The dramatic abnormal grain growth (AGG) in longitudinal weld of 2196 Al-Cu-Li extrusion profiles during solution treatment leads to performance deterioration. In this paper, the profile was subjected to cold rolling with different reduction along transverse direction (TD) and extrusion direction (ED) before T6 treatment, and the effects of above processes on the AGG behavior were clarified. The cold rolling changed the morphology and orientation of grains in the longitudinal weld area, and the number of Cube grains that can work as AGG precursor decreased. Meanwhile, numerous dislocations and stored strain energy promoted the DRX of the whole section, thus AGG process transformed to synchronous grain growth. However, the increasing grain boundary energy stimulated grain growth, thus this method could not suppress AGG completely. Grains of welding area have special rotation path when they were cold rolled along ED, the Cube grains transformed to the Copper grains during rolling, hence the growth advantage of welding area disappeared and then transformed to R-Copper texture after solution treatment, which improved the homogeneity of microstructure, thereby removed the local strain concentration and local brittle failure of welding area induced by AGG, and improved the comprehensive properties of the profiles.