Background: Frozen shoulder is a common reason for shoulder pain and impairment. Several treatments are used to relieve pain and enhance range of motion (ROM) in patients. Recent study has focused on the injection of platelet-rich plasma (PRP). Aim of the Study: The goal of this study is to find out the impact and possible outcome of PRP treatment in frozen shoulder management. Methods: This study was conducted in TMSS Medical College and Rafatullah Community Hospital, Bogura, Bangladesh, from January 2019 to December 2019. In the study, 65 patients in stages I or II with frozen shoulder were treated with PRP. All acquired data was entered into a Microsoft Excel work sheet and evaluated with descriptive statistics in SPSS 11.5. Results: The majority of the participants (84.62%) were female, with 15.38% being male. The average age of the participants was 57.45 years. The investigation comprised participants who received PRP injections for frozen shoulder (62.4% right limb, 37.6% left limb). Before therapy, the average flexion was around 61°, abduction was 70°, and external rotation was 21°. Furthermore, the baseline scores for VAS, DASH, and the SF-12 Health Survey questionnaire were 9.41, 64.86, and 24 correspondingly. All patients demonstrated significant improvement in shoulder ROM, discomfort, and function (p < 0.001). Conclusion: This case series study found a significant improvement in pain and disability outcomes for individuals after PRP injection. These findings support PRP as a safe therapy protocol that reduces pain and improves upper limb function. It can also increase shoulder range of motion.