of past and present extraterrestrial environments. The facility we describe represents a new frontier in planetary simulation-continuous flow-through simulation of extraterrestrial aqueous environments.

Robotics and Automation for “Icebreaker”

The proposed “Icebreaker” mission is a return to the Mars polar latitudes first visited by the Phoenix mission in 2007–2008. Exploring and interrogating the shallow subsurface of Mars from the surface will require some form of excavation and penetration, with drilling being the most mature approach. A series of 0.5–5 m automated rotary and rotary‐percussive drills developed over the past decade by NASA Ames and Honeybee Robotics provide the capability to fly on a Mars surface mission within the next decade. Surface robotics have been integrated for sample transfer to deck instruments, and the Icebreaker sample acquisition system has been tested successfully in Mars chambers and analog field sites to depths between 1 and 3 m, most recently in the Antarctic Dry Valleys in January of 2013. This paper provides a hardware and software systems overview of the Icebreaker sample acquisition system, and discusses test results of this robotic system in relevant environments. Test results from recent Arctic and Antarctic field campaigns demonstrate a hands‐off “dust to data” capability.

A new multisource and high‐frequency approach to measuring δ2H and δ18O in hydrological field studies

Measurements of δ2H and δ18O in isotope‐based field studies have fundamentally improved our understanding of water flow and transport time scales in soils and headwater catchments. Until recently, however, technical constraints have limited the temporal resolution at which water samples could be collected and analyzed. We introduce a new sample acquisition system—consisting of a four‐channel peristaltic pump, custom flow manifold, and CTC LCPAL auto‐sampler—that is paired with a field‐deployable laser spectrometer (LGR LWIA). Our system enables high‐frequency (subhourly) measurement of δ2H and δ18O in as many as four water sources. We deployed the system at a field site in Corvallis, OR, USA, where we measured the δ2H and δ18O composition of precipitation and the drainage from two lysimeters. The system produced δ2H and δ18O time series for precipitation and drainage from each lysimeter at a temporal frequency of one sample every 34 min, which, on average, corresponded to 0.84, 0.63, and 0.48 mm of precipitation or lysimeter drainage per sample. The high‐frequency data showed substantially greater short‐term variability than observed when sampling at successively longer time intervals. The system and sampling configuration are versatile and can be adapted to sample multiple water flows at variable frequencies depending on the characteristic transit times of each source.

Evidence for perchlorates and the origin of chlorinated hydrocarbons detected by SAM at the Rocknest aeolian deposit in Gale Crater

A single scoop of the Rocknest aeolian deposit was sieved (< 150 µm), and four separate sample portions, each with a mass of ~50 mg, were delivered to individual cups inside the Sample Analysis at Mars (SAM) instrument by the Mars Science Laboratory rover's sample acquisition system. The samples were analyzed separately by the SAM pyrolysis evolved gas and gas chromatograph mass spectrometer analysis modes. Several chlorinated hydrocarbons including chloromethane, dichloromethane, trichloromethane, a chloromethylpropene, and chlorobenzene were identified by SAM above background levels with abundances of ~0.01 to 2.3 nmol. The evolution of the chloromethanes observed during pyrolysis is coincident with the increase in O2 released from the Rocknest sample and the decomposition of a product of N‐methyl‐N‐(tert‐butyldimethylsilyl)‐trifluoroacetamide (MTBSTFA), a chemical whose vapors were released from a derivatization cup inside SAM. The best candidate for the oxychlorine compounds in Rocknest is a hydrated calcium perchlorate (Ca(ClO4)2·nH2O), based on the temperature release of O2 that correlates with the release of the chlorinated hydrocarbons measured by SAM, although other chlorine‐bearing phases are being considered. Laboratory analog experiments suggest that the reaction of Martian chlorine from perchlorate decomposition with terrestrial organic carbon from MTBSTFA during pyrolysis can explain the presence of three chloromethanes and a chloromethylpropene detected by SAM. Chlorobenzene may be attributed to reactions of Martian chlorine released during pyrolysis with terrestrial benzene or toluene derived from 2,6‐diphenylphenylene oxide (Tenax) on the SAM hydrocarbon trap. At this time we do not have definitive evidence to support a nonterrestrial carbon source for these chlorinated hydrocarbons, nor do we exclude the possibility that future SAM analyses will reveal the presence of organic compounds native to the Martian regolith.

Collecting Samples in Gale Crater, Mars; an Overview of the Mars Science Laboratory Sample Acquisition, Sample Processing and Handling System

The Mars Science Laboratory Mission (MSL), scheduled to land on Mars in the summer of 2012, consists of a rover and a scientific payload designed to identify and assess the habitability, geological, and environmental histories of Gale crater. Unraveling the geologic history of the region and providing an assessment of present and past habitability requires an evaluation of the physical and chemical characteristics of the landing site; this includes providing an in-depth examination of the chemical and physical properties of Martian regolith and rocks. The MSL Sample Acquisition, Processing, and Handling (SA/SPaH) subsystem will be the first in-situ system designed to acquire interior rock and soil samples from Martian surface materials. These samples are processed and separated into fine particles and distributed to two onboard analytical science instruments SAM (Sample Analysis at Mars Instrument Suite) and CheMin (Chemistry and Mineralogy) or to a sample analysis tray for visual inspection. The SA/SPaH subsystem is also responsible for the placement of the two contact instruments, Alpha Particle X-Ray Spectrometer (APXS), and the Mars Hand Lens Imager (MAHLI), on rock and soil targets. Finally, there is a Dust Removal Tool (DRT) to remove dust particles from rock surfaces for subsequent analysis by the contact and or mast mounted instruments (e.g. Mast Cameras (MastCam) and the Chemistry and Micro-Imaging instruments (ChemCam)).

LunarVader: Development and Testing of Lunar Drill in Vacuum Chamber and in Lunar Analog Site of Antarctica

AbstractFuture exploration of the Moon will require access to the subsurface and acquisition of samples for scientific analysis and ground truthing of water-ice and mineral reserves for in situ resource utilization purposes. The LunarVader drill described in this paper is a 1-m class drill and cuttings acquisition system enabling subsurface exploration of the Moon. The drill employs rotary-percussive action, which reduces the weight on bit and energy consumption. This drilling approach has been successfully used by previous lunar missions, such as the Soviet Luna 16, 20, and 24, and United States Apollo 15, 16, and 17. These missions and drilling systems are described in detail. The passive sample acquisition system of the LunarVader drill delivers cuttings directly into a sample cup or an instrument inlet port. The drill was tested in a vacuum chamber and penetrated various formations, such as a water-saturated lunar soil simulant (JSC-1A) at −80°C, water-ice, and rocks to a depth of 1 m. The system was ...

MarcoPolo-R near earth asteroid sample return mission

MarcoPolo-R is a sample return mission to a primitive Near-Earth Asteroid (NEA) proposed in collaboration with NASA. It will rendezvous with a primitive NEA, scientifically characterize it at multiple scales, and return a unique sample to Earth unaltered by the atmospheric entry process or terrestrial weathering. MarcoPolo-R will return bulk samples (up to 2 kg) from an organic-rich binary asteroid to Earth for laboratory analyses, allowing us to: explore the origin of planetary materials and initial stages of habitable planet formation; identify and characterize the organics and volatiles in a primitive asteroid; understand the unique geomorphology, dynamics and evolution of a binary NEA. This project is based on the previous Marco Polo mission study, which was selected for the Assessment Phase of the first round of Cosmic Vision. Its scientific rationale was highly ranked by ESA committees and it was not selected only because the estimated cost was higher than the allotted amount for an M class mission. The cost of MarcoPolo-R will be reduced to within the ESA medium mission budget by collaboration with APL (John Hopkins University) and JPL in the NASA program for coordination with ESA’s Cosmic Vision Call. The baseline target is a binary asteroid (175706) 1996 FG3, which offers a very efficient operational and technical mission profile. A binary target also provides enhanced science return. The choice of this target will allow new investigations to be performed more easily than at a single object, and also enables investigations of the fascinating geology and geophysics of asteroids that are impossible at a single object. Several launch windows have been identified in the time-span 2020–2024. A number of other possible primitive single targets of high scientific interest have been identified covering a wide range of possible launch dates. The baseline mission scenario of MarcoPolo-R to 1996 FG3 is as follows: a single primary spacecraft provided by ESA, carrying the Earth Re-entry Capsule, sample acquisition and transfer system provided by NASA, will be launched by a Soyuz-Fregat rocket from Kourou into GTO and using two space segment stages. Two similar missions with two launch windows, in 2021 and 2022 and for both sample return in 2029 (with mission duration of 7 and 8 years), have been defined. Earlier or later launches, in 2020 or 2024, also offer good opportunities. All manoeuvres are carried out by a chemical propulsion system. MarcoPolo-R takes advantage of three industrial studies completed as part of the previous Marco Polo mission (see ESA/SRE (2009)3, Marco Polo Yellow Book) and of the expertise of the consortium led by Dr. A.F. Cheng (PI of the NASA NEAR Shoemaker mission) of the JHU-APL, including JPL, NASA ARC, NASA LaRC, and MIT.

Sample acquisition, processing and handling systems for future Mars missions

The next generation of Mars exploration robotics will have equipment to acquire subsurface samples, process and refine them, and transfer them to science instruments for observation. In 2003, MD Robotics and NORCAT, under contract with the Canadian Space Agency, designed, developed and tested building block technologies for a sample acquisition, processing and handling system for a future Mars mission. Four key technologies were developed to support this system: drill bit development for varied substrates, sample acquisition mechanisms to acquire cores at depth, material transport technologies to move waste material up the hole, and sample reduction technologies, studying the means to efficiently reduce samples into uniform particle sizes. This paper will discuss the technology development, the driving requirements and the test results.

Planning for a Mars in situ sample preparation and distribution (SPAD) system

For Mars in situ landed missions, it has become increasingly apparent that significant value may be provided by a shared system that we call a Sample Preparation and Distribution (SPAD) System. A study was conducted to identify the issues and feasibility of such a system for these missions that would provide common functions for: receiving a variety of sample types from multiple sample acquisition systems; conducting preliminary characterization of these samples with non-destructive science instruments and making decisions about what should happen to the samples; performing a variety of sample preparation functions; and, finally, directing the prepared samples to additional science instruments for further analysis. Scientific constraints on the functionality of the system were identified, such as triage, contamination management, and various sample preparation steps, e.g., comminution, splitting, rock surfacing, and sieving. Some simplifying strategies were recommended and an overall science flow was developed. Engineering functional requirements were also investigated and example architectures developed. Preliminary conclusions are that shared SPAD facility systems could indeed add value to future Mars in situ landed missions if they are designed to respond to the particular requirements and constraints of those missions, that such a system appears feasible for consideration, and that certain standards should be developed for key SPAD interfaces.

Validation of atmospheric VOC measurements by proton-transfer-reaction mass spectrometry using a gas-chromatographic preseparation method.

Proton-transfer-reaction mass spectrometry (PTR-MS) has emerged as a useful tool to study volatile organic compounds (VOCs) in the atmosphere. In PTR-MS, proton-transfer reactions with H30+ ions are used to ionize and measure VOCs in air with a high sensitivity and fast time response. Only the masses of the ionized VOCs and their fragments, if any, are determined, and these product ions are not unique indicators of VOC identities. Here, a combination of gas chromatography and PTR-MS (GC-PTR-MS) is used to validate the measurements by PTR-MS of a number of common atmospheric VOCs. We have analyzed 75 VOCs contained in standard mixtures by GC-PTR-MS, which allowed detected masses to be unambiguously related to a specific compound. The calibration factors for PTR-MS and GC-PTR-MS were compared and showed that the loss of VOCs in the sample acquisition and GC system is small. GC-PTR-MS analyses of 56 air samples from an urban site were used to address the specificity of PTR-MS in complex air masses. It is demonstrated that the ions associated with methanol, acetonitrile, acetaldehyde, acetone, benzene, toluene, and higher aromatic VOCs are free from significant interference. A quantitative intercomparison between PTR-MS and GC-PTR-MS measurements of the aforementioned VOCs was performed and shows that they are accurately measured by PTR-MS.

MA_MISS: Mars multispectral imager for subsurface studies

The Italian drill “DEEDRI” is going to be the lander based sample acquisition system for the Mars Surveyor Program of the Mars Sample Return mission. DEEDRI is capable to collect core/sand sample of the martian soil down to 50 cm in depth. The MA_MISS experiment belongs to the DEEDRI system and it will be dedicated to observe the wall of the excavated hole in terms of infrared spectral reflectance in the range 0.8–2.8 μm. The spectral sampling is about 20 nm while the spatial sampling is 100 μm over the target. The optical window of MA_MISS is placed very close to the drill tip so that the target view to be observed can span from the soil down to 50 cm. The proximity optics and electronics of MA_MISS have to be very miniaturized since they will be collocated inside the drill tool in a very limited volume of about 25 mm in diameter. On the other side the main electronics will be on the lander and it will communicate through an interface based on slip rings devices. MA_MISS can acquire in different observation modes. The images are scanned by moving the DEEDRI itself. One image ring is built up by acquiring contiguous images of the MA_MISS slit. The study of the Martian subsurface will provide important constraints on the nature, timing and duration of alteration and sedimentation processes on Mars, as well as on the complex interactions between the surface and the atmosphere. This study will permit to infer the history of erosion, transport and deposition of loose material. Alteration processes can dominate the mineralogy of the Martian surface: it will be essential to study the mineralogy of deeper layers, where a more limited alteration took place. MA_MISS can provide very important scientific return from the subsurface of Mars along with a selection criteria for the samples collection.