The objective of this study is to evaluate the effect of cross-blade slot casing treatment on the stability and performance of an axial flow compressor rotor. The experimental and unsteady calculated results both show that cross-blade slot casing treatment can generate about 22% stall margin improvement, and the compressor peak efficiency is reduced by about 13%. The detailed flow-field analyses indicate that the sucked and injected flow caused by the slots of cross-blade slot casing treatment can restrain the rotor tip passage blockage, which is made by the low energy tip clearance leakage vortex. When cross-blade slot casing treatment is applied, not only the rotor wheel flange work becomes lower in most of the rotor blade span, but also the flow loss in the blade tip passage becomes fairly large due to the strong interaction between the mainstream and the injected flows made by the slots. As a result, the compressor total pressure ratio and efficiency for cross-blade slot casing treatment are reduced obviously. Three kinds of new cross-blade slot casing treatment were designed according to the previous successful experience and investigated in this paper. The numerical results show that the new three cross-blade slot casing treatments both generate about 54% stall margin improvement at the cost of minor peak efficiency. For one new cross-blade slot casing treatment (CSCT2), the compressor peak efficiency is reduced by about 0.3%. The low energy TLV, which is present for cross-blade slot casing treatment, is removed by the strong sucked flow made by CSCT2. Moreover, the interaction between the mainstream and the injected flows caused by CSCT2 becomes weak obviously, and the corresponding flow loss is reduced greatly. Hence, the compressor stability and performance with CSCT2 are higher than those with cross-blade slot casing treatment.