The Vostochny Space Center is a new facility of the Russian space industry, which began launching space technology in 2016. In the normal operation of the cosmodrome, the impact of rocket fuel components on personnel, taking into account the data of sanitary and hygienic monitoring, is not expected, however, the influence of a chemical factor is possible in cases of emergency situations. The purpose of the study is a hygienic assessment of the impact of harmful and dangerous factors of the production environment on the health of the personnel of the Vostochny cosmodrome using an information and analytical system of sanitary and hygienic monitoring. The study was based on the classical methodological basis of a comprehensive sanitary and epidemiological assessment of the production environment. The analysis showed the absence of differences in the levels and dynamics of morbidity by the main classes of the disease, the absence of professionally determined pathology, which indicates the sufficiency of the complex of organizational, technical and sanitary measures implemented during the creation of the Vostochny Space Center. Thus, the introduction of information and analytical approaches to the organization and implementation of monitoring studies makes it possible to obtain the necessary comprehensive information, timely and fully record the impact of negative factors of the production environment on employees, and perform a comprehensive assessment of the health status of the personnel of the Vostochny cosmodrome.