Sad Mood Induction Research Articles

Emotion-Induced Frontal Alpha Asymmetry as a Candidate Predictor of Relapse After Discontinuation of Antidepressant Medication

BackgroundOne in 3 patients relapse after antidepressant discontinuation. Thus, the prevention of relapse after achieving remission is an important component in the long-term management of major depressive disorder. However, no clinical or other predictors are established. Frontal reactivity to sad mood as measured by functional magnetic resonance imaging has been reported to relate to relapse independently of antidepressant discontinuation and is an interesting candidate predictor. MethodsPatients (n = 56) who had remitted from a depressive episode while taking antidepressants underwent electroencephalography (EEG) recording during a sad mood induction procedure prior to gradually discontinuing their medication. Relapse was assessed over a 6-month follow-up period. Thirty five healthy control participants were also tested. Current source density of the EEG power in the alpha band (8–13 Hz) was extracted and alpha asymmetry was computed by comparing the power across 2 hemispheres at frontal electrodes (F5 and F6). ResultsSad mood induction was robust across all groups. Reactivity of alpha asymmetry to sad mood did not distinguish healthy control participants from patients with remitted major depressive disorder on medication. However, the 14 (25%) patients who relapsed during the follow-up period after discontinuing medication showed significantly reduced reactivity in alpha asymmetry compared with patients who remained well. This EEG signal provided predictive power (69% out-of-sample balanced accuracy and a positive predictive value of 0.75). ConclusionsA simple EEG-based measure of emotional reactivity may have potential to contribute to clinical prediction models of antidepressant discontinuation. Given the very small sample size, this finding must be interpreted with caution and requires replication in a larger study.

No evidence from a negative mood induction fMRI task for frontal functional asymmetry as a suitable neurofeedback target

Frontal functional asymmetry (FA) has been proposed as a potential target for neurofeedback (NFB) training for mental disorders but most FA NFB studies used electroencephalography while the investigations of FA NFB in functional magnetic resonance imaging (fMRI) are rather limited. In this study, we aimed at identifying functional asymmetry effects in fMRI and exploring its potential as a target for fMRI NFB studies by re-analyzing an existing data set containing a resting state measurement and a sad mood induction task of n = 30 participants with remitted major depressive disorder and n = 30 matched healthy controls. We applied low-frequency fluctuations (ALFF), fractional ALFF, and regional homogeneity and estimated functional asymmetry in both a voxel-wise and regional manner. We assessed functional asymmetry during rest and negative mood induction as well as functional asymmetry changes between the phases, and associated the induced mood change with the change in functional asymmetry. Analyses were conducted within as well as between groups. Despite extensive analyses, we identified only very limited effects. While some tests showed nominal significance, our results did not contain any clear identifiable patterns of effects that would be expected if a true underlying effect would be present. In conclusion, we do not find evidence for FA effects related to negative mood in fMRI, which questions the usefulness of FA measures for real-time fMRI neurofeedback as a treatment approach for affective disorders.

The influence of induced dysphoria on autobiographical memory specificity and social problem solving: Examining the role of executive function

Negative mood induction leads to reductions in autobiographical memory specificity (AMS) and social problem-solving (SPS). The aim was to establish if executive function contributes to changes in AMS and SPS following negative mood induction. Forty-four participants (study 1) completed the autobiographical memory test and measures of executive function (letter & category fluency) before and after a positive or negative mood induction (MI). Forty participants (study 2) completed the means-end problem solving task (MEPS) and (letter & category) fluency tasks before and after a positive or negative MI. In study 1, participants exhibited impaired AMS and fluency performance following a sad MI. Decrease in memory specificity pre-to post-MI was related to reductions in happy mood and letter fluency. In study 2, participants exhibited poorer performance on the MEPS and fluency tasks following a sad MI. Decreases in the number of relevant solutions generated on the MEPS pre-to post-MI was linked to increases in sad mood and decreases in letter fluency. In both studies, the influence of mood became non-significant once the effect of executive function was accounted for, which suggests that changes in AMS and SPS in response to induced mood were related to concomitant changes in executive function.

Thermal grill illusion of pain in patients with chronic pain: a clinical marker of central sensitization?

The thermal grill illusion of pain (TGIP) is a paradoxical burning pain sensation elicited by the simultaneous application of innocuous cutaneous warm and cold stimuli with a thermode ("thermal grill") consisting of interlaced heated and cooled bars. Its neurophysiological mechanisms are unclear, but TGIP may have some mechanisms in common with pathological pain, including central sensitization in particular, through the involvement of N-methyl- d -aspartate receptors. However, few studies have investigated TGIP in patients with chronic pain and its clinical relevance is uncertain. We hypothesized that the TGIP would be increased in comparison with controls in patients with fibromyalgia or irritable bowel syndrome, which are regarded as typical "nociplastic" primary pain syndromes related to changes in central pain processing. We compared the sensations elicited by a large range of combinations of temperature differentials between the warm and cold bars of a thermal grill applied to the hand between patients with fibromyalgia (n = 30) or irritable bowel syndrome (n= 30) and controls (n = 30). The percentage of TGIP responses and the intensity and unpleasantness of TGIP were significantly greater in patients than controls. Furthermore, positive correlations were found between TGIP intensity and clinical pain intensity and between TGIP intensity and the cold pain threshold measured on the hand. These results are consistent with our working hypothesis of shared mechanisms between TGIP and clinical pain mechanisms in patients with nociplastic chronic pain syndromes and suggest that TGIP might represent a clinical marker of central sensitization in these patients.

EEG-responses to mood induction interact with seasonality and age.

The EEG is suggested as a potential diagnostic and prognostic biomarker for seasonal affective disorder (SAD). As a pre-clinical form of SAD, seasonality is operationalized as seasonal variation in mood, appetite, weight, sleep, energy, and socializing. Importantly, both EEG biomarkers and seasonality interact with age. Inducing sad mood to assess cognitive vulnerability was suggested to improve the predictive value of summer assessments for winter depression. However, no EEG studies have been conducted on induced sad mood in relation to seasonality, and no studies so far have controlled for age. We recorded EEG and calculated bandpower in 114 participants during rest and during induced sad mood in summer. Participants were grouped by age and based on a seasonality score as obtained with the seasonal pattern assessment questionnaire (SPAQ). Participants with high seasonality scores showed significantly larger changes in EEG power from rest to sad mood induction, specifically in the alpha frequency range (p = 0.027), compared to participants with low seasonality scores. Furthermore, seasonality interacted significantly with age (p < 0.001), with lower activity in individuals with high seasonality scores that were older than 50 years but the opposite pattern in individuals up to 50 years. Effects of sad mood induction on brain activity are related to seasonality and can therefore be consider as potential predicting biomarkers for SAD. Future studies should control for age as a confounding factor, and more studies are needed to elaborate on the characteristics of EEG biomarkers in participants above 50 years.

Economic Choice and Heart Rate Fractal Scaling Indicate That Cognitive Effort Is Reduced by Depression and Boosted by Sad Mood

BackgroundPeople with depression typically exhibit diminished cognitive control. Control is subjectively costly, prompting speculation that control deficits reflect reduced cognitive effort. Evidence that people with depression exert less cognitive effort is mixed, however, and motivation may depend on state affect. MethodsWe used a cognitive effort discounting task to measure propensity to expend cognitive effort and fractal structure in the temporal dynamics of interbeat intervals to assess on-task effort exertion for 49 healthy control subjects, 36 people with current depression, and 67 people with remitted depression. ResultsPeople with depression discounted more steeply, indicating that they were less willing to exert cognitive effort than people with remitted depression and never-depressed control subjects. Also, steeper discounting predicted worse functioning in daily life. Surprisingly, a sad mood induction selectively boosted motivation among participants with depression, erasing differences between them and control subjects. During task performance, depressed participants with the lowest cognitive motivation showed blunted autonomic reactivity as a function of load. ConclusionsDiscounting patterns supported the hypothesis that people with current depression would be less willing to exert cognitive effort, and steeper discounting predicted lower global functioning in daily life. Heart rate fractal scaling proved to be a highly sensitive index of cognitive load, and data implied that people with lower motivation for cognitive effort had a diminished physiological capacity to respond to rising cognitive demands. State affect appeared to influence motivation among people with current depression given that they were more willing to exert cognitive effort following a sad mood induction.

Even when you know it is a placebo, you experience less sadness: First evidence from an experimental open-label placebo investigation

BackgroundRecent studies demonstrate substantial effects of deceptive placebo on experimentally induced sadness, even on autonomic activity. Whether deception is necessary, remains to be elucidated. We investigated the effect of an open-label placebo (OLP) treatment, i.e. an openly administered placebo delivered with a convincing rationale for its sadness-protecting effect. MethodsEighty-four healthy females were randomized to an OLP group or a no-treatment control group. All participants received the same detailed information about the OLP effect, only the OLP group received an OLP nasal spray. Before and after the OLP intervention, participants underwent a sad mood induction procedure combining self-deprecating statements (Velten's method) and sad music. Sadness was assessed by the Positive and Negative Affect Schedule (PANAS-X). Autonomic activity was measured continuously. ResultsParticipants in the OLP group reported a significantly attenuated increase in sadness upon mood induction and less sadness after induction compared to the control group (d = 0.79). Regardless of intervention, heart rate decreased during mood inductions with a more pronounced deceleration in the second mood induction. LimitationsGeneralizability is limited due to the selective sample and the reliance on an experimentally controlled mood induction. ConclusionOLP treatment had a beneficial effect on perceived sadness, at least at the subjective level. Hence, deception may not necessarily be required for placebos to modulate experienced sad mood. Investigating the beneficial effects of OLP in (sub-)clinical samples would seem a promising and required next step towards a clinical use of placebo-associated positive treatment expectations.

Suppression and acceptance in unipolar depression: Short-term and long-term effects on emotional responding.

Transdiagnostic treatments increasingly include emotion regulation training focused on use of emotional suppression and acceptance. Despite the frequent use of these treatments in depression, little is known about the effects of these strategies in this population. An experimental study. Eighty Veterans with unipolar depression participated in a study examining effects of these strategies on emotional responding (subjective, behavioural, and physiological). Physiological measures included: heart rate (HR), respiration (Resp), skin conductance (SC), and corrugator electromyography. On Day 1, participants were randomised to one of three conditions (acceptance, suppression, or control) and underwent an autobiographical sad mood induction. On Day 2, participants underwent a similar mood induction one week later. The suppression group demonstrated reduced physiological reactivity (Resp and SC) on Day 1. However, the suppression group reported decreased positive affect on Day 2. Results support short-term effectiveness and longer term costs from suppression use among depressed individuals. Findings may inform application of transdiagnostic emotion regulation treatments and suggest suppression functions differently in depressed versus other clinical populations.

Attentional bias in eating disorders: A meta-review.

This meta-review summarizes and synthesizes the most reliable findings regarding attentional bias in eating disorders across paradigms and stimulus types and considers implications for theory and future research. Four databases were systematically searched, along with reference lists of included reviews, yielding 15 systematic reviews (four of which were also meta-analyses). The quality of each review was appraised using the AMSTAR-2. Key findings from systematic reviews are summarized, organized by paradigm and stimulus type. The authors synthesize evidence from the highest-quality studies. There is evidence for attentional avoidance and vigilance in eating disorders depending on stimulus properties (low vs. high-calorie food; high-body mass vs. low-body mass index photos of others) and attentional avoidance of food stimuli in those with anorexia nervosa. Sad mood induction may generate attentional bias for food in those with binge-eating disorder. There may also be attentional bias to general threat in eating disorder samples. This meta-review concludes that most systematic reviews in this field are low in quality and summarizes the main areas that could be improved upon in future reviews. Implications of this study's findings for theory and intervention research are also discussed.

The influence of sad mood induction on task performance and metacognition.

In many situations, the ability to make appropriate metacognitive judgements on our performance is essential to make decisions and adapt our behaviour. Past research suggests a strong relationship between metacognition and emotional disorders such as depression. Depressive disorders have been associated with an underestimation bias: depressive patients report lower confidence in their performance than healthy individuals. It is currently not clear whether the induction of a negative mood in healthy participants has similar consequences. Yet, such knowledge would permit to isolate the causal influence of the negative affect on metacognition, free of all the comorbidities associated with depression. In this study, we used a combination of films, pictures, and recalls to induce negative and neutral moods during a perceptual metacognitive task. Negative mood induction had no impact on the perceptual task. Participants did report lower confidence levels in the negative condition compared with a neutral condition. This study thus confirms a causal relationship between negative affect and metacognitive abilities.

How Drawing to Distract Improves Mood in Children.

Previous research has shown that drawing improves short-term mood in children when used to distract from rather than express negative thoughts and feelings. The current study sought to examine (a) how drawing might elevate mood in children ages 6–12 by examining the role played by absorption, enjoyment, and perceived competence as well as entering an imaginary world; and (b) whether children spontaneously use drawing to distract from a sad mood. Across three studies, children were asked to think of a disappointing event. After a sad mood induction, they drew for 5 min. Mood was measured before and after the mood induction and after drawing. Three main findings emerged. First, drawing to distract led to greater absorption and enjoyment than did drawing to express. Second, children’s mood improved equally when drawing imaginary and real scenes showing that the key ingredient is that the content of the drawings be distracting in nature. Third, drawing improved mood even when children were given no instructions on the content of their drawings and children were more likely to use drawing as a way to distract themselves from a sad mood. These studies help to define the characteristics of drawing activities that foster mood improvement in children and highlight the important role of the arts in emotion regulation.

Mood Induction Differently Affects Early Neural Correlates of Evaluative Word Processing in L1 and L2.

We investigate how mood inductions impact the neural processing of emotional adjectives in one’s first language (L1) and a formally acquired second language (L2). Twenty-three student participants took part in an EEG experiment with two separate sessions. Happy or sad mood inductions were followed by series of individually presented positive, negative, or neutral adjectives in L1 (German) or L2 (English) and evaluative decisions had to be performed. Visual event-related potentials elicited during word processing were analyzed during N1 (125–200 ms), Early Posterior Negativities (EPN, 200–300 ms and 300–400 ms), N400 (350–450 ms), and the Late Positive Potential (LPP, 500–700 ms). Mood induction differentially impacted word processing already on the N1, with stronger left lateralization following happy than sad mood induction in L1, but not in L2. Moreover, regardless of language, early valence modulation was found following happy but not sad mood induction. Over occipital areas, happy mood elicited larger amplitudes of the mood-congruent positive words, whereas over temporal areas mood-incongruent negative words had higher amplitudes. In the EPN-windows, effects of mood and valence largely persisted, albeit with no difference between L1 and L2. N400 amplitude was larger for L2 than for L1. On the LPP, mood-incongruent adjectives elicited larger amplitudes than mood-congruent ones. Results reveal a remarkably early valence-general effect of mood induction on cortical processing, in line with previous reports of N1 as a first marker of contextual integration. Interestingly, this effect differed between L1 and L2. Moreover, mood-congruent effects were found in perceptual processing and mood-incongruent ERP amplification in higher-order evaluative stages.

Memory improvement in aging as a function of exposure to mood-matching music

This study examined the effect of matching musical emotion and the mood of the listener on working memory and free recall in normal aging. Memory measures were taken at baseline in healthy young and older participants, and, following a happy or sad mood induction, again after exposure to both mood-matching and -mismatching music in a counterbalanced repeated measures design. Compared to baseline, [i] recall was greater following mood-matching than mood-mismatching music in both groups, and was reduced following mood-mismatching music in older adults, [ii] working memory was greater in the mood-matching condition, but did not differ from baseline in the mismatching condition. The results have significant implications for the increasingly popular forms of intervention involving music used with older populations experiencing cognitive decline.

Sympathetic arousal during the processing of dysphoric affect by youths at high and low familial risk for depression.

Youths at high risk for depression have been shown to have problems in repairing their own sad mood. Given that sympathetic arousal has been implicated both in the experience and regulation of affect, an atypical pattern of arousal may be one of the factors that contribute to mood repair problems. In the current study, we measured sympathetic arousal of never-depressed youths at high (n=56) and low (n=67) familial risk for depression during sad mood induction and instructed mood repair. Sympathetic arousal was indexed by skin conductance level (SCL) and cardiac pre-ejection period (PEP); mood repair outcome was indexed by self-rated affect. High-risk youths demonstrated increased SCL during sadness induction, which persisted during mood repair; low-risk youths evidenced increased SCL only during mood repair. Shortened PEP was evident only among high-risk youths and only during mood repair. Furthermore, shortened PEP during mood induction predicted less successful mood repair in the low-risk but not in the high-risk group. The findings suggest that: (a) depression-prone youths differ from control peers in patterns of sympathetic responses to emotional stimuli, which may impair their ability to relieve sadness, and (b) activation patterns differ across subsystems (SCL vs. PEP) of sympathetic activity, in conjunction with depression risk status.

Does An Acute Bout Of Aerobic Exercise Bolster Reactivity To A Sad Mood Induction In Clinically Depressed Individuals? A Study Of Responders And Non-responders

Does An Acute Bout Of Aerobic Exercise Bolster Reactivity To A Sad Mood Induction In Clinically Depressed Individuals? A Study Of Responders And Non-responders

Sad mood and poor sleep are related to task-unrelated thoughts and experience of diminished cognitive control

Previous studies have indicated that a sad mood and sleep deprivation increase mind wandering, but it is unclear whether these associations reflect reduced effort in concentrating on the task at hand or diminished cognitive control. In an internet-based experiment, participants completed a sleep disturbance questionnaire followed by a complex span task and a 2-back task with thought-sampling probes. Subsequently, participants underwent a positive, neutral, or negative mood induction prior to repeating the 2-back. The results (N = 504) replicated the finding of increased task-unrelated thoughts following sad mood induction, B = 0.56 (SE = 0.14), p < 0.01, d = 0.31. Unguided thoughts were increased following sad mood induction, B = 0.31 (0.13), p = 0.02, but working memory did not significantly moderate this association (p = 0.31). People reported a lower degree of trying to concentrate on the 2-back after the sad mood induction, B = −0.07 (0.04), p = 0.04, but actual performance was not affected (p = 0.46). Sleep disturbances showed small associations with task-unrelated, B = 0.23 (0.08), p < 0.01, and unguided thoughts, B = 0.32 (0.08), p < 0.01. This study strengthens the evidence that a sad mood and poor sleep relate to mind wandering.

Body image-related cognitive fusion and disordered eating: the role of self-compassion and sad mood.

The extent to which body image-related thoughts are endorsed and drive behaviors, a process known as Body Image-Related Cognitive Fusion (BI-CF), is an important contributor to disordered eating. Moreover, negative mood and negative self-referential processes (e.g., low self-compassion) have been reportedly associated with disordered eating; however, their associations with BI-CF are not known. The aim of this study was to investigate, among young adults, the association between (1) BI-CF and disordered eating attitudes and behaviors (2) BI-CF and self-compassion, and (3) whether sad mood influences BI-CF. Participants completed online questionnaires that assessed BI-CF, self-compassion, negative affect, cognitive reactivity and disordered eating (N = 601). A subsample (n = 51) underwent an in-lab session in which they were exposed to a validated psychological sad mood induction task followed by the assessment of BI-CF. 67.8% of variation in disordered eating was accounted for by BI-CF while controlling for covariates. Self-compassion was the strongest predictor of BI-CF levels, irrespective of other eating disorder or depression risk factors (p < 0.001). Increases in sad mood did not influence levels of BI-CF. The endorsement of body image-related thoughts seems to play an important role in disordered eating. Compassionate self-responding may have positive influences on reducing negative body image-related thoughts. Furthermore, BI-CF appears to be a relatively stable phenomenon, irrespective of change in mood state. Results offer implications for the improvements in prevention and intervention models targeted towards disordered eating through self-compassion and cognitive defusion. Part I:Level V, cross-sectional descriptivestudy. Part II: Level I, experimental study.

Ambiguity Processing Bias Induced by Depressed Mood Is Associated with Diminished Pleasantness

Depressed individuals are biased to perceive, interpret, and judge ambiguous cues in a negative/pessimistic manner. Depressed mood can induce and exacerbate these biases, but the underlying mechanisms are not fully understood. We theorize that depressed mood can bias ambiguity processing by altering one’s subjective emotional feelings (e.g. pleasantness/unpleasantness) of the cues. This is because when there is limited objective information, individuals often rely on subjective feelings as a source of information for cognitive processing. To test this theory, three groups (induced depression vs. spontaneous depression vs. neutral) were tested in the Judgement Bias Task (JBT), a behavioral assay of ambiguity processing bias. Subjective pleasantness/unpleasantness of cues was measured by facial electromyography (EMG) from the zygomaticus major (ZM, “smiling”) and from the corrugator supercilii (CS, “frowning”) muscles. As predicted, induced sad mood (vs. neutral mood) yielded a negative bias with a magnitude comparable to that in a spontaneous depressed mood. The facial EMG data indicates that the negative judgement bias induced by depressed mood was associated with a decrease in ZM reactivity (i.e., diminished perceived pleasantness of cues). Our results suggest that depressed mood may bias ambiguity processing by affecting the reward system.

Elated or sad mood induction affects the attention of patients with a bipolar disorder less than that of patients with a depressive disorder

ABSTRACTIntroduction: The role of acute mood states as mediating factors in cognitive impairment in patients with mania or depression is not sufficiently clear. Similarly, the extent to which cognitive impairment is trait or state-specific remains an open question. Therefore, the aim of this study was to investigate the effect of a mood-induction on attention in patients with an affective disorder.Methods: Twenty-two depressed bipolar patients, 10 manic bipolar patients, 17 with a depressive episode (MDE), and 24 healthy controls performed the Attention-Network-Test (ANT). In a within-participants design, elated and sad moods were induced by an autobiographic recall and measured on a self-report scale. Subsequently, participants performed the ANT again.Results: The modulating effect of the elated mood induction on attention was small. Only the MDE group displayed moderate improvements in selective attention and tonic alertness. Surprisingly, after the sad mood induction, patients with MDE improved moderately on phasic and tonic alertness. Phasic alertness was also enhanced in patients with mania. Finally, after the mood induction, patients with MDE showed the largest variability in attentional performance.Conclusions: Results showed only small effects of mood induction on attention. This supports the view that attention deficits reflect trait variables.

The persistence of hedonically-based mood repair among young offspring at high- and low-risk for depression

ABSTRACTThe aim of the present study was to examine whether offspring at high and low familial risk for depression differ in the immediate and more lasting behavioural and physiological effects of hedonically-based mood repair. Participants (9- to 22-year olds) included never-depressed offspring at high familial depression risk (high-risk, n = 64), offspring with similar familial background and personal depression histories (high-risk/DEP, n = 25), and never-depressed offspring at low familial risk (controls, n = 62). Offspring provided affect ratings at baseline, after sad mood induction, immediately following hedonically-based mood repair, and at subsequent, post-repair epochs. Physiological reactivity, indexed via respiratory sinus arrhythmia (RSA), was assessed during the protocol. Following mood induction and mood repair, high- and low-risk (control) offspring reported comparable changes in levels of sadness and RSA. However, sadness increased among high-risk offspring following the post-repair epoch, whereas low-risk offspring maintained mood repair benefits. High-risk/DEP offspring also reported higher levels of sadness following the post-repair epoch than did low-risk offspring. Change in RSA did not differ across the three offspring groups. Self-ratings confirm that one source of difficulty associated with depression risk is diminished ability to maintain hedonically-based mood repair gains, which were not apparent at the physiological level.