In the conditions of administrative reform and changes in the regulatory and legislative framework on labor relations, labor protection and industrial safety, there are conditions for changing the methods of organization and conducting state supervision in order to improve safety and preserve health at work. Ensuring information needs regarding the state of labor safety and labor relations at the enterprises of Ukraine plays an increasingly important role in the implementation of the control and supervision activities of State Labor inspectors. The purpose of the conducted research is to create instrumental means of assessing the state of labor relations and labor safety in Ukraine in order to properly organize measures of state supervision (control) on matters of labor relations and labor protection, to ensure the unity of approaches for the assessment by labor inspectors of the risks of violations of legislation by business entities. The article discusses theoretical approaches and practical implementation of the creation of a program-analytical complex of the industrial safety and health analysis system. The purpose of the system is described, and its structure is considered in detail. A description of the components of the program and analytical complex of the industrial safety and health analysis system is given, and the functional capabilities of each subsystem are given. Methodological approaches to the creation of an analytical complex of the industrial safety and health analysis system are considered in detail.