This experiment was conducted to determine the blood chemistry and carcass characteristics of broilers fed malted sorghum sprouts (MSP) or wheat offal (W/O)-based diets supplemented with yeast culture and enzyme. A total of two hundred and forty 28-day old, Marshal Broiler chickens used for the experiment were randomly allotted to 8 dietary treatment groups of 30 birds each. Each treatment group was replicated thrice with 10 birds per replicate. Data on selected blood indices and carcass traits of the birds were collected during the course of the feeding trial that lasted for 4 weeks. The experiment was a 2X4 factorial consisting of two (2) test ingredients (MSP and wheat offal) at 4 inclusion levels of enzyme or yeast (0g kg-1, +0.01gkg-1 yeast and Roxazyme G2(G) enzyme, +0.01gkg-1 yeast ,+ Roxazyme G2(G) enzyme. At the end of the trial, the effect of MSP and wheat offal inclusion showed a significant effect (P<0.05) for uric acid, WBC, Total protein, albumin and globulin. However, uric acid, total protein, Albumin and Globulin were highest for wheat offal diet. Furthermore, the results show that values obtained for white blood cell, uric acid, total protein, albumin, globulin, creatinine, ALT& AST were significantly (P<0.05) affected by the enzyme, yeast and their combination. The carcass results show that none of the parameters measured differed significantly. In conclusion, supplementation with yeast + enzyme improves total protein, albumin and globulin. Meanwhile, it reduced concentrations of uric acid, ALT and AST by broiler chickens. Therefore MSP diet should be supplemented with yeast+ enzyme or enzyme singly to improve Livestock ration for better utilisation.