Safety Index Research Articles

Effect of Belin-Ambrósio deviation index on 2-year refractive outcomes of PRK.

To assess the effect of preoperative Belin-Ambrósio deviation (BAD-D) index on 2-year visual, refractive, and tomographic outcomes, as well as the efficacy and safety of photorefractive keratectomy (PRK) surgery. Eye clinic, Mashhad, Iran. Prospective cohort study. This study included 66 patients (66 eyes) who underwent PRK surgery, with a minimum follow-up period of 2 years. Participants were divided into 2 groups: preoperative BAD-D ≥1.60 (high BAD-D) and preoperative BAD-D <1.60 (low BAD-D). Preoperative and postoperative visual, refractive, and tomographic parameters were evaluated, and the efficacy and safety of the procedure were compared between groups. 66 patients with a mean age of 35.50 ± 8.21 years (range 22 to 55 years) were included. Postoperatively, the mean spherical equivalent (SE) of refractive error was +0.32 ± 0.65 diopters (D) in the high BAD-D group and +0.18 ± 0.66 D in the low BAD-D group ( P = .40). In addition, at 2 years of follow-up, the mean uncorrected distance visual acuity was 0.98 ± 0.07 in the high BAD-D group and 0.97 ± 0.08 in the low BAD-D group ( P = .905). Among the postoperative tomographic parameters, front elevation thickness, maximum Ambrósio relational thickness, astigmatism, and central corneal thickness were significantly different between the 2 groups (all, P < .05). At the 2-year follow-up, the mean Safety Index was 1.02 ± 0.04, and 1.01 ± 0.04 in high and low BAD-D groups, respectively ( P = .37), and the mean Efficacy Index was 0.99 ± 0.07 and 0.98 ± 0.06 in high and low BAD-D groups, respectively ( P = .40). The preoperative BAD-D index does not predict postoperative visual, refractive, and tomographic outcomes in patients with low-to-moderate myopia. However, in patients with normal preoperative BAD-D values, higher agreement was expected between the attempted and achieved SE.

One-Year Visual and Refractive Outcomes of SmartPulse® Technology in Transepithelial Photorefractive Keratectomy for Myopic and Astigmatic Patients.

Background/Objectives: This study aims to evaluate the efficacy, safety, and predictability of Transepithelial Photorefractive Keratectomy (TPRK) using the SmartPulse® technology excimer laser for the correction of myopia and myopic astigmatism, assessing visual and refractive outcomes over a one-year follow-up period. Methods: This retrospective cohort study analyzed data from patients who underwent TPRK at the Ophthalmology Department-"Victor Babes" University of Medicine and Pharmacy in Timisoara (Romania), between January 2019 and June 2023. The procedure was performed using the SmartPulse® Technology of the SmartSurfACE AMARIS 750S excimer laser (SCHWIND eye-tech-solutions, Kleinostheim, Germany). Preoperative assessments included visual acuity, refraction, and corneal measurements, with postoperative evaluations conducted for up to 12 months. Results: This study included 92 eyes from 46 patients (mean age 29.02 years, 63% male). At 12 months post-op, 100% achieved UDVA 20/25 or better, with an efficacy index of 1.01. Refractive accuracy was 96% within ±0.50 D of the target and astigmatism ≤ 0.50 D in 99% of eyes. The safety index was 1.01. Corneal haze occurred in 8.70% of eyes and was effectively managed with dexamethasone drops. Conclusions: TPRK with the SmartPulse® technology excimer laser demonstrated high efficacy and safety in correcting myopia and myopic astigmatism, achieving stable visual outcomes over one year. The procedure also showed excellent predictability with a low incidence of complications, supporting its use as a reliable refractive surgery option.

Targeting Ferroptosis: Small-molecule Inducers as Novel Anticancer Agents.

Ferroptosis, a distinct form of regulated cell death characterized by iron-dependent lipid peroxidation and reactive oxygen species (ROS) accumulation, is increasingly recognized for its role in cancer development and as a potential therapeutic target. This review consolidates insights into the molecular mechanisms underpinning ferroptosis and evaluates the therapeutic potential of small-molecule inducers, such as erastin, RSL3, sulfasalazine, and sorafenib, which selectively trigger ferroptosis in cancer cells. It highlights the distinct morphological and molecular signatures of ferroptosis, its complex interplay with iron, lipid, and amino acid metabolic pathways, and the resultant implications for cancer treatment strategies. Strategic manipulation of the ferroptosis pathway offers a groundbreaking approach to cancer treatment, potentially circumventing the resistance that cancers develop against traditional apoptosis-inducing agents. Furthermore, it also emphasizes the necessity of refining these small molecules for clinical application and exploring their synergistic potential when combined with current therapies to augment overall treatment efficacy and improve patient outcomes. Ferroptosis thus emerges as a promising avenue in the realm of cancer therapy. Moving forward, research endeavors should focus on a more nuanced understanding of the interconnections between ferroptosis and other cell death modalities. Additionally, comprehensive evaluations of the long-term safety and therapeutic indices of the involved compounds are imperative. Such investigations are poised to herald a transformative shift in the paradigm of oncology, paving the way for innovative and targeted interventions.

One-year outcomes after intraocular collamer lens implantation in hyperopic astigmatism: a retrospective single-center study.

Astigmatism is the most prevalent refractive error among children and adults, and it can lead to visual impairment if left uncorrected. The management of compound hyperopic astigmatism is more challenging. This study presents the 12-month outcomes of toric implantable collamer lens (ICL) implantation in eyes with hyperopic astigmatism. This interventional case series included patients with simple or compound hyperopic astigmatism who underwent toric ICL implantation. All eligible individuals underwent a detailed ocular examination. Uncorrected and corrected distance visual acuities (UDVA and CDVA, respectively), intraocular pressure, and manifest and cycloplegic refraction results were documented. Pentacam corneal tomography was performed to assess the central corneal thickness, iridocorneal angle width, and anterior chamber depth. Endothelioscopy was performed to determine endothelial cell density. The ICL V4b model was implanted in all the included eyes. Safety and efficacy indices were calculated as postoperative CDVA/preoperative CDVA and postoperative UDVA/preoperative CDVA, respectively. Twenty-six eyes with low-grade simple or compound hyperopic astigmatism were included. All eyes experienced a significant improvement of four lines in postoperative UDVA (P < 0.001), and their postoperative CDVA remained stable at the 12-month follow-up (P > 0.05). The safety and efficacy indices were 1.0. None of the eyes lost two or more lines of CDVA; in 81% of the eyes, CDVA was unchanged, and the proportion of eyes with 20/30 or better postoperative UDVA was identical to that with 20/30 or better preoperative CDVA (81% for each). The mean manifest spherical equivalent at the 12-month postoperative visit had significantly improved (P < 0.001). The percentages of eyes with postoperative spherical equivalent within ± 0.50 D and ± 1.00 D were 81% and 96%, respectively. The postoperative refractive cylinder improved significantly (P < 0.05), and the percentage of eyes with refractive cylinder within ± 0.50 DC and ± 1.00 DC were 50% and 77%, respectively. Our outcomes indicate that toric ICL implantation is safe and effective for managing low-grade simple or compound hyperopic astigmatism. The proportion of eyes with 20/30 or better postoperative UDVA was identical to that with a 20/30 or better preoperative CDVA. The manifest spherical equivalent and refractive cylinder were significantly reduced. No serious safety concerns were observed. Further prospective large-scale studies with a wide range of ages and grades of hyperopic astigmatism are required to verify these preliminary outcomes.

Visual and patient reported outcomes provided by a refractive multifocal intraocular lens based on continuous transitional focus

PurposeTo analyze the quality of vision of patients implanted bilaterally with the multifocal Precizon Presbyopic intraocular lens (IOL), as well as to evaluate the visual performance provided by the lens.SettingVissum Miranza Alicante.DesignProspective multicenter study.Methods56 patients (mean age 65.0 ± 8.7 years old) underwent bilateral implantation with multifocal Precizon Presbyopic IOL. The quality of vision was assessed by a quality of vision questionnaire at 6 months after the implantation procedure, a complete eye examination was also performed including visual and refractive measurements, defocus curve and contrast sensitivity assessment. Visual and refractive variables were compared in preoperative, 3-month postoperative and 6-month postoperative visits by Wilcoxon test.ResultsThe quality of vision analysis showed the absence of severe glare and severe haloes in all evaluated patients. Likewise, non-symptoms of glare, haloes and starbursts were seen in 75%, 68%, and 55% of subjects, respectively. Efficacy and safety index was 1.26 and 1.42, respectively. The 6-month postoperative binocular uncorrected distance visual acuity and near uncorrected visual acuity were 0.00 ± 0.09 and 0.20 ± 0.13 logMAR, respectively. Mean spherical equivalent was 0.29 ± 0.45 D.ConclusionsThe Precizon Presbyopic NVA IOL (OPHTEC BV) provides a suitable quality of vision with a low rate of disturbance photic phenomena induction, as well as an excellent visual performance at main distances of sight accomplishing the visual demands of the majority of patients.

2-Aryl-Benzoimidazoles as Type II NADH Dehydrogenase Inhibitors of Mycobacterium tuberculosis.

The nonproton pumping type II NADH dehydrogenase in Mycobacterium tuberculosis is essential for meeting the energy needs in terms of ATP under normal aerobic and stressful hypoxic environmental states. Type II NADH dehydrogenase conduits electrons into the electron transport chain in Mycobacterium tuberculosis, which results in ATP synthesis. Therefore, the inhibition of NDH-2 ensures the abolishment of the entire ATP synthesis machinery. Also, type II NADH dehydrogenase is absent in the mammalian genome, thus making it a potential target for antituberculosis drug discovery. Herein, we have screened a commercially available library of drug-like molecules and have identified a hit having a benzimidazole core moiety (6, H37Rv mc26230; minimum inhibitory concentration (MIC) = 16 μg/mL and ATP IC50 = 0.23 μg/mL) interfering with the oxidative phosphorylation pathway. Extensive medicinal chemistry optimization resulted in analogue 8, with MIC = 4 μg/mL and ATP IC50 = 0.05 μg/mL against the H37Rv mc26230 strain of Mycobacterium tuberculosis. Compounds 6 and 8 were found to be active against mono- and multidrug-resistant mycobacterium strains and demonstrated a bactericidal response. The Peredox-mCherry experiment and identification of single-nucleotide polymorphisms in mutants of CBR-5992 (a known type II NADH dehydrogenase inhibitor) were used to confirm the molecules as inhibitors of the type II NADH dehydrogenase enzyme. The safety index >10 for the test active molecules revealed the safety of test molecules.

Study of the Micro-Vibration Response and Related Vibration Isolation of Complex Traffic Load-Induced Experimental Buildings

In view of the high-sensitivity vibration effect of precision instrument laboratory buildings under the influence of surrounding traffic loads, field micro-vibration tests under various working conditions were carried out based on actual projects. Combined with numerical simulation, measured data served as input loads to simulate the vibration effect of various traffic loads on the floor of a building structure, and the structural vibration laws under the comprehensive action of various loads were analyzed. The vibration isolation effect of the isolation ditch on the oblique orthogonal load was investigated according to the corresponding safety index. The results show that the main frequency components of the site vibration frequency caused by various traffic loads are approximately 25 Hz and that the root-mean-square speed value is stable below VC-E, which meets the design requirements. Under the comprehensive action of multiple loads, the site structure will produce a vibration amplification effect, which is obvious when all types of loads are distributed symmetrically and the curve distribution is controlled by load factors with large amplitudes. The isolation effect of a small isolation ditch is best when it is located close to the source and the building. The depth of the isolation ditch must be greater than the maximum depth of the source to achieve better results, and the width has little influence. The effect of a small isolation trench on vertical vibration is poor, and the oblique orthogonal triaxial load has a counteracting effect on the vertical component. Thus, additional structural vibration isolation measures are needed. The research results provide a reference for engineering vibration isolation, damping measures, and structural design.

Comparing Visual Outcomes of KLEx, PRK, and LASIK Procedures in the Military Population.

To assess the 6-month visual and refractive outcomes of keratorefractive lenticule extraction (KLEx) as compared to laser in situ keratomileusis (LASIK) and photorefractive keratectomy (PRK) in a military population at a Joint Warfighter Refractive Surgery Center. Joint Warfighter Refractive Surgery Center (JWRSC), Lackland Air Force Base, San Antonio, TX. Retrospective Study. Patients who underwent either KLEx, PRK, or LASIK between 2019-2022 were included. Anonymized data collected included demographics, pre- and post-operative uncorrected and corrected visual acuity, and manifest refraction. Of the 4,466 treated eyes, 737 (16.5%) underwent the KLEx, 2,801 (62.7%) underwent PRK, and 928 (20.8%) underwent LASIK treatment. In terms of efficacy, there was no statistically significant difference at post-operative month (POM)6 between the percentage of eyes reaching an uncorrected distance visual acuity (UDVA) of 20/20 or better between the three procedures. At POM1 (P < 0.001) and POM3 (P < 0.001), there were a greater number of eyes in the KLEx group that achieved the same or 1 line better of distance visual acuity than the PRK group. The efficacy index of KLEx, PRK, and LASIK at POM6 were 1.09, 1.10, and 0.97, respectively. The safety index for KLEx, PRK, and LASIK at POM6 were 0.96, 1.01, and 0.81, respectively. After the initial recovery period, KLEx demonstrates comparable outcomes in terms of efficacy, safety, and accuracy as compared to LASIK and PRK.

Assessment of Ecological Safety of Packing Materials

The issues of assessing the environmental safety of packaging materials based on life cycle analysis are considered. The results of calculations of material environmental safety indices and product ecological risk indices are given. The ecological footprint at all stages of the life cycle of the investigated packaging materials is revealed and their comparative analysis is carried out. The obtained results allow to choose the packaging material with the smallest ecological footprint during its life cycle.

Seven-year refractive outcomes comparing small incision lenticule extraction and femtosecond laser-assisted in situ keratomileusis for myopia and myopic astigmatism.

This study aimed to compare the seven-year refractive outcomes of small incision lenticule extraction (SMILE) and femtosecond laser-assisted laser in situ keratomileusis (FS-LASIK) for correction of myopia and myopic astigmatism. This retrospective cohort study included 97 eyes of 53 patients who had undergone SMILE or FS-LASIK for myopia seven years prior. Measured parameters included uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), and manifest refraction. There were no significant differences between the SMILE and FS-LASIK groups in logMAR UDVA, cylinder, and logMAR CDVA at 7 years postoperatively (P>0.05). However, there were significant differences between the two groups in sphere and spherical equivalent (P=0.035 and P=0.016, respectively). UDVA was better than or equal to 20/20 in 81% of the eyes after SMILE and in 63% after FS-LASIK (P = 0.045). The efficacy indices of the SMILE and FS-LASIK groups were 1.04 ± 0.23 and 0.97 ± 0.23 (P=0.405), and the safety indices were 1.18 ± 0.19 and 1.10 ± 0.17 (P=0.543), respectively. This study demonstrates the good predictivity of both SMILE and FS-LASIK. SMILE could offer superior refractive outcomes than FS-LASIK during a 7-year follow-up in correcting myopia and myopic astigmatism.

A hybrid approach combining UD and GA-CV-SVM to evaluate shear performance in high asphalt concrete core

The shear effect on high asphalt concrete core is significant. However, studies on the reliability of 100-meter-scale cores against shear damage remain limited. A key challenge in this research field is establishing the control criteria for the core and improving the computational efficiency of implicit limit state function (LSF). Additionally, the impact of material parameter uncertainty on the shear failure reliability of the core during the dam construction and impoundment stages remains unclear. To address this, a safety evaluation method based on time discretization was proposed, combining uniform design (UD), K-fold cross-validation (K-CV), and genetic algorithm (GA) to optimize the support vector machines (SVM). The core parameters of 52 asphalt concrete-core rockfill dams (ACCRDs) were analyzed, with the statistical values of the basic variables considered in determining the reliability index. The theoretical derivation of the critical shear failure safety index established a stability formula to assess the safety state of the dam core. The significance parameters were identified, and the sample points were generated at each stage using UD, and the Support Vector Regression (SVR) was applied to reconstruct the LSF, and reliability was calculated through the checking point method.

Study on radial deviation amplitude of out-of-roundness of resilient wheel installed on a subway vehicle based on vehicle operation safety regulation

Following the extensive use of resilient wheels on trams, several subways in China have also started to pre-launch testing of resilient wheels, while it remains to be at a beginning stage, the wheel maintenance during its long-term service has become a great concern by subway operators and wheel suppliers. An effort is presented in this paper, trying to provide an invaluable reference. Firstly, a metro vehicle-track dynamic system model fitted with the resilient wheels is built. Then, based on the operation safety index and current wheel re-profiling regulations, the influence of wheel axial and radial stiffness combination on radial deviation maximum of resilient wheel polygonization wear is analyzed. The equivalent stiffnesses of the resilient wheel involve the radial stiffness within 600 kN/mm and the axial stiffness within 100 kN/mm. The amplitude of polygonization below the 10th order on the resilient wheel is within 1 mm. A contour chart is drawn to present how the wheel weight reduction rate varies with wheel polygonization order and amplitude under different combinations of resilient wheel equivalent axial and radial stiffnesses. A series of contours is abstracted to query the amplitude limits of the polygonization of different orders on resilient wheels with different equivalent stiffnesses.

Assessment of internal disaster and emergency preparedness in hospitals using the Hospital Safety Index tool

BackgroundWhile being vital infrastructure in circumstances of crisis, health and treatment facilities' equipment is at risk of destruction, and harm to healthcare structures may prevent medical services from being delivered. Enhancements could promote resilience, and assessing current facilities for internal disaster preparedness is crucial. An evaluation of three hospitals' internal emergency and disaster preparedness is presented in this paper. MethodsHospital safety and preparedness were assessed using the World Health Organization's (WHO) Second Edition of Hospital Safety Index (HSI) tool. The safety indices were determined by three modules: emergency and disaster management, non-structural, and structural. A safety rating, represented as a probability with a maximum value of one and a minimum value of zero, is determined by adding up the weighted results. Over three days, a multi-disciplinary team performed three hospital assessments through staff interviews and visual inspections. ResultsThe study hospitals' safety indices were 0.90, 0.60, and 0.73; two were classified as Classification A, meaning they will probably be able to function in emergencies and disasters, and one was classified as Classification B, meaning that short-term intervention measures would be required to ensure the hospital's proper operation in the event of an internal disaster. This study has identified areas that must be prepared for internal disasters to increase resilience. These areas include (a) infrastructure, which has weaker protection, access, and physical security due to relatively old buildings; (b) critical systems, which have emergency response committees established by hospitals and can be improved by hospital staff receiving emergency response training; and (c) non-structural issues, which include the need to improve fuel storage, cupboard safety, shelf contents, and fitting protection. ConclusionClassification A applies to hospitals 1 and 3, whereas Classification B applies to Hospital 2. The HSI tool is a user-friendly, all-inclusive instrument offered by a reputable organisation that should be frequently used to evaluate the internal preparation of different hospitals for disasters.

Visual Outcome and Patient Satisfaction with Implantation of Trifocal Intraocular Lens After Radial Keratotomy.

To investigate the visual outcomes and patient satisfaction following trifocal intraocular lens (IOL) implantation after radial keratotomy (RK). This was a retrospective chart review wherein we studied 14 eyes from 7 patients who had undergone cataract surgery and had trifocal intraocular lens (IOL) implanted in the Eastern Province of Saudi Arabia's King Fahd University Hospital and Kahhal private centre. Data such as demographic characteristics, the time between RK and cataract removal, intraoperative and postoperative complications, preoperative and postoperative uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), and refraction were evaluated. In addition, visual complaints and satisfaction were assessed through a questionnaire. All eyes included had 8 RK sections. The mean spherical equivalent was +1.81 ± 4.27 D preoperatively and was -0.41 ± 1.2 D at the last follow-up. The mean uncorrected distance visual acuity (UDVA) increased from 0.32 ± 0.2 prior to surgery to 0.64 ± 0.2 following surgery. The mean efficacy index was 1.01 and a safety index was 1.26. In the last follow-up, 29% reported having 0.5 spherical equivalents, while 86% were within 1D. Improvement in cylindrical correction was noticed in the last follow-up with 36% not more than 0.5 D and 43% within 1D. In total, 80% of patients had a distance-corrected near visual acuity (DCNVA) of better than 20/40. The survey response rate was 100%, and two patients reported a lower degree of satisfaction. Glare and difficulty seeing at night were the most often reported complaints, with a mean of 2.86 ± 1.95 and 22 ± 1.9, respectively. Our results suggest that implantation of a trifocal IOL is safe and effective in patients with previous RK. However, several factors, including the patient's preoperative expectations, glare testing, refractive error, number of cuts, optical zone size, and visual phenomena related to RK, should be considered before implantation.

Diosgenin Alleviates Obesity-Induced Insulin Resistance by Modulating PI3K/Akt Signaling Pathway in Mice Fed a High-Fat Diet.

Obesity is a global medical issue that can be effectively treated by relieving adipose inflammation and subsequent insulin resistance. Diosgenin (DIOS) has various effects as a steroidal saponin in inflammatory disorders. This study explored the effects and mechanism of DIOS on adipose inflammation and insulin sensitivity, both in silico and in vivo. The high-fat diet-induced obesity model in C57BL/6 mice was divided into five groups: normal chow (NC), high-fat diet (HFD), HFD with atorvastatin 10 mg/kg (AT), HFD with DIOS 100 mg/kg (DIOS 100), and HFD with DIOS 200 mg/kg (DIOS 200). Each group underwent an oral intervention for seven weeks. DIOS significantly suppressed weight gain in the body, liver, and epididymal fat pads. Additionally, it significantly improved fasting glucose and insulin levels, homeostatic model assessment of insulin resistance (HOMA-IR), and oral glucose tolerance test results, and reduced the proportion of total and M1 adipose tissue macrophages. Significant changes were shown in mRNA expression of janus kinase 2 (JAK2), insulin receptor (INRS), insulin receptor substrate 1 (IRS-1), phosphatidylinositol 3-kinase (PI3K), and protein kinase B (Akt), all of which exhibited high binding affinity in the in silico. Safety indices, including aspartate aminotransferase (AST), alanine transaminase (ALT), and creatinine level indicated the preventive effects of DIOS. In conclusion, DIOS improves insulin resistance and obesity-associated inflammation via the PI3K/Akt signaling pathway.

Assessment of clinical efficacy and safety of ICL implantation in patients with relatively shallow anterior chamber depth in early and midterm postoperative time

ObjectiveTo investigate the clinical effect and safety of ICL implantation in myopic patients with relatively shallow anterior chamber depth ( ACD ). MethodsRetrospective analysis,comparative, non-interventional case series. Patients with myopia who underwent ICL implantation were included in the study and were categorized into two groups: one with a relatively shallow ACD ( 2.60 mm ≤ ACD ＜ 2.80 mm ) and the other with a normal ACD ( ACD ≥ 2.80 mm ). Each group comprised 51 eyes and were reviewed for at least 6 months. To evaluate preoperative and postoperative visual acuity, intraocular pressure ( IOP ), central vault, ACD, endothelial cell density ( ECD ) and anterior chamber angle parameters( trabecular iris angle ( TIA ), angle opening distance at 500 μm and 750 μm ( AOD500, AOD750 ), trabecular iris space area at 500 μm and 750 μm ( TISA500, TISA750 ). Analyze the trend of postoperative data changes of 1 week, 1 month, 3 months, and at least 6 months. Patients in relatively shallow ACD with vault <100 μm or >1000 μm were performed detailed follow-up. ResultThe postoperative uncorrected distance visual acuity ( UDVA ) and best corrected visual acuity ( BCVA ) surpassed the preoperative BCVA in two groups. The group differences of effectiveness index ( EI ) was p=0.409 and of safety index ( SI ) was p=0.563. The EI were 1.07 and 1.09, SI were1.10 and 1.21. Postoperative vision and refractive error were effectively corrected. The preoperative and postoperative IOP and ECD values of the two groups were within the normal range, and the preoperative and postoperative differences and the group differences of IOP and ECD were p=0.649, p=0.501, p=0.222, p=0.276. The ACD in two groups were reduced by approximately 25% and 26%, the nasal and temporal TIA were reduced to 45% and 50% approximately. The nasal and temporal AOD500, AOD750, TISA500, and TISA750 in the relatively shallow ACD group were reduced 40% approximately and in the normal ACD group were reduced to 30% approximately. All the preoperative and postoperative differences and the group differences of anterior segment parameters were statistically significant ( all p<0.01 ), with more significant anterior segment changes in normal ACD group.The postoperative data in two groups showed that when the follow-up time was prolonged, the central vault was decreasing, and the postoperative ACD was increasing, the postoperative TIA increased slowly in relatively shallow ACD group and decreased slowly in normal ACD group, temporal TIA were greater than nasal TIA, with no significant variation. There were four eyes in the relatively shallow ACD group in the remarkable abnormal postoperative central vault. Three eyes had second operation: one eye had an ICL alignment, and two eyes had ICL replacement. ConclusionPatients with relatively shallow ACD who underwent ICL implantation had fine postoperative clinical efficacy and safety.

A promising class of Antiprotozoal agents, design and synthesis of novel Pyrimidine–Cinnamoyl Hybrids

Malaria, caused by parasitic protozoans of the Plasmodium genus, continues to be one of the greatest global health crises, especially in Africa. The emergence of antimalarial drug resistance continues to be a health problem necessitating an urgent need for alternative and cost-effective antimalarials. Using a molecular hybridization approach, we report the design and synthesis of an efficacious novel class of antiprotozoal agents; (E)-1-(4-(4,6-diphenylpyrimidin-2-yl)piperazin-1-yl)-3-phenyl prop-2-en-1-one derivatives (8a-r). The in vitro inhibitory activity of the synthesized compounds was evaluated against the NF54 chloroquine-sensitive strain of Plasmodium falciparum. From the antiprotozoal screening, three compounds displayed propitious activity with IC50 values (0.18-0.21μM), using quinine and chloroquine as standard antimalarials. Compounds 8o and 8l emerged as the most potent candidates with IC50 values of 0.18 ± 0.02 μM and 0.21 ± 0.001 μM with an associated good safety index of 18.59 and 16.75 to human kidney epithelial (HEK293) cells, respectively. The synthesized analogues present a new chemical architecture structurally unrelated to the current regime of antimalarial drugs, representing a valid strategy to combat resistance in P. falciparum species to current commercial drugs. We further investigated the binding affinities of the compounds against recombinant forms of two P. falciparum heat shock protein 70 homologues; PfHsp70-1 and PfHsp70-z, both of which are essential and promising druggable candidates. Compound 8l exhibited the highest binding affinity for both PfHsp70s. Furthermore, molecular docking revealed that compounds 8k, 8l, 8m, and 8o exhibited better fitness to PfHsp70-1, with compounds 8l and 8o showing the highest binding affinity of 10.5 kcal/mol and 10.1 kcal/mol, respectively. Therefore, it can be speculated that PfHsp70-1 may be a possible target of some of the inhibitors tested in this study. The presence of electron-donating groups on the phenyl ring of 4,6-pyrimidine moiety and cinnamoyl group demonstrated a positive correlation between the observed computational data and the biological activity. Taken together, this paper demonstrates the importance of using the molecular hybridization approach in the development of newer cinnamoyl clubbed with 4,6-diphenyl pyrimidine hybrids as potential antiprotozoal agents.

Safety Assessment Approach to UAVs Based on Profust Safety Index and HIL Simulation

Safety Assessment Approach to UAVs Based on Profust Safety Index and HIL Simulation

소비자 안전보건을 위한 ESG 공시기준에의 제품안전 지표설정 연구

ESG management has now become a new management paradigm both domestically and internationally. ESG is a non-financial performance indicator to achieve corporate sustainability, and encompasses responsibilities and obligations to stakeholders. Recently, as the safety issue of overseas products imported from online shopping malls in China has emerged, the need to ensure consumer safety and health from hazardous products is increasing. Accordingly, the establishment of product safety disclosure standards for consumer protection is required in the ESG information disclosure process. In this paper, in order to establish product safety indicators for sustainability disclosure standards for ESG management, the disclosure standards of major domestic and foreign initiatives were reviewed and analyzed to examine the introduction of product safety-related indicators, and product safety indicators that can be set for consumer safety and health were developed and presented. As product safety indicators, this paper first presented the occurrence of illegal and defective products, occurrence of product accidents, block hazardous products, number of recall orders and recommendations, and recall recovery rate as indicators that can be introduced throughout the entire product life cycle. In addition, the product risk level, the number and ratio of products for which risk assessment was performed, and the methods and standards used for risk assessment were presented as indicators related to product risk that indicate the level of impact of the product on consumer safety and health. In addition, the consumer safety index was presented as an indicator related to product safety accidents that occur during the consumer product use phase. The consumer safety index is an index that allows consumers to directly feel the level of product safety due to product accidents that occur when consumers use the product. It can be said to be a product safety index from the consumer's perspective that can protect consumer safety.

Application of Interactive Psychological Exercises for Psychological Rehabilitation of Combatants

Aim. Military operations in Ukraine have caused signs of mental trauma in the combatants. Such individuals need active psychological rehabilitation involving effective methods. One of them is the use of interactive psychological simulators that help to rethink one’s perception of reality and oneself in it, learn new types of behaviour. The aim is to identify the effectiveness of using interactive psychological simulators in improving the psycho-emotional state of combatants. Methods. The following methods were employed during the diagnostics: Diagnosis of Psychological Safety of a Person (DPSP-88), Lemur-Tessier-Fillion Psychological Stress Measure (PSM25), Beck’s Depression Inventory (BDI), Taylor Manifest Anxiety Scale (TMAS). Descriptive statistics and Student’s t-test were applied for statistical processing. Results. The study proved that the use of an interactive psychological simulator by combatants increased their Psychological Safety Index (t = 8.42; p≤0.001), reduced stress (t = 4.39; p≤0.001), depression (t = 5, 14; p≤0.001), and anxiety (t = 5.43; p≤0.001). This makes it possible to expand the range of psychological rehabilitation of combatants through the introduction of psychological simulators. Conclusion. The obtained results are important for psychologists and rehabilitators, as they prove the effectiveness of the use of psychological simulators in the psychological rehabilitation of combatants. This can improve the process of psychological recovery of the military, contribute to their social and psychological adaptation, resocialisation. Based on the obtained results, it is planned to expand the possibilities of using psychological simulators in the rehabilitation of combatants. Their introduction into the mandatory system of providing assistance to victims of hostilities will reduce the time of their psychological recovery.