The paper presents a high-frequency modeling approach tailored for the electromagnetic (EM) scattering characteristics from electrically large radar targets coated with multi-layered anisotropic mediums (MLAMs). The approach begins by deriving the plane-wave spectrum expression for the incident EM field within MLAMs. It then employs spectral domain full-wave analysis method (SDFWAM) to obtain an analytical representation of the scattering field, further leveraging saddle point evaluation (SPE) to derive asymptotic solutions in the spatial domain. By integrating principles of physical optics (PO) and the tangent plane approximation, the far-field scattering characteristics of target enveloped in the specified medium are efficiently delineated. Validations against standard structure and the Misty satellite model reveal the method's pronounced alignment with the method of moments – finite element method (MoM-FEM) hybrid numerical algorithm, underscoring its notable computational efficiency. Furthermore, in conjunction with scattering sources decomposition technique, the approach is applied to optimize the radar cross-section (RCS) of the Su-57 aircraft, achieving precise and intelligent RCS control at minimal material cost. In conclusion, this research offers pivotal technological and theoretical foundations for EM scattering prediction, stealth design, and performance assessment in radar target domains.