To maintain high quality in mammography, a routine quality control program is necessary to detect drifting or degradation of system performance overtime and it is becoming more important especially when the machine is used for population screening, a large number of asymptomatic women will receive a large amount of dose. Therefore, the importance of optimization of image quality and minimization of radiation dose is essential to accomplish the goals of mammography screening, and this require to have and make sure that the Mammography X-ray machine working properly and stable. Due to advances in technology, the regulation and testing of digital mammography systems has become complicated. Not only does each mammographic X-ray unit model have its own test protocol, peripheral equipment must also be tested according to manufacturer specifications. And this program must be followed in detail by both physicists testing the device and other clinical users performing routine QC functions on a daily basis. In this lecture the Mammography QC testing program will be discussed and recent advances in the automation of QC measurements by some manufacturers will be highlighted.