The El Niño and Southern Oscillation (ENSO), a phenomenon of air–sea coupling in the tropical Pacific, has strong response to global climate change. In this study, the primary region where ENSO occurred during the period 1955–2020 was selected as the key ENSO region, and the changes in air–sea coupling in this region were explored. The New Southern Oscillation Index (NSOI), modified from the previous Southern Oscillation Index, represents atmospheric changes, and the Niño-3.4 index represents oceanic changes. The absolute value of the running correlation coefficient between the Niño-3.4 index and NSOI in the 121-month time window was defined as the Intensity of Air–Sea Coupling (IASC) in the key ENSO region. The results showed that the IASC has significantly increased, with a confidence level of 95%, during the period 1955–2020, and the range where the correlation coefficient between the Niño-3.4 index and the sea level pressure anomaly over the key ENSO region was greater than 0.6 has evidently expanded in the context of global warming, which corresponded to the increase in IASC. Moreover, the coupling positions of sea surface temperature and wind anomalies changed, tending to the east of the equatorial Pacific during 1977–1998, and to the west during 1999–2020.