Fractional calculus is an important branch of mathematical analysis which deals with investigations of integrals and derivatives of arbitrary order. It has been applied to almost every field of Science, Engineering and Mathematics. The aim of this paper is to study the generalized Marichev- Saigo- Maeda fractional integral operators. We will establish two theorems which give the image of the product of H-function and K-function in Saigo operators. Certain Special cases of main results are also discussed.