In recent decades, there have been a number of large-scale infectious diseases on large cruise ships, which has had a huge negative impact on the development of the cruise industry. A large number of passengers and crew members did not receive timely and adequate medical treatment, resulting in illness aggravation and even death. This paper investigates the weaknesses of luxury cruise in the field of public health and epidemic prevention in the law through the analysis of luxury cruise public health events. In the daily operation of large cruise ships, there are also some health and safety loopholes that are not taken seriously. Some shortages of the epidemic prevention and security risks are found in the field of personnel composition, the health security check during boarding, frequent flow of personnel and medical conditions aboard luxury cruise. There are some suggestions on perfecting the existing legal standard system, improving public health management, speeding up the ventilation system upgrade, improving the ability of medical, etc. The above deficiencies are found and summarized in this paper. It analyzes two cases during the COVID-19 outbreak, and gives suggestions on the prevention and control of the epidemic in the case of outbreaks of infectious diseases on luxury cruise ships. It is hoped that under the cooperation and efforts of various parties, a complete epidemic prevention system and emergency response plan will be established, which will help improve the epidemic prevention and control and response capacity of cruise ships.