S-benzyldithiocarbazate (SBDTC) and S-methyldithiocarbazate (SMDTC) are working as a preliminary reactant for the synthesis of several Schiff base ligands. SBDTC and SMDTC can act as NS, SNNS, SNNNS, and NOS chelating agents and have biological and chemical potential for synthesizing many transition and inner transition metal complexes. The metal complexes prepared from SBDTC, SMDTC, and their derivatives have shown promising biological activities like antibacterial, cytotoxicity, antioxidant, antitumor, and anticancer activity. Last few decades, a lot of works have been reported on SBDTC and SMDTC containing Schiff base metal complexes. In this review, it is cosidered to show the various synthesis procedures, and structural and biological activities of SBDTC and SMDTC-containing metal complexes.