Sami Ulus Children's Hospital Research Articles

Hematological parameters in pediatric patients with primary headache

Aim: The present study aimed to evaluate the pain parameters in children with primary headache according to the International Classification of Headache Disorders, 3rd edition, diagnostic criteria and to investigate the role of hematological parameters in diagnosis in case the distinguish is difficult especially in children with migraine and tension headache. Materials and Methods: Medical data belonging age, gender, headache characteristics, hematological parameters of the outpatients with headache consulted in Beþtepe Child Neurology Outpatient Clinic of Dr. Sami Ulus Children's Hospital between July 2017 and August 2019 were examined retrospectively. SPSS statistical software was used to perform statistical data analysis. Results: A total of 243 patients (151 female, 92 male) were included in the study. The mean age was 13.68 ± 2.25 years. One hundred and one (58 female, 43 male) patients were diagnosed with migraine and 142 (93 female, 49 male) with tension type headache. Migraine presented the characteristics of unilateral (61.2%), pulsatile (88.5%) headache of moderate to severe intensity that worsens with physical activity, occurs usually in mornings (%46,5) and is accompanied by nausea or by photophobia and phonophobia (%34,3). Tension-type headache presented the characteristics of circumferential (53,2%), pressing (87.7%) headache of mild severe intensity that is triggered by school stress and accompanied phonophobia (65.2%), and occurs usually in evenings (55.3%). White blood cells, neutrophil, monocyte, monocyte-lymphocyte ratio and neutrophil-lymphocyte ratio were significantly higher in patients with migraine and lymphocyte and platelet counts were significantly higher in patients with tension type headache. Conclusion: In terms of shining a light on the future, consideration of the contribution of hematological parameters to differential diagnosis as a diagnostic support, due to the difficulties associated in particular with the presence of overlapping symptoms in the differential diagnosis of migraine and tension headache in childhood could make a significant difference.

Serum IgG, and IgM Levels in Children with Febrile Convulsions

At the Dr. Sami Ulus Children's Hospital Ankara, Turkiye, 20 patients, twelve being between 6 months-2 year old and eight being between 2-4 years, with their first febrile convulsions (FC) were examined for serum IgG, IgA, IgM levels during the period of March 1989-]uly 1989. Twenty healthy children were used as controls, seven being between 6 months-2 years old and thirteen being between 2-6 years. The serum IgG, IgA and IgM levels of the patients between 6 months-2 years were 805.000 + 307.8984 mg/ dl, 49.7167 + 27.9807 mg/dl and i55.1833 + 62.9696 mg/dl respecttvelly.
 The serum IgG, IgA and IgM levels of the patients between 2-4 years were : 989.1250 ± 314.5359 mg/dl, 92.6125 ± 34.5663 mg/dl and 159.8750 ± 45.6647 mg.ldl respectivelly. The mean IgA levels of the 12 FC patients between 6 months-2years were 49.7167 ± 27.9807 mg/dl and the mean level of IgA in the age matched control group was 81.0427± 31.3551 mg/dl and the difference between them was statistically significant (p <0. 005).
 We conclude that FC under 2 years of age is associated with low serum IgA levels.

Acute rheumatic fever in the Central Anatolia Region of Turkey: a 30-year experience in a single center

The study was carried out in Dr. Sami Ulus Children's Hospital to investigate and to compare the incidence and findings of acute rheumatic fever patients (ARF) seen in the past 30 years. The medical records of 1,115 patients with ARF admitted to Dr. Sami Ulus Children's Hospital Department of Pediatric Cardiology during 1980-2009 were retrospectively analyzed. Twenty-one percent of those patients were admitted between 1980 and 1989, 44.6% between 1990 and 1999, and 34.2% between 2000 and 2009. The highest incidence was detected in the second decade with a rate of 60.0:100,000. Male/female ratio was 1:18. The age of patients ranged between 2 and 15 years. Carditis was detected in 64.7% of patients, arthritis in 59.1%, and chorea in 14.1%. Mitral regurgitation was the most common echocardiographic finding. Heart failure was detected in 13.8%. Recurrent attacks occurred in 8.1% of patients. The median follow-up was 6.8 years (range, 1.2-10.5 years). The prevalence of chronic rheumatic valvular disease was 58%. Mortality rate was 0.8%. Although the incidence of ARF has decreased in the last decade, it still continues to be an important public health problem in Turkish pediatric population.

Attitudes of Parents and Physicians Toward Febrile Seizures

Although febrile seizures are common in children, attitudes may change among parents. The management of a child may differ depending on the specialty of the attending physician. This study was carried out to analyze attitudes of Turkish parents and physicians toward febrile seizures. 308 children with febrile seizure who were admitted to the Department of Pediatric Neurology at Dr Sami Ulus Children's Hospital and Gazi University in Turkey between January 2006 and March 2007 were enrolled. Prior to seizure, approximately half of the parents took appropriate steps in reducing fever. The data also showed that there was a wide variation of treatment practice depending on the specialty of the attending physician. Educational level and economic status are important variables affecting attitudes of parents toward fever and febrile seizure. The management of the child with a febrile seizure differs even within the same specialty in Turkish physicians.

Correspondence: Is it a Proteus syndrome?

aDr Sami Ulus Children's Hospital, Babur cad. Telsizler, Ankara bPediatric Surgery Department, Dıskapı Children's Hospital, Ankara cGenetic Department, Dr Zekai Tahir Burak Hospital, Ankara, Turkey Correspondence to Saliha Senel, MD, Dr Sami Ulus Children's Hospital, Babur cad. Telsizler, Ankara, Turkey Tel: +903123056199; fax: +903123170353; e-mail: [email protected]

Evaluation of shigellosis in a Turkish children’s hospital

The aim of the present study was to evaluate cases of Shigella and determine the pattern of antimicrobial resistance of shigella species in central Turkey. One hundred and ninety-eight patients with shigella gastroenteritis presenting to Sami Ulus Children's Hospital from June 2002 to December 2002 were included in the study. The clinical and laboratory data of the patients with shigellosis were collected by chart review. Male/female ratio was 1.35 and mean age was 4.83 +/- 3.2 years (range: 1-16 years). Shigella sonnei (83.3%) was the most common serogroup. This was followed by S. flexneri (10.1%), then S. dysenteria (5.1%), and S. boydii (1.5%). The antibiotic susceptibility of the shigella strains was determined. Most strains of Shigella species were resistant to trimethoprim-sulfamethoxazole (90.4%). All strains were found to be sensitive to ciprofloxacin (100%). Ampicillin susceptibility was 86.4% and cefotaxim (and/or ceftriaxon) susceptibility was 98%. Ampicillin is the drug of choice in the treatment of shigella infection in this region of Turkey. Cefotaxim or ceftriaxon was the second choice of antibiotics. Thus, Shigella is an important etiologic agent of diarrhea in Turkey. To determine the antibiotic susceptibility of the Shigella strains and appropriate empiric antibiotic treatment in Turkey, further studies will be needed.

Hemostatic Side Effects of High-Dose Methotrexate in Childhood Acute Lymphoblastic Leukemia

The purpose of this study is to investigate the hemostatic side effects of HDMTX. Between 2001 and 2002, 20 children with acute lymphoblastic leukemia at the Dr. Sami Ulus Children's Hospital, Department of Pediatric Hematology and Oncology, treated according to the St. Jude ALL XIII protocol were eligible to this study. Methotrexate at a dose of 2 g/m2was infused over 24 hours. Coagulation screening studies included prothrombin time (PT), APTT, fibrinogen, fibrin degradation product (D-Dimer), factor II, factor V, factor VII, factor VIII, factor IX, factor X, PC, PS, AT-III determinations before HDMTX therapy (PreT), 1 day after (PostT1D), and 1 week after (PostT1W) the end of the HDMTX infusion. We found that PT and APTT were prolonged, PC, PS, and AT-III levels were decreased with a slight increase in D-Dimer 1 day after the administration of HDMTX and all of them returned to the normal levels by 7 days. In addition we found that FVII, FIX, FX were significantly decreased 1 day after therapy and normalised by 7 days.

Çocukluk Çağı Akut Lenfoblastik Lösemili Olgularda Yüksek Doz Methotreksat Uygulamasının Oral Glukoz Tolerans Testi Üzerine Etkileri

Effects of High-Dose Methotrexate Therapy on Glucose Metabolism in Childhood Acute Lymphoblastic Leukemia Methotrexate (MTX) has been used in the treatment of childhood acute lymphoblastic leukemia (ALL) for over 40 years. A number of the acute toxicities are common with high dose methotrexate (HDMTX) infusion, including myelosuppression, vomiting, orointestinal mucositis, hepatic and renal toxicities, neurological disturbances. On the other hand, effect of HDMTX therapy on glucose metabolism was not known. Between 2001 and 2002, twenty children with acute lymphoblastic leukemia at the Dr. Sami Ulus Children's Hospital, Department of Pediatric Hematology and Oncology were treated according to the St. Jude ALL XIII protocol were eligible to this study. Dose of MTX (2 gr/m2) was infused over 24 hours. Orally glucose tolerance test was performed at before HDMTX therapy, 1 day and 1 week after the therapy. We found that HDMTX infusion did not significantly effect on orally glucose tolerance test during the first week. Methotreksat (MTX), akut lenfoblastik losemi (ALL) tedavisinde 40 yildan fazla suredir kullanilmaktadir. Yuksek doz MTX (YDMTX) tedavisine bagli myelosupresyon, kusma, mukozit, norolojik bozukluklar, hepatik ve renal toksisite bildirilmistir. Ancak, YDMTX tedavisinin oral glukoz tolerans testi uzerine etkileri bilinmemektedir. Dr. Sami Ulus Cocuk Sagligi ve Hastaliktan Merkezi Pediatrik Hematoloji ve Onkoloji bolumlerinde 2001 - 2002 tarihleri arasi ALL tanisi ile, St. Jude Total XIII ALL protokolunde bulunan ve YDMTX tedavisi almakta olan 20 hasta calismaya alindi. Yuksek DMTX tedavisi 2gr/m2 dozunda, 24 saatlik infizyon seklinde verildi. Tedavi oncesi (TO), tedavi sonrasi 1. gun (TS1G) ve tedavi sonrasi 7. gun (TS7G) oral glukoz tolerans testi (OGTT) uygulandi. Yuksek DMTX tedavisi sonrasindaki 1 hafta suresince glukoz metabolizmasinda belirgin bir degisiklik saptamadik.

Folic acid supplementation and neural tube defects

American Journal of Medical GeneticsVolume 109, Issue 1 p. 67-69 Research Letter De novo translocation t(5;6)(q35;q21) in an infant with Walker-Warburg syndrome Nilüfer Karadeniz, Corresponding Author trkaradeniz@hotmail.com Dr. Zekai Tahir Burak Woman's Hospital, Department of Medical Genetics, Ankara, TurkeySevil sokak 16/3, 06590 Cebeci-Ankara, Turkey.Search for more papers by this authorAyşegül Zenciroğlu, Dr. Sami Ulus Children's Hospital, Department of Neonatology, Ankara, TurkeySearch for more papers by this authorY.K. Yavuz Gürer, Dr. Sami Ulus Children's Hospital, Department of Child Neurology, Ankara, TurkeySearch for more papers by this authorNesrin Şenbil, Dr. Sami Ulus Children's Hospital, Department of Child Neurology, Ankara, TurkeySearch for more papers by this authorYasemin Karadeniz, Kırıkkale University, Medical Faculty, Department of Radiology, Ankara, TurkeySearch for more papers by this authorHaluk Topalŏlu, Hacettepe Children's Hospital, Department of Child Neurology, Ankara, TurkeySearch for more papers by this author Nilüfer Karadeniz, Corresponding Author trkaradeniz@hotmail.com Dr. Zekai Tahir Burak Woman's Hospital, Department of Medical Genetics, Ankara, TurkeySevil sokak 16/3, 06590 Cebeci-Ankara, Turkey.Search for more papers by this authorAyşegül Zenciroğlu, Dr. Sami Ulus Children's Hospital, Department of Neonatology, Ankara, TurkeySearch for more papers by this authorY.K. Yavuz Gürer, Dr. Sami Ulus Children's Hospital, Department of Child Neurology, Ankara, TurkeySearch for more papers by this authorNesrin Şenbil, Dr. Sami Ulus Children's Hospital, Department of Child Neurology, Ankara, TurkeySearch for more papers by this authorYasemin Karadeniz, Kırıkkale University, Medical Faculty, Department of Radiology, Ankara, TurkeySearch for more papers by this authorHaluk Topalŏlu, Hacettepe Children's Hospital, Department of Child Neurology, Ankara, TurkeySearch for more papers by this author First published: 22 March 2002 https://doi.org/10.1002/ajmg.10286Citations: 1Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinked InRedditWechat Citing Literature Volume109, Issue115 April 2002Pages 67-69 RelatedInformation

Etiology of chronic diarrhea.

With worldwide use of oral rehydration solutions, the treatment of acute diarrhea does not pose much of a problem. However, chronic diarrhea is still harmful, especially for the growth and development status of the children. Between January 1993 to December 1996, patients who suffered from chronic diarrhea for more than one month duration and admitted to Dr. Sami Ulus Children's Hospital were evaluated for epidemiological and etiologic factors. Seventy consecutive patients were evaluated. The mean age was 40.8 months and 52% were males. Malnutrition was detected in 80% of cases. Etiologic factors included celiac disease 30%, cow milk allergy 17%, bacterial and parasitic factors 26%, cystic fibrosis 10% and postinfectious gastroenteritis 10%. Eosinophilic gastroenteritis, chronic nonspecific diarrhea, pseudo-obstruction, neurofibromatosis and inflammatory bowel disease were rarely detected. Celiac disease and cow milk allergy were implicated as the most common causes of chronic diarrhea. The vicious cycle of faulty nutrition, malnutrition and infection and postinfectious enteropathy were also significant factors in the etiology of chronic diarrhea. It may be considered that cow milk protein prick test, sweat test, immunologic tests and mucosal biopsies should be performed for the definite diagnosis of chronic diarrhea.

Post-streptococcal acute glomerulonephritis in Turkey.

Acta PaediatricaVolume 84, Issue 7 p. 817-819 Post-streptococcal acute glomerulonephritis in Turkey A Oner, Corresponding Author A Oner Dr Sami Ulus Children's Hospital, Nephrology Unit, Ankara, TurkeyA Öner, Gala Loj. Salam apt. No. 23/11, Etlik, Ankara, TurkeySearch for more papers by this authorG Demircin, G Demircin Dr Sami Ulus Children's Hospital, Nephrology Unit, Ankara, TurkeySearch for more papers by this authorM Bulbul, M Bulbul Dr Sami Ulus Children's Hospital, Nephrology Unit, Ankara, TurkeySearch for more papers by this author A Oner, Corresponding Author A Oner Dr Sami Ulus Children's Hospital, Nephrology Unit, Ankara, TurkeyA Öner, Gala Loj. Salam apt. No. 23/11, Etlik, Ankara, TurkeySearch for more papers by this authorG Demircin, G Demircin Dr Sami Ulus Children's Hospital, Nephrology Unit, Ankara, TurkeySearch for more papers by this authorM Bulbul, M Bulbul Dr Sami Ulus Children's Hospital, Nephrology Unit, Ankara, TurkeySearch for more papers by this author First published: July 1995 https://doi.org/10.1111/j.1651-2227.1995.tb13766.xCitations: 4AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Citing Literature Volume84, Issue7July 1995Pages 817-819 RelatedInformation

Acute rheumatic fever in children in the Ankara area in 1990–1992 and comparison with a previous study in 1980–1989

Two hundred and twenty-eight patients with acute rheumatic fever (ARF), who were admitted to Dr Sami Ulus Children's Hospital between January 1990 and November 1992, were evaluated. Compared with the 1980s, an increase in the frequency of the disease was observed. The majority of patients (56.5%) were between 9 and 12 years old and 36.8% were admitted in winter. One hundred patients had arthritis only, 59 carditis and 40 chorea; 5 had carditis and chorea and 24 had arthritis and carditis. Nineteen percent of patients had a history of a previous attack. Seven of 84 patients with carditis had congestive heart failure and 2 had pericarditis. Cardiomegaly was present in 36 patients. The mitral valve was affected in 77 patients, tricuspid valve in 1 patient and both miral and aortic valves in 6 patients. One patient died as a result of severe congestive cardiac failure. Twenty-one patients had a recurrent attack. We observed that ARF is still a significant cause of morbidity in our country. As the disease is preventable by the eradication of streptococcus, we conclude that more effort should be made in the early detection and treatment of streptococcal infections.