Implementing a quantitative occupational risk assessment is legislated as an employer’s responsibility nowadays. Yet, there is no unified approach to risk assessment. Employers make decision on a certain methodological approach depending on current industrial processes and existing occupational health and management system on their own. The study aims to develop a unified methodological approach to quantitative occupational risk assessment. The research methodology is based on the provisions of regulatory documents in occupational health and safety, scientific publications on occupational risk assessment. The research method involves analyzing normative and methodological literature on occupational risk management and the statistical data on occupational safety expenditures of companies. The article presents a comparison of the main available approaches used in companies to implement a quantitative occupational risk assessment. The results show there is no possibility to justify the costs of risk response activities in a vast majority of methods. The authors propose a methodological approach to occupational risk assessment based on determining the costs of ensuring life and health of employees. This approach allows to develop and substantiate activities on occupational risk reduction and the improvement of industrial safety level in a company as well as to assess the effect expected of the implementation of corrective actions. The actual vector of scientific research on the subject is to create and implement information systems for occupational risk management and decision-making support based on the developed approach in companies.